ID   TIP_PLAYO               Reviewed;         701 AA.
AC   Q7RRM4;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=T-cell immunomodulatory protein homolog;
DE   Flags: Precursor;
GN   ORFNames=PY00695;
OS   Plasmodium yoelii yoelii.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=73239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17XNL;
RX   PubMed=12368865; DOI=10.1038/nature01099;
RA   Carlton J.M., Angiuoli S.V., Suh B.B., Kooij T.W., Pertea M., Silva J.C.,
RA   Ermolaeva M.D., Allen J.E., Selengut J.D., Koo H.L., Peterson J.D., Pop M.,
RA   Kosack D.S., Shumway M.F., Bidwell S.L., Shallom S.J., van Aken S.E.,
RA   Riedmuller S.B., Feldblyum T.V., Cho J.K., Quackenbush J., Sedegah M.,
RA   Shoaibi A., Cummings L.M., Florens L., Yates J.R. III, Raine J.D.,
RA   Sinden R.E., Harris M.A., Cunningham D.A., Preiser P.R., Bergman L.W.,
RA   Vaidya A.B., van Lin L.H., Janse C.J., Waters A.P., Smith H.O., White O.R.,
RA   Salzberg S.L., Venter J.C., Fraser C.M., Hoffman S.L., Gardner M.J.,
RA   Carucci D.J.;
RT   "Genome sequence and comparative analysis of the model rodent malaria
RT   parasite Plasmodium yoelii yoelii.";
RL   Nature 419:512-519(2002).
CC   -!- FUNCTION: May protect the parasite against attack by the host immune
CC       system by immunomodulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TIP family. {ECO:0000305}.
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DR   EMBL; AABL01000189; EAA17888.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7RRM4; -.
DR   STRING; 73239.Q7RRM4; -.
DR   PRIDE; Q7RRM4; -.
DR   EnsemblProtists; EAA17888; EAA17888; EAA17888.
DR   InParanoid; Q7RRM4; -.
DR   OMA; PGDWIPW; -.
DR   Proteomes; UP000008553; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR024881; Tip.
DR   PANTHER; PTHR13412; PTHR13412; 1.
DR   Pfam; PF13517; FG-GAP_3; 1.
DR   SUPFAM; SSF69318; SSF69318; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..701
FT                   /note="T-cell immunomodulatory protein homolog"
FT                   /id="PRO_0000034358"
FT   TOPO_DOM        30..657
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        658..678
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        679..701
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        217
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        258
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        458
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        522
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        571
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   701 AA;  80082 MW;  CAA48E7BF054FFE4 CRC64;
     MVKCGKYVLI LELLLLTLLY NLIKRVSNSG ETVSSFVDGY NWNIMERWKA ITPKEKLEYK
     VNYDLGLDID AEIGDFGDYN SDVKTDLILF KYDKTTMIST IFVYIFSPSE NKFIYHTEAK
     LEGKIVNLMV IDLNFDGSLD ALVLFKDNSS QDKFYISTFI QNENDELEEK FNTKKKETEN
     ETISDFEDQN FYFTNIHPLL CDINNDGLPD LIAQHPNKSK SFSRFIWIND GDGGFKSILW
     ENLNIFEYTD ISEISNPNSS AIVDLNGDCK ADLVFTVINK KNTKRIFLEI WINKIVDGKS
     LYVKADEDYM LPANSMQILF ADFNADGSID MVVPTCVKSS SCNYCCTSDD KIYFIPNIQT
     KICENSWTKN EDNKCRLASN LCSESDFEFA KKLSPDYISL LDDKGLHFSG DASYPSYLSV
     GDVDDDGYLD LLVSLRNDKG QKFVRIYKNE QISNNEQNHT DIRRFYNYYQ FISSLEESTP
     DVYNAAFFDI FENGILDVII FGTYNSNSKI KKYSSVGFVR SNETDSLFLK STALNGICVN
     DCYKEKDKIS TKTLGGNAHG PTFKITVIDA NGTKSSKIGI QKSQSAHSPL QLPYVLFGLG
     RTSNYVEEFY VGMPTHEHSY YNMWVSIIPN SHIIVIPYPL DDSNKWQIQL SVNPSNKFYS
     IIYITLICLS VIGVLIFILD RKEKIEDSKE EMGFKSHFVI G