TIPE_DROME
ID TIPE_DROME Reviewed; 452 AA.
AC P48613; A4V1G4; Q9VZG6;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein tipE;
DE AltName: Full=Temperature-induced paralytic E;
GN Name=tipE; ORFNames=CG1232;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=Canton-S; TISSUE=Head;
RX PubMed=7553842; DOI=10.1016/0092-8674(95)90279-1;
RA Feng G., Deak P., Chopra M., Hall L.M.;
RT "Cloning and functional analysis of TipE, a novel membrane protein that
RT enhances Drosophila para sodium channel function.";
RL Cell 82:1001-1011(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Enhances para sodium channel function. Required during pupal
CC development to rescue adult paralysis and also protects adult flies
CC against heat-induced lethality. {ECO:0000269|PubMed:7553842}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in the central nervous
CC system of developing embryos, weaker expression is seen in the
CC peripheral nervous system. In pupae and adults, expression is seen
CC predominantly in heads, body and legs. {ECO:0000269|PubMed:7553842}.
CC -!- DEVELOPMENTAL STAGE: Expressed weakly in middle to late embryos, absent
CC in larvae and is most abundantly expressed in middle to late pupal
CC stages. {ECO:0000269|PubMed:7553842}.
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DR EMBL; U27561; AAC48307.1; -; mRNA.
DR EMBL; AE014296; AAF47857.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN11591.1; -; Genomic_DNA.
DR EMBL; AY060317; AAL25356.1; -; mRNA.
DR PIR; A57217; A57217.
DR RefSeq; NP_523920.1; NM_079196.3.
DR RefSeq; NP_728952.1; NM_168067.2.
DR AlphaFoldDB; P48613; -.
DR BioGRID; 63982; 1.
DR STRING; 7227.FBpp0073076; -.
DR TCDB; 8.A.19.1.1; the sodium channel auxiliary subunit tipe (scat) family.
DR GlyGen; P48613; 5 sites.
DR PaxDb; P48613; -.
DR PRIDE; P48613; -.
DR DNASU; 38504; -.
DR EnsemblMetazoa; FBtr0073219; FBpp0073075; FBgn0003710.
DR EnsemblMetazoa; FBtr0073220; FBpp0073076; FBgn0003710.
DR GeneID; 38504; -.
DR KEGG; dme:Dmel_CG1232; -.
DR CTD; 38504; -.
DR FlyBase; FBgn0003710; tipE.
DR VEuPathDB; VectorBase:FBgn0003710; -.
DR eggNOG; ENOG502RCF1; Eukaryota.
DR GeneTree; ENSGT00940000167912; -.
DR HOGENOM; CLU_041592_0_0_1; -.
DR InParanoid; P48613; -.
DR OMA; DMWQNTL; -.
DR OrthoDB; 924380at2759; -.
DR PhylomeDB; P48613; -.
DR BioGRID-ORCS; 38504; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38504; -.
DR PRO; PR:P48613; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0003710; Expressed in brain and 33 other tissues.
DR Genevisible; P48613; DM.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR GO; GO:0017080; F:sodium channel regulator activity; IDA:FlyBase.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; TAS:FlyBase.
DR GO; GO:0034605; P:cellular response to heat; IDA:FlyBase.
DR GO; GO:0045433; P:male courtship behavior, veined wing generated song production; IMP:FlyBase.
DR GO; GO:0002028; P:regulation of sodium ion transport; IDA:FlyBase.
DR GO; GO:0006814; P:sodium ion transport; NAS:FlyBase.
DR InterPro; IPR031578; TipE.
DR PANTHER; PTHR12335; PTHR12335; 1.
DR Pfam; PF16972; TipE; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..452
FT /note="Protein tipE"
FT /id="PRO_0000072546"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..452
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 423..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 452 AA; 50190 MW; 1E81443B5E9ACF24 CRC64;
MGDEQDKRTG KEKLLFYTTA FFILLGTFSL FAFLFLVPFV IEPAFTTIFM QFEEVPALCE
TYDTEIYYGA KNCSWSSCRE GCTKDIYTCT QIRVNYRLNL YNFTDEFNFT EYHINLKEAE
RILPPVKRTD RYERALRSDY EYDNLGGGTG LDIDLGAGRM EQLNFGDADG SNGYLIEDSE
DTRGLSASGT LISDERRPFD EISELNEGLM GNRSMYYYVG ARLFPNVKGC GYPPMLNCTI
WLKRYTKIGM KFPCYYSKVD PSLVISDLDY WQNTLNLVYS MAIPIPSFII SVIYLTYAYF
KIYNEDEETA PLDKNAEDMD IDDIDAVDDS DGAVLADNVA GSQIINMDST TNDSCLEGVL
PNGGPGMTAS ISQGGSVTTP GPYIAQSPAG SQMTPNSEIN SFGHQLKVQM ADELSRDSLE
NGAISTSNSV QGNLSKTMTT SISTPPGPTA AV
