ID   TIPD_DICDI              Reviewed;         612 AA.
AC   O15736; Q553S4;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Protein tipD;
GN   Name=tipD; ORFNames=DDB_G0275323;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX4;
RA   Stege J.T., Loomis W.F.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Not known; disruption of the gene for tipD results in
CC       morphological defects.
CC   -!- SIMILARITY: Belongs to the WD repeat tipD family. {ECO:0000305}.
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DR   EMBL; AF019236; AAB70659.1; -; Genomic_DNA.
DR   EMBL; AAFI02000013; EAL69727.1; -; Genomic_DNA.
DR   PIR; T08602; T08602.
DR   RefSeq; XP_643673.1; XM_638581.1.
DR   AlphaFoldDB; O15736; -.
DR   SMR; O15736; -.
DR   BioGRID; 1244942; 2.
DR   STRING; 44689.DDB0215341; -.
DR   PaxDb; O15736; -.
DR   EnsemblProtists; EAL69727; EAL69727; DDB_G0275323.
DR   GeneID; 8619939; -.
DR   KEGG; ddi:DDB_G0275323; -.
DR   dictyBase; DDB_G0275323; tipD.
DR   eggNOG; KOG0288; Eukaryota.
DR   HOGENOM; CLU_000288_57_10_1; -.
DR   InParanoid; O15736; -.
DR   OMA; LFVWEVN; -.
DR   PhylomeDB; O15736; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   PRO; PR:O15736; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0034274; C:Atg12-Atg5-Atg16 complex; ISS:dictyBase.
DR   GO; GO:0000421; C:autophagosome membrane; IBA:GO_Central.
DR   GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR   GO; GO:0019776; F:Atg8 ligase activity; ISS:dictyBase.
DR   GO; GO:0000045; P:autophagosome assembly; IMP:dictyBase.
DR   GO; GO:0097352; P:autophagosome maturation; IMP:dictyBase.
DR   GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0016236; P:macroautophagy; IMP:dictyBase.
DR   GO; GO:0006909; P:phagocytosis; IMP:dictyBase.
DR   GO; GO:0006907; P:pinocytosis; IMP:dictyBase.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:dictyBase.
DR   GO; GO:0030587; P:sorocarp development; HMP:dictyBase.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR045160; ATG16.
DR   InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19878; PTHR19878; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF08614; ATG16; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 5.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..612
FT                   /note="Protein tipD"
FT                   /id="PRO_0000051275"
FT   REPEAT          322..361
FT                   /note="WD 1"
FT   REPEAT          364..403
FT                   /note="WD 2"
FT   REPEAT          406..444
FT                   /note="WD 3"
FT   REPEAT          447..486
FT                   /note="WD 4"
FT   REPEAT          490..530
FT                   /note="WD 5"
FT   REPEAT          535..576
FT                   /note="WD 6"
FT   REPEAT          582..611
FT                   /note="WD 7"
FT   REGION          95..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   612 AA;  68747 MW;  4DB6D03EDEC0B6E1 CRC64;
     MFSSQNNSYM MMMGGGGIGN INNNQFYSPI ISTSAQSFNS IVEWKRDIIR QLNDRNQNQT
     NNYSEFMRIY TDLLKRERTL NDRTLLYEKE IVSLRNEKKT QQQPPSGSSK MDSSSSSSSS
     NRVSGMGSTI EEMEQKLFKL QEDLTNSYKR NADNASSILL LNDKNKDLQN ELMSKEIEIE
     RIRSTIQQDL DSIKRLEMVV IEKENVSQII RDELSSLQTE FLHNESKVVK LEQENSSLVE
     RWLRKKNEEA SKMNEANDFY QKMVEQRDST PAKAAVQLSE SISNLVVKLP DANDVPIPIV
     LERGVFSSEA MLPSKAKKRW TGHNSEIYCM AFNSIGNLLA TGGGDKCVKV WDVISGQQKS
     TLLGASQSIV SVSFSPNDES ILGTSNDNSA RLWNTELGRS RHTLTGHIGK VYTGKFINSN
     RVVTGSHDRT IKLWDLQKGY CTRTIFCFSS CNDLVILGGS GTHLASGHVD HSVRFWDSNA
     GEPTQVLSSI HEGQITSITN SPTNTNQILT NSRDHTLKII DIRTFDTIRT FKDPEYRNGL
     NWTKASWSPD GRYIASGSID GSICIWDATN GKTVKVLTKV HNNGSSVCCC SWSPLANIFI
     SADKDKNIIQ WE