TIP_RAT
ID TIP_RAT Reviewed; 610 AA.
AC Q8R4E1;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=T-cell immunomodulatory protein;
DE Short=Protein TIP;
DE AltName: Full=CDA08-like protein;
DE AltName: Full=Integrin-alpha FG-GAP repeat-containing protein 1;
DE AltName: Full=Linkin {ECO:0000250|UniProtKB:Q8TB96};
DE Flags: Precursor;
GN Name=Itfg1 {ECO:0000312|RGD:619898};
GN Synonyms=Cda08 {ECO:0000312|RGD:619898},
GN Lnkn-1 {ECO:0000250|UniProtKB:Q8TB96}, Tip {ECO:0000250|UniProtKB:Q8TB96};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Cerebellum;
RA Vie-Luton M.-P., Francon J.;
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-480, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24090084; DOI=10.1021/pr400783j;
RA Parker B.L., Thaysen-Andersen M., Solis N., Scott N.E., Larsen M.R.,
RA Graham M.E., Packer N.H., Cordwell S.J.;
RT "Site-specific glycan-peptide analysis for determination of N-glycoproteome
RT heterogeneity.";
RL J. Proteome Res. 12:5791-5800(2013).
CC -!- FUNCTION: Modulator of T-cell function. Has a protective effect in
CC graft versus host disease model (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RUVBL1, RUVBL2 and alpha-tubulin.
CC {ECO:0000250|UniProtKB:Q8TB96}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cell membrane
CC {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TIP family. {ECO:0000305}.
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DR EMBL; AF480856; AAL84891.1; -; mRNA.
DR AlphaFoldDB; Q8R4E1; -.
DR STRING; 10116.ENSRNOP00000021711; -.
DR GlyGen; Q8R4E1; 11 sites, 2 N-linked glycans (1 site).
DR iPTMnet; Q8R4E1; -.
DR PhosphoSitePlus; Q8R4E1; -.
DR jPOST; Q8R4E1; -.
DR PaxDb; Q8R4E1; -.
DR PRIDE; Q8R4E1; -.
DR RGD; 619898; Itfg1.
DR eggNOG; KOG4550; Eukaryota.
DR InParanoid; Q8R4E1; -.
DR PhylomeDB; Q8R4E1; -.
DR PRO; PR:Q8R4E1; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.130.10.130; -; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR024881; Tip.
DR PANTHER; PTHR13412; PTHR13412; 1.
DR Pfam; PF13517; FG-GAP_3; 1.
DR SUPFAM; SSF69318; SSF69318; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Secreted; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..610
FT /note="T-cell immunomodulatory protein"
FT /id="PRO_0000034356"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 98..135
FT /note="FG-GAP 1; atypical"
FT REPEAT 153..183
FT /note="FG-GAP 2; atypical"
FT REPEAT 256..291
FT /note="FG-GAP 3; atypical"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 369
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 480
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0007744|PubMed:24090084"
SQ SEQUENCE 610 AA; 67337 MW; F5943D993D7D1CBA CRC64;
MAAGLLPSAR AVLALLFLGL ALLSVGPAPA QALHNVTAEL FGGEAWGTLA AFGDLNSDKQ
TDLFVLRERN DLIVFLADQS APYFKPKVKV SLKNFSALVT SVVPGDYDGD SQMDVLLTYF
PQNHSNNELG AVIFWGQNQT LDPKNMTILN RTFHDQPLIM DFNGDLIPDV FAITNESSQP
QILLGGDLSW HPALTTKSKM RDPHSRAFID LTEDFTADLF LTTLSASNTF QFEIWENLGG
NFSIRSVFEK PKNLVVVGQS AFADFDGDGH MDHLLPGCED KDCQKSAIYL MRSGTGQWAP
VLQDSSNKGT LWGFVPFVHE ERPTAIPVPL TLHIGDYNMD GYPDALAILK NTSGSNQQAF
LLENVPCNNA SCEEVHRMFK VYWDLAGLNL IKDAMVATFF DIYEDGTLDI IVLSKGYTKS
DVAIHTLKNN FEADAYFVKV IVLSGLCSSD CPRKITPFGV NQPGPYIMYT TVDANGYLKN
GSAGQLSQSA HLALQLPYNV LGLGRSANFL DHLFVGIPRP SGEKSIRKQE WTAIIPNSQL
MVIPYPHSVP RSWSAKLYLT PSNIVLLTAV ALTGVCVFIL AIIAILHWQE KKADDREKRQ
EAHRFHFDAM
