TITIN_DROME
ID TITIN_DROME Reviewed; 18141 AA.
AC Q9I7U4; O76275; O76276; O76277; O76278; O96767; O96768; Q7KA82; Q7KAJ1;
AC Q7KPQ8; Q7RTL4; Q8T3N3; Q9N2P7; Q9N680; Q9N9Y5; Q9N9Y6; Q9N9Y7; Q9NFS3;
AC Q9NJP4; Q9NL88; Q9UB79; Q9W055; Q9XZT9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 3.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Titin {ECO:0000305};
DE AltName: Full=D-Titin;
DE AltName: Full=Kettin;
GN Name=sls; Synonyms=titin {ECO:0000312|EMBL:CAB93524.1}; ORFNames=CG1915;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAA90301.2}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10629221; DOI=10.1083/jcb.148.1.101;
RA Hakeda S., Endo S., Saigo K.;
RT "Requirements of Kettin, a giant muscle protein highly conserved in overall
RT structure in evolution, for normal muscle function, viability, and flight
RT activity of Drosophila.";
RL J. Cell Biol. 148:101-114(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAB93524.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM D), NUCLEOTIDE SEQUENCE [GENOMIC
RP DNA] OF 1-187, NUCLEOTIDE SEQUENCE [MRNA] OF 4789-4963 AND 13411-13939
RP (ISOFORMS B/C/D/E), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15913-16691
RP (ISOFORM E), NUCLEOTIDE SEQUENCE [MRNA] OF 18064-18141 (ISOFORMS C/D/E),
RP FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Berkeley {ECO:0000269|PubMed:10934048}, and Oregon-R;
RC TISSUE=Embryo {ECO:0000312|EMBL:CAB96426.1},
RC Larva {ECO:0000312|EMBL:CAB96426.1}, and
RC Ovary {ECO:0000269|PubMed:10934048};
RX PubMed=10934048; DOI=10.1242/jcs.113.17.3103;
RA Zhang Y., Featherstone D., Davis W., Rushton E., Broadie K.;
RT "Drosophila D-titin is required for myoblast fusion and skeletal muscle
RT striation.";
RL J. Cell Sci. 113:3103-3115(2000).
RN [3] {ECO:0000312|EMBL:AAF47604.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAF47604.1}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING (ISOFORMS A AND C).
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5] {ECO:0000305, ECO:0000312|EMBL:AAC23966.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-880 (ISOFORMS A/C/D/E), NUCLEOTIDE SEQUENCE
RP [MRNA] OF 7219-7572 (ISOFORMS B/C/D/E), NUCLEOTIDE SEQUENCE [GENOMIC DNA]
RP OF 10456-10723, NUCLEOTIDE SEQUENCE [MRNA] OF 11358-11461 (ISOFORMS
RP B/C/D/E), FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=9548712; DOI=10.1083/jcb.141.2.321;
RA Machado C., Sunkel C.E., Andrew D.J.;
RT "Human autoantibodies reveal titin as a chromosomal protein.";
RL J. Cell Biol. 141:321-333(1998).
RN [6] {ECO:0000305, ECO:0000312|EMBL:CAB76253.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3999, FUNCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Berkeley {ECO:0000269|PubMed:10669599};
RX PubMed=10669599; DOI=10.1006/jmbi.1999.3461;
RA Kolmerer B., Clayton J., Benes V., Allen T., Ferguson C., Leonard K.,
RA Weber U., Knekt M., Ansorge W., Labeit S., Bullard B.;
RT "Sequence and expression of the kettin gene in Drosophila melanogaster and
RT Caenorhabditis elegans.";
RL J. Mol. Biol. 296:435-448(2000).
RN [7] {ECO:0000305, ECO:0000312|EMBL:CAA09971.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 371-500 AND 3126-3354, ACTIN-BINDING, AND
RP SUBCELLULAR LOCATION.
RX PubMed=9917396; DOI=10.1006/jmbi.1998.2386;
RA van Straaten M., Goulding D., Kolmerer B., Labeit S., Clayton J.,
RA Leonard K., Bullard B.;
RT "Association of kettin with actin in the Z-disc of insect flight muscle.";
RL J. Mol. Biol. 285:1549-1562(1999).
RN [8] {ECO:0000305, ECO:0000312|PIR:S35341}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1691-2214, FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=8335002; DOI=10.1002/j.1460-2075.1993.tb05948.x;
RA Lakey A., Labeit S., Gautel M., Ferguson C., Barlow D., Leonard K.,
RA Bullard B.;
RT "Kettin, a large modular protein in the Z-disc of insect muscles.";
RL EMBO J. 12:2863-2871(1993).
RN [9] {ECO:0000305, ECO:0000312|EMBL:DAA00021.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3091-3407, NUCLEOTIDE SEQUENCE [GENOMIC DNA]
RP OF 6635-7000, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP IDENTIFICATION (ISOFORMS A AND B), DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RC TISSUE=Muscle {ECO:0000312|EMBL:AAG40155.1};
RX PubMed=11062264; DOI=10.1083/jcb.151.3.639;
RA Machado C., Andrew D.J.;
RT "D-Titin: a giant protein with dual roles in chromosomes and muscles.";
RL J. Cell Biol. 151:639-652(2000).
RN [10] {ECO:0000312|EMBL:AAM11102.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13581-14436 (ISOFORMS B/C/D/E).
RC STRAIN=Berkeley {ECO:0000269|PubMed:12537569};
RC TISSUE=Ovary {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [11]
RP INTERACTION WITH MSP300.
RX PubMed=22927463; DOI=10.1083/jcb.201204102;
RA Elhanany-Tamir H., Yu Y.V., Shnayder M., Jain A., Welte M., Volk T.;
RT "Organelle positioning in muscles requires cooperation between two KASH
RT proteins and microtubules.";
RL J. Cell Biol. 198:833-846(2012).
RN [12]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=22467859; DOI=10.1242/jcs.097345;
RA Katzemich A., Kreiskoether N., Alexandrovich A., Elliott C., Schoeck F.,
RA Leonard K., Sparrow J., Bullard B.;
RT "The function of the M-line protein obscurin in controlling the symmetry of
RT the sarcomere in the flight muscle of Drosophila.";
RL J. Cell Sci. 125:3367-3379(2012).
RN [13]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=26251439; DOI=10.1242/jcs.170639;
RA Katzemich A., West R.J., Fukuzawa A., Sweeney S.T., Gautel M., Sparrow J.,
RA Bullard B.;
RT "Binding partners of the kinase domains in Drosophila obscurin and their
RT effect on the structure of the flight muscle.";
RL J. Cell Sci. 128:3386-3397(2015).
CC -!- FUNCTION: Key component in the assembly and functioning of adult and
CC embryonic striated muscles and muscle tendons. By providing connections
CC at the level of individual microfilaments, it contributes to the fine
CC balance of forces between the two halves of the sarcomere. The size and
CC extensibility of the cross-links are the main determinants of sarcomere
CC extensibility properties of muscle. In non-muscle cells, seems to play
CC a role in chromosome condensation and chromosome segregation during
CC mitosis. Might link the lamina network to chromatin or nuclear actin,
CC or both during interphase. {ECO:0000269|PubMed:10629221,
CC ECO:0000269|PubMed:10669599, ECO:0000269|PubMed:10934048,
CC ECO:0000269|PubMed:11062264, ECO:0000269|PubMed:8335002,
CC ECO:0000269|PubMed:9548712}.
CC -!- SUBUNIT: Interacts with Msp300; this interaction mediates the
CC recruitment of Msp300 to the Z-disks. {ECO:0000269|PubMed:22927463}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11062264}. Nucleus
CC {ECO:0000269|PubMed:9548712}. Chromosome {ECO:0000269|PubMed:9548712}.
CC Note=Uniformly distributed along condensed mitotic chromosomes
CC (PubMed:9548712).
CC -!- SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm, myofibril, sarcomere, Z
CC line {ECO:0000269|PubMed:22467859, ECO:0000269|PubMed:26251439,
CC ECO:0000269|PubMed:8335002}. Note=Colocalizes with ball and mask in Z-
CC lines of indirect flight muscle (PubMed:26251439). In the embryo,
CC localizes across the muscles in a striped pattern positioned at the
CC sites at which muscles are attached to the epidermis. In the larval
CC body wall muscles, localizes to the Z line and is still present as a
CC doublet at the muscle-epidermal attachment sites. During pupa
CC development, progressively forms broad striations at the Z line which
CC become more defined after the pupa eclosion.
CC {ECO:0000269|PubMed:26251439}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=C {ECO:0000269|PubMed:10731132};
CC IsoId=Q9I7U4-1; Sequence=Displayed;
CC Name=A {ECO:0000269|PubMed:10629221, ECO:0000269|PubMed:11062264};
CC Synonyms=Ket {ECO:0000312|EMBL:CAA09971.1}, Kettin
CC {ECO:0000312|EMBL:BAA90301.2};
CC IsoId=Q9I7U4-2; Sequence=VSP_052103, VSP_052104;
CC Name=B {ECO:0000269|PubMed:11062264};
CC IsoId=Q9I7U4-3; Sequence=VSP_052098, VSP_052099, VSP_052100,
CC VSP_052101, VSP_052102, VSP_052105,
CC VSP_052106, VSP_052107, VSP_052108,
CC VSP_052109, VSP_052110, VSP_052112,
CC VSP_052113, VSP_052115, VSP_052117,
CC VSP_052118, VSP_052119, VSP_052120,
CC VSP_052121;
CC Name=D {ECO:0000269|PubMed:10934048};
CC IsoId=Q9I7U4-4; Sequence=VSP_052111, VSP_052114;
CC Name=E {ECO:0000269|PubMed:10934048};
CC IsoId=Q9I7U4-5; Sequence=VSP_052116;
CC -!- TISSUE SPECIFICITY: Expressed in the mesoderm at stage 11, several
CC hours before myoblast fusion, and persists in most muscle cells,
CC somatic, visceral and pharyngeal muscles and their precursors, until
CC the third instar (PubMed:10629221, PubMed:10934048, PubMed:9548712,
CC PubMed:10669599, PubMed:8335002, PubMed:11062264). Isoform A: Expressed
CC in the indirect flight muscle (at protein level) (PubMed:8335002,
CC PubMed:22467859, PubMed:26251439). {ECO:0000269|PubMed:10629221,
CC ECO:0000269|PubMed:10669599, ECO:0000269|PubMed:10934048,
CC ECO:0000269|PubMed:11062264, ECO:0000269|PubMed:22467859,
CC ECO:0000269|PubMed:26251439, ECO:0000269|PubMed:8335002,
CC ECO:0000269|PubMed:9548712}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically
CC (PubMed:11062264). Expressed throughout larval, pupal and adult stages
CC (PubMed:22467859). {ECO:0000269|PubMed:11062264,
CC ECO:0000269|PubMed:22467859}.
