TIP_MACFA
ID TIP_MACFA Reviewed; 311 AA.
AC Q95KC8;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 2.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=T-cell immunomodulatory protein;
DE Short=Protein TIP;
DE AltName: Full=Integrin-alpha FG-GAP repeat-containing protein 1;
DE AltName: Full=Linkin {ECO:0000250|UniProtKB:Q8TB96};
DE Flags: Fragment;
GN Name=ITFG1 {ECO:0000250|UniProtKB:Q8TB96};
GN Synonyms=LNKN-1 {ECO:0000250|UniProtKB:Q8TB96},
GN TIP {ECO:0000250|UniProtKB:Q8TB96}; ORFNames=QmoA-10172;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Medulla oblongata;
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Modulator of T-cell function. Has a protective effect in
CC graft versus host disease model (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RUVBL1, RUVBL2 and alpha-tubulin.
CC {ECO:0000250|UniProtKB:Q8TB96}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cell membrane
CC {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB60741.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB062962; BAB60741.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q95KC8; -.
DR STRING; 9541.XP_005591903.1; -.
DR eggNOG; KOG4550; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR024881; Tip.
DR PANTHER; PTHR13412; PTHR13412; 1.
DR SUPFAM; SSF69318; SSF69318; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Secreted;
KW Transmembrane; Transmembrane helix.
FT CHAIN <1..311
FT /note="T-cell immunomodulatory protein"
FT /id="PRO_0000059046"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 1
SQ SEQUENCE 311 AA; 34906 MW; 8F21871DBCFC0257 CRC64;
PVLQDFSNKG TLWGFVPFVD EQQPTEIPIP ITLHIGDYNM DGYPDALVIL KNTSGSNQQA
FLLENVPCNN ASCEEARRMF KVYWELTDLN QIKDAMVATF FDIYEDGILD IVVLSKGYTK
NDFAIHTLKN NFEADAYFVK VIVLSGLCSN DCPRKITPFG VNQPGPYIMY TTVDANGYLK
NGSAGQLSQS AHLALQLPYN VLGLGRSANF LDHLYVGIPR PSGEKSIRKQ EWTAIIPNSQ
LIVIPYPHNV PRSWSAKLYL TPSNIVLLTA IALIGVCVFI LAIIGILHWQ EKKADDREKR
QEAHRFHFDA M