TITIN_HUMAN
ID TITIN_HUMAN Reviewed; 34350 AA.
AC Q8WZ42; A6NKB1; E7EQE6; E7ET18; K7ENY1; Q10465; Q10466; Q15598; Q2XUS3;
AC Q32Q60; Q4U1Z6; Q4ZG20; Q6NSG0; Q6PDB1; Q6PJP0; Q7KYM2; Q7KYN4; Q7KYN5;
AC Q7LDM3; Q7Z2X3; Q8TCG8; Q8WZ51; Q8WZ52; Q8WZ53; Q8WZB3; Q92761; Q92762;
AC Q9UD97; Q9UP84; Q9Y6L9;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 4.
DT 03-AUG-2022, entry version 203.
DE RecName: Full=Titin;
DE EC=2.7.11.1;
DE AltName: Full=Connectin;
DE AltName: Full=Rhabdomyosarcoma antigen MU-RMS-40.14;
GN Name=TTN;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF
RP 3336-12202 (ISOFORM 4), AND VARIANTS ILE-498; GLU-1201; MET-3261; ASN-3419;
RP SER-3491; GLU-12679; ILE-19762; ILE-20718; ASN-23807; MET-24980 AND
RP THR-27755.
RC TISSUE=Skeletal muscle;
RX PubMed=7569978; DOI=10.1126/science.270.5234.293;
RA Labeit S., Kolmerer B.;
RT "Titins, giant proteins in charge of muscle ultrastructure and
RT elasticity.";
RL Science 270:293-296(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND VARIANTS
RP LEU-1295; GLN-1572; ILE-2610; ASN-2831; SER-3491; PRO-4215; PHE-4283 AND
RP ARG-12383.
RX PubMed=10850961; DOI=10.1161/01.res.86.11.1114;
RA Freiburg A., Trombitas K., Hell W., Cazorla O., Fougerousse F., Centner T.,
RA Kolmerer B., Witt C., Beckmann J.S., Gregorio C.C., Granzier H., Labeit S.;
RT "Series of exon-skipping events in the elastic spring region of titin as
RT the structural basis for myofibrillar elastic diversity.";
RL Circ. Res. 86:1114-1121(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE
RP SPECIFICITY, INTERACTION WITH OBSCN, AND VARIANTS LEU-1295; GLN-1572;
RP ILE-2610; ASN-2831; SER-3491; PRO-4215 AND PHE-4283.
RX PubMed=11717165; DOI=10.1161/hh2301.100981;
RA Bang M.-L., Centner T., Fornoff F., Geach A.J., Gotthardt M., McNabb M.,
RA Witt C.C., Labeit D., Gregorio C.C., Granzier H., Labeit S.;
RT "The complete gene sequence of titin, expression of an unusual ~700 kDa
RT titin isoform and its interaction with obscurin identify a novel Z-line to
RT I-band linking system.";
RL Circ. Res. 89:1065-1072(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-626 AND 34071-34350 (ISOFORM
RP 3).
RC TISSUE=Muscle, and Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 405-709 (ISOFORMS 1 AND 2).
RC TISSUE=Heart muscle;
RX PubMed=8937992; DOI=10.1242/jcs.109.11.2747;
RA Gautel M., Goulding D., Bullard B., Weber K., Furst D.O.;
RT "The central Z-disk region of titin is assembled from a novel repeat in
RT variable copy numbers.";
RL J. Cell Sci. 109:2747-2754(1996).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2023-2060, AND TISSUE SPECIFICITY.
RC TISSUE=Heart muscle;
RX PubMed=7819249; DOI=10.1021/bi00002a021;
RA Musco G., Tziatzos C., Schuck P., Pastore A.;
RT "Dissecting titin into its structural motifs: identification of an alpha
RT helix near the N-terminus.";
RL Biochemistry 34:553-561(1995).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3455-4473, AND VARIANTS PRO-4215 AND
RP PHE-4283.
RX PubMed=10051295; DOI=10.1161/01.cir.99.8.1022;
RA Siu B.L., Niimura H., Osborne J.A., Fatkin D., MacRae C., Solomon S.,
RA Benson D.W., Seidman J.G., Seidman C.E.;
RT "Familial dilated cardiomyopathy locus maps to chromosome 2q31.";
RL Circulation 99:1022-1026(1999).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9806-12017 (ISOFORM 5).
RC TISSUE=Heart ventricle;
RX PubMed=12785098; DOI=10.1023/a:1023410523184;
RA Greaser M.L., Berri M., Warren C.M., Mozdziak P.E.;
RT "Species variations in cDNA sequence and exon splicing patterns in the
RT extensible I-band region of cardiac titin: relation to passive tension.";
RL J. Muscle Res. Cell Motil. 23:473-482(2002).
RN [10]
RP PROTEIN SEQUENCE OF 11773-11783; 17908-17931; 18656-18669; 26545-26553;
RP 28758-28774 AND 32920-32928, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Fetal brain cortex;
RA Lubec G., Chen W.-Q., Sun Y.;
RL Submitted (DEC-2008) to UniProtKB.
RN [11]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12947-13797.
RC TISSUE=Embryonic rhabdomyosarcoma;
RA Behrends U., Gotz C., Mautner J.;
RT "Serological identification of rhabdomyosarcoma antigens.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE OF 14257-14543.
RX PubMed=8351016; DOI=10.1212/wnl.43.8.1581;
RA Gautel M., Lakey A., Barlow D.P., Holmes Z., Scales S., Leonard K.,
RA Labeit S., Mygland A., Gilhus N.E., Aarli J.A.;
RT "Titin antibodies in myasthenia gravis: identification of a major
RT immunogenic region of titin.";
RL Neurology 43:1581-1585(1993).
RN [13]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 21021-22120, AND NUCLEOTIDE SEQUENCE [GENOMIC
RP DNA] OF 23754-24284.
RX PubMed=1582406; DOI=10.1002/j.1460-2075.1992.tb05222.x;
RA Labeit S., Gautel M., Lakey A., Trinick J.;
RT "Towards a molecular understanding of titin.";
RL EMBO J. 11:1711-1716(1992).
RN [14]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 29701-34350, AND PHOSPHORYLATION.
RX PubMed=8404852; DOI=10.1002/j.1460-2075.1993.tb06061.x;
RA Gautel M., Leonard K., Labeit S.;
RT "Phosphorylation of KSF motifs in the C-terminal region of titin in
RT differentiating myoblasts.";
RL EMBO J. 12:3827-3834(1993).
RN [15]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33119-34350.
RC TISSUE=Skeletal muscle;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [16]
RP INTERACTION WITH TCAP.
RX PubMed=9645487; DOI=10.1016/s0014-5793(98)00501-8;
RA Mues A., van der Ven P.F.M., Young P., Furst D.O., Gautel M.;
RT "Two immunoglobulin-like domains of the Z-disc portion of titin interact in
RT a conformation-dependent way with telethonin.";
RL FEBS Lett. 428:111-114(1998).
RN [17]
RP INTERACTION WITH NEB.
RX PubMed=12482578; DOI=10.1016/s0014-5793(02)03655-4;
RA Ma K., Wang K.;
RT "Interaction of nebulin SH3 domain with titin PEVK and myopalladin:
RT implications for the signaling and assembly role of titin and nebulin.";
RL FEBS Lett. 532:273-278(2002).
RN [18]
RP INTERACTION WITH FHL2.