CC -!- DISRUPTION PHENOTYPE: Flies exhibit chromosome undercondensation,
CC chromosome breakage, loss of diploidy, and premature sister chromatid
CC separation. They also exhibit defects in myoblast fusion, muscle
CC organization and gut morphogenesis. {ECO:0000269|PubMed:11062264}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM11102.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB026845; BAA90301.2; -; mRNA.
DR EMBL; AJ238575; CAB43710.1; -; Genomic_DNA.
DR EMBL; AJ238577; CAB43739.2; -; Genomic_DNA.
DR EMBL; AJ271740; CAB93524.1; -; Genomic_DNA.
DR EMBL; AJ400900; CAB96426.1; -; mRNA.
DR EMBL; AJ400901; CAB96427.1; -; mRNA.
DR EMBL; AJ400902; CAB96531.1; -; mRNA.
DR EMBL; AE014296; AAF47604.1; -; Genomic_DNA.
DR EMBL; AF045775; AAC23966.1; -; mRNA.
DR EMBL; AF045776; AAC23965.1; -; mRNA.
DR EMBL; AF045777; AAC23964.1; -; mRNA.
DR EMBL; AF045778; AAC23963.1; -; Genomic_DNA.
DR EMBL; AJ245406; CAB76253.1; -; Genomic_DNA.
DR EMBL; AJ012279; CAA09970.1; -; mRNA.
DR EMBL; AJ012280; CAA09971.1; -; mRNA.
DR EMBL; AF135062; AAF61414.1; -; mRNA.
DR EMBL; AF135167; AAF62351.1; -; Transcribed_RNA.
DR EMBL; AF241648; AAG40155.1; -; mRNA.
DR EMBL; AF241649; AAF44704.1; -; Genomic_DNA.
DR EMBL; BK000146; DAA00021.1; -; mRNA.
DR EMBL; AY094749; AAM11102.1; ALT_INIT; mRNA.
DR PIR; S35341; S35341.
DR RefSeq; NP_524676.2; NM_079937.4.
DR BioGRID; 68776; 10.
DR IntAct; Q9I7U4; 1.
DR STRING; 7227.FBpp0304920; -.
DR PaxDb; Q9I7U4; -.
DR PeptideAtlas; Q9I7U4; -.
DR PRIDE; Q9I7U4; -.
DR EnsemblMetazoa; FBtr0072848; FBpp0072727; FBgn0086906.
DR EnsemblMetazoa; FBtr0332679; FBpp0304925; FBgn0086906.
DR GeneID; 44013; -.
DR KEGG; dme:Dmel_CG1915; -.
DR CTD; 44013; -.
DR FlyBase; FBgn0086906; sls.
DR VEuPathDB; VectorBase:FBgn0086906; -.
DR eggNOG; KOG0613; Eukaryota.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR GeneTree; ENSGT00940000169215; -.
DR InParanoid; Q9I7U4; -.
DR Reactome; R-DME-5658623; FGFRL1 modulation of FGFR1 signaling.
DR SignaLink; Q9I7U4; -.
DR BioGRID-ORCS; 44013; 0 hits in 3 CRISPR screens.
DR ChiTaRS; sls; fly.
DR GenomeRNAi; 44013; -.
DR PRO; PR:Q9I7U4; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0086906; Expressed in gastrula and 40 other tissues.
DR ExpressionAtlas; Q9I7U4; baseline and differential.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:UniProtKB.
DR GO; GO:0031674; C:I band; IDA:FlyBase.
DR GO; GO:0030017; C:sarcomere; IDA:UniProtKB.
DR GO; GO:0005863; C:striated muscle myosin thick filament; IDA:FlyBase.
DR GO; GO:0030018; C:Z disc; IDA:UniProtKB.
DR GO; GO:0003779; F:actin binding; IDA:UniProtKB.
DR GO; GO:0008307; F:structural constituent of muscle; IMP:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0040011; P:locomotion; IMP:UniProtKB.
DR GO; GO:0007498; P:mesoderm development; IEP:FlyBase.
DR GO; GO:0007076; P:mitotic chromosome condensation; IMP:UniProtKB.
DR GO; GO:0016203; P:muscle attachment; IMP:UniProtKB.
DR GO; GO:0007520; P:myoblast fusion; IMP:UniProtKB.
DR GO; GO:0035206; P:regulation of hemocyte proliferation; IMP:FlyBase.
DR GO; GO:0045214; P:sarcomere organization; IDA:FlyBase.
DR GO; GO:0007062; P:sister chromatid cohesion; IMP:UniProtKB.
DR GO; GO:0007525; P:somatic muscle development; IMP:UniProtKB.
DR GO; GO:0007522; P:visceral muscle development; IEP:BHF-UCL.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; -; 58.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 53.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 53.
DR SMART; SM00408; IGc2; 47.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48726; SSF48726; 53.
DR SUPFAM; SSF49265; SSF49265; 3.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 51.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Chromosome; Coiled coil;
KW Cytoplasm; Developmental protein; Disulfide bond; Immunoglobulin domain;
KW Mitosis; Muscle protein; Nucleus; Reference proteome; Repeat; SH3 domain;
KW TPR repeat.
FT CHAIN 1..18141
FT /note="Titin"
FT /id="PRO_0000247656"
FT DOMAIN 86..177
FT /note="Ig-like 1"
FT /evidence="ECO:0000255"
FT DOMAIN 255..343
FT /note="Ig-like 2"
FT /evidence="ECO:0000255"
FT DOMAIN 372..461
FT /note="Ig-like 3"
FT /evidence="ECO:0000255"
FT DOMAIN 471..559
FT /note="Ig-like 4"
FT /evidence="ECO:0000255"
FT DOMAIN 618..708
FT /note="Ig-like 5"
FT /evidence="ECO:0000255"
FT DOMAIN 751..842
FT /note="Ig-like 6"
FT /evidence="ECO:0000255"
FT DOMAIN 890..981
FT /note="Ig-like 7"
FT /evidence="ECO:0000255"
FT DOMAIN 1024..1115
FT /note="Ig-like 8"
FT /evidence="ECO:0000255"
FT DOMAIN 1158..1249
FT /note="Ig-like 9"
FT /evidence="ECO:0000255"
FT DOMAIN 1291..1381
FT /note="Ig-like 10"
FT /evidence="ECO:0000255"
FT DOMAIN 1424..1515
FT /note="Ig-like 11"
FT /evidence="ECO:0000255"
FT DOMAIN 1558..1643
FT /note="Ig-like 12"
FT /evidence="ECO:0000255"
FT DOMAIN 1691..1781
FT /note="Ig-like 13"
FT /evidence="ECO:0000255"
FT DOMAIN 1824..1917
FT /note="Ig-like 14"
FT /evidence="ECO:0000255"
FT DOMAIN 1958..2050
FT /note="Ig-like 15"
FT /evidence="ECO:0000255"
FT DOMAIN 2089..2180
FT /note="Ig-like 16"
FT /evidence="ECO:0000255"
FT DOMAIN 2222..2313
FT /note="Ig-like 17"
FT /evidence="ECO:0000255"
FT DOMAIN 2356..2449
FT /note="Ig-like 18"
FT /evidence="ECO:0000255"
FT DOMAIN 2488..2581
FT /note="Ig-like 19"
FT /evidence="ECO:0000255"
FT DOMAIN 2622..2715
FT /note="Ig-like 20"
FT /evidence="ECO:0000255"
FT DOMAIN 2754..2844
FT /note="Ig-like 21"
FT /evidence="ECO:0000255"
FT DOMAIN 2891..2983
FT /note="Ig-like 22"
FT /evidence="ECO:0000255"
FT DOMAIN 3029..3116
FT /note="Ig-like 23"
FT /evidence="ECO:0000255"
FT DOMAIN 3130..3221
FT /note="Ig-like 24"
FT /evidence="ECO:0000255"
FT DOMAIN 3263..3354
FT /note="Ig-like 25"
FT /evidence="ECO:0000255"
FT DOMAIN 3401..3494
FT /note="Ig-like 26"
FT /evidence="ECO:0000255"
FT DOMAIN 3539..3625
FT /note="Ig-like 27"
FT /evidence="ECO:0000255"
FT DOMAIN 3676..3767
FT /note="Ig-like 28"
FT /evidence="ECO:0000255"
FT DOMAIN 3811..3901
FT /note="Ig-like 29"
FT /evidence="ECO:0000255"
FT REPEAT 3910..3944
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT DOMAIN 3954..4047
FT /note="Ig-like 30"
FT /evidence="ECO:0000255"
FT DOMAIN 4092..4181
FT /note="Ig-like 31"
FT /evidence="ECO:0000255"
FT DOMAIN 4394..4482
FT /note="Ig-like 32"
FT /evidence="ECO:0000255"
FT REPEAT 4403..4438
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT DOMAIN 4497..4585
FT /note="Ig-like 33"
FT /evidence="ECO:0000255"
FT DOMAIN 4604..4692
FT /note="Ig-like 34"
FT /evidence="ECO:0000255"
FT DOMAIN 4703..4791
FT /note="Ig-like 35"
FT /evidence="ECO:0000255"
FT REPEAT 5575..5613
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT DOMAIN 6536..6624
FT /note="Ig-like 36"
FT /evidence="ECO:0000255"
FT DOMAIN 6633..6728
FT /note="Ig-like 37"
FT /evidence="ECO:0000255"
FT DOMAIN 6741..6830
FT /note="Ig-like 38"
FT /evidence="ECO:0000255"
