ID   TITF1_CAVPO             Reviewed;         112 AA.
AC   P97273;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Thyroid transcription factor 1;
DE            Short=TTF-1;
DE   AltName: Full=Homeobox protein Nkx-2.1;
DE   AltName: Full=Thyroid nuclear factor 1;
DE   Flags: Fragment;
GN   Name=TITF1; Synonyms=TTF1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Dunkin-Hartley; TISSUE=Lung;
RA   Yuan H.T., Bingle C.D.;
RL   Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds and activates the promoter of
CC       thyroid specific genes such as thyroglobulin, thyroperoxidase, and
CC       thyrotropin receptor. Crucial in the maintenance of the thyroid
CC       differentiation phenotype. May play a role in lung development and
CC       surfactant homeostasis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR   EMBL; U82718; AAB40921.1; -; mRNA.
DR   AlphaFoldDB; P97273; -.
DR   BMRB; P97273; -.
DR   SMR; P97273; -.
DR   STRING; 10141.ENSCPOP00000019607; -.
DR   eggNOG; KOG0842; Eukaryota.
DR   InParanoid; P97273; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           <1..>112
FT                   /note="Thyroid transcription factor 1"
FT                   /id="PRO_0000049342"
FT   DNA_BIND        1..60
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          59..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         112
SQ   SEQUENCE   112 AA;  12723 MW;  AEEAEDF06905F9DB CRC64;
     RRNRRVLFSQ AQVYELERRF KQQKYLSAPE REHLASMIHL TPTQVKIWFQ NHRYKMKRQA
     KDKAAQQQLQ QDSGGGGGGG GAGCPQQQQA QQQSPRRVAV PVLVKDGKPC PA