ID   TIPA_STRCO              Reviewed;         253 AA.
AC   P0A4T8; P32184;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=HTH-type transcriptional activator TipA;
GN   Name=tipA; OrderedLocusNames=SCO3413; ORFNames=SCE9.20;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Transcriptional activator. Is activated when bound to the
CC       antibiotic thiostrepton (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
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DR   EMBL; AL939116; CAB42766.1; -; Genomic_DNA.
DR   PIR; T36339; T36339.
DR   RefSeq; NP_627619.1; NC_003888.3.
DR   RefSeq; WP_003975420.1; NZ_VNID01000023.1.
DR   AlphaFoldDB; P0A4T8; -.
DR   BMRB; P0A4T8; -.
DR   SMR; P0A4T8; -.
DR   GeneID; 1098850; -.
DR   KEGG; sco:SCO3413; -.
DR   PATRIC; fig|100226.15.peg.3476; -.
DR   eggNOG; COG0789; Bacteria.
DR   HOGENOM; CLU_060077_0_6_11; -.
DR   InParanoid; P0A4T8; -.
DR   OMA; HAGHRRY; -.
DR   PhylomeDB; P0A4T8; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.490.50; -; 1.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   InterPro; IPR036244; TipA-like_antibiotic-bd.
DR   InterPro; IPR012925; TipAS_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   Pfam; PF07739; TipAS; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   SUPFAM; SSF89082; SSF89082; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..253
FT                   /note="HTH-type transcriptional activator TipA"
FT                   /id="PRO_0000098157"
FT   DOMAIN          1..71
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   253 AA;  28711 MW;  0B32F6191BF2B779 CRC64;
     MSYSVGQVAG FAGVTVRTLH HYDDIGLLVP SERSHAGHRR YSDADLDRLQ QILFYRELGF
     PLDEVAALLD DPAADPRAHL RRQHELLSAR IGKLQKMAAA VEQAMEARSM GINLTPEEKF
     EVFGDFDPDQ YEEEVRERWG NTDAYRQSKE KTASYTKEDW QRIQDEADEL TRRFVALMDA
     GEPADSEGAM DAAEDHRQGI ARNHYDCGYE MHTCLGEMYV SDERFTRNID AAKPGLAAYM
     RDAILANAVR HTP