FT DOMAIN 6841..6929
FT /note="Ig-like 39"
FT /evidence="ECO:0000255"
FT DOMAIN 6942..7034
FT /note="Ig-like 40"
FT /evidence="ECO:0000255"
FT DOMAIN 7066..7151
FT /note="Ig-like 41"
FT /evidence="ECO:0000255"
FT DOMAIN 7189..7279
FT /note="Ig-like 42"
FT /evidence="ECO:0000255"
FT REPEAT 11872..11905
FT /note="TPR 4"
FT REPEAT 13566..13599
FT /note="TPR 5"
FT REPEAT 14904..14936
FT /note="TPR 6"
FT DOMAIN 16409..16470
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 16501..16590
FT /note="Ig-like 43"
FT DOMAIN 16625..16719
FT /note="Ig-like 44"
FT DOMAIN 16728..16811
FT /note="Ig-like 45"
FT DOMAIN 16822..16916
FT /note="Ig-like 46"
FT DOMAIN 16919..17001
FT /note="Ig-like 47"
FT DOMAIN 17007..17091
FT /note="Ig-like 48"
FT DOMAIN 17097..17180
FT /note="Ig-like 49"
FT DOMAIN 17184..17270
FT /note="Ig-like 50"
FT DOMAIN 17277..17363
FT /note="Ig-like 51"
FT DOMAIN 17374..17467
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17473..17558
FT /note="Ig-like 52"
FT DOMAIN 17563..17653
FT /note="Ig-like 53"
FT DOMAIN 17660..17755
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 17694..17728
FT /note="TPR 7"
FT DOMAIN 17760..17861
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17862..17958
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17982..18078
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2338..2357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2731..2750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4226..4254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4299..4336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4803..4891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5317..5368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5413..5648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5667..5701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5718..5748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5775..5982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6034..6350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6364..6393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7773..7793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9414..9440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9485..9510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9556..9582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9627..9652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9698..9724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9769..9796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9838..9865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9911..9937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9982..10008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10053..10080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10125..10149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10195..10220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10266..10291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10337..10364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10408..10433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10479..10504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10550..10576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10621..10648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10692..10717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10763..10788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10834..10860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10905..10932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11047..11073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11118..11143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11189..11216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11260..11286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11679..11703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11767..11795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12003..12201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12451..12471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12685..12767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12943..12971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13131..13154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13325..13349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13471..13492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13554..13576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13702..13792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13891..13914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13951..13994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14073..14094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14109..14322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14354..14377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14414..14448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14533..14566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14583..14720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14756..14789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14956..15208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15301..15329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15425..15448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15578..15597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15697..15722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15825..15876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15951..15973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 16181..16206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 17741..17771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4204..4229
FT /evidence="ECO:0000255"
FT COILED 7621..7663
FT /evidence="ECO:0000255"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2343..2357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2733..2747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4226..4245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4300..4325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4826..4852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5340..5358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5435..5449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5490..5504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5538..5566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5576..5648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5724..5748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5780..5794
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5795..5823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5824..5857
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5883..5900
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5919..5982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6052..6076
