TIP39_DANRE
ID TIP39_DANRE Reviewed; 157 AA.
AC Q8QGA2; Q67FW3;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Tuberoinfundibular peptide of 39 residues {ECO:0000303|PubMed:15297442};
DE Short=TIP39 {ECO:0000303|PubMed:15297442};
DE AltName: Full=Parathyroid hormone 2 {ECO:0000312|ZFIN:ZDB-GENE-041102-1};
DE Flags: Precursor;
GN Name=pth2 {ECO:0000312|ZFIN:ZDB-GENE-041102-1};
GN Synonyms=tip39 {ECO:0000303|PubMed:15297442,
GN ECO:0000312|ZFIN:ZDB-GENE-041102-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN [1] {ECO:0000312|EMBL:AAQ75380.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND SYNTHESIS OF
RP 119-157.
RX PubMed=15297442; DOI=10.1210/en.2004-0159;
RA Papasani M.R., Gensure R.C., Yan Y.L., Gunes Y., Postlethwait J.H.,
RA Ponugoti B., John M.R., Jueppner H., Rubin D.A.;
RT "Identification and characterization of the zebrafish and fugu genes
RT encoding tuberoinfundibular peptide 39.";
RL Endocrinology 145:5294-5304(2004).
RN [2] {ECO:0000312|EMBL:AAL92028.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAL92028.1};
RA Hansen I.A., Wortmann S.F., Blind E.;
RT "Cloning and expression of the tuberoinfundibular peptide of 39 residues
RT (TIP39) precursor cDNA of the zebrafish.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000312|EMBL:AAH76066.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=21880859; DOI=10.1530/joe-10-0439;
RA Bhattacharya P., Yan Y.L., Postlethwait J., Rubin D.A.;
RT "Evolution of the vertebrate pth2 (tip39) gene family and the regulation of
RT PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog
RT signaling in zebrafish development.";
RL J. Endocrinol. 211:187-200(2011).
CC -!- FUNCTION: Plays a role as a potent and selective agonist of pth2r
CC resulting in adenyl cyclase activation and intracellular calcium level
CC elevation. {ECO:0000269|PubMed:15297442}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:15297442}.
CC -!- DEVELOPMENTAL STAGE: Detected at the cleavage and blastula stages,
CC 1.75-4 hours post-fertilization (hpf) (PubMed:21880859). Expressed in
CC forebrain, midbrain, hindbrain and cells lining the brain ventricles at
CC 19-22 hpf (PubMed:21880859). Expressed in midbrain and otic vesicles at
CC 26-36 hpf (PubMed:21880859). Detected in bilateral domains in brain
CC near the hypothalamus, and in heart, at 48-72 hpf (PubMed:15297442,
CC PubMed:21880859). {ECO:0000269|PubMed:15297442,
CC ECO:0000269|PubMed:21880859}.
CC -!- INDUCTION: Up-regulated in the developing brain by shh signaling.
CC {ECO:0000269|PubMed:21880859}.
CC -!- SIMILARITY: Belongs to the parathyroid hormone family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ76286.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY306196; AAQ75380.1; -; mRNA.
DR EMBL; AY307076; AAQ76286.1; ALT_SEQ; mRNA.
DR EMBL; AF486190; AAL92028.1; -; mRNA.
DR EMBL; CR628327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC076066; AAH76066.1; -; mRNA.
DR EMBL; BC164665; AAI64665.1; -; mRNA.
DR RefSeq; NP_991140.1; NM_205577.3.
DR AlphaFoldDB; Q8QGA2; -.
DR SMR; Q8QGA2; -.
DR STRING; 7955.ENSDARP00000029759; -.
DR PaxDb; Q8QGA2; -.
DR Ensembl; ENSDART00000033691; ENSDARP00000029759; ENSDARG00000022951.
DR Ensembl; ENSDART00000184724; ENSDARP00000151244; ENSDARG00000022951.
DR GeneID; 402812; -.
DR KEGG; dre:402812; -.
DR CTD; 113091; -.
DR ZFIN; ZDB-GENE-041102-1; pth2.
DR eggNOG; ENOG502S3PJ; Eukaryota.
DR GeneTree; ENSGT00410000026259; -.
DR HOGENOM; CLU_1677252_0_0_1; -.
DR InParanoid; Q8QGA2; -.
DR OMA; EHKRVDW; -.
DR OrthoDB; 1412376at2759; -.
DR TreeFam; TF353520; -.
DR Reactome; R-DRE-373080; Class B/2 (Secretin family receptors).
DR Reactome; R-DRE-418555; G alpha (s) signalling events.
DR PRO; PR:Q8QGA2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000022951; Expressed in midbrain and 25 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048018; F:receptor ligand activity; IDA:ZFIN.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:ZFIN.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR029396; TIP39.
DR PANTHER; PTHR28585; PTHR28585; 1.
DR Pfam; PF14980; TIP39; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..116
FT /evidence="ECO:0000305"
FT /id="PRO_0000443088"
FT PEPTIDE 119..157
FT /note="Tuberoinfundibular peptide of 39 residues"
FT /evidence="ECO:0000305|PubMed:15297442"
FT /id="PRO_0000443089"
SQ SEQUENCE 157 AA; 17750 MW; FEC5584079C32D91 CRC64;
MALSLPPRPA LLFLVLMSVT LMASAFPQPQ LRPLQSNLPA IGQEDSKGEQ WEVVYPSISL
RDWSIQMLTA PDFGAAKTGR EQLVADDWLP LSQSQMEEEL VKGWTGDWPS RVGHQQKRNI
VVADDAAFRE KSKLLTAMER QKWLNSYMQK LLVVNSK
