ID   TIPRL_ARATH             Reviewed;         290 AA.
AC   Q8VXY4; Q9SYZ2; Q9XGU2;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=TIP41-like protein {ECO:0000312|EMBL:AEE86352.1};
GN   Name=TIP41L {ECO:0000303|PubMed:24810976};
GN   OrderedLocusNames=At4g34270 {ECO:0000312|Araport:AT4G34270};
GN   ORFNames=F10M10.40 {ECO:0000312|EMBL:CAB36704.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-111.
RX   PubMed=8893552; DOI=10.1046/j.1365-313x.1996.10040761.x;
RA   Xia G., Ramachandran S., Hong Y., Chan Y.-S., Simanis V., Chua N.-H.;
RT   "Identification of plant cytoskeletal, cell cycle-related and polarity-
RT   related proteins using Schizosaccharomyces pombe.";
RL   Plant J. 10:761-769(1996).
RN   [5]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=16166256; DOI=10.1104/pp.105.063743;
RA   Czechowski T., Stitt M., Altmann T., Udvardi M.K., Scheible W.R.;
RT   "Genome-wide identification and testing of superior reference genes for
RT   transcript normalization in Arabidopsis.";
RL   Plant Physiol. 139:5-17(2005).
RN   [6]
RP   REVIEW.
RX   PubMed=24810976; DOI=10.1111/pce.12364;
RA   Lillo C., Kataya A.R., Heidari B., Creighton M.T., Nemie-Feyissa D.,
RA   Ginbot Z., Jonassen E.M.;
RT   "Protein phosphatases PP2A, PP4 and PP6: mediators and regulators in
RT   development and responses to environmental cues.";
RL   Plant Cell Environ. 37:2631-2648(2014).
CC   -!- FUNCTION: May be involved in the regulation of the TOR signaling
CC       pathway. Indirectly activates the PP2A phosphatase via interaction with
CC       its suppressor TAP46. Could play a role in cytoskeleton functions.
CC       {ECO:0000250|UniProtKB:Q12199}.
CC   -!- SUBUNIT: Interacts with TAP46. {ECO:0000250|UniProtKB:Q12199}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16166256}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout all development stages.
CC       {ECO:0000269|PubMed:16166256}.
CC   -!- MISCELLANEOUS: Considered as a reference gene in terms of expression
CC       stability throughout development. {ECO:0000303|PubMed:16166256}.
CC   -!- SIMILARITY: Belongs to the TIP41 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD38207.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAD38207.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAB36704.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB80144.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL035521; CAB36704.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161585; CAB80144.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE86352.1; -; Genomic_DNA.
DR   EMBL; AY074349; AAL67045.1; -; mRNA.
DR   EMBL; AY091389; AAM14328.1; -; mRNA.
DR   EMBL; AF156565; AAD38207.1; ALT_SEQ; mRNA.
DR   PIR; T04773; T04773.
DR   RefSeq; NP_195153.2; NM_119592.5.
DR   AlphaFoldDB; Q8VXY4; -.
DR   SMR; Q8VXY4; -.
DR   STRING; 3702.AT4G34270.1; -.
DR   PaxDb; Q8VXY4; -.
DR   PRIDE; Q8VXY4; -.
DR   ProteomicsDB; 234303; -.
DR   DNASU; 829577; -.
DR   EnsemblPlants; AT4G34270.1; AT4G34270.1; AT4G34270.
DR   GeneID; 829577; -.
DR   Gramene; AT4G34270.1; AT4G34270.1; AT4G34270.
DR   KEGG; ath:AT4G34270; -.
DR   Araport; AT4G34270; -.
DR   TAIR; locus:2116169; AT4G34270.
DR   eggNOG; KOG3224; Eukaryota.
DR   HOGENOM; CLU_039187_2_0_1; -.
DR   InParanoid; Q8VXY4; -.
DR   OMA; GIPIPEM; -.
DR   OrthoDB; 1377237at2759; -.
DR   PhylomeDB; Q8VXY4; -.
DR   PRO; PR:Q8VXY4; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q8VXY4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IBA:GO_Central.
DR   GO; GO:0031929; P:TOR signaling; IMP:TAIR.
DR   InterPro; IPR007303; TIP41-like.
DR   Pfam; PF04176; TIP41; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..290
FT                   /note="TIP41-like protein"
FT                   /id="PRO_0000440569"
SQ   SEQUENCE   290 AA;  33075 MW;  DBD7BE5D9F9589F4 CRC64;
     METVVDKDVL KSSGAELLPD GRRGLRIHDW EIETLRGTIL TSLAVEEWEK KLKTSHLPEM
     VFGENALVLK HLGSNTKIHF NAFDALAGWK QEGLPPVEVP AAAQWKFRSK PSQQVILDYD
     YTFTTPYCGS EVVEKDKETV EAKANPKGEA TLQWENCEDQ IDLAALSLKE PILFYDEVVL
     YEDELADNGV SLLTVKVRVM PSSWFLLLRF WLRVDGVLMR LRETRMHYRF GEDEAPTVLR
     ENCWREATFQ SLSAKGYPVD LAVWSDPSSI SQRLPVIKHT TQKLKIPSKV