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6077..6170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6177..6246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6328..6348
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10195..10211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12003..12136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12173..12201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12685..12711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12723..12750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13728..13744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14143..14161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14183..14266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14305..14322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14358..14377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14414..14441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14538..14566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14583..14598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14628..14645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14648..14686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14687..14720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14757..14776
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14956..15006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15015..15098
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15110..15147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15164..15208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15301..15327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 393..445
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1312..1365
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1446..1499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1579..1632
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1846..1899
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2111..2164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2775..2828
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3152..3205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3560..3613
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3698..3751
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3832..3885
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3976..4029
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4625..4676
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6557..6608
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6964..7016
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 16940..16989
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 17494..17542
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 2..57
FT /note="QRQNPNPYQQQNQQHQQVQQFSSQEYSHSSQEQHQEQRISRTEQHVQRSQVT
FT TQRQ -> NKVSSLYNDVMNIFQSFIKLKMDINVVQERLKQEQRQKEQRERDARDQAER
FT EKAIKEAEAKERLHREEQSRLENQRQQAAIEQAQRELAARELALREQAVREEEARLQAI
FT REQATREQLAREQAAREEELRIQSLRDIARREEEVRLQNIRDEETRIRREEEERIRREN
FT ESRSKREEEARIQREEITRLQTLRDQVDQQRIVTENIRKDIQVNSIFTELRYASPLFTR
FT PLKDAVSREGDRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKTTFDKGICRLVIEETF
FT AADSARFSCRASNLVGTCDTNATLSVRENAAEVQLVPPRILRFLQSGKATEGSSFQFAC
FT VVAGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEVFLEDDAVYTCSASNPAGI
FT EHCSASLIVEPLEPTELPSFKVPLSNAMARVGQKIKLEAIVGGIPRPEVYWLHNGKPFQ
FT PRDSKYEYGRVTLIIPQAYPNDAGSYVLSAKNLAGEAYTSCNVIVKGRLPNETSDSEMA
FT SDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLLFQ
FT GDRCSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPK
FT DSQPKFERLLSDVLADEGEQVVLEVQASGDQPLTAQWFLTNKELQLDQRITTQSDSELG
FT VFKLILNNVSGDDKGVYTVKVTNPAGDAKCFSHLIVKSVNAPENRRSSQSSVEIIERHQ
FT CPEFKELFSDKQGEIDEVIKFECIVKGKPTPKVHWFFNDQPVHGHNFLVSTSGERQVLT
FT IQKLTHDAVGKISCVAENEAGKATCVAFLNIRGSGLPASSDVQTVSQEHNTESSRVTIK
FT KQTFTTTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVESHHYQELHKSKE
FT MSSPTVQQKSFSFIQSSGANGQSAVAIPDSPTRLRREIAPRFTTPLSGKIVDQGADVSM
FT EAIYDGFPSPEIKVEKNGGQLFEDAHTRISNKCNRVTIELKQVGVGDAGRYAVTASNTV
FT GQSTSTADLVVKKTIFPPVFGRRLQAQVSKKGEKLTMEVEVTGLPEPTVTWLKDDKPLK
FT DAGISEHRLLAQGNSYRLIIEKAQTTDSGKYMVRATNAGGEAKSIADCAILEPSPERLQ
FT EVVKTIVYETGPVAPASEFKTEVQKQIQNSENQQSYQNSQTEVTSANDLHGLSESKVIT
FT EHRCTTEATMRLEHKSNYLDLPELTTRPKTPTTNDTITITTNTATVSMDQPDLTQPTIT
FT NTTTTNTTKVPPPVPPKPCTPVVATTFGQQQQQPPQTLTSTRYEQSEHKSTTSSSSFDY
FT FKKIDEETIIQRPNPLTFKPLDTVVRQPQAQSLAEELRSLNLIPGDAPEFCYSPKTERS
FT EPKIPLITEKIKILSEVQPKEPPPQGGVPVFPPPLGLQTVQHESTTTKEVKVEYGQPIV
FT RPAAVLATPAQQNPRSPSPKPSAEGVAMSRLWTPTGVTGYTSDVEQKSEKTVISKLATP
FT TPTKELNAPFLVNQIAKSIPPTTAPVTHLVNVELEPGTPPEICFAPKVEETRRRSLVET
FT MEQKLEQNLIQGPSKVLPHSVPTLTPNTAAPVQPKPLGNTTYRPPPPVLPTRLGVYESD
FT YESDRYKYSGSESDVEPGIRKQPQLTTMETSFKSSGYTADTEEHSSYRKSESSFYETKS
FT SSTMGGAPQLQTQFPKLQPEPPAPIYFTAKPQPQVPPQVPPSQSNVSSQEAKVRIRSSL
FT CLSVCRYYCRSLSLLLALG (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052098"
FT VAR_SEQ 586..663
FT /note="EPIPGPEIIYLRHVERAKPHLRPGEEDRVYPPPQFIIPLQNVQQTEGGRVHM
FT EARIEPVGDPTMVVEWYLNGRPLAAS -> G (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052099"
FT VAR_SEQ 1106..1118
FT /note="GEAQQQATMIVET -> A (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052100"
FT VAR_SEQ 4751..4753
FT /note="MIF -> QPG (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052101"
FT VAR_SEQ 4754..4835
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052102"
FT VAR_SEQ 4794..4796
FT /note="KRR -> SKD (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10629221,
FT ECO:0000303|PubMed:11062264"
FT /id="VSP_052103"
FT VAR_SEQ 4797..18074
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10629221,
FT ECO:0000303|PubMed:11062264"
FT /id="VSP_052104"
FT VAR_SEQ 6626..6634
FT /note="EKEQGVPPQ -> GK (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052105"
FT VAR_SEQ 7030..7213
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052106"
FT VAR_SEQ 7214..7218
FT /note="GNPIP -> NVKIQ (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052107"
FT VAR_SEQ 7577..7592
FT /note="TSQIIESHEAITHVKI -> RSTLSLFNYITFT (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052108"
FT VAR_SEQ 9111..9114
FT /note="NVSE -> NVSEVNVYEQTKAIQDQNKHGLFVKVSKNSDTSKAYLTTIQSTF
FT LKEDILPKPNILQ (in isoform B)"
FT /evidence="ECO:0000303|PubMed:11062264"
FT /id="VSP_052109"
FT VAR_SEQ 9329..9525
FT /note="VKGNKQEFTKIETVEEDDKQPETTVTVEELPYEEEKPEEIQELPEEVCVVET
FT VTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEI
FT QELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVE
FT EVPYEEEKPEEIQELPEEVRVVETVTE -> GGIPYVQITVEEAKLVNTRADVEENITS
FT VTTEQPNMCIAASIQLPAIEEKKLENALQTPQFASESILKTSPQISRNAHFETRTHEEE
FT YSTTTESLVTTQALRDDIDSTQKNVMQDVQMYKHFATKSLDKTVKVETDTNQATDTTHI
FT KQKTPTHKLASSTTQITESPEIIKTIETISEDGSPSKKMIRTRLIKKVKGN (in
FT isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052110"
