TIP_PLAF7
ID TIP_PLAF7 Reviewed; 719 AA.
AC Q8I3H7;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=T-cell immunomodulatory protein homolog;
DE Flags: Precursor;
GN ORFNames=PFE1445c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP PUTATIVE FUNCTION.
RX PubMed=12833085; DOI=10.1038/nbt0703-733;
RA Kaczanowski S., Zielenkiewicz P.;
RT "A TIP on malaria (genomics).";
RL Nat. Biotechnol. 21:733-733(2003).
CC -!- FUNCTION: May protect the parasite against attack by the host immune
CC system by immunomodulation.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TIP family. {ECO:0000305}.
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DR EMBL; AL844504; CAD51651.1; -; Genomic_DNA.
DR RefSeq; XP_001351844.1; XM_001351808.1.
DR AlphaFoldDB; Q8I3H7; -.
DR STRING; 5833.PFE1445c; -.
DR SwissPalm; Q8I3H7; -.
DR PRIDE; Q8I3H7; -.
DR EnsemblProtists; CAD51651; CAD51651; PF3D7_0529000.
DR GeneID; 813103; -.
DR KEGG; pfa:PF3D7_0529000; -.
DR VEuPathDB; PlasmoDB:PF3D7_0529000; -.
DR HOGENOM; CLU_020272_1_0_1; -.
DR InParanoid; Q8I3H7; -.
DR OMA; PGDWIPW; -.
DR PhylomeDB; Q8I3H7; -.
DR Proteomes; UP000001450; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.130.10.130; -; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR024881; Tip.
DR PANTHER; PTHR13412; PTHR13412; 1.
DR Pfam; PF13517; FG-GAP_3; 1.
DR SUPFAM; SSF69318; SSF69318; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..719
FT /note="T-cell immunomodulatory protein homolog"
FT /id="PRO_0000034357"
FT TOPO_DOM 33..677
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 678..697
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 698..719
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 410
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 540
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 659
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 719 AA; 82905 MW; B4DE47410A8D81C1 CRC64;
MYNFLSCKKK SIILQVLLII CTYNILLNFV NIFVNNNEKN HKNKYENRIK SFYVEAYNWN
FLEKWKSINT NEKLEYKINY NIGLNIDAEI GDFGDYNSDV KTDLILFKYD KDKLLSTIFI
YVFSVKENKF IYHTEVSFEG KIMNVTAIDL NFDGALDVLV LFKDNKDSSK SNKYYVAAFL
QNDNDQLEEI WNSKKKEQND ESITDNEEDN IYYTNIHPLI CDINNDGLPD IIGQQSGGPD
GFFRFIWINT RNGFKSFLWK NINIFKYSEL DEITNPNSSA IVDINGDCKS DLVFTVYNSY
EKRIGLEIWL NKIIDGKSFY VKYSQDYLLP PNSLQVLFGD FNGDGSIDLV VPTCVKSSFC
NYCCVSDDKI YFIPNIQKKI CDSSWKKPDE TKCRPASNLC SESDFEFQQN LTDDFISVVD
TSGLHLSGNA DYPYYLSVGD IDDDGYLDLL ITLKNDKGQK YVRIYKNELK IHYEENSLEV
RGFYNFYQFV TSPEESVTDV YNAAFFDIFE NGVLDILIFG KYITSNKKTK YAAVGFIRNN
ETDSLFLKST ALNGICVNDC YKEKDKITTK TLGGNAHGPT FKITVIDVNG VKSSRIGVQK
SQSAHFPLQL PYVLFGLGRT SNYVEEFYVG MPTHEQKYYN MWVSIIPNSH IIVIPYPLNN
SNKWQIQLSV NPSKKFYSIL YITLICLSVI GVLIFILDRK EKVEDSKEEL GFKSHFVIG
