BSH_CHICK
ID BSH_CHICK Reviewed; 233 AA.
AC Q6RFL5;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Brain-specific homeobox protein homolog;
GN Name=BSX {ECO:0000312|EMBL:AAR89086.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000312|EMBL:AAR89086.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Forebrain {ECO:0000312|EMBL:AAR89086.1};
RA Assimacopoulos S., Ragsdale C.W.;
RT "Identification of vertebrate homologs of the Drosophila brain-specific
RT homeobox gene.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA binding protein that function as transcriptional
CC activator. May play a role in the determination and function of cell
CC types in the brain. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q810B3}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000255}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Of fidgets and food - Issue
CC 85 of August 2007;
CC URL="https://web.expasy.org/spotlight/back_issues/085";
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DR EMBL; AY500594; AAR89086.1; -; mRNA.
DR RefSeq; NP_989843.1; NM_204512.1.
DR AlphaFoldDB; Q6RFL5; -.
DR SMR; Q6RFL5; -.
DR STRING; 9031.ENSGALP00000010513; -.
DR PaxDb; Q6RFL5; -.
DR Ensembl; ENSGALT00000010527; ENSGALP00000010513; ENSGALG00000006515.
DR GeneID; 395183; -.
DR KEGG; gga:395183; -.
DR CTD; 390259; -.
DR VEuPathDB; HostDB:geneid_395183; -.
DR eggNOG; KOG0491; Eukaryota.
DR GeneTree; ENSGT00940000161473; -.
DR HOGENOM; CLU_104234_0_0_1; -.
DR InParanoid; Q6RFL5; -.
DR OMA; DLPGKHC; -.
DR OrthoDB; 1572711at2759; -.
DR PhylomeDB; Q6RFL5; -.
DR TreeFam; TF350735; -.
DR PRO; PR:Q6RFL5; -.
DR Proteomes; UP000000539; Chromosome 24.
DR Bgee; ENSGALG00000006515; Expressed in granulocyte.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..233
FT /note="Brain-specific homeobox protein homolog"
FT /id="PRO_0000048843"
FT DNA_BIND 110..170
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 164..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 26452 MW; 7CF5E9DA4953AB6C CRC64;
MNLNFTSPVH PVPAPRPTSF FIEDILLHKP KPLREVPPEH FAGSLASRVP LLDYGYPLMP
APALLAPHPH PALHKPEHHH HHPYFLTTSG VPVPALFPHH AHAELPGKHC RRRKARTVFS
DSQLSGLEKR FEIQRYLSTP ERVELATALS LSETQVKTWF QNRRMKHKKQ LRKSQDDPIH
EENREQSSPE PELPEPAAAE PRKGPPGPFL LQDPEDEVDI LEEGDILAAP HRL
