ID   BSHC_SYMTH              Reviewed;         556 AA.
AC   Q67L72;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Putative cysteine ligase BshC {ECO:0000255|HAMAP-Rule:MF_01867};
DE            EC=6.-.-.- {ECO:0000255|HAMAP-Rule:MF_01867};
GN   Name=bshC {ECO:0000255|HAMAP-Rule:MF_01867}; OrderedLocusNames=STH2589;
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC   Symbiobacterium.
OX   NCBI_TaxID=292459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863;
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K.,
RA   Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium
RT   that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- FUNCTION: Involved in bacillithiol (BSH) biosynthesis. May catalyze the
CC       last step of the pathway, the addition of cysteine to glucosamine
CC       malate (GlcN-Mal) to generate BSH. {ECO:0000255|HAMAP-Rule:MF_01867}.
CC   -!- SIMILARITY: Belongs to the BshC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01867}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD41574.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP006840; BAD41574.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_043714106.1; NC_006177.1.
DR   AlphaFoldDB; Q67L72; -.
DR   SMR; Q67L72; -.
DR   STRING; 292459.STH2589; -.
DR   EnsemblBacteria; BAD41574; BAD41574; STH2589.
DR   KEGG; sth:STH2589; -.
DR   eggNOG; COG4365; Bacteria.
DR   HOGENOM; CLU_022249_1_0_9; -.
DR   OMA; TTGHQLN; -.
DR   OrthoDB; 295429at2; -.
DR   Proteomes; UP000000417; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01867; BshC; 1.
DR   InterPro; IPR011199; Bacillithiol_biosynth_BshC.
DR   Pfam; PF10079; BshC; 1.
DR   PIRSF; PIRSF012535; UCP012535; 1.
DR   TIGRFAMs; TIGR03998; thiol_BshC; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ligase; Reference proteome.
FT   CHAIN           1..556
FT                   /note="Putative cysteine ligase BshC"
FT                   /id="PRO_0000378271"
FT   COILED          408..442
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
FT   COILED          468..513
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01867"
SQ   SEQUENCE   556 AA;  62442 MW;  38C9C55FE74FEAC6 CRC64;
     MHIERVPGIA LSPSGAVAAY LGDWARVAPA YEYDWRRQES FERRAAYLTG GGYAGDRAAV
     AAALERYNRA LGADEASLEN ARLLGRPETL AAVTGQQAGI LTGPAYSIYK AMTTIRLARQ
     QSQRLGVPVV PVFWIAGEDH DWHEVSWVMV PAGNETRRLA LSERFDGERR SVALAPMPAS
     VSDLIDEFAQ LMPDTEFKEE VIAHLREAAV GGPALDPEAT GGAPSLADWF GRLMAWVFRG
     TGLVFLNSSD PALRRIEAPF FARALQQQAE VEAACAAGVD RWERELGFAC TVEQTPNSLN
     LFIYIDGERL PLLGEGDRVW VRGRPDLSWS RSELVDLALR SPERFSTNVV LRPVVQSYLL
     PDLFYVGGPG EISYFGLLRD VYRAMGRQMP VVVPREGFTL VEPPIARILQ KHELTLDDAF
     HRLDDLRQEL LEREDRLGIA QAFASFRQDF ERRHAELAAL VLQLDPGLGQ VVEENRRQIE
     HQINRLEEKA KQQHRKNCET ALRQFDRLKA NLTPNGLQER AFSILPYLVK YGPDLVRRLV
     DEVPLEEGWS HRAIYL