RX PubMed=12432079; DOI=10.1242/jcs.00181;
RA Lange S., Auerbach D., McLoughlin P., Perriard E., Schafer B.W.,
RA Perriard J.-C., Ehler E.;
RT "Subcellular targeting of metabolic enzymes to titin in heart muscle may be
RT mediated by DRAL/FHL-2.";
RL J. Cell Sci. 115:4925-4936(2002).
RN [19]
RP INTERACTION WITH ANK1.
RX PubMed=12444090; DOI=10.1074/jbc.m209012200;
RA Kontrogianni-Konstantopoulos A., Bloch R.J.;
RT "The hydrophilic domain of small ankyrin-1 interacts with the two N-
RT terminal immunoglobulin domains of titin.";
RL J. Biol. Chem. 278:3985-3991(2003).
RN [20]
RP INTERACTION WITH ANKRD1; ANKRD2; ANKRD23 AND CAPN3.
RX PubMed=14583192; DOI=10.1016/j.jmb.2003.09.012;
RA Miller M.K., Bang M.-L., Witt C.C., Labeit D., Trombitas C., Watanabe K.,
RA Granzier H., McElhinny A.S., Gregorio C.C., Labeit S.;
RT "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family
RT of titin filament-based stress response molecules.";
RL J. Mol. Biol. 333:951-964(2003).
RN [21]
RP INTERACTION WITH CRYAB.
RX PubMed=14676215; DOI=10.1074/jbc.m307473200;
RA Bullard B., Ferguson C., Minajeva A., Leake M.C., Gautel M., Labeit D.,
RA Ding L., Labeit S., Horwitz J., Leonard K.R., Linke W.A.;
RT "Association of the chaperone alphaB-crystallin with titin in heart
RT muscle.";
RL J. Biol. Chem. 279:7917-7924(2004).
RN [22]
RP INTERACTION WITH TRIM63 AND TRIM55.
RX PubMed=15967462; DOI=10.1016/j.jmb.2005.05.021;
RA Witt S.H., Granzier H., Witt C.C., Labeit S.;
RT "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins
RT redundantly: towards understanding MURF-dependent muscle ubiquitination.";
RL J. Mol. Biol. 350:713-722(2005).
RN [23]
RP INTERACTION WITH LAMIN, AND SUBCELLULAR LOCATION.
RX PubMed=16410549; DOI=10.1242/jcs.02728;
RA Zastrow M.S., Flaherty D.B., Benian G.M., Wilson K.L.;
RT "Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.";
RL J. Cell Sci. 119:239-249(2006).
RN [24]
RP REVIEW.
RX PubMed=16537787; DOI=10.1152/ajpheart.00816.2005;
RA Hoshijima M.;
RT "Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk,
RT titin, and associated structures.";
RL Am. J. Physiol. 290:H1313-H1325(2006).
RN [25]
RP INTERACTION WITH CMYA5.
RX PubMed=20634290; DOI=10.1074/jbc.m110.108720;
RA Sarparanta J., Blandin G., Charton K., Vihola A., Marchand S., Milic A.,
RA Hackman P., Ehler E., Richard I., Udd B.;
RT "Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to
RT tibial and limb-girdle muscular dystrophies.";
RL J. Biol. Chem. 285:30304-30315(2010).
RN [26]
RP STRUCTURE BY NMR OF 33483-33579.
RX PubMed=7613868; DOI=10.1016/s0969-2126(01)00170-8;
RA Pfuhl M., Pastore A.;
RT "Tertiary structure of an immunoglobulin-like domain from the giant muscle
RT protein titin: a new member of the I set.";
RL Structure 3:391-401(1995).
RN [27]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 32172-32489, FUNCTION, ACTIVITY
RP REGULATION, INTERACTION WITH CALM, PHOSPHORYLATION AT TYR-32341, AND
RP MUTAGENESIS OF LYS-32207 AND TYR-32341.
RX PubMed=9804419; DOI=10.1038/27603;
RA Mayans O., van der Ven P.F.M., Wilm M., Mues A., Young P., Furst D.O.,
RA Wilmanns M., Gautel M.;
RT "Structural basis for activation of the titin kinase domain during
RT myofibrillogenesis.";
RL Nature 395:863-869(1998).
RN [28]
RP STRUCTURE BY NMR OF 22283-22385.
RX PubMed=9782056; DOI=10.1016/s0969-2126(98)00129-4;
RA Goll C.M., Pastore A., Nilges M.;
RT "The three-dimensional structure of a type I module from titin: a prototype
RT of intracellular fibronectin type III domains.";
RL Structure 6:1291-1302(1998).
RN [29]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 2073-2171, AND DISULFIDE BOND.
RX PubMed=11525170; DOI=10.1016/s0969-2126(01)00591-3;
RA Mayans O., Wuerges J., Canela S., Gautel M., Wilmanns M.;
RT "Structural evidence for a possible role of reversible disulphide bridge
RT formation in the elasticity of the muscle protein titin.";
RL Structure 9:331-340(2001).
RN [30]
RP X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 1-196 IN COMPLEX WITH TCAP.
RX PubMed=16407954; DOI=10.1038/nature04343;
RA Zou P., Pinotsis N., Lange S., Song Y.-H., Popov A., Mavridis I.,
RA Mayans O.M., Gautel M., Wilmanns M.;
RT "Palindromic assembly of the giant muscle protein titin in the sarcomeric
RT Z-disk.";
RL Nature 439:229-233(2006).
RN [31]
RP VARIANT CMH9 LEU-740.
RX PubMed=10462489; DOI=10.1006/bbrc.1999.1221;
RA Satoh M., Takahashi M., Sakamoto T., Hiroe M., Marumo F., Kimura A.;
RT "Structural analysis of the titin gene in hypertrophic cardiomyopathy:
RT identification of a novel disease gene.";
RL Biochem. Biophys. Res. Commun. 262:411-417(1999).
RN [32]
RP INVOLVEMENT IN LGMDR10, AND VARIANT TMD PRO-34315.
RX PubMed=12145747; DOI=10.1086/342380;
RA Hackman P., Vihola A., Haravuori H., Marchand S., Sarparanta J.,
RA De Seze J., Labeit S., Witt C., Peltonen L., Richard I., Udd B.;
RT "Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the
RT gene encoding the giant skeletal-muscle protein titin.";
RL Am. J. Hum. Genet. 71:492-500(2002).
RN [33]
RP VARIANTS CMD1G MET-54; VAL-743; TYR-3799 AND ASN-4465, VARIANTS CYS-328;
RP GLN-4084 AND PRO-4215, CHARACTERIZATION OF VARIANTS CMD1G MET-54 AND
RP VAL-743, AND FUNCTION.
RX PubMed=11846417; DOI=10.1006/bbrc.2002.6448;
RA Itoh-Satoh M., Hayashi T., Nishi H., Koga Y., Arimura T., Koyanagi T.,
RA Takahashi M., Hohda S., Ueda K., Nouchi T., Hiroe M., Marumo F.,
RA Imaizumi T., Yasunami M., Kimura A.;
RT "Titin mutations as the molecular basis for dilated cardiomyopathy.";
RL Biochem. Biophys. Res. Commun. 291:385-393(2002).
RN [34]
RP VARIANT CMD1G ARG-976.
RX PubMed=11788824; DOI=10.1038/ng815;
RA Gerull B., Gramlich M., Atherton J., McNabb M., Trombitas K.,
RA Sasse-Klaassen S., Seidman J.G., Seidman C., Granzier H., Labeit S.,
RA Frenneaux M., Thierfelder L.;
RT "Mutations of TTN, encoding the giant muscle filament titin, cause familial
RT dilated cardiomyopathy.";
RL Nat. Genet. 30:201-204(2002).