FT VAR_SEQ 9335..11180
FT /note="Missing (in isoform D)"
FT /evidence="ECO:0000305"
FT /id="VSP_052111"
FT VAR_SEQ 9526..11249
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052112"
FT VAR_SEQ 14333..14478
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052113"
FT VAR_SEQ 14438..14457
FT /note="STKVPNEETPVQEQYAKVNV -> TICKGQC (in isoform D)"
FT /evidence="ECO:0000305"
FT /id="VSP_052114"
FT VAR_SEQ 16100
FT /note="K -> KTKLYSSRKRRSRRSPVEEAADELKLQQTVVE (in isoform
FT B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052115"
FT VAR_SEQ 16100
FT /note="K -> KVTEETSDQTVQLKKKKKPQKPVEEAADELKLQQTVVE (in
FT isoform E)"
FT /evidence="ECO:0000305"
FT /id="VSP_052116"
FT VAR_SEQ 16492..16498
FT /note="PGPEDKP -> KLLPKQK (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052117"
FT VAR_SEQ 16499..16573
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052118"
FT VAR_SEQ 17341..17344
FT /note="VVDD -> DVVS (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052119"
FT VAR_SEQ 17345..17484
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052120"
FT VAR_SEQ 17686..18141
FT /note="GLDIEKYTLEKCDVQNNVWMKVSDFNKDIKSYAVQKLSMNAQYMFRVVAANP
FT IGESEPTESDPVTITKKFEKPSPPRGPTTVSGMNDTSFNLAWEPSETDGGSKIIEYIVE
FT IREETETTYRSVGVTLGTVTNIHVEKVVRNKGYFFRIYARNEVGTSEAFETTEKIVLGR
FT KITPPSPPQNLRAPDVTSRSVTLDWEVPARNGGSEITGYCVEKRSSTSTNWTKVITLDA
FT HQLHYTIDNLKEKCEYWFRVSAENEVGLGAPAVTESISLKTHASEFILVVRNCGSYTEF
FT GFLKAVPSPPTGPLEARVLAANAHIFEWGLPESDGGAPLLGYHIAIRDMKKTMWIEVGR
FT VPAGVLKFQIRDLQENHEYMIRIFAKNEIGLSEPLESEEPYKAMTAGHESLPDEPRTEM
FT SSCNTSSWLRDHHMDADIHSYARGRLLQRDEYFFRLWAELPKSKKKKSSK -> DEDEV
FT KRSAENAWGKLLPHQKKYFEVSMSQLCFYATVFTTPVDQVRPKETPVKRMLPAARKKPK
FT NQKKKAVPKWRYRSRKRPMAKPTPNPNNPAMSTAFIGFLREYQRRNTIVDVKKRLQRAA
FT KMWSKLSKAQKNKFRTAVSIAAYSLPSADFPPAPATCHLRRRFAWQHIGHVHRSITQNC
FT QSRAAPSLGDFSTLLTTPHWAKFQVLKVCNWIFQVQGNPFRSPLLTAHFYLLSFKKHTK
FT LPGHLRGKFLQTGRIGLYLGFYNVGYSEQLRQFVCDEQLYVQIMAVVNLLASWLYLCFS
FT HRWIYDQFVILLYVPLYIYFLILRRHLTKLLNECAGLHKSMQMIMGDRLCAKIHRECIY
FT TLLLIIMSILRLLWQIRIYSVYQSIFIFGVAFIYHFELLFFGNYLIWLSCIFRSLNVFL
FT AKDMRSDRLQILKGVLRQQTIIWRVHRTVSRYFALHIISFMIQPGIKICIILKCSGIQM
FT NAQIISLILHLLLLGLFMIIASNLQKQHRTFQKSYIGLKDDPNYFVLKSWRLLQNRTLP
FT QAFGVTFLRKREKVQYKQDVITMLLRFSDSQQVYQQRANCCRFLPAVFITMILFLHKLF
FT SYELQKESKLVNLLQIEKRTLKSEIELWNENLTSIYIFLTLVCSLVNKNELWKLINEAQ
FT LTYKQLKSLLGKHLVLKCSYDVLIHGLLLILLLAVMVVDIIFFNWPKASGERNTVTLTE
FT LHQIFDYLMGIPRLLFVLIMAMRILYHLISAGWLQCLGMLRLQRNLKLYQFQLRSIFYN
FT QKCENILAGHYFKVSYMYFLWMMPFRIAELMQFLKYDYDELVQKQKSQEDLEDEAIWEG
FT EENSRQQNLQELLMKPLLILSWHFALWMLLLAAAYTQQKEYSTLMAKSWNFKSDENGCE
FT MKEFLDEICWTGHAFKQLDILDLLVCTENEQDCICL (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052121"
FT CONFLICT 7
FT /note="N -> S (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 382
FT /note="E -> G (in Ref. 5; AAC23966)"
FT /evidence="ECO:0000305"
FT CONFLICT 568
FT /note="N -> S (in Ref. 1; BAA90301, 5; AAC23966 and 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 722
FT /note="P -> S (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 875..880
FT /note="QQRRHV -> PASVVM (in Ref. 5; AAC23966)"
FT /evidence="ECO:0000305"
FT CONFLICT 1059
FT /note="E -> G (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 1345
FT /note="F -> L (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 1405
FT /note="E -> G (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 1691..1692
FT /note="PV -> NS (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 1779
FT /note="S -> P (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 1905
FT /note="L -> H (in Ref. 1; BAA90301 and 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 1952
FT /note="Q -> H (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 2050
FT /note="T -> TVT (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 2104
FT /note="G -> R (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 2661
FT /note="N -> S (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 2934
FT /note="M -> V (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 3091..3094
FT /note="VLGT -> EGVR (in Ref. 9; AAF61414/AAG40155)"
FT /evidence="ECO:0000305"
FT CONFLICT 3174
FT /note="R -> C (in Ref. 6; CAB76253 and 7; CAA09971)"
FT /evidence="ECO:0000305"
FT CONFLICT 3303
FT /note="G -> D (in Ref. 9; AAF61414/AAG40155)"
FT /evidence="ECO:0000305"
FT CONFLICT 3379..3381
FT /note="ANL -> RGM (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 3500..3502
FT /note="IME -> FMD (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 3526..3528
FT /note="STE -> GTG (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 3592
FT /note="D -> E (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 3598..3599
FT /note="LE -> PQ (in Ref. 6; CAB76253)"
FT /evidence="ECO:0000305"
FT CONFLICT 3701
FT /note="E -> D (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 3857
FT /note="H -> N (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 3891
FT /note="Y -> H (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 3997
FT /note="L -> F (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 4130
FT /note="H -> Q (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 4229
FT /note="Q -> H (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 4330
FT /note="I -> T (in Ref. 1; BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 4512..4529
FT /note="QLARFDAKVTGTRPLDVY -> SWLASMPRLQALAHWMCT (in Ref. 1;
FT BAA90301)"
FT /evidence="ECO:0000305"
FT CONFLICT 6650
FT /note="E -> K (in Ref. 9; AAF62351/AAF44704)"
FT /evidence="ECO:0000305"
FT CONFLICT 7412
FT /note="T -> S (in Ref. 5; AAC23965)"
FT /evidence="ECO:0000305"
FT CONFLICT 7450
FT /note="A -> T (in Ref. 5; AAC23965)"
FT /evidence="ECO:0000305"
FT CONFLICT 7454
FT /note="G -> A (in Ref. 5; AAC23965)"
FT /evidence="ECO:0000305"
FT CONFLICT 7525
FT /note="D -> G (in Ref. 5; AAC23965)"
FT /evidence="ECO:0000305"
FT CONFLICT 7532
FT /note="T -> P (in Ref. 5; AAC23965)"
FT /evidence="ECO:0000305"
FT CONFLICT 7537
FT /note="A -> P (in Ref. 3; CAB93524)"
FT /evidence="ECO:0000305"
FT CONFLICT 7552
FT /note="V -> A (in Ref. 5; AAC23965)"
FT /evidence="ECO:0000305"
FT CONFLICT 10456..10457
FT /note="KI -> EF (in Ref. 5; AAC23963)"
FT /evidence="ECO:0000305"
FT CONFLICT 11204..11207
FT /note="VPYE -> LPFQ (in Ref. 3; CAB93524)"
FT /evidence="ECO:0000305"
FT CONFLICT 11217
FT /note="L -> I (in Ref. 3; CAB93524)"
FT /evidence="ECO:0000305"
FT CONFLICT 11444
FT /note="V -> T (in Ref. 5; AAC23964)"
FT /evidence="ECO:0000305"
FT CONFLICT 11460..11461
FT /note="DG -> KK (in Ref. 5; AAC23964)"
FT /evidence="ECO:0000305"
FT CONFLICT 11863
FT /note="Q -> H (in Ref. 3; CAB93524)"
FT /evidence="ECO:0000305"
FT CONFLICT 13709
FT /note="K -> T (in Ref. 2; CAB96531)"
FT /evidence="ECO:0000305"
FT CONFLICT 13713..13715
FT /note="KSP -> ESR (in Ref. 2; CAB96531)"
FT /evidence="ECO:0000305"
FT CONFLICT 13723
FT /note="Q -> S (in Ref. 2; CAB96531)"
