TINAL_HUMAN
ID TINAL_HUMAN Reviewed; 467 AA.
AC Q9GZM7; A8K9Q5; B4DPK6; D3DPN8; Q8TEJ9; Q8WZ23; Q96GZ4; Q96JW3;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Tubulointerstitial nephritis antigen-like;
DE AltName: Full=Glucocorticoid-inducible protein 5;
DE AltName: Full=Oxidized LDL-responsive gene 2 protein;
DE Short=OLRG-2;
DE AltName: Full=Tubulointerstitial nephritis antigen-related protein;
DE Short=TIN Ag-related protein;
DE Short=TIN-Ag-RP;
DE Flags: Precursor;
GN Name=TINAGL1; Synonyms=GIS5, LCN7, OLRG2, TINAGL;
GN ORFNames=PP6614, PSEC0088, UNQ204/PRO230;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), AND SUBCELLULAR LOCATION.
RC TISSUE=Muscle;
RX PubMed=10799322; DOI=10.1006/bbrc.2000.2639;
RA Broemme N.C., Wex T., Wex H., Levy B., Lipyansky A., Broemme D.;
RT "Cloning, characterization, and expression of the human TIN-ag-RP gene
RT encoding a novel putative extracellular matrix protein.";
RL Biochem. Biophys. Res. Commun. 271:474-480(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-27, TISSUE
RP SPECIFICITY, GLYCOSYLATION, AND SUBCELLULAR LOCATION.
RC TISSUE=Muscle;
RX PubMed=11170462; DOI=10.1021/bi002266o;
RA Wex T., Lipyansky A., Broemme N.C., Wex H., Guan X.Q., Broemme D.;
RT "TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with
RT EGF domains, is predominantly expressed in vascular smooth muscle cells.";
RL Biochemistry 40:1350-1357(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Zhang K.M., Chen B.S.;
RT "Identification of oxidized-LDL responsive gene 2 (OLRG-2), encoding a
RT novel extracellular matrix protein in vascular endothelial cells.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RA Yoshida H., Takaishi K., Harada M., Nagasaka T., Tsurufuji S.,
RA Taniguchi M.;
RT "Identification of a novel glucocorticoid-inducible cDNA partially
RT homologous to tubulointerstitial nephritis antigen.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Kidney, Placenta, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [13]
RP PROTEIN SEQUENCE OF 22-36.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [14]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78 AND ASN-161.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
CC -!- FUNCTION: May be implicated in the adrenocortical zonation and in
CC mechanisms for repressing the CYP11B1 gene expression in adrenocortical
CC cells. This is a non catalytic peptidase C1 family protein (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q9GZM7; O95429: BAG4; NbExp=3; IntAct=EBI-715869, EBI-2949658;
CC Q9GZM7; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-715869, EBI-10176379;
CC Q9GZM7; Q99697-2: PITX2; NbExp=3; IntAct=EBI-715869, EBI-12138495;
CC Q9GZM7; O75360: PROP1; NbExp=3; IntAct=EBI-715869, EBI-9027467;
CC Q9GZM7; Q15645: TRIP13; NbExp=6; IntAct=EBI-715869, EBI-358993;
CC Q9GZM7-3; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10303636, EBI-10176379;
CC Q9GZM7-3; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-10303636, EBI-10172511;
CC Q9GZM7-3; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10303636, EBI-945833;
CC Q9GZM7-3; Q93062: RBPMS; NbExp=3; IntAct=EBI-10303636, EBI-740322;
CC Q9GZM7-3; Q15645: TRIP13; NbExp=3; IntAct=EBI-10303636, EBI-358993;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10799322,
CC ECO:0000269|PubMed:11170462}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9GZM7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9GZM7-2; Sequence=VSP_013094, VSP_013095, VSP_013096,
CC VSP_013097, VSP_013098;
CC Name=3;
CC IsoId=Q9GZM7-3; Sequence=VSP_043712;
CC -!- TISSUE SPECIFICITY: Highly expressed in aorta, heart, placenta, kidney
CC and a colorectal adenocarcinoma cell line. Moderately expressed in
CC skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone
CC marrow and thyroid. Weakly expressed in colon, small intestine, ovary,
CC spleen, testis and prostate. Predominantly found in vascular smooth
CC muscle cells, but also in cardiac and skeletal muscle cells as well as
CC kidney. {ECO:0000269|PubMed:11170462}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:11170462,
CC ECO:0000269|PubMed:19159218}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU10089}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH09048.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB55403.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF236155; AAG40154.1; -; Genomic_DNA.