RN [35]
RP VARIANT TMD ASN-34306.
RX PubMed=12891679; DOI=10.1002/ana.10647;
RA Van den Bergh P.Y.K., Bouquiaux O., Verellen C., Marchand S., Richard I.,
RA Hackman P., Udd B.;
RT "Tibial muscular dystrophy in a Belgian family.";
RL Ann. Neurol. 54:248-251(2003).
RN [36]
RP VARIANT CMD1G GLN-32996.
RX PubMed=16465475; DOI=10.1007/s10974-005-9018-5;
RA Matsumoto Y., Hayashi T., Inagaki N., Takahashi M., Hiroi S., Nakamura T.,
RA Arimura T., Nakamura K., Ashizawa N., Yasunami M., Ohe T., Yano K.,
RA Kimura A.;
RT "Functional analysis of titin/connectin N2-B mutations found in
RT cardiomyopathy.";
RL J. Muscle Res. Cell Motil. 26:367-374(2005).
RN [37]
RP VARIANT MFM9 TRP-279, CHARACTERIZATION OF VARIANT MFM9 TRP-279, AND
RP INTERACTION WITH NBR1.
RX PubMed=15802564; DOI=10.1126/science.1110463;
RA Lange S., Xiang F., Yakovenko A., Vihola A., Hackman P., Rostkova E.,
RA Kristensen J., Brandmeier B., Franzen G., Hedberg B., Gunnarsson L.G.,
RA Hughes S.M., Marchand S., Sejersen T., Richard I., Edstroem L., Ehler E.,
RA Udd B., Gautel M.;
RT "The kinase domain of titin controls muscle gene expression and protein
RT turnover.";
RL Science 308:1599-1603(2005).
RN [38]
RP INVOLVEMENT IN SALMY.
RX PubMed=17444505; DOI=10.1002/ana.21089;
RA Carmignac V., Salih M.A.M., Quijano-Roy S., Marchand S., Al Rayess M.M.,
RA Mukhtar M.M., Urtizberea J.A., Labeit S., Guicheney P., Leturcq F.,
RA Gautel M., Fardeau M., Campbell K.P., Richard I., Estournet B.,
RA Ferreiro A.;
RT "C-terminal titin deletions cause a novel early-onset myopathy with fatal
RT cardiomyopathy.";
RL Ann. Neurol. 61:340-351(2007).
RN [39]
RP VARIANTS [LARGE SCALE ANALYSIS] TYR-60; MET-115; CYS-328; THR-360; ILE-498;
RP MET-799; ILE-811; HIS-922; ASP-937; THR-1081; ARG-1137; GLU-1201; ALA-1202;
RP LEU-1295; ASP-1345; THR-1347; HIS-1350; LEU-1353; VAL-1393; CYS-1416;
RP PRO-1441; VAL-1544; GLN-1572; GLY-1658; GLN-1664; ASP-1692; LEU-1744;
RP GLY-1772; ILE-1907; HIS-1998; LEU-2107; THR-2118; THR-2164; TYR-2240;
RP SER-2392; PHE-2432; ILE-2610; MET-2771; PHE-2823; ASN-2831; ILE-2930;
RP ARG-3154; GLU-3191; LEU-3238; GLY-3250; MET-3261; GLN-3367; LYS-3482;
RP LYS-3570; VAL-3590; VAL-3762; PHE-3877; LEU-3965; PRO-4215; TRP-4238;
RP PHE-4283; THR-4291; ASP-4303; GLU-4427; GLU-12310; ALA-12469; CYS-12642;
RP LYS-12657; GLU-12679; PHE-12720; CYS-12798; GLY-13049; LYS-13083;
RP LEU-13096; ARG-13099; ALA-13297; MET-13399; THR-13418; VAL-13428;
RP THR-13430; LYS-13434; ASN-13469; ASN-13495; SER-13785; HIS-13870;
RP ILE-14109; GLN-14131; THR-14208; VAL-14728; THR-14999; THR-15021;
RP VAL-15520; ILE-15555; GLN-15620; ILE-15629; CYS-15635; GLN-15700;
RP PRO-15705; MET-15837; HIS-16058; ILE-16067; THR-16090; HIS-16195;
RP CYS-16409; PRO-16424; MET-16629; ARG-16877; ASP-17060; VAL-17637;
RP HIS-17838; ASN-17866; GLU-17906; ALA-18094; SER-18109; THR-18164;
RP LEU-18221; THR-18222; GLN-18726; ALA-18835; LYS-18881; SER-18939;
RP GLN-19000; GLN-19060; LYS-19091; SER-19224; ILE-19367; LYS-19392;
RP SER-19480; GLY-19495; HIS-19665; ILE-19762; ARG-19947; MET-19956;
RP GLN-19992; CYS-20057; LEU-20075; LYS-20179; THR-20198; VAL-20198;
RP HIS-20331; THR-20408; LYS-20564; ILE-20718; PRO-20726; ASN-20892;
RP ARG-20894; GLU-21125; SER-21403; CYS-21730; GLN-21747; ARG-21851;
RP ARG-21851; ARG-21925; HIS-21995; VAL-22045; HIS-22149; ILE-22160;
RP THR-22261; ASN-22306; HIS-22357; PRO-22408; HIS-22537; LEU-22584;
RP PRO-22646; ALA-22670; ASP-22770; THR-22801; TRP-22823; GLN-22968;
RP LEU-23074; PHE-23079; ASN-23282; TYR-23303; CYS-23306; SER-23515;
RP GLN-23551; ASN-23807; ASN-23872; ALA-23891; HIS-23933; MET-23939;
RP LEU-23952; GLY-24098; SER-24119; ILE-24133; ALA-24159; ALA-24239;
RP LYS-24265; THR-24584; THR-24781; HIS-24799; HIS-24954; MET-24980;
RP HIS-25659; THR-25679; ALA-25720; LYS-25821; LYS-25859; LYS-25879;
RP VAL-25923; ILE-26045; GLU-26059; VAL-26134; CYS-26477; TYR-26843;
RP ARG-27346; CYS-27652; VAL-27728; LEU-27754; THR-27755; VAL-27929;
RP LEU-28132; GLN-28168; HIS-28538; THR-28572; THR-28948; VAL-28986;
RP GLU-28993; VAL-28998; MET-29070; VAL-29090; CYS-29419; PRO-29479;
RP LEU-29880; GLU-29976; GLY-30042; CYS-30107; PHE-30125; PRO-30211;
RP THR-30412; SER-30617; ILE-30674; ILE-30809; ILE-30818; LYS-30825;
RP THR-30856; ASP-30887; SER-30887; HIS-30897; HIS-30907; HIS-30946;
RP PHE-31081; CYS-31107; GLY-31124; SER-31156; THR-31246; HIS-31330;
RP ARG-31690; GLN-31724; ILE-31725; SER-31732; ILE-31886; CYS-32097;
RP ASN-32171; ILE-32248; HIS-32281; HIS-32323; TRP-32411; VAL-32558;
RP VAL-32610; VAL-32637; ALA-32922; ARG-32943; HIS-32953; LEU-33213;
RP CYS-33242; MET-33387; ASP-33419; MET-33536; GLN-33568; LYS-33616;
RP LEU-33620; VAL-33886; THR-33899; PRO-33904; ILE-33955 AND ALA-34115.
RX PubMed=17344846; DOI=10.1038/nature05610;
RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
RA Futreal P.A., Stratton M.R.;
RT "Patterns of somatic mutation in human cancer genomes.";
RL Nature 446:153-158(2007).
