TINAL_MOUSE
ID TINAL_MOUSE Reviewed; 466 AA.
AC Q99JR5; Q9EQT9;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Tubulointerstitial nephritis antigen-like;
DE AltName: Full=Adrenocortical zonation factor 1;
DE Short=AZ-1;
DE AltName: Full=Androgen-regulated gene 1 protein;
DE AltName: Full=Tubulointerstitial nephritis antigen-related protein;
DE Short=TARP;
DE Flags: Precursor;
GN Name=Tinagl1; Synonyms=Arg1, Lcn7, Tinagl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=11377975; DOI=10.1016/s0960-0760(01)00039-5;
RA Kobayashi M., Kinouchi T., Hakamata Y., Kamiakito T., Kuriki K., Suzuki K.,
RA Tokue A., Fukayama M., Tanaka A.;
RT "Isolation of an androgen-inducible novel lipocalin gene, Arg1, from
RT androgen-dependent mouse mammary Shionogi carcinoma cells.";
RL J. Steroid Biochem. Mol. Biol. 77:109-115(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND FUNCTION.
RC TISSUE=Adrenal cortex;
RX PubMed=12600995; DOI=10.1074/jbc.m301477200;
RA Mukai K., Mitani F., Nagasawa H., Suzuki R., Suzuki T., Suematsu M.,
RA Ishimura Y.;
RT "An inverse correlation between expression of a preprocathepsin B-related
RT protein with cysteine-rich sequences and steroid 11beta - hydroxylase in
RT adrenocortical cells.";
RL J. Biol. Chem. 278:17084-17092(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be implicated in the adrenocortical zonation and in
CC mechanisms for repressing the CYP11B1 gene expression in adrenocortical
CC cells. This is a non catalytic peptidase C1 family protein.
CC {ECO:0000269|PubMed:12600995}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highly expressed in kidney, heart and
CC adrenocortical cells of adrenal glands. Moderately expressed in spleen
CC and liver. Also found in prostate, seminal vesicle, epididymis and
CC testis in male reproductive organs. In adrenal glands is found in the
CC outer cortical regions corresponding to the zona glomerulosa (zG) and
CC the undifferentiated cell zone (zU) (at protein level).
CC {ECO:0000269|PubMed:11377975, ECO:0000269|PubMed:12600995}.
CC -!- INDUCTION: Down-regulated in prostate after castration.
CC {ECO:0000269|PubMed:11377975}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU10089}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB20596.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB047402; BAB20596.1; ALT_SEQ; mRNA.
DR EMBL; AB050626; BAC76038.1; -; mRNA.
DR EMBL; BC005738; AAH05738.1; -; mRNA.
DR EMBL; BC018539; AAH18539.1; -; mRNA.
DR CCDS; CCDS18708.2; -.
DR RefSeq; NP_001161805.1; NM_001168333.1.
DR RefSeq; NP_075965.2; NM_023476.3.
DR AlphaFoldDB; Q99JR5; -.
DR SMR; Q99JR5; -.
DR BioGRID; 220489; 3.
DR STRING; 10090.ENSMUSP00000101620; -.
DR MEROPS; C01.975; -.
DR GlyGen; Q99JR5; 2 sites.
DR PhosphoSitePlus; Q99JR5; -.
DR MaxQB; Q99JR5; -.
DR PaxDb; Q99JR5; -.
DR PeptideAtlas; Q99JR5; -.
DR PRIDE; Q99JR5; -.
DR ProteomicsDB; 259103; -.
DR Antibodypedia; 31121; 192 antibodies from 26 providers.
DR DNASU; 94242; -.
DR Ensembl; ENSMUST00000030560; ENSMUSP00000030560; ENSMUSG00000028776.
DR Ensembl; ENSMUST00000105998; ENSMUSP00000101620; ENSMUSG00000028776.
DR Ensembl; ENSMUST00000105999; ENSMUSP00000101621; ENSMUSG00000028776.
DR GeneID; 94242; -.
DR KEGG; mmu:94242; -.
DR UCSC; uc008uyz.2; mouse.
DR CTD; 64129; -.
DR MGI; MGI:2137617; Tinagl1.
DR VEuPathDB; HostDB:ENSMUSG00000028776; -.
DR eggNOG; KOG1544; Eukaryota.
DR GeneTree; ENSGT00940000160023; -.
DR InParanoid; Q99JR5; -.
DR OMA; EVPDQGW; -.
DR OrthoDB; 1436535at2759; -.
DR PhylomeDB; Q99JR5; -.
DR TreeFam; TF313765; -.
DR BioGRID-ORCS; 94242; 3 hits in 76 CRISPR screens.
DR ChiTaRS; Tinagl1; mouse.
DR PRO; PR:Q99JR5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q99JR5; protein.
DR Bgee; ENSMUSG00000028776; Expressed in placenta labyrinth and 196 other tissues.
DR ExpressionAtlas; Q99JR5; baseline and differential.
DR Genevisible; Q99JR5; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0043236; F:laminin binding; IPI:MGI.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..466
FT /note="Tubulointerstitial nephritis antigen-like"
FT /id="PRO_0000026483"
FT DOMAIN 49..96
FT /note="SMB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 53..72
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 70..84
FT /note="Alternate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 70..72
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 76..83
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT DISULFID 84..91
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
SQ SEQUENCE 466 AA; 52665 MW; D12ABDCC8F63F36D CRC64;
MWGCWLGLLL LLLAGQAALE ARRSRWRREL APGLHLRGIR DAGGRYCQEQ DMCCRGRADE
CALPYLGATC YCDLFCNRTV SDCCPDFWDF CLGIPPPFPP VQGCMHGGRI YPVFGTYWDN
CNRCTCHEGG HWECDQEPCL VDPDMIKAIN RGNYGWQAGN HSAFWGMTLD EGIRYRLGTI
RPSSTVMNMN EIYTVLGQGE VLPTAFEASE KWPNLIHEPL DQGNCAGSWA FSTAAVASDR
VSIHSLGHMT PILSPQNLLS CDTHHQQGCR GGRLDGAWWF LRRRGVVSDN CYPFSGREQN
EASPTPRCMM HSRAMGRGKR QATSRCPNGQ VDSNDIYQVT PAYRLGSDEK EIMKELMENG
PVQALMEVHE DFFLYQRGIY SHTPVSQGRP EQYRRHGTHS VKITGWGEET LPDGRTIKYW
TAANSWGPWW GERGHFRIVR GTNECDIETF VLGVWGRVGM EDMGHH
