TIPIN_CAEEL
ID TIPIN_CAEEL Reviewed; 233 AA.
AC Q9TXI0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Protein TIPIN homolog;
DE AltName: Full=CSM3 homolog;
GN Name=tipn-1 {ECO:0000312|WormBase:F23C8.9};
GN ORFNames=F23C8.9 {ECO:0000312|WormBase:F23C8.9};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for normal progression of S-phase. Important for
CC cell survival after DNA damage or replication stress.
CC {ECO:0000250|UniProtKB:Q9BVW5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BVW5}. Nucleus
CC {ECO:0000250|UniProtKB:Q9BVW5}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR EMBL; FO081207; CCD69893.1; -; Genomic_DNA.
DR PIR; T33829; T33829.
DR RefSeq; NP_490977.1; NM_058576.4.
DR AlphaFoldDB; Q9TXI0; -.
DR SMR; Q9TXI0; -.
DR BioGRID; 37288; 1.
DR STRING; 6239.F23C8.9; -.
DR EPD; Q9TXI0; -.
DR PaxDb; Q9TXI0; -.
DR PeptideAtlas; Q9TXI0; -.
DR PRIDE; Q9TXI0; -.
DR EnsemblMetazoa; F23C8.9.1; F23C8.9.1; WBGene00017738.
DR GeneID; 171803; -.
DR KEGG; cel:CELE_F23C8.9; -.
DR UCSC; F23C8.9; c. elegans.
DR CTD; 171803; -.
DR WormBase; F23C8.9; CE20718; WBGene00017738; tipn-1.
DR eggNOG; KOG3004; Eukaryota.
DR GeneTree; ENSGT00390000005764; -.
DR HOGENOM; CLU_1181146_0_0_1; -.
DR InParanoid; Q9TXI0; -.
DR OMA; MKKYAYW; -.
DR OrthoDB; 1505397at2759; -.
DR PhylomeDB; Q9TXI0; -.
DR PRO; PR:Q9TXI0; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00017738; Expressed in embryo and 4 other tissues.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0031298; C:replication fork protection complex; ISS:WormBase.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0044770; P:cell cycle phase transition; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; ISS:UniProtKB.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR GO; GO:0048478; P:replication fork protection; ISS:WormBase.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; PTHR13220; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; DNA damage; Mitosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..233
FT /note="Protein TIPIN homolog"
FT /id="PRO_0000305260"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 27078 MW; 1B59CDE39DF64655 CRC64;
MDEMEDFFEN DELDREPSPM GDEAIEDNSG EGGTRRVVEP KLLRTKRLAN PRLALNERIL
TGPKGISALR ETLKDFKPNP KDDPYANLEK LMKKYAYWGH LMFPKMKTED VLNRVETLGT
RRQVKVFMIK HRLGETGEDS EHEEQENQKN GIIDDGASDN DDDLFKDLPE KEVTTEKAKN
SEKSDQKTAE IDENVEEEYR MMEEERLREE QEAKEAADED ALMEDFGDMN NDW