FT /evidence="ECO:0000305"
FT CONFLICT 14433
FT /note="D -> K (in Ref. 10; AAM11102)"
FT /evidence="ECO:0000305"
FT CONFLICT 14436
FT /note="S -> K (in Ref. 10; AAM11102)"
FT /evidence="ECO:0000305"
FT CONFLICT 15987
FT /note="V -> A (in Ref. 2; CAB43739)"
FT /evidence="ECO:0000305"
FT CONFLICT 17206
FT /note="F -> C (in Ref. 3; CAB93524)"
FT /evidence="ECO:0000305"
FT CONFLICT 18065
FT /note="E -> R (in Ref. 2; CAB96427)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 18141 AA; 2065766 MW; 41CA5977EB611933 CRC64;
MQRQNPNPYQ QQNQQHQQVQ QFSSQEYSHS SQEQHQEQRI SRTEQHVQRS QVTTQRQVQQ
HHGGSIGGAY VPPSLTHVYA QGDISPPVFE QIFKNARFAQ GGNALFEGRL RGNPKPFVTW
TRKGAPLLES QKFRMSYNEA TGDVSLLINQ IGPGDEGEYT CTARNQYGEA ICSVYIQPEG
APMPALQPIQ NLEKNIYSNG YSYTSIEEEF RVDTFEYRLL REVSFREAIT RRSGYEQDSQ
LSQELDRNQG PAQAPQISQK PRSSKLIEGS DAVFTARVGS NPKPRLTWFH NGQRLVASQK
YEISYSSGVA TLRVKNATAR DGGHYTLLAE NLQGCVVSSA VLAVEPAAET AYEPKPVDVM
AEQLEAGKAL PPAFVKAFGD REITEGRMTR FDCRVTGNPY PEVFWLINGR QVRDDASHKI
LVNESGSHSL MITNVTRLDA GAVQCLARNK AGEVAIEAQL NVLEKEQVVA PQFVQRFSTM
TVREGEPITM SANAIGTPQP RITWQKDGVQ ISSTAERFVG IDGGATCLEI PRVTANDAGW
YQCTAQNIAG STANRARLYV EVPREQPNYE QRRLNLPRPT KVIEPEPIPG PEIIYLRHVE
RAKPHLRPGE EDRVYPPPQF IIPLQNVQQT EGGRVHMEAR IEPVGDPTMV VEWYLNGRPL
AASARATSVF KFGFIALDLL SIMGHDSGEY MCRVTNASGV AESRAILSVV QRPSIEQSSQ
NPNSLQYINQ LEDYSRYQRT ESIDEQLNQA PQFIRPLRDL GEFEEGKNVH FEAQVTPVND
PSMRVEWYKD GLPITASSRI TAIFNFGYVS LNILHLRAED AGTYTVRAVN RIGEAISQSS
IRVHSRSQVT ADLGIPEQQR YIEKVEELED YRKSQQRRHV QEAAEAIAPP QFKTPIQNQL
DLREHAHAHF EARLEPVGDS TMRVEWLKDG QPLEASSRIT TYHNFGYVAL TIKQLTIYDA
GTYTCRAYNA MGQDTTVAQL TVISKNEIVS ESQHPGGLQK IQHLEDSSRY GRREEEETYI
TQAPRFLGPL KGTTKILEGQ RAHFEARVEP QSDLGLVIEW YHNGRSITAA NRIQTYYDFG
YVALDISQVR AEDAGVYLVV ARNKLGEAQQ QATMIVETRS SIDTSSMHRG LYEKTQNLEN
KPFVEPQYDI EEISKSKPVF VTPLSDPKPI HDGKNIHLEC RLEPMGDPTM RVEWFHNGRP
VTVGSRFRTY YDFGFVALDI IKATAADSGE YTVRATNHLG TAHTSACVRV IDHTDVVTET
QNEQSLEQIQ LLEDSRRRHH QEEDITIMQA PQFTRGLHNI ETIEGTNVHL ECRLQPVGDP
SMRIEWFVNG KPVKTGHRFR PAYEFDYVAL DLLGCYAIDS GVYTCQARNQ LGEAVTSCSV
RIIAKNDLIL ETQNESGLQK IQYLEDSTRH RRSEFVDEVV NIRPRFLTHP KSLTNTREGG
HAHFECKIEP VTDPNLKVEW FKNGRPITVG HRFRPIHDFG YVALDIVHLI AEDSGVYTCR
AVNLIGSDET QVELQCRSGE QIVTVTQNEA GLEQIHYLED RSRYTRREEI DESTKQAPVF
TTSLKNVEIK ENQRAHFECR LIPVSDPSMR VEWYHNNLPL KSGSRFTETN NFGFVALDIM
STLPEDAGTY TCRAYNAVGE AITSAVAVVH TKKSIYLESQ HETALPRLQH LEDGSKRQRI
SVQDEFVSQA PVFTMPVRDV RVAENQAVHF EARLIPVGDP KLTVEWLRNG QPIEASNRTT
TMHDFGYVAL NMKYVNPEDS GTYTCRAVNE LGQAVTSASL IVQSKTSIQL ETQHEAAMHK
IHQLEDHSRY QRREEEEYTV TTAPVFVTKL IGPSNLVEGQ SAHYECRIEP YPDPNLKVEW
FHNGKPLSTG HRFRTTYDFG FAALDILTVY AEDSGEYTCR VTNNLGEAIN SIVLNVTSRS
SIIHETQHEE ALTKIQHLED TSRFQRKTDE EQFHAERPQF GRPLRNAKVN EGAPVHLEAT
LIPVNDPTMK VEWYCNGRPI QTGHRFKTTY DFGFVALDIL YAHAEDTGTY MCKAKNAIGE
AVTTCAVNVT ANKTLDLDTL DAQRLEKIRQ LETYAPPPKP VVEEKGQKPI FLTPLSNLEH
LKEGEHAHLE CRVEPINDPN LKIEWFCNGK QLPTGHRYRT THDFGYVALD ILYVYGEDTG
TYICKATNQL GEAVNTCNVR VLNRRSMILD TQHPDALEKI QKLESKVPNA RTEVGDAPIS
PPHFTAELRG STEIYEGQTA HFEAQVAPVH DPNLRIEFYH NGKPLPSASR FHITFDFGYV
SLDITHAVAE DAGEYSVRAV NALGQAVSST NLRVIPRGTI ISDTQHPEGL EKIRKLESTA
PHQRQEPETP GTRQRPVFTQ PLQNIDRINE HQTAHFEARL IPVGDPNLKV EWYRNEKIIE
DSSRITKQHD FGFVSLDISH IRKEDEGVYM CRAVNPLGEA VTTASMRVVS EASIQMDTQH
PDSISRIHQL EKPLAPRPTE PERLFEKPIF TQLLTGPSEL WEGTHAHFEA RVVPVGDPSL
KFEWFINGVE LQMGSRLRTT HDFGFVTLDI TAVVPEDAGV YMCRAYNAAG EAVSSTAMKV
KTKSNIDGQP LIPESWEAIR LKEAAMNRVP EMFVDSTPQQ APVFTTHLQS YDKLHEGQHV
LLEAQVEPRA DPNLRIEWFK NGISLTTGSR IRSTFDFGLV TLSINGLRAD DSAIYTCKAT
NQVGEAVSTS SLKIEDRHWL QAESLHPDSL PRIGELEAPK EGRPEAPEPT YETPVFITHL
NNIECKESDN VRFECNVEPA RDPTMSIEWF YNGQPLQAAA KFKSIYDFGY CALDLTNSYA
ENSGVYTCKA TNSKGSATTS GTLKCTGGKT MFLDTQHPQG EAGLEAVQET EEELANRYTS
KTTKPETQYP PPVWTKPLQA EFHLSEAQPI HLEANVEPKE DPNLFIEWYF NGKMLNHGSR
FKMTSEFGFV TMDMIEVYAR DQGIYTCKAY NKAGEAFTST TIFCSSKENI IESTQHPKGA
EGLEQIQDLE DSLRKDGSKP EQPDLGIPPR FTTEFVNIAD IGEGELAHFE ANLIPVGDQS
MVIEWFYNGK VLEASHRVRT IYAFGTVALE VLGTKIEDTG TYTCRATNKH GTAEISCNLE
CVDKPRGQKP RFTSHIQPLE GLKDGQSAHF ECTLIPVNDP DLKVEWYHNG KLMRHSNRIK
TVSDFGYVVL DISYLQDHDS GEYVCRAWNK YGEDFTRTTL NCGGRGGVFY DSLQPDSLQR
IRELECPQGQ QADTSAPLVA EPPKFITQIV DVTKLVEGQS AHFEARLTPI TDPDLVVEWY
FNGKKLPHGH RFRTFHDFGI VILDILYCYE ENSGVYEARA RNKYGEDVTR ASLKCASKSS
LILDSQLPRG MEGGLEKIAN LEYSMVRTRE ETTEETKGKA PVFTVPLENI ENLREGENAH
FEARITPADD PKLKVEWYWN GRPLKAGSRF RTFCDFGFVI LEISPVYPED SGEYSCRAIN
EYGEAVTTAT MKIQGKRSII MESQLPKGME GTIDRIAELE GLGSRSTEFV PDDDTGKPPE
FITSPFDMVI GENALAHFEC RLQPINDPSM RVDWFHNGKA LWAGSRIKTI NDFGFVILEI
AGCYQRDSGL YTCKATNKHG EATVSCKLQV KGRQGIVMEP QLPSNFRTGT ESLQKLEETM
HKREELVTED EQPNPPKFTE EIKDNLDVPE GGPIHFDCRV EPVGDPTMRI EWFYNGHVMA
TGSRVHQLND FGFIALDVDY IYARDSGEYT CRATNKWGTA TTSAKVTCKG KHNIVYESQL
PEGMTSEKLK ELERGRIPEA PKVVEEVFGP PKFTTQITSV TVDEAEAVRF ECQVEPKTDP
SLRVEWYRNG KPLPSGHRYR NIFDMGFVSL DILYVYGEDS GEYVCRAINN YGEDRTRATV
SCKKLPTILL QNQVPRGMKR SDALTQMEAT IKKYTSEVHL TEDDLFDPDR KQPPRFVTQI
KEQLTLTEMA VTKFECQLAP VGDPNMKVEW FFNGKPLLHK NRFQPIYDFG YVAMNFGWVY
PEDSGEYVCR ATNLYGKDET RAIIKVSGKP GIVYDSQLPA HMQSIDRIRE MEASWQVVPD
EVDPDAKPRT KPVFVSKLEP QTVEEGDPAR FCVRVTGHPR PRVMWLINGH TVVHGSRYKL
TNDGMFHLDV PKTRQYDTGK VEVIARNSVG ESIATTELKV VARSDDYRNV LKNSPRPWYD
YELAAYQKER QENELEKVFD ERKQVLSEQS SHTLKGVEHL KPKQYKPPTP DWQQNVKAKK
SEDYYNKLQT LETEQLLKET NLRRDTHQYA IPGEKVVSSS QAKGMAQSYE ENLQEKTSTT
EVQAAPPKGI AQPSESSVHG REVHMNKQQQ VQKEIQGDLE ITRKITATET TEVEHKGTIQ
ERVVQGPVKP AKAPVFTKKI QPCRVFENEQ AKFEVEFEGE PNPTVKWYRE SFPIQNSPDL
QIHTFSGKSI LIIRQVFVED SAVFSCVAEN RGGTAKCSAN LVVEERRRAG KGGIQPPSFV
TTIQSTTVAT GQLARFDAKV TGTRPLDVYW LKNGMKIQPS IKFKMLEEDS VHTLLIIEPF
AEDSGRYECV AVNAAGEARC DGDCIVQSPS KPEKPTTPGS EKAPHIVEQL KSQTVEEGSK
VIFRCRVDGK PTPTARWMRG ENFVKPSRYF QMSRQGEYYQ LVISEAFPED EGTYKCVAEN
KLGSIQTSAQ LKVRPIENLD APPTITALKD VSVTEGMPAQ FKTTVTGKVK ATSVQWFREG
QLIPETPDFQ MIFDGNSAVL LIGTTYEEDS GIFTVRVTSS TGQVESSAKL TVKKRRISAF
QLRTIDSAED ESSSSGREDS APESPHAFQP GQQPGQQFGQ FLGVNGQGQH QGRSRQKKPK
VRSKSLQPAT KVIPWRKSSR PTRGRSLDKG VFLPGFKPEP VKSWTEETIN LKATPIEKKK
PAPKLEAAKV VLKSIKTERD QGIMSLGATL EQIIAGKTEK EAIPWITMRE KLKAVESVQQ
QLNKFDLDEV YLQPLEGQIE TEGQLPQQAQ VEQVQRTKEI QRLKSMESVE IMEMTDQIDK
LITQQQNAKD LIPWKEMRQQ LKSVQRVTKQ IDKFKIEEVE LRHLQAQQAI TEEYQTGTAE
ETVVMIDESS KGSISKVLRR DEQLQYEDQS NIYKQKFITT EDVNIMHVSE REKLEAQRLI
REQQAVNWRQ QQQRPQLQPL TSVEDTVISQ TSERQKLVQQ QSFIEEAQRQ QFVQVEDSQM
MSLEEYEHQK IINQRTQQEA FSWRQPREPQ KFIQVEDSTL LHLQERHDTQ EQQLLQQQPV
MWDRGRKKPD QPQYVQPQEQ RVKEEFVEKP KTYEEMHDEL VEPTPIEQPQ PVPVMWERGK
KKPQPQEKTF EEAHDELVEP TPVQQPEPVP VMWERGKKKV AQQETVLSQE VVQTSQVVEQ
QIVEETKKTA VRRVIPPREP EQKVEQVTLK PTPRPRPKEA VKAEEIQLKP LRSTRPVPQP
VEAEQKAYEE ATDELTEEPI PQPQPVMWER GKKKPQKPQE EVTEIPKTLE IAVDTLEEEV
PKPTEPQPQP VLWARGQKKP QKPDEQKQEL PKSLEIAVDT IEEDLIKPVQ PEPQPVLWER
KKKKPQPQDV IEEKLDVAPT KTYEKAVDVL PDEPKVEEKP EPVLWQRGKK KIPKSEPTEE
VHPDEVDAQI ETVVKEDEMI VEEKRRIKKT KRPKSTKEVT EELFEEQPEE EISPEEEVPQ