RN [40]
RP VARIANTS VAL-16046 AND GLN-32742.
RX PubMed=23033978; DOI=10.1056/nejmoa1206524;
RA de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G.,
RA Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P., Gilissen C.,
RA del Rosario M., Hoischen A., Scheffer H., de Vries B.B., Brunner H.G.,
RA Veltman J.A., Vissers L.E.;
RT "Diagnostic exome sequencing in persons with severe intellectual
RT disability.";
RL N. Engl. J. Med. 367:1921-1929(2012).
RN [41]
RP VARIANTS PRO-2963 AND GLN-14750.
RX PubMed=25173926; DOI=10.1161/circgenetics.113.000486;
RA Girolami F., Iascone M., Tomberli B., Bardi S., Benelli M., Marseglia G.,
RA Pescucci C., Pezzoli L., Sana M.E., Basso C., Marziliano N., Merlini P.A.,
RA Fornaro A., Cecchi F., Torricelli F., Olivotto I.;
RT "Novel alpha-actinin 2 variant associated with familial hypertrophic
RT cardiomyopathy and juvenile atrial arrhythmias: a massively parallel
RT sequencing study.";
RL Circ. Cardiovasc. Genet. 7:741-750(2014).
CC -!- FUNCTION: Key component in the assembly and functioning of vertebrate
CC striated muscles. By providing connections at the level of individual
CC microfilaments, it contributes to the fine balance of forces between
CC the two halves of the sarcomere. The size and extensibility of the
CC cross-links are the main determinants of sarcomere extensibility
CC properties of muscle. In non-muscle cells, seems to play a role in
CC chromosome condensation and chromosome segregation during mitosis.
CC Might link the lamina network to chromatin or nuclear actin, or both
CC during interphase. {ECO:0000269|PubMed:11846417,
CC ECO:0000269|PubMed:9804419}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC -!- ACTIVITY REGULATION: Full activation of the protein kinase domain
CC requires both phosphorylation of Tyr-32341, preventing it from blocking
CC the catalytic aspartate residue, and binding of Ca/CALM to the C-
CC terminal regulatory tail of the molecule which results in ATP binding
CC to the kinase. {ECO:0000269|PubMed:9804419}.
CC -!- SUBUNIT: Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts
CC with actin, primarily via the PEVK domains and with MYPN (By
CC similarity). Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and
CC LMNB/lamin-B. Interacts with TCAP/telethonin and/or ANK1 isoform
CC Mu17/ank1.5, via the first two N-terminal immunoglobulin domains.
CC Interacts with TRIM63 and TRIM55, through several domains including
CC immunoglobulin domains 141 and 142. Interacts with ANKRD1, ANKRD2 and
CC ANKRD23, via the region between immunoglobulin domains 77 and 78 and
CC interacts with CAPN3, via immunoglobulin domain 79. Interacts with NBR1
CC through the protein kinase domain. Interacts with CALM/calmodulin.
CC Isoform 6 interacts with OBSCN isoform 3. Interacts with CMYA5.
CC {ECO:0000250, ECO:0000269|PubMed:11717165, ECO:0000269|PubMed:12432079,
CC ECO:0000269|PubMed:12444090, ECO:0000269|PubMed:12482578,
CC ECO:0000269|PubMed:14583192, ECO:0000269|PubMed:14676215,
CC ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15967462,
CC ECO:0000269|PubMed:16407954, ECO:0000269|PubMed:16410549,
CC ECO:0000269|PubMed:20634290, ECO:0000269|PubMed:9645487,
CC ECO:0000269|PubMed:9804419}.
CC -!- INTERACTION:
CC Q8WZ42; P12814: ACTN1; NbExp=2; IntAct=EBI-681210, EBI-351710;
CC Q8WZ42; P35609: ACTN2; NbExp=16; IntAct=EBI-681210, EBI-77797;
CC Q8WZ42; P62158: CALM3; NbExp=2; IntAct=EBI-681210, EBI-397435;
CC Q8WZ42; P20807: CAPN3; NbExp=4; IntAct=EBI-681210, EBI-5655000;
CC Q8WZ42; O75953: DNAJB5; NbExp=4; IntAct=EBI-681210, EBI-5655937;
CC Q8WZ42; O75923: DYSF; NbExp=17; IntAct=EBI-681210, EBI-2799016;
CC Q8WZ42; P06733: ENO1; NbExp=3; IntAct=EBI-681210, EBI-353877;
CC Q8WZ42; Q9H492: MAP1LC3A; NbExp=3; IntAct=EBI-681210, EBI-720768;
CC Q8WZ42; Q9GZQ8: MAP1LC3B; NbExp=4; IntAct=EBI-681210, EBI-373144;
CC Q8WZ42; Q14324: MYBPC2; NbExp=14; IntAct=EBI-681210, EBI-5653200;
CC Q8WZ42; Q13203: MYBPH; NbExp=3; IntAct=EBI-681210, EBI-5655165;
CC Q8WZ42; P20929: NEB; NbExp=6; IntAct=EBI-681210, EBI-1049657;
CC Q8WZ42; Q5VST9: OBSCN; NbExp=15; IntAct=EBI-681210, EBI-941850;
CC Q8WZ42; O75147: OBSL1; NbExp=13; IntAct=EBI-681210, EBI-1223896;
CC Q8WZ42; O15061: SYNM; NbExp=3; IntAct=EBI-681210, EBI-7843148;
CC Q8WZ42; O15273: TCAP; NbExp=9; IntAct=EBI-681210, EBI-954089;
CC Q8WZ42; Q969Q1: TRIM63; NbExp=3; IntAct=EBI-681210, EBI-5661333;
CC Q8WZ42; Q8WZ42: TTN; NbExp=16; IntAct=EBI-681210, EBI-681210;
CC Q8WZ42-3; O15273: TCAP; NbExp=2; IntAct=EBI-15564183, EBI-954089;
CC Q8WZ42-3; Q8WZ42-3: TTN; NbExp=9; IntAct=EBI-15564183, EBI-15564183;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:16410549}. Nucleus
CC {ECO:0000269|PubMed:16410549}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=13;
CC Comment=A number of isoforms may be produced, ranging from 27000 to
CC 33000 residues in different striated muscle tissues, the size of the
CC full-length protein may be up to 38138 residues.;
CC Name=1;
CC IsoId=Q8WZ42-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WZ42-2; Sequence=VSP_019138;
CC Name=3; Synonyms=Small cardiac N2-B;
CC IsoId=Q8WZ42-3; Sequence=VSP_019139, VSP_019145;
CC Name=4; Synonyms=Soleus;
CC IsoId=Q8WZ42-4; Sequence=VSP_019142, VSP_019151;
CC Name=5;
CC IsoId=Q8WZ42-5; Sequence=VSP_019147, VSP_019148, VSP_019149,
CC VSP_019150, VSP_019152;
CC Name=6; Synonyms=Small cardiac novex-3;
CC IsoId=Q8WZ42-6; Sequence=VSP_019143, VSP_019146;
CC Name=7; Synonyms=Cardiac novex-2;
CC IsoId=Q8WZ42-7; Sequence=VSP_019141, VSP_019144;
CC Name=8; Synonyms=Cardiac novex-1;
CC IsoId=Q8WZ42-8; Sequence=VSP_019140;
CC Name=9;
CC IsoId=Q8WZ42-9; Sequence=VSP_019139, VSP_042903, VSP_019145;
CC Name=10;
CC IsoId=Q8WZ42-10; Sequence=VSP_019139, VSP_019140, VSP_019145;
CC Name=11;
CC IsoId=Q8WZ42-11; Sequence=VSP_019142;
CC Name=12;
CC IsoId=Q8WZ42-12; Sequence=VSP_045935, VSP_045929, VSP_045930,
CC VSP_045931, VSP_045932, VSP_045933,
CC VSP_045934;
CC Name=13;
CC IsoId=Q8WZ42-13; Sequence=VSP_047142;
CC -!- TISSUE SPECIFICITY: Isoforms 3, 7 and 8 are expressed in cardiac
CC muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6
CC is expressed in skeletal muscle (at protein level).
