TIP39_MOUSE
ID TIP39_MOUSE Reviewed; 100 AA.
AC Q91W27; Q91ZA0;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Tuberoinfundibular peptide of 39 residues;
DE Short=TIP39;
DE AltName: Full=Parathyroid hormone 2;
DE Flags: Precursor;
GN Name=Pth2; Synonyms=Tip39, Tipf39;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=12098667; DOI=10.1677/joe.0.1740095;
RA Hansen I.A., Jakob O., Wortmann S., Arzberger T., Allolio B., Blind E.;
RT "Characterization of the human and mouse genes encoding the
RT tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid
RT hormone receptor family.";
RL J. Endocrinol. 174:95-102(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=11818570; DOI=10.1073/pnas.042416199;
RA Dobolyi A., Ueda H., Uchida H., Palkovits M., Usdin T.B.;
RT "Anatomical and physiological evidence for involvement of
RT tuberoinfundibular peptide of 39 residues in nociception.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:1651-1656(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12559132; DOI=10.1016/s0028-3908(02)00335-0;
RA Della Penna K., Kinose F., Sun H., Koblan K.S., Wang H.;
RT "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and
RT activity for parathyroid hormone 2 receptor.";
RL Neuropharmacology 44:141-153(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-90, FUNCTION, INTERACTION WITH PTH2R, AND
RP TISSUE SPECIFICITY.
RC STRAIN=Swiss Webster; TISSUE=Brain;
RX PubMed=11861531; DOI=10.1210/endo.143.3.8698;
RA John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.;
RT "Identification and characterization of the murine and human gene encoding
RT the tuberoinfundibular peptide of 39 residues.";
RL Endocrinology 143:1047-1057(2002).
RN [5]
RP FUNCTION OF TRUNCATED PEPTIDE.
RX PubMed=12084532; DOI=10.1016/s0196-9781(02)00023-2;
RA Hoare S.R.J., Usdin T.B.;
RT "Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-
RT 39).";
RL Peptides 23:989-998(2002).
CC -!- FUNCTION: Plays a role as a potent and selective agonist of PTH2R
CC resulting in adenyl cyclase activation and intracellular calcium levels
CC elevation. Induces protein kinase C beta activation, recruitment of
CC beta-arrestin and PTH2R internalization. May inhibit cell proliferation
CC via its action of PTH2R activation. Neuropeptide which may also have a
CC role in spermatogenesis. May activate nociceptors and nociceptive
CC circuits. {ECO:0000269|PubMed:11818570, ECO:0000269|PubMed:11861531,
CC ECO:0000269|PubMed:12084532}.
CC -!- SUBUNIT: Ligand of high affinity for the PTH2 receptor (PTH2R).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in testis and, less abundantly, in liver
CC and kidney. Expressed in seminiferous tubuli and several brain regions,
CC including nucleus ruber, caudal paralemniscal nucleus, nucleus
CC centralis pontis, and nucleus subparafascicularis thalami. Expressed in
CC neurons of cerebral cortex and subcortical areas. Expressed in Purkinje
CC cells of cerebellum. {ECO:0000269|PubMed:11818570,
CC ECO:0000269|PubMed:11861531, ECO:0000269|PubMed:12098667}.
CC -!- MISCELLANEOUS: The N-terminal truncation of tuberoinfundibular peptide
CC of 39 residues [TIP39(7-39)] reverses PTH2R/PTHR1 binding selectivity,
CC then is a highly potent and selective antagonist for PTHR1.
CC -!- SIMILARITY: Belongs to the parathyroid hormone family. {ECO:0000305}.
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DR EMBL; AF399674; AAK84862.1; -; mRNA.
DR EMBL; AY048587; AAL06596.1; -; mRNA.
DR CCDS; CCDS21233.1; -.
DR RefSeq; NP_444486.1; NM_053256.2.
DR RefSeq; XP_006540625.1; XM_006540562.1.
DR RefSeq; XP_006540626.1; XM_006540563.2.
DR RefSeq; XP_006540627.1; XM_006540564.3.
DR RefSeq; XP_006540628.1; XM_006540565.3.
DR RefSeq; XP_017177420.1; XM_017321931.1.
DR AlphaFoldDB; Q91W27; -.
DR SMR; Q91W27; -.
DR STRING; 10090.ENSMUSP00000041047; -.
DR PhosphoSitePlus; Q91W27; -.
DR PaxDb; Q91W27; -.
DR PRIDE; Q91W27; -.
DR Antibodypedia; 31997; 48 antibodies from 13 providers.
DR DNASU; 114640; -.
DR Ensembl; ENSMUST00000042754; ENSMUSP00000041047; ENSMUSG00000038300.
DR GeneID; 114640; -.
DR KEGG; mmu:114640; -.
DR UCSC; uc009gtz.1; mouse.
DR CTD; 113091; -.
DR MGI; MGI:2152297; Pth2.
DR VEuPathDB; HostDB:ENSMUSG00000038300; -.
DR eggNOG; ENOG502S3PJ; Eukaryota.
DR GeneTree; ENSGT00410000026259; -.
DR HOGENOM; CLU_2319483_0_0_1; -.
DR InParanoid; Q91W27; -.
DR PhylomeDB; Q91W27; -.
DR TreeFam; TF353520; -.
DR Reactome; R-MMU-373080; Class B/2 (Secretin family receptors).
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 114640; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tfip11; mouse.
DR PRO; PR:Q91W27; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91W27; protein.
DR Bgee; ENSMUSG00000038300; Expressed in olfactory epithelium and 25 other tissues.
DR ExpressionAtlas; Q91W27; baseline and differential.
DR Genevisible; Q91W27; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; TAS:MGI.
DR GO; GO:0006171; P:cAMP biosynthetic process; TAS:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR029396; TIP39.
DR PANTHER; PTHR28585; PTHR28585; 1.
DR Pfam; PF14980; TIP39; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT PROPEP 31..59
FT /evidence="ECO:0000250"
FT /id="PRO_0000045944"
FT PEPTIDE 62..100
FT /note="Tuberoinfundibular peptide of 39 residues"
FT /id="PRO_0000045945"
FT CONFLICT 92
FT /note="Q -> H (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 100 AA; 11022 MW; DC778742E13E0243 CRC64;
METCQMSRSP RERLLLLLLL LLLVPWGTGP ASGVALPLAG VFSLRAPGRA WAGLGSPLSR
RSLALADDAA FRERARLLAA LERRRWLDSY MQKLLLLDAP
