ID   TINAG_BOVIN             Reviewed;         476 AA.
AC   Q3SZI1;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Tubulointerstitial nephritis antigen;
DE            Short=TIN-Ag;
GN   Name=TINAG;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates adhesion of proximal tubule epithelial cells via
CC       integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic
CC       peptidase C1 family protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix, basement membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10090}.
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DR   EMBL; BC102843; AAI02844.1; -; mRNA.
DR   RefSeq; NP_001030279.1; NM_001035107.2.
DR   AlphaFoldDB; Q3SZI1; -.
DR   SMR; Q3SZI1; -.
DR   STRING; 9913.ENSBTAP00000016790; -.
DR   MEROPS; C01.973; -.
DR   PaxDb; Q3SZI1; -.
DR   Ensembl; ENSBTAT00000016790; ENSBTAP00000016790; ENSBTAG00000012652.
DR   GeneID; 512517; -.
DR   KEGG; bta:512517; -.
DR   CTD; 27283; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012652; -.
DR   VGNC; VGNC:35874; TINAG.
DR   eggNOG; KOG1544; Eukaryota.
DR   GeneTree; ENSGT00940000161065; -.
DR   HOGENOM; CLU_012184_3_2_1; -.
DR   InParanoid; Q3SZI1; -.
DR   OMA; HTNGPCP; -.
DR   OrthoDB; 1436535at2759; -.
DR   TreeFam; TF313765; -.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000012652; Expressed in metanephros cortex and 22 other tissues.
DR   ExpressionAtlas; Q3SZI1; baseline.
DR   GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   InterPro; IPR033164; TINAG.
DR   PANTHER; PTHR12411:SF274; PTHR12411:SF274; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   Pfam; PF01033; Somatomedin_B; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SMART; SM00201; SO; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00524; SMB_1; 1.
DR   PROSITE; PS50958; SMB_2; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
PE   2: Evidence at transcript level;
KW   Basement membrane; Cell adhesion; Disulfide bond; Extracellular matrix;
KW   Glycoprotein; Reference proteome; Secreted.
FT   CHAIN           1..476
FT                   /note="Tubulointerstitial nephritis antigen"
FT                   /id="PRO_0000239654"
FT   DOMAIN          59..107
FT                   /note="SMB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   SITE            49..50
FT                   /note="Cleavage; by furin"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        314
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        360
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        455
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        63..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        87..94
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
SQ   SEQUENCE   476 AA;  54235 MW;  029F9805F0A4D73B CRC64;
     MCAGYKILIL AYLTTEIWME RQYLSQREVD PGAEFTRNHT ISEGTRFKRA VFEGQYCRRF
     GCCADRDDGC VTQFYEADAL CYCDKFCERE NSDCCPDYKS FCREEKGWPP RTKPWSPEGC
     HRDGQHYEEG SVIKENCNSC TCSGQQWKCS QHVCLVQPGL IEHVNKGDYG WTAQNYSQFW
     GMTLEEGFKY RLGTLPPSPL LLSMNEVTAS LTKTTDLPEF FIASYKWPGW THGPLDQKNC
     AASWAFSTAS VAADRIAIQS QGRYTANLSP QNLISCCAKK RHGCNSGSVD RAWWYLRKRG
     LVSHACYPLF KDQNATNNGC AMASRSDGRG KRHATTPCPN SIEKSNRIYQ CSPPYRVSSN
     ETEIMREIMQ NGPVQAIMQV HEDFFNYKTG IYRHITSTNE DSEKYRKFRT HAVKLTGWGT
     LRGAQGQKEK FWIAANSWGK SWGENGYFRI LRGVNESDIE KLIIAAWGQL TSADEP