KEVIEEIEEI VEEKRRLKKT KKPKLTQQVT EEETPHEEII KESEEVVQEQ EEIVEEKKKV
KKVKKPKTVA EKQLKEEEIP TEETVEEEET AEDQQLVVEE SKKVKKVKKP TGTVEKTDVE
ELPGEEVPVE EVPVEEVPED VAPEEELIEE QEEIVDQDEI QEQKRKVKKA KKPKKTIEKT
EIEIEEDQPE EEVLQEEIIG EQEEITERQR KVKSIKKPKK VVTEKTVDQT EQPEKPEESQ
AEEVKETVTE EPKKPKPAPE EAKVEQVEKI SLKPAPRKQR LLPEKEQVEE VLLKPVKKIV
AVSEAEQPET PETEFEVKEF AITTTEDILD VTKKRVKKKK PKTKVAAEES TEEPAEETEE
FEEEATQPEE VQPVEEIPEE PQVKEVADER KTAPKPKPRK EEIIEKVEEV ALKRVTRPKK
ELPQEATIEE VRLKPTQRTS IKPEEVKLEE VDLQHVEKKE DEIVQEEKRK TRKVKKPKHE
DLPEIPDAEP TQLEEAEHIE LEKQPKPEED QPQVPWKRGE KKQPVEEVLE EKKWPSGKRR
PLPEQQPEEV QLKPIPSKPI EEQQKPEKAI PGPQLVPEEK PESEEEELEL EPLKLPEDKK
PKEPKAKKEK KKKPKLKKAT PSVDEVSEEV AEPFDEPIAE EDEVEEMPVD DVKVVAVSED
VLPEEEVVPT EETPEAKQKA HKKRTKRLKE ASVEGQPQLL EAAIAEIEKV DEISQEISQK
TITLLKKTED TRPQFITTEQ LIELDVEDVR RDLEMKVTSN IIKKEKRRVV LDDSQPLPEL
ELITQKRIQE GIDKVADEEL IEDQQLIQNQ QETTTSEVIG QERKLVKKKK KEIKPPRITE
KLRPRQCVPE EPTVLECKVE GVPFPEIKWY FNDILLFASE KYEITVMEQV AKLKIAKVTP
SDVGVYTCEA KNEAGVATSR TNIILEKEQG VPPQFTKPLK IEFIEEKQPE RLKVTVTCQV
TGKPNPEVKW YRGIEEVIPS ETVQMFYDEK TGDVALEVIN PTPNEAVVYS VQAQNQFGRA
IGNANILSRV DEVPREILKA PTVTPLSAVV VPTGGTLFFE AKYDGLPRPE VKWMRNGREI
IENEETIIET TETTTTIKVV NMTRKRTGKY EVWAKNKVGE AKSSGSVVVS DQKPDEQIKP
PRFIQPLEPK YFGEHEVAII EAIVESEPLS SFQWFVHNEP IKSSNEVRIV SQANKSTLLI
ENFQSKFVGP FTCRAENVGG SVTSTATVNL IPQEEAEEFE SPRFVEELVQ PVEVMDGEAL
LLTCQVTGKP TPKVEWYHNA EKITENKETT ISQDLQGVCQ LQITEVFPEN EGQYECVATN
KIGKSVSKTN VKIQAFEYIP DSEITGLTGS EEDLLDRTLS IDEQAPKIIK KLPEKIEPKE
GEQAKLEVKV VGKPKPKVKW LRDDEQIFAS EEYQIENFED GTSVLVINHV YPDDLGTISF
EAYNPLGVAV TTALFAVEGI VGSKDYRKPE WVSQMEEMQV ALKAAKCSPS LLNEMRDCRA
ALGETAKFSI QFAGNPIPDI QWYFNNVQLR ASEKYRMVVQ EQEATLEIMK ITSEDCGYYN
CKLINEIGMT MTRAKFDISS TSTIVEETKA KTTVKKKSGK KTMVKRSGAS ESQNVQKTEI
RIIPTSAVET SMNVIKVKQP VSVLVEKSEI SEVLVVKDRE VADAEERSSQ LIEEIEEEEE
IEEKVQHDEE DEVEVQVEQK ETYTSSKKIE ITKTVELIRT KISEKIITIE DVQVLSHHEE
VQWLLESIEA ESFGQIGESA LRDLATIGLL LRYGCEHYEI TYMYEQNIFI SLKKPESQSA
LVQLVEREGH EELISQILSE SSNEDETILA ATVGFKAFIR MIQTYEITIE IVIRKFVRED
FISQDWKICG KERIVETSQI IESHEAITHV KIETATTKVE KLFKKQEQEH VQNLEQQEQV
KIQVQTKQIA QMNTKIKKHK KHKQQEQEVS ETTIQCEQKE TLAHETSAEL PQSETLEQIE
ESLSTYETLP IQNLSKDTLQ TVAVSVTTEL STPSPTASRV QEEILPQKVL AINEEVLPLD
EFGLRKESPR PKENKLTENI EVRLKHALNV SHAKTAESSK ELPSKIPKSV KAQRKMKESR
SLVVEAPNAE EAIEDLKPLK AVSQEVQSDI LFSHEITEEQ HQALETIEKL KPTSAIEDTV
QQKLLSQEEL IIAEVLPSET VGRDVTDVRP PGETISPRLT PNMSLCITEC QPEDSIGEMQ
QAAKERMETP SMSVTESKAV GGQELEVLEN VDHMPLITQP TKGLADYTIK AEEVPVQVQE
IITFDSLERE TVAKTQTAKS NALELFELSE GLVSSTADSH SPIAEDLPIF EKDVKEATID
MQMQHHVTTS ETVSNENAVK DLKAVDTPKM AEGTLGQSSA LTIGETQQMN LVETTVELIE
PNVESTKPAK GALTEAYGTA ESNEETLLES LGLVPDDNRK IEQGKVNISE GEYVAKVQTT
TVTDTEGEFV SVAPKLVNPK FDFVEQSALQ IKQDTTVEKE EILSSNIELA PQLATSNMFP
AELKVTSIYE VQPGLTSSDI ITEQTKSVSA NQVFETMSIG VTSKPDMLES TSHIDAFQHP
EFKTGDTILD ENQQPLEVTN VQITESSTDI IDVLPNQKLT KAETVTDGFK YAEGLVVLPM
ESTIDKTEDT KPTAVNADIS MHQQFGTDVR EQEPLESTLT RTEDLKPQTQ TTESQFGLLQ
SLETSSCVTL EGESVLSVKE RHPEQSAAIG TSSALQVANI TRPQHMESLD RLDEQKVPYY
QANVNIGEIT LPNVEKIDSF DVLSDLNTPD YNKSSKGRVQ LIESTTSLKT TTAVVSESTE
ELKDLNITQP VHIKPKPYES DQKISISEQT NVLEHVSSLN PVLPALETIQ SSIKSLHEIN
VRETDILEKE ESLKDVDHIS GRLAKIILDC TTGIAQVRQE ETLEHEEDLK APLIPLEKAI
PASSELHRLP LTEYVQEQQG TSDMTDFKVS NKCASPNIDH LYETKSSEMI VYDSSINSVD
SEFPAGIVPQ KSLVPFRHTM VTENVAFNAS ENFEILSADQ QIATNVQDSL SQSIIAEDQI
AFETEQNLGL ETTPTHKPKL LKDDQNLHAK LVDEATVYEA MGQEQKVDKY NIQQAEITHD
LPQVYATDLQ QTFEAEKEIT TREQSYVAAT TDIIPSRLGL AMTTKTHPVE GIDVLLSSPP
KPSLAQTNYE ETQHEVRVRE TQAIEESEEL TDGRLLPVSA VESIDSTFKV TSDSQQPPVF
DKELSIPTVS PLEARAKPSL NLLQGTTTFD VIPLESSVLL KDTHVAVQKA QQEYVAQVES
NKVHVQMDNL VMHKEDIFEN AEIENFCKPI TEGTQLETVV IEVVPIDNVG GIHLAPQPST
LLATLTSTDI VNQSHVIDTQ VPLEMESEAQ APLDNIAQAR IKSAEDHVHT NVSEVNVYEQ
TKAIQDQNKH GLFVKVSKNS DTSKAYLTTI QSTFLKEDIL PKPNILQDTA QAAADELQSL
VTEEVVSVSS IQETYELKIP LQKTANLTQQ TPQNSVNVCQ QLAYEETPDI AFEPHALTRA
TTSSVPTFLK PAENATVNIY ENIEGHGDFK PGTVNLTSNS NLNSELVVSV VQEVTSVPSL
GSLATVEPQE LKAMPVTKSS TNLAYSEEVK GNKQEFTKIE TVEEDDKQPE TTVTVEELPY
EEEKPEEIQE LPEEVCVVET VTEDGKPKKK KIRTRVIKKV KGDKQEVTKI ETVEEDDKQP
ETTVTVEEVP YEEEKPEEIQ ELPEEVRVVE TVTEDGKPKK KKIRTRVIKK VKGDKQEVTK
IETVEEDDKQ PETTVTVEEV PYEEEKPEEI QELPEEVRVV ETVTEDGKPK KKKIRTRFIK
KVKGDKQEVT KIETVEEDDK QPETTVTVEE VPYEEEKPEE IQELPEEVRV VETVTEDGKP
KKKKIRTRVI KKVKGDKQEV TKIETVEEDD KQPETTVTVE EVPYEEEKPE EIQELPEEVR
VVETVTEDGK PKKKKIRTRV IKKVKGDKQE VTKIETVEED DKQPETTVTV EEVPYEEEKP
EEIQELPEEV RVVETVTEDG KPKKKKIRTR VIKKVKGDKQ EVTKIETVEE DDKQPETTVT
VEEVPYEEEK PEEIQELPEE VRVVETVTED GKPKKKKIRT RVIKKVKGDK QEVTKIETAE
EDDKQPETTV TVEEVPYEEE KPEEIQELPE EVRVVETVTE DGKPKKKKIR TRVIKKVKGD
KQEVTKIETV EEDDKQPETT VTVEEVPYEE EKPEEIQELP EEVRVVETVT EDGKPKKKKI
RTRVIKKVKG DKQEVTKIET VEEDDKQPET TVTVEEVPYE EEKPEEIQEL PEEVRVVETV
TEDGKPKKKK IRTRVIKKVK GDKQEVTKIE TVEEDDKQPE TTVTVEEVPY EEEKPEEIQE
LPEEVRVVET VTEDGKPKKK KIRTRVIKKV KGDKQEVTKI ETVEENDKQP ETTVTVEEVP
YEEEKPEEIQ ELPEEVRVVE TVTEDGKPKK KKIRTRVIKK VKGDKQEVTK IETVEEDDKQ
PKTTVTVEEV PYEEEKPEEI QELPEEVRVV ETVTEDGKPK KKKIRTRVIK KVKGDNQEVT
KIETVEEDDK QPETTVTVEE VPYEEEKPEE IQELPEEVRV VETVTEDGKP KKKKIRTRVI
KKVKGDKQEV TKIETVEEDD KQPETTVTVE EVPYEEEKPE EIQELPEEVR VVETVTEDGK
PKKKKIRTRV IKKVKGDMQE VTKIETVEED DKQPETTVTV EEVPYEEEKP EEIQELPEEV
RVVETVTEDG KPKKKKIRTR VIKKVKGDKQ EVTKIETVEE DDKQPETTVT VEEVPYEEEK
PEEIQELPEE VRVVETVTED GKPKKKKIRT RVIKKVKGDK QEVTKIETVE EDDKQPETTV
TVEEVPYEEE KPEEIQELPE EVRVVETVTE DGKPKKKKIR TRVIKKVKGD KQEVTKIETV
EEDDKQPETT VTVEEVPYEE EKPEEIQELP EEVRVVETVT EDGKPKKKKI RTRVIKKVKG
DKQEVTKIET VEEDDKQPET TVTVEEVPYE EEKPEEIQEL PEEVRVVETV TEDGKPKKKK
IRTRVIKKVK GDKQEVTKIE TVEEDDKQPE TTVTVEEVPY EEEKPEEIQE LPEEVRVVET
VTEDGKPKKK KIRTRVIKKV KGDKQEVTKI ETVEEDDKQP ETTVTVEEVP YEEEKPEEIQ
ELPEEVRVVE TVTEDGKPKK KKIRTRVIKK VKGDKQEVTK IETVEEDDKQ PETTVTVEEV
PYEEEKPEEI QELPEEVRVV ETVTEDGKPK KKKIRTRVIK KVKGDKQEVT KIETVEEDDK
QPETTVTVEE VPYEVEKPDE IQELPEEVRV VETVTEDGKP KKKKIRTRVI KKVKGDKQEV
TKIETVEEDD KQPETTVTVE EVPYEEEKPE EIQELPEEVR VVETVTEDGK PKKKKIRTRV
IKKVKGDKQE VTKIETVEED DKQPETTVTV EEVPYEEEKP EEIQELPEEV RVVETVTEDG
KPKKKKIRTR VIKKVKGDKQ EVTKIETVEE DDKQPETTVT VEEVPYEEEK PEEIQELPEE
VRVVETVTED GKPKKKKIRT RVIKKVKGDK QEVTKIETVE EDDKQPETTV TVEEVPYEEE
KPEEIQELPE EVRVVETVTE DGKPKKKKIR TRVIKKVKGD KQEVTKIETV EEDDKQPETT
VTVEEVPYEE EKLEEIQELP EEVRVVETVT EDGKPKKKKI RTRVIKKVKG DKQEVTTIET
VEEDDKKAET TVTVEETELS APSVGKVQLK KRVIVQKPED AVTVFELPER KSVILSEKED
GTPTKTVIKT RIIKKIQGPN MEVTKVQTVE EYEKAPQTIV SVEKFNTPFP ELPEERLSEV
VMLPDEVFES EAVDEEGRLK MIKTKKRIIR KPALDNTEEV TEIGIIEQDN VEPIYSVKIQ
ERPLTESKPE DSKLIELPEH VTELNVILPD GKKKRRTVKS RAFKKSLDDD LDEVTTIHII
EEEDKEPLTK VNIEVVPSDE ISITPIPIEE LPEETVFTEE LDENKKPKKK TTKTRTFKKR
GPDDDEYFQI QTIDEEGKEP ISLIRVVSDE NIADIIDISK LDDEKVLKHK QKPHKHKDQY
YKEYTITEPE EASADALQKP TKDKTPKQKK TLETPIEEVD ETVIIDEGTG EQTDQIAIKR
KPRKVQGNVQ VEAVDEKPIE KKEKAKKKKV VKTKRDEMDD YIQFLIHQEI PKTVLQPYQR
TEMELPQRAR RDSSFKQPVK LTPMKIEKVE FKKPKMVEIS SVVEFPQMLK LKAPKQRPQE
