ID   TIP41_SCHPO             Reviewed;         252 AA.
AC   Q9USK5;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Type 2A phosphatase activator tip41;
DE   AltName: Full=PP2A phosphatase activator tip41;
GN   Name=tip41; ORFNames=SPCC4B3.16;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=16297994; DOI=10.1016/j.bbamcr.2005.09.006;
RA   Fenyvuesvolgyi C., Elder R.T., Benko Z., Liang D., Zhao R.Y.;
RT   "Fission yeast homologue of Tip41-like proteins regulates type 2A
RT   phosphatases and responses to nitrogen sources.";
RL   Biochim. Biophys. Acta 1746:155-162(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Involved in negative regulation of the TOR signaling pathway
CC       in response to type of available nitrogen source. Activates the PP2A
CC       phosphatase ppa2. {ECO:0000269|PubMed:16297994}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TIP41 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAB60690.1; -; Genomic_DNA.
DR   PIR; T50432; T50432.
DR   RefSeq; NP_588074.1; NM_001023066.2.
DR   AlphaFoldDB; Q9USK5; -.
DR   SMR; Q9USK5; -.
DR   BioGRID; 275476; 34.
DR   STRING; 4896.SPCC4B3.16.1; -.
DR   MaxQB; Q9USK5; -.
DR   PaxDb; Q9USK5; -.
DR   EnsemblFungi; SPCC4B3.16.1; SPCC4B3.16.1:pep; SPCC4B3.16.
DR   GeneID; 2538898; -.
DR   KEGG; spo:SPCC4B3.16; -.
DR   PomBase; SPCC4B3.16; tip41.
DR   VEuPathDB; FungiDB:SPCC4B3.16; -.
DR   eggNOG; KOG3224; Eukaryota.
DR   HOGENOM; CLU_039187_0_1_1; -.
DR   InParanoid; Q9USK5; -.
DR   OMA; GIPIPEM; -.
DR   PhylomeDB; Q9USK5; -.
DR   PRO; PR:Q9USK5; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; ISO:PomBase.
DR   GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IBA:GO_Central.
DR   GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR   InterPro; IPR007303; TIP41-like.
DR   PANTHER; PTHR21021:SF16; PTHR21021:SF16; 1.
DR   Pfam; PF04176; TIP41; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..252
FT                   /note="Type 2A phosphatase activator tip41"
FT                   /id="PRO_0000247902"
SQ   SEQUENCE   252 AA;  29455 MW;  347E0836F0AB18E0 CRC64;
     MQKQDDFSFK YWTIKVQRGS ILKSHEMENL QSTLGFPPPE MTFGNNYISI EYKNQPVVGF
     FTEDALKMVG TKPEDVMQVS FAKDWAKSRI KPGEEYPVIY PFDWTYYTDY QGTIQRPNAK
     FIEIDQVIPV QKILNAGQNL WFNEIILFED ELADNGKSMF DVRARVVQGH LILLARLVVR
     LDKVNVRLNE TRIYIDLLND FLLKDCRKKQ ATYDKIIKQI PVGGDKAALL DDNNWLSERL
     DTVDHKIYKL NF