DR EMBL; AF236151; AAG40154.1; JOINED; Genomic_DNA.
DR EMBL; AF236152; AAG40154.1; JOINED; Genomic_DNA.
DR EMBL; AF236153; AAG40154.1; JOINED; Genomic_DNA.
DR EMBL; AF236154; AAG40154.1; JOINED; Genomic_DNA.
DR EMBL; AF236150; AAG38876.1; -; mRNA.
DR EMBL; AF205436; AAG33699.1; -; mRNA.
DR EMBL; AB050716; BAB18636.1; -; mRNA.
DR EMBL; AB050719; BAB18727.1; -; Genomic_DNA.
DR EMBL; AK074124; BAB84950.1; -; mRNA.
DR EMBL; AY358421; AAQ88787.1; -; mRNA.
DR EMBL; AF289569; AAL55753.1; -; mRNA.
DR EMBL; AK027839; BAB55403.1; ALT_INIT; mRNA.
DR EMBL; AK292770; BAF85459.1; -; mRNA.
DR EMBL; AK298382; BAG60618.1; -; mRNA.
DR EMBL; AK075398; BAC11596.1; -; mRNA.
DR EMBL; AC114488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07604.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07605.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07606.1; -; Genomic_DNA.
DR EMBL; BC009048; AAH09048.1; ALT_INIT; mRNA.
DR EMBL; BC064633; AAH64633.1; -; mRNA.
DR CCDS; CCDS343.1; -. [Q9GZM7-1]
DR CCDS; CCDS55586.1; -. [Q9GZM7-3]
DR RefSeq; NP_001191343.1; NM_001204414.1. [Q9GZM7-3]
DR RefSeq; NP_001191344.1; NM_001204415.1.
DR RefSeq; NP_071447.1; NM_022164.2. [Q9GZM7-1]
DR AlphaFoldDB; Q9GZM7; -.
DR SMR; Q9GZM7; -.
DR BioGRID; 122078; 67.
DR IntAct; Q9GZM7; 66.
DR MINT; Q9GZM7; -.
DR STRING; 9606.ENSP00000271064; -.
DR MEROPS; C01.975; -.
DR GlyConnect; 1864; 7 N-Linked glycans (2 sites).
DR GlyGen; Q9GZM7; 3 sites, 7 N-linked glycans (2 sites), 1 O-linked glycan (1 site).
DR iPTMnet; Q9GZM7; -.
DR PhosphoSitePlus; Q9GZM7; -.
DR BioMuta; TINAGL1; -.
DR DMDM; 61213628; -.
DR EPD; Q9GZM7; -.
DR jPOST; Q9GZM7; -.
DR MassIVE; Q9GZM7; -.
DR MaxQB; Q9GZM7; -.
DR PaxDb; Q9GZM7; -.
DR PeptideAtlas; Q9GZM7; -.
DR PRIDE; Q9GZM7; -.
DR ProteomicsDB; 80089; -. [Q9GZM7-1]
DR ProteomicsDB; 80090; -. [Q9GZM7-2]
DR ProteomicsDB; 80091; -. [Q9GZM7-3]
DR Antibodypedia; 31121; 192 antibodies from 26 providers.
DR DNASU; 64129; -.
DR Ensembl; ENST00000271064.12; ENSP00000271064.7; ENSG00000142910.16. [Q9GZM7-1]
DR Ensembl; ENST00000457433.6; ENSP00000395137.2; ENSG00000142910.16. [Q9GZM7-3]
DR GeneID; 64129; -.
DR KEGG; hsa:64129; -.
DR MANE-Select; ENST00000271064.12; ENSP00000271064.7; NM_022164.3; NP_071447.1.
DR UCSC; uc001bta.4; human. [Q9GZM7-1]
DR CTD; 64129; -.
DR DisGeNET; 64129; -.
DR GeneCards; TINAGL1; -.
DR HGNC; HGNC:19168; TINAGL1.
DR HPA; ENSG00000142910; Low tissue specificity.
DR MIM; 616064; gene.
DR neXtProt; NX_Q9GZM7; -.
