TIS11_DROME
ID TIS11_DROME Reviewed; 436 AA.
AC P47980; Q8IR77; Q9VYK1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein TIS11;
DE AltName: Full=dTIS11;
GN Name=Tis11; Synonyms=TIScc1; ORFNames=CG4070;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND INDUCTION.
RC STRAIN=Oregon-R; TISSUE=Eye imaginal disk, and Larva;
RX PubMed=7936658;
RA Ma Q., Wadleigh D., Chi T., Herschman H.;
RT "The Drosophila TIS11 homologue encodes a developmentally controlled
RT gene.";
RL Oncogene 9:3329-3334(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Oregon-R; TISSUE=Embryo;
RX PubMed=7828883; DOI=10.1016/0378-1119(94)90664-5;
RA Warbrick E., Glover D.;
RT "A Drosophila melanogaster homolog of the TIS11 family of immediate early
RT genes that can rescue a cdr1 cdc25 mutant strain of fission yeast.";
RL Gene 151:243-246(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Present
CC throughout the preblastoderm and remains at a high level during
CC syncytial divisions. From cellularization, expression decreases and at
CC cellular blastoderm maternal expression has nearly completely
CC disappeared. {ECO:0000269|PubMed:7936658}.
CC -!- INDUCTION: The zygotic transcript but not the maternal transcript is
CC moderately induced by forskolin and tetradecanoyl phorbol acetate.
CC {ECO:0000269|PubMed:7936658}.
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DR EMBL; U13397; AAA62666.1; -; mRNA.
DR EMBL; X81194; CAA57066.1; -; mRNA.
DR EMBL; AE014298; AAF48194.2; -; Genomic_DNA.
DR EMBL; AE014298; AAN09314.2; -; Genomic_DNA.
DR RefSeq; NP_001259490.1; NM_001272561.1.
DR RefSeq; NP_511141.2; NM_078586.5.
DR RefSeq; NP_727633.2; NM_167333.4.
DR AlphaFoldDB; P47980; -.
DR SMR; P47980; -.
DR BioGRID; 58616; 8.
DR IntAct; P47980; 9.
DR STRING; 7227.FBpp0073516; -.
DR PaxDb; P47980; -.
DR DNASU; 32222; -.
DR EnsemblMetazoa; FBtr0073683; FBpp0073516; FBgn0011837.
DR EnsemblMetazoa; FBtr0333756; FBpp0305898; FBgn0011837.
DR EnsemblMetazoa; FBtr0345165; FBpp0311375; FBgn0011837.
DR GeneID; 32222; -.
DR KEGG; dme:Dmel_CG4070; -.
DR CTD; 32222; -.
DR FlyBase; FBgn0011837; Tis11.
DR VEuPathDB; VectorBase:FBgn0011837; -.
DR eggNOG; KOG1677; Eukaryota.
DR GeneTree; ENSGT00940000170800; -.
DR HOGENOM; CLU_669507_0_0_1; -.
DR InParanoid; P47980; -.
DR OMA; SFPFHDA; -.
DR OrthoDB; 757651at2759; -.
DR PhylomeDB; P47980; -.
DR Reactome; R-DME-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
DR Reactome; R-DME-450513; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
DR BioGRID-ORCS; 32222; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Tis11; fly.
DR GenomeRNAi; 32222; -.
DR PRO; PR:P47980; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0011837; Expressed in embryonic/larval hemocyte (Drosophila) and 25 other tissues.
DR ExpressionAtlas; P47980; baseline and differential.
DR Genevisible; P47980; DM.
DR GO; GO:0005829; C:cytosol; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IDA:FlyBase.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:FlyBase.
DR GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; IDA:FlyBase.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:FlyBase.
DR GO; GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IMP:FlyBase.
DR GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IMP:FlyBase.
DR InterPro; IPR045877; ZFP36-like.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR12547; PTHR12547; 1.
DR Pfam; PF00642; zf-CCCH; 2.
DR SMART; SM00356; ZnF_C3H1; 2.
DR SUPFAM; SSF90229; SSF90229; 2.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..436
FT /note="Protein TIS11"
FT /id="PRO_0000089172"
FT ZN_FING 135..163
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 173..201
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 205..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 15
FT /note="S -> A (in Ref. 2; CAA57066)"
FT /evidence="ECO:0000305"
FT CONFLICT 96..97
FT /note="PA -> QPP (in Ref. 1; AAA62666)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 47166 MW; 3FCCA3BD643D3838 CRC64;
MSADILQKSR EQDDSHYFER GDISKYVTMN DHLGDFDCNE VRKEIRMLLA HGANLDQQHQ
QQPHRHHGGL TRTISQPAQL IQQQQQQHQQ QQQQQPAVAS LVTITENLGN MNLHRKLERT
QSEPLPPQQP MNTSRYKTEL CRPFEEAGEC KYGEKCQFAH GSHELRNVHR HPKYKTEYCR
TFHSVGFCPY GPRCHFVHNA DEARAQQAAQ AAKSSTQSQS QSQQSSSQNF SPKSNQSSNQ
SSNSSSSSSS SGGGGGGGNS INNNNGSQFY LPLSPPLSMS TGSDRESPTG SLSLSPTNSL
TSFPFHDALQ HGYLASNGAK SNSSASSTSS ASGMGLGMSM GIGQGMIIGQ GLGMGHHGPA
TPPESPNVPI SPVHTPPPYD VVVSGSGAGN NSVGSKQLLQ KSVSTPMQQE DTPRLPVFNR
LSSGVEAYQQ QSNLGL
