ID   TINAL_RAT               Reviewed;         467 AA.
AC   Q9EQT5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Tubulointerstitial nephritis antigen-like;
DE   AltName: Full=Glucocorticoid-inducible protein 5;
DE   Flags: Precursor;
GN   Name=Tinagl1; Synonyms=Gis5, Lcn7, Tinagl;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yoshida H., Takaishi K., Harada M., Nagasaka T., Tsurufuji S.,
RA   Taniguchi M.;
RT   "Identification of a novel glucocorticoid-inducible cDNA partially
RT   homologous to tubulointerstitial nephritis antigen.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be implicated in the adrenocortical zonation and in
CC       mechanisms for repressing the CYP11B1 gene expression in adrenocortical
CC       cells. This is a non catalytic peptidase C1 family protein (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: Glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10089}.
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DR   EMBL; AB050717; BAB18637.1; -; mRNA.
DR   RefSeq; NP_446034.1; NM_053582.2.
DR   AlphaFoldDB; Q9EQT5; -.
DR   SMR; Q9EQT5; -.
DR   STRING; 10116.ENSRNOP00000018464; -.
DR   MEROPS; C01.975; -.
DR   GlyGen; Q9EQT5; 2 sites.
DR   PaxDb; Q9EQT5; -.
DR   PRIDE; Q9EQT5; -.
DR   GeneID; 94174; -.
DR   KEGG; rno:94174; -.
DR   UCSC; RGD:70956; rat.
DR   CTD; 64129; -.
DR   RGD; 70956; Tinagl1.
DR   eggNOG; KOG1544; Eukaryota.
DR   InParanoid; Q9EQT5; -.
DR   OrthoDB; 1436535at2759; -.
DR   PhylomeDB; Q9EQT5; -.
DR   PRO; PR:Q9EQT5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0043236; F:laminin binding; ISO:RGD.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00524; SMB_1; 1.
DR   PROSITE; PS50958; SMB_2; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..467
FT                   /note="Tubulointerstitial nephritis antigen-like"
FT                   /id="PRO_0000026484"
FT   DOMAIN          49..96
FT                   /note="SMB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        53..72
FT                   /note="Alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        70..84
FT                   /note="Alternate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        70..72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        76..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
FT   DISULFID        84..91
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00350"
SQ   SEQUENCE   467 AA;  52821 MW;  FB844FAEE7B1EC8B CRC64;
     MWGCPLGLLL LLLAGQAALE ARRSRWRREL APGLHLRGIR DAGGRYCQEQ DMCCRGRADE
     CALPYLGATC YCDLFCNRTV SDCCPDFWDF CLGIPPPFPP VQGCMHAGRI YPIFGTYWEN
     CNRCTCHEKG QWECDQEPCL VDPAMIKAIN RGNYGWQAGN HSAFWGMTLD EGIRYRLGTI
     RPSSSVMNMN EIYTVLGQGE VLPTAFEASE KWPNLIHEPL DQGNCAGSWA FSTAAVASDR
     VSIHSLGHMT PILSPQNLLS CDTHHQKGCR GGRLDGAWWF LRRRGVVSDN CYPFSGREQN
     DEASPTPRCM MHSRAMGRGK RQATSRCPNS QVDSNDIYQV TPVYRLASDE KEIMKELMEN
     GPVQALMEVH EDFFLYQRGI YSHTPVSQGR PEQYRRHGTH SVKITGWGEE TLPDGRTIKY
     WTAANSWGPW WGERGHFRIV RGINECDIET FVLGVWGRVG MEDMGHH