TINA1_DROME
ID TINA1_DROME Reviewed; 167 AA.
AC Q9W0Y1; Q95T30;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Troponin C-akin-1 protein;
DE EC=2.3.2.-;
DE AltName: Full=Putative gamma-glutamylcyclotransferase;
GN Name=Tina-1; ORFNames=CG2803;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-167.
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=12397110; DOI=10.1242/dev.129.21.5019;
RA Lovato T.L., Nguyen T.P., Molina M.R., Cripps R.M.;
RT "The Hox gene abdominal-A specifies heart cell fate in the Drosophila
RT dorsal vessel.";
RL Development 129:5019-5027(2002).
CC -!- FUNCTION: Putative gamma-glutamylcyclotransferase. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In embryos, expression is seen in heart cells of
CC the dorsal vessel and hindgut visceral mesoderm.
CC {ECO:0000269|PubMed:12397110}.
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL25392.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE013599; AAF47298.1; -; Genomic_DNA.
DR EMBL; BT011448; AAR99106.1; -; mRNA.
DR EMBL; AY060353; AAL25392.1; ALT_INIT; mRNA.
DR RefSeq; NP_001033974.1; NM_001038885.2.
DR RefSeq; NP_611983.2; NM_138139.4.
DR AlphaFoldDB; Q9W0Y1; -.
DR SMR; Q9W0Y1; -.
DR BioGRID; 63557; 3.
DR DIP; DIP-23056N; -.
DR STRING; 7227.FBpp0072317; -.
DR PaxDb; Q9W0Y1; -.
DR PRIDE; Q9W0Y1; -.
DR DNASU; 37989; -.
DR EnsemblMetazoa; FBtr0072411; FBpp0072317; FBgn0035083.
DR GeneID; 37989; -.
DR KEGG; dme:Dmel_CG2803; -.
DR CTD; 37989; -.
DR FlyBase; FBgn0035083; Tina-1.
DR VEuPathDB; VectorBase:FBgn0035083; -.
DR eggNOG; KOG4450; Eukaryota.
DR GeneTree; ENSGT00390000010543; -.
DR HOGENOM; CLU_083466_1_0_1; -.
DR InParanoid; Q9W0Y1; -.
DR OMA; YQRTALR; -.
DR PhylomeDB; Q9W0Y1; -.
DR BioGRID-ORCS; 37989; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37989; -.
DR PRO; PR:Q9W0Y1; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0035083; Expressed in spermathecum and 31 other tissues.
DR ExpressionAtlas; Q9W0Y1; baseline and differential.
DR Genevisible; Q9W0Y1; DM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0061929; F:gamma-glutamylaminecyclotransferase activity; ISS:FlyBase.
DR GO; GO:0008307; F:structural constituent of muscle; NAS:FlyBase.
DR GO; GO:0007507; P:heart development; TAS:FlyBase.
DR CDD; cd06661; GGCT_like; 1.
DR InterPro; IPR009288; AIG2-like_dom.
DR InterPro; IPR039126; GGACT.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR PANTHER; PTHR12510; PTHR12510; 1.
DR Pfam; PF06094; GGACT; 1.
DR SUPFAM; SSF110857; SSF110857; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Reference proteome; Transferase.
FT CHAIN 1..167
FT /note="Troponin C-akin-1 protein"
FT /id="PRO_0000184784"
FT ACT_SITE 92
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 17..20
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 167 AA; 19056 MW; 8FCDE6E575950F5F CRC64;
MGQAKKVSSA LSKLFVYGAL KYGQPSNSIL ASSGNGFAKF WCKATTTQKL PLVIATRYNI
PFLLNKPGVG YYVTGEIYEV DDRMLNSLDN LEDCEEIYTR EMHDMNIGVG EGTVPCWVYL
LQKYPENLLS LRYLSSYENS TTHPYIMRHR RTHKHPAQDD LTYEAQN