CC {ECO:0000269|PubMed:11717165, ECO:0000269|PubMed:7819249}.
CC -!- DOMAIN: ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for
CC ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1
CC could adopt a closed conformation which would block the TCAP-binding
CC site.
CC -!- DOMAIN: The PEVK region may serve as an entropic spring of a chain of
CC structural folds and may also be an interaction site to other
CC myofilament proteins to form interfilament connectivity in the
CC sarcomere.
CC -!- PTM: Autophosphorylated. {ECO:0000250}.
CC -!- DISEASE: Myopathy, myofibrillar, 9, with early respiratory failure
CC (MFM9) [MIM:603689]: An autosomal dominant myopathy characterized by
CC adulthood onset of weakness in proximal, distal, axial and respiratory
CC muscles. Pelvic girdle weakness, foot drop and neck weakness are the
CC main symptoms at onset, but ultimately the weakness usually involves
CC the proximal compartment of both upper and lower limbs. Additional
CC features include variable degrees of Achilles tendon contractures,
CC spinal rigidity and muscle hypertrophy. Respiratory involvement often
CC leads to requirement for non-invasive ventilation support.
CC {ECO:0000269|PubMed:15802564}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Cardiomyopathy, familial hypertrophic 9 (CMH9) [MIM:613765]: A
CC hereditary heart disorder characterized by ventricular hypertrophy,
CC which is usually asymmetric and often involves the interventricular
CC septum. The symptoms include dyspnea, syncope, collapse, palpitations,
CC and chest pain. They can be readily provoked by exercise. The disorder
CC has inter- and intrafamilial variability ranging from benign to
CC malignant forms with high risk of cardiac failure and sudden cardiac
CC death. {ECO:0000269|PubMed:10462489}. Note=The disease is caused by
CC variants affecting the gene represented in this entry.
CC -!- DISEASE: Cardiomyopathy, dilated 1G (CMD1G) [MIM:604145]: A disorder
CC characterized by ventricular dilation and impaired systolic function,
CC resulting in congestive heart failure and arrhythmia. Patients are at
CC risk of premature death. {ECO:0000269|PubMed:11788824,
CC ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:16465475}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- DISEASE: Tardive tibial muscular dystrophy (TMD) [MIM:600334]:
CC Autosomal dominant, late-onset distal myopathy. Muscle weakness and
CC atrophy are usually confined to the anterior compartment of the lower
CC leg, in particular the tibialis anterior muscle. Clinical symptoms
CC usually occur at age 35-45 years or much later.
CC {ECO:0000269|PubMed:12145747, ECO:0000269|PubMed:12891679}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- DISEASE: Muscular dystrophy, limb-girdle, autosomal recessive 10
CC (LGMDR10) [MIM:608807]: An autosomal recessive degenerative myopathy
CC characterized by progressive weakness of the pelvic and shoulder girdle
CC muscles. Severe disability is observed within 20 years of onset.
CC {ECO:0000269|PubMed:12145747}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Salih myopathy (SALMY) [MIM:611705]: An autosomal recessive,
CC early-onset muscular disorder characterized by dilated cardiomyopathy,
CC delayed motor development with generalized muscle weakness
CC predominantly affecting proximal and distal lower limbs. Skeletal
CC muscle biopsies show minicore-like lesions with mitochondrial depletion
CC and sarcomere disorganization, centralized nuclei, and type 1 fiber
CC predominance. Dystrophic changes become apparent in the second decade.
CC Cardiac muscle biopsies show disruption of myocardial architecture,
CC nuclear hypertrophy, and endomysial fibrosis. Sudden death may occurr
CC due to cardiomyopathy. {ECO:0000269|PubMed:17444505}. Note=The disease
CC is caused by variants affecting the gene represented in this entry.
CC -!- MISCELLANEOUS: In some isoforms, after the PEVK repeat region there is
CC a long PEVK duplicated region. On account of this region, it has been
CC very difficult to sequence the whole protein. The length of this region
CC (ranging from 183 to 2174 residues), may be a key elastic element of
CC titin.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH58824.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 553.; Evidence={ECO:0000305};
CC Sequence=AAH70170.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 627.; Evidence={ECO:0000305};
CC Sequence=CAA62188.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAD12455.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Titin entry;
CC URL="https://en.wikipedia.org/wiki/Titin";
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DR EMBL; X90568; CAA62188.1; ALT_FRAME; mRNA.
DR EMBL; X90569; CAA62189.1; -; mRNA.
DR EMBL; AJ277892; CAD12455.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AJ277892; CAD12456.1; -; Genomic_DNA.
DR EMBL; AJ277892; CAD12457.1; -; Genomic_DNA.
DR EMBL; AJ277892; CAD12458.1; -; Genomic_DNA.
DR EMBL; AJ277892; CAD12459.1; -; Genomic_DNA.
DR EMBL; AC009948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FJ695199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC023270; AAX88844.1; -; Genomic_DNA.
DR EMBL; BC013396; AAH13396.1; -; mRNA.
DR EMBL; BC058824; AAH58824.1; ALT_SEQ; mRNA.
DR EMBL; BC070170; AAH70170.1; ALT_SEQ; mRNA.
DR EMBL; BC107797; AAI07798.1; -; mRNA.
DR EMBL; X98114; CAA66795.1; -; mRNA.
DR EMBL; X98115; CAA66796.1; -; mRNA.
DR EMBL; X83270; CAA58243.1; -; mRNA.
DR EMBL; AF058332; AAD22603.1; -; Genomic_DNA.
DR EMBL; AF058332; AAD22604.1; -; Genomic_DNA.
DR EMBL; AF525413; AAP80791.1; -; mRNA.
DR EMBL; DQ248309; ABB55264.1; -; mRNA.
DR EMBL; X64698; CAA45939.1; -; mRNA.
DR EMBL; X64699; CAA45940.1; -; Genomic_DNA.
DR EMBL; X64697; CAA45938.1; -; mRNA.
DR EMBL; X69490; CAA49245.1; -; mRNA.
DR EMBL; AL713647; CAD28458.1; -; mRNA.
DR CCDS; CCDS33337.1; -. [Q8WZ42-6]
DR CCDS; CCDS54421.1; -. [Q8WZ42-3]
DR CCDS; CCDS54422.1; -. [Q8WZ42-9]
DR CCDS; CCDS54423.1; -. [Q8WZ42-10]
DR CCDS; CCDS54424.1; -. [Q8WZ42-11]
DR CCDS; CCDS59435.1; -. [Q8WZ42-12]
DR CCDS; CCDS74610.1; -. [Q8WZ42-1]
DR PIR; I38344; I38344.
DR PIR; I38346; I38346.
