ID   TIRC_DICDI              Reviewed;         201 AA.
AC   Q54F65;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Protein tirC;
DE   AltName: Full=TIR domain-containing protein C;
GN   Name=tirC; ORFNames=DDB_G0291083;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA   Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA   Skelton J., Ivens A., Bozzaro S.;
RT   "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT   bacteria in Dictyostelium.";
RL   BMC Genomics 9:291-291(2008).
CC   -!- INDUCTION: Up-regulated by phagocytic stimuli.
CC       {ECO:0000269|PubMed:18559084}.
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DR   EMBL; AAFI02000175; EAL61889.1; -; Genomic_DNA.
DR   RefSeq; XP_635389.1; XM_630297.1.
DR   AlphaFoldDB; Q54F65; -.
DR   STRING; 44689.DDB0189226; -.
DR   PaxDb; Q54F65; -.
DR   EnsemblProtists; EAL61889; EAL61889; DDB_G0291083.
DR   GeneID; 8627973; -.
DR   KEGG; ddi:DDB_G0291083; -.
DR   dictyBase; DDB_G0291083; -.
DR   eggNOG; ENOG502RHG0; Eukaryota.
DR   HOGENOM; CLU_1382021_0_0_1; -.
DR   InParanoid; Q54F65; -.
DR   OMA; LGYVWIN; -.
DR   PhylomeDB; Q54F65; -.
DR   PRO; PR:Q54F65; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; -; 1.
DR   InterPro; IPR019302; TIR-like_dom.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF10137; TIR-like; 1.
DR   SUPFAM; SSF52200; SSF52200; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="Protein tirC"
FT                   /id="PRO_0000384458"
FT   DOMAIN          52..186
FT                   /note="TIR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
SQ   SEQUENCE   201 AA;  23006 MW;  5DC080744A22AD7F CRC64;
     MNSNIIKSID IIPNNNNNNN NSVSTVNTNS SVINNNNNNN YNNNSISNGN NERIKVFIVH
     GHNNIVREKV SKFLFEMGFE PILLFEKPNN GQTIIEKLEK EISNCKFGIV IMSPDNKAFT
     KKDSNSDYVE IAYPRLNVVF EFGYLIGKFG RSNVIYLSVP YNGKSQNYDL PSDLLGYVWI
     NYTEDLKELE NEINFGNYKK L