ID   TIPM_LAMBD              Reviewed;         109 AA.
AC   P03737;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Tail tip protein M;
GN   Name=M; OrderedLocusNames=lambdap17;
OS   Escherichia phage lambda (Bacteriophage lambda).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Lambdavirus.
OX   NCBI_TaxID=10710;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6221115; DOI=10.1016/0022-2836(82)90546-0;
RA   Sanger F., Coulson A.R., Hong G.F., Hill D.F., Petersen G.B.;
RT   "Nucleotide sequence of bacteriophage lambda DNA.";
RL   J. Mol. Biol. 162:729-773(1982).
RN   [2]
RP   FUNCTION.
RX   PubMed=1003470; DOI=10.1016/s0022-2836(76)80007-1;
RA   Katsura I.;
RT   "Morphogenesis of bacteriophage lambda tail. Polymorphism in the assembly
RT   of the major tail protein.";
RL   J. Mol. Biol. 107:307-326(1976).
CC   -!- FUNCTION: Part of the distal tail tip which plays a role in DNA
CC       ejection during entry, and in tail assembly initiation during exit. May
CC       bind tail tip complex associated with tape measure protein and allow
CC       tail tube protein polymerization on top of tail tip.
CC       {ECO:0000269|PubMed:1003470}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm.
CC   -!- SIMILARITY: Belongs to the lambda-like tail tip protein M family.
CC       {ECO:0000305}.
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DR   EMBL; J02459; AAA96549.1; -; Genomic_DNA.
DR   PIR; I43008; TLBPML.
DR   RefSeq; NP_040596.1; NC_001416.1.
DR   IntAct; P03737; 6.
DR   GeneID; 2703512; -.
DR   KEGG; vg:2703512; -.
DR   Proteomes; UP000001711; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0098015; C:virus tail; IEA:UniProtKB-KW.
DR   GO; GO:0099001; P:viral genome ejection through host cell envelope, long flexible tail mechanism; IEA:UniProtKB-KW.
DR   GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR010265; Phage_lambda_TipM.
DR   Pfam; PF05939; Phage_min_tail; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Late protein; Reference proteome;
KW   Viral genome ejection through host cell envelope;
KW   Viral long flexible tail ejection system;
KW   Viral penetration into host cytoplasm; Viral release from host cell;
KW   Viral tail assembly; Viral tail protein; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..109
FT                   /note="Tail tip protein M"
FT                   /id="PRO_0000077668"
SQ   SEQUENCE   109 AA;  12530 MW;  4D19F7308377DCA9 CRC64;
     MKTFRWKVKP GMDVASVPSV RKVRFGDGYS QRAPAGLNAN LKTYSVTLSV PREEATVLES
     FLEEHGGWKS FLWTPPYEWR QIKVTCAKWS SRVSMLRVEF SAEFEQVVN