ID   TIPI_LAMBD              Reviewed;         223 AA.
AC   P03730;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   23-FEB-2022, entry version 67.
DE   RecName: Full=Tail tip assembly protein I;
GN   Name=I; OrderedLocusNames=lambdap20;
OS   Escherichia phage lambda (Bacteriophage lambda).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Lambdavirus.
OX   NCBI_TaxID=10710;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6221115; DOI=10.1016/0022-2836(82)90546-0;
RA   Sanger F., Coulson A.R., Hong G.F., Hill D.F., Petersen G.B.;
RT   "Nucleotide sequence of bacteriophage lambda DNA.";
RL   J. Mol. Biol. 162:729-773(1982).
RN   [2]
RP   FUNCTION.
RX   PubMed=1003470; DOI=10.1016/s0022-2836(76)80007-1;
RA   Katsura I.;
RT   "Morphogenesis of bacteriophage lambda tail. Polymorphism in the assembly
RT   of the major tail protein.";
RL   J. Mol. Biol. 107:307-326(1976).
CC   -!- FUNCTION: Plays a role in distal tail tip complex assembly. The tail
CC       tip complex is assembled successively with three tail tip proteins J,
CC       one tail tip protein I, one tail tip protein L and one tail tip protein
CC       K. The tail tip complex interacts with tail measure protein to initiate
CC       tail tube assembly. The formation of the tail tip complex is completed
CC       by the addition of tail tip protein M, which is followed by tail tube
CC       polymerization. May be excluded form tail tip during maturation and
CC       would be absent from virions. {ECO:0000269|PubMed:1003470}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm.
CC   -!- SIMILARITY: Belongs to the lambda-like tail tip protein I family.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1, Met-14 or Val-34 is the
CC       initiator. {ECO:0000305}.
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DR   EMBL; J02459; AAA96552.1; -; Genomic_DNA.
DR   PIR; A43008; TJBPIL.
DR   RefSeq; NP_040599.1; NC_001416.1.
DR   SMR; P03730; -.
DR   GeneID; 2703515; -.
DR   KEGG; vg:2703515; -.
DR   Proteomes; UP000001711; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR010654; Phage_lambda_tail_I.
DR   Pfam; PF06805; Lambda_tail_I; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Late protein; Reference proteome;
KW   Viral release from host cell; Viral tail assembly.
FT   CHAIN           1..223
FT                   /note="Tail tip assembly protein I"
FT                   /id="PRO_0000077709"
SQ   SEQUENCE   223 AA;  23124 MW;  7014719A94D3DACA CRC64;
     MAATHTLPLA SPGMARICLY GDLQRFGRRI DLRVKTGAEA IRALATQLPA FRQKLSDGWY
     QVRIAGRDVS TSGLTAQLHE TLPDGAVIHI VPRVAGAKSG GVFQIVLGAA AIAGSFFTAG
     ATLAAWGAAI GAGGMTGILF SLGASMVLGG VAQMLAPKAR TPRIQTTDNG KQNTYFSSLD
     NMVAQGNVLP VLYGEMRVGS RVVSQEISTA DEGDGGQVVV IGR