EKKKKNEASF KNKKLKSWIR FVPYAPYCFP YVVTELETNR EVGELSRNVD EAEEVLKLRP
KKFKHSKPEK AELEEADLGA YESDHSDKSN KELLHPKYKR GKKEKIETPD ESRKLKFGKG
KVPQNEEASE EVNLKPVKLD IAEIEDAEMP VRTQEEEVVK KKKPKKSSKP EEGLQFEPIE
FEEMERTSDI REESDTSVSV DTSTQEKPIY KKKKKVTPSP QKNQYKILPG QPREFEETPE
DDLNLRKRQG ERPDDDKADT KLKPFYKFEV LDLEPEGVQA ETVPLSETIA KEPKKKRKIK
VKTEQEDNTI EIVPLSPEDN DEQIFEITVT SSEIPQGDAK AKTIGKKKVK RMNKQELDDF
VTELQEEPNQ EVYETRMSDF YEVKLTELPS EMDSDKPTKR ILRHEKGDEV QVLEIVESVV
APGEEPFYEI NVISSANTEG DSEEITTDKI KKKSRKIKKD DLDAYIQQLI NAEIPVTELE
KYEKIDVDGK AKKPKKLKAK TKKPIIDEGE TLQVGVTEHE PTKKLKTKKP EEKKNVIEKE
LAEHEAVPEY DEFLINKTES ERPQEKRVEE TEKDIVPIVD KVLADLNDCL PFVVVEEDLK
DMPLATDVIA LEDEKIIRKR KVRAKKDSKQ YEIEIIETEK PGDIPDEARV IVITTEVSGD
TIDGPAPSTT EAPKKSVRKV KKEKLKEFIV NIVEEAPLDH VSEIYEDVLR TPFRESSEKE
DIPSFTTTVV EDEIVNPVLP EKIKTVDDVR VPKDKKKKID NQKKIKISEF EPTPTSEDST
IEEYTPKLSE HDEDLQTDEY SVDVKDSLPK SKKKSTKKQK KESLPGPISL YTIRIEETTP
EPITEKIYED GKEVVRVINK RRIKKKAGPK EYLIEVIETY EDNNPEADVV IRTIETTPSI
DSKPQEDHKI QVVQEKKPKT ESLDNYIQKL IDQEIPQVDH KEFKATVLET SPESKKAKKI
KKHHKKTTEV IDGIPITVIE VTIQETETDD EDFKPDEVTL KEIDHENAEE APKVLKSKVS
EEKPKSKKEK SLEFKIAEED KPKPVLEDIS EDVQVVQIIE EDGTPKQVEI KKKKVSRKHG
PKEQVFEITE TKAIDEPLSE VTVVEITDEQ PQEEVLPAQE KKPIKKQKKL KPEDVNTYVV
KVLEELTEPT QFETIPEDAD DKPQPVIEDI SENVQVVQII EEDGTPKQVE IKKKKVSPKH
GPKEQVFEIT ETRPSDEPLA EVTIVELTEE GLNKDIVIPQ EKKTVKKPKK LKPEDIQSYV
IRVLEEFNEP QWPASTEKPI IEDIAESIEI VPVTEEDGIT KEVEVKKKKV SRKQGTKNQV
FEIIETKTSD EPLAEVTILE LSGDKSQEVT ILPKEKKPIK KTIKLKPEDV ESYVVNVLEE
FCEPQSFESP EPTEGEAHET KTKTKKPKKP IVKAPENVIL IEEMAPETVI ENIVNEIGEE
VKQVKTTKKL KKKEGPKEYL IEIKETYEEN KPEGDIEITT TELVPEGSPD ASDDQPVIVV
QKIKKKKPVK DDLDKYIQQL IEQEITKTPL EEYEPTEMDS KKKPKKKVKS HNKKTIEVID
GLPVTIHEFN VEDIVSEPED METPKTLLDE IKEIPQLPDD SSKYLVNISD EFGEADKPIK
QPTQDQPIKK EKPLKKKKDV EYPVSLEAFD HTVKVVSEPT LEGTVKEVTV KKRKVSRRKG
SKDHIFEITE TTSEDRPTAE VTVVELSSDE VLDSEEKPKH ERKIVKKPKQ LKKDDVEEYI
INIIEEFIQP IPVGLVEDEV EKVQKEETKK PKKSPITYIA TEQEDNDNNY DALVKEDLDQ
PIERALEKPS SPLEYTISVE EDSVGEEQKQ PKPKKISKPK SIKQPSVDKS PDYLVNVISE
ESIIDEPIPE DYVVTEAAEE KPSEEPTFKV EELETEAVEK EVTDDDKGET TKQSVTKRKI
KKLVGPKEEI IEIVETKTGD TPEYEVIVTT EEVQEKSKEA PEEKKAKTVR KAKKIPKDDL
QDYIQKLIEQ DIPKTELEKY EKIDLDEPVK MKRKPIKKVK QSEEQPKEET EEPIEDKPVE
KISEYSEVDS DEPKLTVAVK EFIPEKPEEK PFEIVVLEET VESKREPDEE GKVREKVVKT
KKIKQNRGSV EVVHDIVEEI DTDTNESVIT VTTTVPTETP DQDQPSVKQK RTKKIKKDEV
EDFVKRVIEE EAPQPEGSVD LVVIEDFVPK PSSEKRKKKP IKDKHTSVEE ETPHEDEVLL
IESVPEDSPL SDDLITVVDS VPIEEEPENK VNQIEDTKKP EKKKKPKPSA KILEENVPED
TVEKPLEALH TDSDLEKPDV QEFSISIKEE EQKHTHPEKK KSSKISSEQP KQPSTEQYEI
SVTEHDLKPE EEKPFTVQVI QSETNVEETK DDTGKVHKQV TTKRMLRRPA GEGEIEIIEV
VRDDQPEAEI TIVEYEPEPV NQDEKPKEPK KKTRKVKKDD IHDYIQKLIE LETPKTELEK
YEKIEFEPIV KDKPLDSPID VLDESPKEVQ KKDKKSRSTK VPNEETPVQE QYAKVNVVEE
EAPEQPEIPV QILEVKPVEV DVKEVITEDG KPVQEKTTKR VLKKIGPEEQ TTFKITMIES
EDNDSVTVIV DEEPEIASPQ SIEEHPEQSK EKLAPKPKKT VRKVKKDDLS DYVKKLIEEE
IPKVDLEKYE KVEMPEKPVK LTVSDSIPEE PKPDKSQPIS VLPDTTKPKK TKTPKTPKTE
DTDQQVPDEP TETTVDTTDI PELTPTQTAQ PEDTATAQIT PSAQEEKSTQ DDTKDTIQKT
VKHKKTKPDT QKSVETSELP EVHKDYQISI IHEELVEEEQ PEKILEVRVI DEVAEVEESQ
PIVEEVEDEE PQPATEETVE DVTKPKSKKK KVVKKKTDDH DELIKKMLEQ EIEKTELEKY
EKIEFDVPKK LKPEFAALEP IKIERKEQKP TKVTILDATD VPKTVKLKPS KRKEKPAEEL
TVQLPKFRLK ARMVLVEYPP APLIPKTTDI GAIKDNGELS RNIEEAEEIL KFKPHKTKKI
KKIKDDLEKV ELEKYEKYIS SEEEPEEKTP YKKPEKAPKP EEKQEDVKLK LGKGKKKPKE
EEAPENVTLK NIPQKPQEVE EEVELKQKPK EVEIVEEQTK KPKDGEFVVE PFEPSEFDRP
EYVPDELEQI EHPEIPEKVK KPSKTKYKPK DKSKSEPETI VSEIVAGVPK EEEAIPEQDV
KFRKPERDAP EETDSEIKLR PVPQASKDEN PDEQALVTPK AEEPIPQEIE DKAIDDEKKP
KKSKPKKVQP KEQEIAKEEP EEFEVSVKEE EALVDKPIEI EKPKDVKVKE KKPKEAPVSE
VVVIEEEPKP EEVPEEIPVE YKITTTVLEP EDAPKEHQVK VIDFDERQET TEEVIEEKVV
TRKKKPKPQQ PEEFEVTLKE PKEEQIQPDV VSAEISLPIE EPEQKPEQYE VELKITQTTP
EEPNDVQIAV KEKVKTKPVK KVKEDKIVVV EAEEEKQPVE ETIVEVEKQE EKKKSEKPKS
YEFKISETQS IEEKPIEVAE EAPEETPKVV EKKVAEKFDS YEFTLKETDE EKVITVDDQP
EEEAPVEVVF KKKPKEPEAV EAEFVMTEPK IVEETSVETA IKQKKTKKPK KDEEEAQLAI
KVVESEAPVA EEVFSEAPES KIVEEEVIAE EKPKEFTIRV SESEPKPEEP SVEQFTVKKR
KPSVTFADEP ATEIVIKESK PAEVVTEDAH IKTKKPKKKV TDVEAEELKI KITEEVPQEI
PILEEVSEEE VITETKKTAP VVEEKTYKIG IKETEPEKPA EAIVEEEEPV VTEPIEEAPK
PEVFEEHKVR VIEETPRELV EEVIEEEVKV IRRKKPKPEI KEEPEAEVTV STPKPVEEVE
ATSSIAVIPE QPTEEEAADL KITIIEEETP PQELVQEIEE IEIVEEPKAP EEQPTDFTFA
TKDSEKKPTV EELPEEQVTI QKKKKKAPVP EVVEEPEAEF LVKPKTPVQE VTEEAKITKS
KKPVKEEEAA AELKVTITEE IPTEPEVQEI IEEIEEIEEE KPAEYVIEVK ESQPEAVEDK
EVSLPKKKPK APIVEEPEAE ITLKPKVKSE EVQEEAKIVK KKPKKIDEVA VADELTVKVE
EEVVPEPIVE EEVIEEFEIK KKPKEPEPED IVDAAIVKLK KPEPVDADEV VAEVTLKPKA
KTEVTEEEFS VDVKLPKEKK ERPVEIEEEE IIEEAVVIRK KPKKPFEPTV EDLEETEFSL
SFKKPHTINE GVEEAATVLK KRPVKPTTLD EAAAELSIKR QEEEYEEGED IEEFVVSQQR
KPKPLQITEE DEEAYTVKKL KRRKQVDIPE YADVENVTFR ARSTKTKEDV DQEFNIALDS
YAEEEISMSG KVKLKKPIKK TFSEAADEAK IKIIQDFDDG EEPIIEEIRD DEDTIDEVEE
PEEYFVEELP PDEVDFKLKP KKHPKPAYSV QDEEEEQFLI GIRHPKRDSV TYDEDSLTFK
KKRKVVQQLF NEDGASLNIT REMNVEESEN LNIMYSICNY IADNNEAINL VEGEKVTVVG
RHSSEWWYVK KSTTEEEGWV PAQYLMEPEE YAQYVQNKLH EKIDKLPVFE RPGPEDKPIA
PRFIEKLQPI HTPDGYTVQF ECKVEGNPRP QIAWFRETAI IKPSQDFQMF YDDDNVATLI
IREVFPEDAG QFTVVAKNAA GFTSSTTELI VESPLSDHGS DATALSRRSM SRESSLADIL
EGIPPTFSKK PKAQYVDENT NVILECRLVA VPEPDIVWTF NGEDIDEEEI KNVRIVTESD
MHMYCSVVHI SKVKKSQEGT YEVIATNREG EARLPITLKV RTTDKEAPQI LEPLRNMVIR
EGESVVLSTQ IVGNPPPKVT WYKDGKPVKN AKSDKDLHTL TLITPQKSEK GEYTVKAVNP
LGSVETTANL TIEEPAGGNA EPPLFVERFE EQNVPQKGEI RLPAKVSGNP VPEVQWLFNN
TPLFPSERIQ QVYDGENIEL IIKDANPETD SGDYKCIASN PIGKTSHGAR VIVEVDEVTF
TKKLKKTITI EEVQSLTLEC ETSHVVTTKW FFNGKELSGM DHRVVVEDGK THKLVIRNTN
LRDSGTYTCK VKKQETQSTV EVLQRKPDFI KVLEDYEVTE KDTAILDVEL TTEATEVTWY
KDGEKITPEN KNVEFIKDGK ARRLVIRDVT IHDEGQYTCK IEGQECSCEL VVIELPPEIV
EPLNDVAVTK GENAVFEVEL SKGDALVKWF KNGKEIVFNE RIQLAIDGKK QSLRIVKAKP
EDVGEYSVQV GEQTSKAKLT VEEPLVDFVI RLPDITLATK TTDAEFTVQL SQPDVEVTWC
KKGKPIKPNQ KHEVFVEGTV RRLVIHDASD EDAGEISCVA ENVTSSTKLC VEELKLPPVI
TSDKDQTIKV KENDDVTFTV KYTGVPTPEA CWTTRKVVIP KSKRTIPTID EQSAKLTIKK
VVDDDEGEYT VKLVNPVGEA EASLHLVIMR KPTAPGTPQP LEIMHDSITL YWKAPEDDGK
SEIIEYILEY QDVKEEKWTE IRKIKDTTYT ISKLKIDTEY VFRSIAVNEV GPSPPSPLSP
PIRLVPKVET KAPSVQEPLQ DVVSELDKEV TLSCVFGGIP EPKVTWKKNG QVFESRSIRY
ENRVAKYTIE KTTIETEATY TCVATNEKGS AETSCRLKLQ QKPVLEVEDK YLTQKLRTGS
ILTIPATVRG YPQPTVTWHK ETIEQKTTKS VTIETTETTS TYTVKKVTRE QSGKYKVTAT
NESGTTYVEC TVQVIDKPSR PQSLEIKDIK KDSIVLEWTP PVDDGGLDIE KYTLEKCDVQ
NNVWMKVSDF NKDIKSYAVQ KLSMNAQYMF RVVAANPIGE SEPTESDPVT ITKKFEKPSP
PRGPTTVSGM NDTSFNLAWE PSETDGGSKI IEYIVEIREE TETTYRSVGV TLGTVTNIHV
EKVVRNKGYF FRIYARNEVG TSEAFETTEK IVLGRKITPP SPPQNLRAPD VTSRSVTLDW
EVPARNGGSE ITGYCVEKRS STSTNWTKVI TLDAHQLHYT IDNLKEKCEY WFRVSAENEV
GLGAPAVTES ISLKTHASEF ILVVRNCGSY TEFGFLKAVP SPPTGPLEAR VLAANAHIFE
WGLPESDGGA PLLGYHIAIR DMKKTMWIEV GRVPAGVLKF QIRDLQENHE YMIRIFAKNE
IGLSEPLESE EPYKAMTAGH ESLPDEPRTE MSSCNTSSWL RDHHMDADIH SYARGRLLQR
DEYFFRLWAE LPKSKKKKSS K