DR OpenTargets; ENSG00000142910; -.
DR PharmGKB; PA38810; -.
DR VEuPathDB; HostDB:ENSG00000142910; -.
DR eggNOG; KOG1544; Eukaryota.
DR GeneTree; ENSGT00940000160023; -.
DR InParanoid; Q9GZM7; -.
DR OMA; EVPDQGW; -.
DR OrthoDB; 1436535at2759; -.
DR PhylomeDB; Q9GZM7; -.
DR TreeFam; TF313765; -.
DR PathwayCommons; Q9GZM7; -.
DR SignaLink; Q9GZM7; -.
DR BioGRID-ORCS; 64129; 13 hits in 1069 CRISPR screens.
DR ChiTaRS; TINAGL1; human.
DR GeneWiki; TINAGL1; -.
DR GenomeRNAi; 64129; -.
DR Pharos; Q9GZM7; Tbio.
DR PRO; PR:Q9GZM7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9GZM7; protein.
DR Bgee; ENSG00000142910; Expressed in metanephros cortex and 137 other tissues.
DR ExpressionAtlas; Q9GZM7; baseline and differential.
DR Genevisible; Q9GZM7; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:BHF-UCL.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0005201; F:extracellular matrix structural constituent; NAS:UniProtKB.
DR GO; GO:0043236; F:laminin binding; IEA:Ensembl.
DR GO; GO:0016197; P:endosomal transport; TAS:UniProtKB.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:11170462,
FT ECO:0000269|PubMed:15340161"
FT CHAIN 22..467
FT /note="Tubulointerstitial nephritis antigen-like"
FT /id="PRO_0000026482"
FT DOMAIN 50..98
FT /note="SMB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT DISULFID 54..73
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 71..85
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 71..73
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 77..84
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 85..92
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT VAR_SEQ 1..134
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5"
FT /id="VSP_013094"
FT VAR_SEQ 126..156
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043712"
FT VAR_SEQ 135..194
FT /note="CDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSS
FT VMNMHEIY -> MVLGSSTQVKIGGSWNPAAAGGLKIKLQKALDLVALQCQWAPEGQAR
FT AEQEADRATFILQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5"
FT /id="VSP_013095"
FT VAR_SEQ 286
FT /note="G -> GYAATGDVGREEGKELRGHGLGHDALSLSAFAPSCCLCR (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5"
FT /id="VSP_013096"
FT VAR_SEQ 365..381
FT /note="ALMEVHEDFFLYKGGIY -> GKPPYPAPWFQKLVPA (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5"
FT /id="VSP_013097"
FT VAR_SEQ 382..467
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15498874, ECO:0000303|Ref.5"
FT /id="VSP_013098"
FT VARIANT 69
FT /note="A -> S (in dbSNP:rs17497479)"
FT /id="VAR_051514"
FT CONFLICT 333
FT /note="N -> Y (in Ref. 7; AAL55753)"
FT /evidence="ECO:0000305"
FT CONFLICT 377
FT /note="K -> E (in Ref. 8; BAB55403)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 467 AA; 52387 MW; E9D72220E3E7B7D5 CRC64;
MWRCPLGLLL LLPLAGHLAL GAQQGRGRRE LAPGLHLRGI RDAGGRYCQE QDLCCRGRAD
DCALPYLGAI CYCDLFCNRT VSDCCPDFWD FCLGVPPPFP PIQGCMHGGR IYPVLGTYWD
NCNRCTCQEN RQWQCDQEPC LVDPDMIKAI NQGNYGWQAG NHSAFWGMTL DEGIRYRLGT
IRPSSSVMNM HEIYTVLNPG EVLPTAFEAS EKWPNLIHEP LDQGNCAGSW AFSTAAVASD
RVSIHSLGHM TPVLSPQNLL SCDTHQQQGC RGGRLDGAWW FLRRRGVVSD HCYPFSGRER
DEAGPAPPCM MHSRAMGRGK RQATAHCPNS YVNNNDIYQV TPVYRLGSND KEIMKELMEN
GPVQALMEVH EDFFLYKGGI YSHTPVSLGR PERYRRHGTH SVKITGWGEE TLPDGRTLKY
WTAANSWGPA WGERGHFRIV RGVNECDIES FVLGVWGRVG MEDMGHH