DR RefSeq; NP_001243779.1; NM_001256850.1. [Q8WZ42-1]
DR RefSeq; NP_003310.4; NM_003319.4. [Q8WZ42-3]
DR RefSeq; NP_596869.4; NM_133378.4. [Q8WZ42-11]
DR RefSeq; NP_596870.2; NM_133379.4. [Q8WZ42-6]
DR RefSeq; NP_597676.3; NM_133432.3. [Q8WZ42-10]
DR PDB; 1BPV; NMR; -; A=22283-22385.
DR PDB; 1G1C; X-ray; 2.10 A; A/B=2073-2171.
DR PDB; 1NCT; NMR; -; A=33483-33579.
DR PDB; 1NCU; NMR; -; A=33483-33579.
DR PDB; 1TIT; NMR; -; A=12680-12765.
DR PDB; 1TIU; NMR; -; A=12680-12765.
DR PDB; 1TKI; X-ray; 2.00 A; A/B=32172-32492.
DR PDB; 1TNM; NMR; -; A=33489-33579.
DR PDB; 1TNN; NMR; -; A=33489-33579.
DR PDB; 1WAA; X-ray; 1.80 A; A/B/C/D/E/F=12677-12765.
DR PDB; 1YA5; X-ray; 2.44 A; A/B=1-196.
DR PDB; 2A38; X-ray; 2.00 A; A/B/C=1-194.
DR PDB; 2BK8; X-ray; 1.69 A; A=32497-32590.
DR PDB; 2F8V; X-ray; 2.75 A; A/B/C/D=1-196.
DR PDB; 2ILL; X-ray; 2.20 A; A=31854-32047.
DR PDB; 2J8H; X-ray; 1.99 A; A=31854-32047.
DR PDB; 2J8O; X-ray; 2.49 A; A/B=31854-32047.
DR PDB; 2NZI; X-ray; 2.90 A; A/B=31854-32155.
DR PDB; 2RQ8; NMR; -; A=12677-12765.
DR PDB; 2WP3; X-ray; 1.48 A; T=34252-34350.
DR PDB; 2WWK; X-ray; 1.70 A; T=34252-34350.
DR PDB; 2WWM; X-ray; 2.30 A; D/T=34252-34350.
DR PDB; 2Y9R; X-ray; 1.90 A; T=34252-34350.
DR PDB; 3B43; X-ray; 3.30 A; A=7945-8511.
DR PDB; 3KNB; X-ray; 1.40 A; A=34253-34350.
DR PDB; 3LCY; X-ray; 2.50 A; A/B/C/D=31456-31649.
DR PDB; 3LPW; X-ray; 1.65 A; A/B=22877-23070.
DR PDB; 3PUC; X-ray; 0.96 A; A=33774-33871.
DR PDB; 3Q5O; X-ray; 2.05 A; A/B=34253-34350.
DR PDB; 3QP3; X-ray; 2.00 A; A/B/C=33294-33395.
DR PDB; 4C4K; X-ray; 1.95 A; T=34252-34350.
DR PDB; 4JNW; X-ray; 2.06 A; A/B=32172-32492.
DR PDB; 4O00; X-ray; 1.85 A; A/B=14217-14319.
DR PDB; 4QEG; X-ray; 2.00 A; A=2880-2967.
DR PDB; 4UOW; X-ray; 3.30 A; 1/3/5/7/9/B/D/F/H/J/L/N/P/R/T/V/X/Z=7-99.
DR PDB; 5BS0; X-ray; 2.40 A; C=24337-24345.
DR PDB; 5JDD; X-ray; 1.53 A; A=2795-3053.
DR PDB; 5JDE; X-ray; 1.90 A; A/B=2795-3053.
DR PDB; 5JDJ; X-ray; 1.74 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2880-2967.
DR PDB; 5JOE; X-ray; 2.00 A; A=9582-9671.
DR PDB; 6DL4; NMR; -; A=1821-1931.
DR PDB; 6FWX; X-ray; 3.00 A; A/B=1-243.
DR PDB; 6H4L; X-ray; 1.60 A; A=33294-33395.
DR PDB; 6HCI; X-ray; 2.12 A; A/B/C/D=32712-32816.
DR PDB; 6I0Y; EM; 3.20 A; z=12677-12765.
DR PDB; 6SDB; X-ray; 2.80 A; A/B/C/D/E=3-196.
DR PDB; 6YGN; X-ray; 2.40 A; A/B=32046-32594.
DR PDB; 7AHS; X-ray; 2.05 A; A/B/C/D=9582-9851.
DR PDB; 7NIP; NMR; -; A=9504-9544.
DR PDBsum; 1BPV; -.
DR PDBsum; 1G1C; -.
DR PDBsum; 1NCT; -.
DR PDBsum; 1NCU; -.
DR PDBsum; 1TIT; -.
DR PDBsum; 1TIU; -.
DR PDBsum; 1TKI; -.
DR PDBsum; 1TNM; -.
DR PDBsum; 1TNN; -.
DR PDBsum; 1WAA; -.
DR PDBsum; 1YA5; -.
DR PDBsum; 2A38; -.
DR PDBsum; 2BK8; -.
DR PDBsum; 2F8V; -.
DR PDBsum; 2ILL; -.
DR PDBsum; 2J8H; -.
DR PDBsum; 2J8O; -.
DR PDBsum; 2NZI; -.
DR PDBsum; 2RQ8; -.
DR PDBsum; 2WP3; -.
DR PDBsum; 2WWK; -.
DR PDBsum; 2WWM; -.
DR PDBsum; 2Y9R; -.
DR PDBsum; 3B43; -.
DR PDBsum; 3KNB; -.
DR PDBsum; 3LCY; -.
DR PDBsum; 3LPW; -.
DR PDBsum; 3PUC; -.
DR PDBsum; 3Q5O; -.
DR PDBsum; 3QP3; -.
DR PDBsum; 4C4K; -.
DR PDBsum; 4JNW; -.
DR PDBsum; 4O00; -.
DR PDBsum; 4QEG; -.
DR PDBsum; 4UOW; -.
DR PDBsum; 5BS0; -.
DR PDBsum; 5JDD; -.
DR PDBsum; 5JDE; -.
DR PDBsum; 5JDJ; -.
DR PDBsum; 5JOE; -.
DR PDBsum; 6DL4; -.
DR PDBsum; 6FWX; -.
DR PDBsum; 6H4L; -.
DR PDBsum; 6HCI; -.
DR PDBsum; 6I0Y; -.
DR PDBsum; 6SDB; -.
DR PDBsum; 6YGN; -.
DR PDBsum; 7AHS; -.
DR PDBsum; 7NIP; -.
DR SASBDB; Q8WZ42; -.
DR SMR; Q8WZ42; -.
DR BioGRID; 113124; 187.
DR ComplexPortal; CPX-101; Titin-Telethonin complex.
DR CORUM; Q8WZ42; -.
DR DIP; DIP-33449N; -.
DR IntAct; Q8WZ42; 138.
DR MINT; Q8WZ42; -.
DR STRING; 9606.ENSP00000467141; -.
DR MoonDB; Q8WZ42; Predicted.
DR CarbonylDB; Q8WZ42; -.
DR GlyGen; Q8WZ42; 11 sites, 2 O-linked glycans (11 sites).
DR iPTMnet; Q8WZ42; -.
DR MetOSite; Q8WZ42; -.
DR PhosphoSitePlus; Q8WZ42; -.
DR SwissPalm; Q8WZ42; -.
DR BioMuta; TTN; -.
DR EPD; Q8WZ42; -.
DR jPOST; Q8WZ42; -.
DR MassIVE; Q8WZ42; -.
DR MaxQB; Q8WZ42; -.
