ID   TIS1_PSEAB              Reviewed;          77 AA.
AC   A0A0H2ZKA1;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=Immune protein Tis1 {ECO:0000303|PubMed:31695193};
GN   Name=tis1; OrderedLocusNames=PA14_01130;
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA   Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
RN   [2]
RP   FUNCTION.
RC   STRAIN=UCBPP-PA14;
RX   PubMed=31695193; DOI=10.1038/s41586-019-1735-9;
RA   Ahmad S., Wang B., Walker M.D., Tran H.R., Stogios P.J., Savchenko A.,
RA   Grant R.A., McArthur A.G., Laub M.T., Whitney J.C.;
RT   "An interbacterial toxin inhibits target cell growth by synthesizing
RT   (p)ppApp.";
RL   Nature 575:674-678(2019).
CC   -!- FUNCTION: Immunity protein that plays a role in preventing early
CC       activation of toxin Tas1. {ECO:0000269|PubMed:31695193}.
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DR   EMBL; CP000438; ABJ15049.1; -; Genomic_DNA.
DR   RefSeq; WP_003083689.1; NZ_CP034244.1.
DR   AlphaFoldDB; A0A0H2ZKA1; -.
DR   SMR; A0A0H2ZKA1; -.
DR   EnsemblBacteria; ABJ15049; ABJ15049; PA14_01130.
DR   KEGG; pau:PA14_01130; -.
DR   HOGENOM; CLU_2555836_0_0_6; -.
DR   OMA; YIDYPFE; -.
DR   BioCyc; PAER208963:G1G74-96-MON; -.
DR   Proteomes; UP000000653; Chromosome.
PE   4: Predicted;
FT   CHAIN           1..77
FT                   /note="Immune protein Tis1"
FT                   /id="PRO_0000449569"
SQ   SEQUENCE   77 AA;  9260 MW;  10356B2EE675F1A1 CRC64;
     MAIEKGEAFA RRDIYIDYDF EDVTYRWDHR QGTIHVRFYG EAESPEPVEH DNRLFNDALR
     FGREITREEY ETGFPKG