TIPIN_CAEBR
ID TIPIN_CAEBR Reviewed; 239 AA.
AC Q61XH2; A8WVX1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Protein TIPIN homolog;
DE AltName: Full=CSM3 homolog;
GN Name=tipn-1 {ECO:0000312|WormBase:CBG03985};
GN ORFNames=CBG03985 {ECO:0000312|WormBase:CBG03985};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Required for normal progression of S-phase. Important for
CC cell survival after DNA damage or replication stress.
CC {ECO:0000250|UniProtKB:Q9BVW5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BVW5}. Nucleus
CC {ECO:0000250|UniProtKB:Q9BVW5}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR EMBL; HE600906; CAP24784.1; -; Genomic_DNA.
DR RefSeq; XP_002639397.1; XM_002639351.1.
DR AlphaFoldDB; Q61XH2; -.
DR SMR; Q61XH2; -.
DR STRING; 6238.CBG03985; -.
DR EnsemblMetazoa; CBG03985.1; CBG03985.1; WBGene00026738.
DR GeneID; 8581390; -.
DR KEGG; cbr:CBG_03985; -.
DR CTD; 8581390; -.
DR WormBase; CBG03985; CBP14958; WBGene00026738; Cbr-tipn-1.
DR eggNOG; KOG3004; Eukaryota.
DR HOGENOM; CLU_1181146_0_0_1; -.
DR InParanoid; Q61XH2; -.
DR OMA; MKKYAYW; -.
DR OrthoDB; 1505397at2759; -.
DR Proteomes; UP000008549; Chromosome I.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0044770; P:cell cycle phase transition; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; ISS:UniProtKB.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; PTHR13220; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; DNA damage; Mitosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..239
FT /note="Protein TIPIN homolog"
FT /id="PRO_0000305259"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..239
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 27956 MW; ED07B0EDAAB22EBB CRC64;
MDEMDDFFGN DELDREPSPF GEEAIEDNTG EEGSRRIIEP KLLRTKKLTN PRLALNEKTL
TGPKGITALR EAFQNFNPNP KDDPYKNLEK MMKKYAYWGH LMFPKMKTED VLNRVETLGT
RRQVKLYIMK QRLGESTDDV ENEKRETKSK NGIIDDGADD DEDDLFNDLP EKETPTKPIN
HTEKVVDSPE KKNGQVSNND AEEEEYRMME EERLREEQEA REAEAEDELM EDFDLNNDW