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BSH_DROME
ID   BSH_DROME               Reviewed;         429 AA.
AC   Q04787; Q4V6V3; Q7KT32; Q9VIS2;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 5.
DT   03-AUG-2022, entry version 181.
DE   RecName: Full=Brain-specific homeobox protein;
GN   Name=bsh; ORFNames=CG10604;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-429, FUNCTION, TISSUE SPECIFICITY,
RP   AND DEVELOPMENTAL STAGE.
RC   STRAIN=Oregon-R;
RX   PubMed=8101170; DOI=10.1242/dev.117.2.793;
RA   Jones B., McGinnis W.;
RT   "A new Drosophila homeobox gene, bsh, is expressed in a subset of brain
RT   cells during embryogenesis.";
RL   Development 117:793-806(1993).
CC   -!- FUNCTION: DNA binding protein that function as transcriptional
CC       activator (By similarity). May play a role in the determination and
CC       function of cell types in the brain. {ECO:0000250,
CC       ECO:0000269|PubMed:8101170}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Embryonic brain; accumulates in approximately 30
CC       cells in each brain hemisphere. One of these cells is closely
CC       associated with the terminus of the larval visual nerve (Bolwig's
CC       nerve). {ECO:0000269|PubMed:8101170}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis with very low
CC       levels found in the larva and adult. {ECO:0000269|PubMed:8101170}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB59219.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE014134; AAF53843.3; -; Genomic_DNA.
DR   EMBL; AE014134; AAS64721.2; -; Genomic_DNA.
DR   EMBL; BT022203; AAY51597.1; -; mRNA.
DR   EMBL; L06475; AAB59219.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; NP_477350.2; NM_058002.3.
DR   RefSeq; NP_995728.2; NM_206006.2.
DR   AlphaFoldDB; Q04787; -.
DR   SMR; Q04787; -.
DR   BioGRID; 61242; 29.
DR   DIP; DIP-17210N; -.
DR   IntAct; Q04787; 7.
DR   STRING; 7227.FBpp0088920; -.
DR   PaxDb; Q04787; -.
DR   DNASU; 35266; -.
DR   EnsemblMetazoa; FBtr0089320; FBpp0088920; FBgn0000529.
DR   EnsemblMetazoa; FBtr0343855; FBpp0310398; FBgn0000529.
DR   GeneID; 35266; -.
DR   KEGG; dme:Dmel_CG10604; -.
DR   CTD; 35266; -.
DR   FlyBase; FBgn0000529; bsh.
DR   VEuPathDB; VectorBase:FBgn0000529; -.
DR   eggNOG; KOG0491; Eukaryota.
DR   GeneTree; ENSGT00940000165097; -.
DR   HOGENOM; CLU_049799_0_0_1; -.
DR   InParanoid; Q04787; -.
DR   OMA; CLMQQGY; -.
DR   OrthoDB; 858478at2759; -.
DR   PhylomeDB; Q04787; -.
DR   Reactome; R-DME-8853884; Transcriptional Regulation by VENTX.
DR   SignaLink; Q04787; -.
DR   BioGRID-ORCS; 35266; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 35266; -.
DR   PRO; PR:Q04787; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0000529; Expressed in embryonic brain and 2 other tissues.
DR   Genevisible; Q04787; DM.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IMP:UniProtKB.
DR   GO; GO:0048663; P:neuron fate commitment; IMP:FlyBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..429
FT                   /note="Brain-specific homeobox protein"
FT                   /id="PRO_0000048841"
FT   DNA_BIND        274..333
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          326..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..194
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..401
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        301
FT                   /note="T -> P (in Ref. 4; AAB59219)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   429 AA;  45714 MW;  32CF539EE0DEE572 CRC64;
     MAMLNEASLS PADAHAHANA TTPTHSKAAA MASATTMLTT KTPFSIEHIL FQNLNSASNN
     NNSSDTNGIA ANTNNYAPKS SRNAVKSARS AFAHDNNPHK HPSQHSHPPQ SHPPASASAS
     ATATARSNQA ASGYAGEDYG KSMHSTPRSN HHSRHGTSHY NGDQISQQLG SGAAQHPPVP
     TTQPQPPPPP PLNGGSGASN GVLYPNAPYT DHGFLQMTLG YLSPSSGTYK SVDPYFLSQA
     SLFGGAPFFG APGCVPELAL GLGMGVNALR HCRRRKARTV FSDPQLSGLE KRFEGQRYLS
     TPERVELATA LGLSETQVKT WFQNRRMKHK KQLRRRDNAN EPVDFSRSEP GKQPGEATSS
     SGDSKHGKLN PGSVGGTPTQ PTSEQQLQMC LMQQGYSTDD YSDLEADSGD EDNSSDVDIV
     GDAKLYQLT
 
 
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