DR PaxDb; Q8WZ42; -.
DR PeptideAtlas; Q8WZ42; -.
DR PRIDE; Q8WZ42; -.
DR ProteomicsDB; 75209; -. [Q8WZ42-1]
DR ProteomicsDB; 75210; -. [Q8WZ42-10]
DR ProteomicsDB; 75211; -. [Q8WZ42-11]
DR ProteomicsDB; 75212; -. [Q8WZ42-2]
DR ProteomicsDB; 75213; -. [Q8WZ42-3]
DR ProteomicsDB; 75214; -. [Q8WZ42-4]
DR ProteomicsDB; 75215; -. [Q8WZ42-5]
DR ProteomicsDB; 75216; -. [Q8WZ42-6]
DR ProteomicsDB; 75217; -. [Q8WZ42-7]
DR ProteomicsDB; 75218; -. [Q8WZ42-8]
DR ProteomicsDB; 75219; -. [Q8WZ42-9]
DR ABCD; Q8WZ42; 2 sequenced antibodies.
DR Antibodypedia; 2056; 211 antibodies from 28 providers.
DR DNASU; 7273; -.
DR Ensembl; ENST00000342992.11; ENSP00000343764.6; ENSG00000155657.29. [Q8WZ42-11]
DR Ensembl; ENST00000359218.10; ENSP00000352154.5; ENSG00000155657.29. [Q8WZ42-10]
DR Ensembl; ENST00000360870.10; ENSP00000354117.4; ENSG00000155657.29. [Q8WZ42-6]
DR Ensembl; ENST00000460472.6; ENSP00000434586.1; ENSG00000155657.29. [Q8WZ42-3]
DR Ensembl; ENST00000591111.5; ENSP00000465570.1; ENSG00000155657.29. [Q8WZ42-1]
DR GeneID; 7273; -.
DR KEGG; hsa:7273; -.
DR UCSC; uc002unb.4; human. [Q8WZ42-1]
DR CTD; 7273; -.
DR DisGeNET; 7273; -.
DR GeneCards; TTN; -.
DR GeneReviews; TTN; -.
DR HGNC; HGNC:12403; TTN.
DR HPA; ENSG00000155657; Group enriched (skeletal muscle, tongue).
DR MalaCards; TTN; -.
DR MIM; 188840; gene.
DR MIM; 600334; phenotype.
DR MIM; 603689; phenotype.
DR MIM; 604145; phenotype.
DR MIM; 608807; phenotype.
DR MIM; 611705; phenotype.
DR MIM; 613765; phenotype.
DR neXtProt; NX_Q8WZ42; -.
DR OpenTargets; ENSG00000155657; -.
DR Orphanet; 169186; Autosomal recessive centronuclear myopathy.
DR Orphanet; 466921; Childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome.
DR Orphanet; 324604; Classic multiminicore myopathy.
DR Orphanet; 289377; Early-onset myopathy with fatal cardiomyopathy.
DR Orphanet; 334; Familial atrial fibrillation.
DR Orphanet; 293899; Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
DR Orphanet; 293888; Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
DR Orphanet; 293910; Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
DR Orphanet; 154; Familial isolated dilated cardiomyopathy.
DR Orphanet; 178464; Hereditary myopathy with early respiratory failure.
DR Orphanet; 155; NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy.
DR Orphanet; 609; Tibial muscular dystrophy.
DR Orphanet; 140922; Titin-related limb-girdle muscular dystrophy R10.
DR PharmGKB; PA37067; -.
DR VEuPathDB; HostDB:ENSG00000155657; -.
DR eggNOG; KOG0613; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR GeneTree; ENSGT01050000244911; -.
DR HOGENOM; CLU_000001_1_0_1; -.
DR InParanoid; Q8WZ42; -.
DR OMA; VYEGDSC; -.
DR TreeFam; TF316477; -.
DR BRENDA; 2.7.11.1; 2681.
DR PathwayCommons; Q8WZ42; -.
DR Reactome; R-HSA-114608; Platelet degranulation.
DR Reactome; R-HSA-390522; Striated Muscle Contraction.
DR SignaLink; Q8WZ42; -.
DR SIGNOR; Q8WZ42; -.
DR BioGRID-ORCS; 7273; 10 hits in 1103 CRISPR screens.
DR ChiTaRS; TTN; human.
DR EvolutionaryTrace; Q8WZ42; -.
DR GeneWiki; Titin; -.
DR GenomeRNAi; 7273; -.
DR Pharos; Q8WZ42; Tbio.
DR PRO; PR:Q8WZ42; -.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000155657; Expressed in gluteal muscle and 162 other tissues.
DR ExpressionAtlas; Q8WZ42; baseline and differential.
DR Genevisible; Q8WZ42; HS.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:BHF-UCL.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0031674; C:I band; IDA:BHF-UCL.
DR GO; GO:0031430; C:M band; IDA:BHF-UCL.
DR GO; GO:0005865; C:striated muscle thin filament; IDA:BHF-UCL.
DR GO; GO:1990733; C:titin-telethonin complex; IPI:ComplexPortal.
DR GO; GO:0030018; C:Z disc; IDA:BHF-UCL.
DR GO; GO:0051015; F:actin filament binding; IDA:BHF-UCL.
DR GO; GO:0042805; F:actinin binding; IDA:BHF-UCL.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IDA:BHF-UCL.
DR GO; GO:0005516; F:calmodulin binding; IPI:BHF-UCL.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0051371; F:muscle alpha-actinin binding; IPI:BHF-UCL.
DR GO; GO:0002020; F:protease binding; IPI:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; IPI:BHF-UCL.
DR GO; GO:0043621; F:protein self-association; IDA:BHF-UCL.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IDA:MGI.
DR GO; GO:0008307; F:structural constituent of muscle; IMP:BHF-UCL.
DR GO; GO:0097493; F:structural molecule activity conferring elasticity; IDA:BHF-UCL.
DR GO; GO:0031433; F:telethonin binding; IPI:BHF-UCL.
DR GO; GO:0055013; P:cardiac muscle cell development; IMP:BHF-UCL.
DR GO; GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
DR GO; GO:0003300; P:cardiac muscle hypertrophy; IMP:BHF-UCL.
DR GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
DR GO; GO:0055003; P:cardiac myofibril assembly; IMP:BHF-UCL.
DR GO; GO:0035995; P:detection of muscle stretch; IDA:MGI.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEP:BHF-UCL.
DR GO; GO:0006936; P:muscle contraction; TAS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:CAFA.
DR GO; GO:0050714; P:positive regulation of protein secretion; IMP:CAFA.
DR GO; GO:0010737; P:protein kinase A signaling; IMP:CAFA.
DR GO; GO:0050790; P:regulation of catalytic activity; IMP:BHF-UCL.
DR GO; GO:0045859; P:regulation of protein kinase activity; IMP:BHF-UCL.
DR GO; GO:0051592; P:response to calcium ion; IDA:BHF-UCL.
DR GO; GO:0045214; P:sarcomere organization; IMP:BHF-UCL.
DR GO; GO:0048769; P:sarcomerogenesis; IMP:BHF-UCL.
DR GO; GO:0030241; P:skeletal muscle myosin thick filament assembly; IMP:BHF-UCL.
DR GO; GO:0030240; P:skeletal muscle thin filament assembly; IMP:BHF-UCL.
DR GO; GO:0006941; P:striated muscle contraction; TAS:UniProtKB.
DR CDD; cd00063; FN3; 132.
DR DisProt; DP00072; -.
