ID   TINCR_HUMAN             Reviewed;         120 AA.
AC   A0A2R8Y7D0;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2018, sequence version 1.
DT   03-AUG-2022, entry version 17.
DE   RecName: Full=Ubiquitin domain-containing protein TINCR {ECO:0000305};
DE   AltName: Full=Placenta-specific protein 2;
DE   AltName: Full=Terminal differentiation-induced cornification regulator {ECO:0000303|PubMed:32012357};
GN   Name=TINCR {ECO:0000312|HGNC:HGNC:14607};
GN   Synonyms=LINC00036 {ECO:0000312|HGNC:HGNC:14607},
GN   NCRNA00036 {ECO:0000312|HGNC:HGNC:14607},
GN   PLAC2 {ECO:0000312|HGNC:HGNC:14607};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND TISSUE SPECIFICITY.
RX   PubMed=32012357; DOI=10.1111/exd.14083;
RA   Eckhart L., Lachner J., Tschachler E., Rice R.H.;
RT   "TINCR is not a non-coding RNA but encodes a protein component of cornified
RT   epidermal keratinocytes.";
RL   Exp. Dermatol. 29:376-379(2020).
CC   -!- TISSUE SPECIFICITY: Detected in stratum corneum (at protein level).
CC       {ECO:0000269|PubMed:32012357}.
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DR   EMBL; AC011533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R8Y7D0; -.
DR   SMR; A0A2R8Y7D0; -.
DR   Ensembl; ENST00000646160.1; ENSP00000496189.1; ENSG00000223573.7.
DR   GeneCards; TINCR; -.
DR   HGNC; HGNC:14607; TINCR.
DR   MIM; 615241; gene.
DR   neXtProt; NX_A0A2R8Y7D0; -.
DR   OpenTargets; ENSG00000223573; -.
DR   VEuPathDB; HostDB:ENSG00000223573; -.
DR   GeneTree; ENSGT01030000234949; -.
DR   SignaLink; A0A2R8Y7D0; -.
DR   ChiTaRS; TINCR; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000223573; Expressed in upper arm skin and 130 other tissues.
DR   ExpressionAtlas; A0A2R8Y7D0; baseline and differential.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..120
FT                   /note="Ubiquitin domain-containing protein TINCR"
FT                   /id="PRO_0000451870"
FT   DOMAIN          14..83
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
SQ   SEQUENCE   120 AA;  13788 MW;  F3E4EE1854D124CF CRC64;
     MEGLRRGLSR WKRYHIKVHL ADEALLLPLT VRPRDTLSDL RAQLVGQGVS SWKRAFYYNA
     RRLDDHQTVR DARLQDGSVL LLVSDPSEAQ RLTPAIPALW EAEASRSLES RSSRPAWPTW