ID   BSH_DANRE               Reviewed;         227 AA.
AC   Q6R3Q6;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Brain-specific homeobox protein homolog;
GN   Name=bsx {ECO:0000312|EMBL:AAR99056.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAR99056.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo {ECO:0000269|Ref.1};
RA   Assimacopoulos S., Ragsdale C.W.;
RT   "Identification of vertebrate homologs of the Drosophila brain-specific
RT   homeobox gene.";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA binding protein that function as transcriptional
CC       activator. May play a role in the determination and function of cell
CC       types in the brain. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q810B3}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000255}.
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DR   EMBL; AY515251; AAR99056.1; -; mRNA.
DR   RefSeq; NP_999892.1; NM_214727.1.
DR   AlphaFoldDB; Q6R3Q6; -.
DR   SMR; Q6R3Q6; -.
DR   STRING; 7955.ENSDARP00000090755; -.
DR   PaxDb; Q6R3Q6; -.
DR   Ensembl; ENSDART00000099983; ENSDARP00000090755; ENSDARG00000068976.
DR   Ensembl; ENSDART00000185401; ENSDARP00000149609; ENSDARG00000110782.
DR   GeneID; 573364; -.
DR   KEGG; dre:573364; -.
DR   CTD; 390259; -.
DR   ZFIN; ZDB-GENE-040628-4; bsx.
DR   eggNOG; KOG0491; Eukaryota.
DR   GeneTree; ENSGT00940000165707; -.
DR   HOGENOM; CLU_104234_0_0_1; -.
DR   InParanoid; Q6R3Q6; -.
DR   OMA; DLPGKHC; -.
DR   OrthoDB; 1572711at2759; -.
DR   PhylomeDB; Q6R3Q6; -.
DR   PRO; PR:Q6R3Q6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000068976; Expressed in brain and 5 other tissues.
DR   ExpressionAtlas; Q6R3Q6; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0021982; P:pineal gland development; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..227
FT                   /note="Brain-specific homeobox protein homolog"
FT                   /id="PRO_0000048842"
FT   DNA_BIND        103..163
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          157..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   227 AA;  26469 MW;  6B46CBA1BD93263E CRC64;
     MNLNYTSPVP QMPTQRSTSF FIEDILLHKP KPLREVFPSP FSNSIASRMP LLEYGYPLMP
     TPILAPHPHH PLHKPEHHPY FFTSGMQMPA LFQHHPELPG KHCRRRKART VFSDSQLSGL
     EKRFEIQRYL STPERVELAT ALSLSETQVK TWFQNRRMKH KKQLRKTQDD QKTPNDVDRS
     LENTSESEMH EKNTDGKNGM SPDRYTLDDN EDDVDIEDDI CSPEHLL