DR Gene3D; 2.60.40.10; -; 299.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR040849; MyBP-C_THB.
DR InterPro; IPR004168; PPAK_motif.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR015129; Titin_Z_rpt.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR Pfam; PF00041; fn3; 132.
DR Pfam; PF07679; I-set; 162.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF02818; PPAK; 9.
DR Pfam; PF18362; THB; 1.
DR Pfam; PF09042; Titin_Z; 6.
DR SMART; SM00060; FN3; 132.
DR SMART; SM00409; IG; 167.
DR SMART; SM00408; IGc2; 148.
DR SMART; SM00406; IGv; 23.
DR SUPFAM; SSF48726; SSF48726; 167.
DR SUPFAM; SSF49265; SSF49265; 74.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50853; FN3; 132.
DR PROSITE; PS50835; IG_LIKE; 143.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; ATP-binding; Calcium;
KW Calmodulin-binding; Cardiomyopathy; Coiled coil; Cytoplasm;
KW Direct protein sequencing; Disease variant; Disulfide bond;
KW Immunoglobulin domain; Kinase; Limb-girdle muscular dystrophy; Magnesium;
KW Metal-binding; Myofibrillar myopathy; Nucleotide-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..34350
FT /note="Titin"
FT /id="PRO_0000239311"
FT DOMAIN 6..96
FT /note="Ig-like 1"
FT DOMAIN 104..192
FT /note="Ig-like 2"
FT REPEAT 417..462
FT /note="Z-repeat 1"
FT REPEAT 466..511
FT /note="Z-repeat 2"
FT REPEAT 512..554
FT /note="Z-repeat 3"
FT REPEAT 555..600
FT /note="Z-repeat 4"
FT REPEAT 601..646
FT /note="Z-repeat 5"
FT REPEAT 647..691
FT /note="Z-repeat 6"
FT REPEAT 692..740
FT /note="Z-repeat 7"
FT DOMAIN 943..1031
FT /note="Ig-like 3"
FT DOMAIN 1082..1172
FT /note="Ig-like 4"
FT DOMAIN 1291..1382
FT /note="Ig-like 5"
FT DOMAIN 1457..1546
FT /note="Ig-like 6"
FT DOMAIN 1556..1646
FT /note="Ig-like 7"
FT DOMAIN 1703..1793
FT /note="Ig-like 8"
FT DOMAIN 1841..1928
FT /note="Ig-like 9"
FT DOMAIN 2078..2167
FT /note="Ig-like 10"
FT DOMAIN 2171..2262
FT /note="Ig-like 11"
FT DOMAIN 2264..2354
FT /note="Ig-like 12"
FT DOMAIN 2353..2443
FT /note="Ig-like 13"
FT DOMAIN 2430..2529
FT /note="Ig-like 14"
FT DOMAIN 2620..2703
FT /note="Ig-like 15"
FT DOMAIN 2880..2965
FT /note="Ig-like 16"
FT DOMAIN 2968..3050
FT /note="Ig-like 17"
FT DOMAIN 3058..3141
FT /note="Ig-like 18"
FT DOMAIN 3239..3327
FT /note="Ig-like 19"
FT DOMAIN 3344..3432
FT /note="Ig-like 20"
FT DOMAIN 3503..3586
FT /note="Ig-like 21"
FT DOMAIN 3621..3712
FT /note="Ig-like 22"
FT DOMAIN 4289..4376
FT /note="Ig-like 23"
FT DOMAIN 4383..4471
FT /note="Ig-like 24"
FT DOMAIN 4478..4566
FT /note="Ig-like 25"
FT DOMAIN 4571..4659
FT /note="Ig-like 26"
FT DOMAIN 4664..4753
FT /note="Ig-like 27"
FT DOMAIN 4758..4846
FT /note="Ig-like 28"
FT DOMAIN 4851..4936
FT /note="Ig-like 29"
FT DOMAIN 4943..5032
FT /note="Ig-like 30"
FT DOMAIN 5040..5128
FT /note="Ig-like 31"
FT DOMAIN 5133..5221
FT /note="Ig-like 32"
FT DOMAIN 5225..5314
FT /note="Ig-like 33"
FT DOMAIN 5320..5408
FT /note="Ig-like 34"
FT DOMAIN 5413..5501
FT /note="Ig-like 35"
FT DOMAIN 5505..5594
FT /note="Ig-like 36"
FT DOMAIN 5602..5690
FT /note="Ig-like 37"
FT DOMAIN 5695..5783
FT /note="Ig-like 38"
FT DOMAIN 5788..5877
FT /note="Ig-like 39"
FT DOMAIN 5882..5970
FT /note="Ig-like 40"
FT DOMAIN 5975..6063
FT /note="Ig-like 41"
FT DOMAIN 6067..6156
FT /note="Ig-like 42"
FT DOMAIN 6164..6252
FT /note="Ig-like 43"
FT DOMAIN 6257..6347
FT /note="Ig-like 44"
FT DOMAIN 6350..6440
FT /note="Ig-like 45"
FT DOMAIN 6444..6534
FT /note="Ig-like 46"
FT DOMAIN 6537..6626
FT /note="Ig-like 47"
FT DOMAIN 6630..6721
FT /note="Ig-like 48"
FT DOMAIN 6727..6815
FT /note="Ig-like 49"
FT DOMAIN 6820..6908
FT /note="Ig-like 50"
FT DOMAIN 6912..7001
FT /note="Ig-like 51"
FT DOMAIN 7005..7093
FT /note="Ig-like 52"
FT DOMAIN 7102..7190
FT /note="Ig-like 53"
FT DOMAIN 7198..7286
FT /note="Ig-like 54"
FT DOMAIN 7291..7380
FT /note="Ig-like 55"
FT DOMAIN 7385..7473
FT /note="Ig-like 56"
FT DOMAIN 7478..7567
FT /note="Ig-like 57"
FT DOMAIN 7571..7662
FT /note="Ig-like 58"
FT DOMAIN 7668..7756
FT /note="Ig-like 59"
FT DOMAIN 7761..7849
FT /note="Ig-like 60"
FT DOMAIN 7853..7942
FT /note="Ig-like 61"
FT DOMAIN 7946..8035
FT /note="Ig-like 62"
FT DOMAIN 8042..8133
FT /note="Ig-like 63"
FT DOMAIN 8138..8229
FT /note="Ig-like 64"
FT DOMAIN 8232..8321
FT /note="Ig-like 65"
FT DOMAIN 8326..8414
FT /note="Ig-like 66"
FT DOMAIN 8419..8508
FT /note="Ig-like 67"
FT DOMAIN 8512..8603
FT /note="Ig-like 68"
FT DOMAIN 8609..8697
FT /note="Ig-like 69"
FT DOMAIN 8702..8790
FT /note="Ig-like 70"
FT DOMAIN 8794..8883
FT /note="Ig-like 71"
FT DOMAIN 8888..8976
FT /note="Ig-like 72"
FT DOMAIN 8984..9074
FT /note="Ig-like 73"
FT DOMAIN 9079..9168
FT /note="Ig-like 74"
FT DOMAIN 9176..9265
FT /note="Ig-like 75"
FT DOMAIN 9272..9361
FT /note="Ig-like 76"
FT DOMAIN 9366..9470
FT /note="Ig-like 77"
FT DOMAIN 9660..9755
FT /note="Ig-like 78"
FT DOMAIN 9760..9851
FT /note="Ig-like 79"
FT REPEAT 10216..10242
FT /note="PEVK 1"
FT REPEAT 10244..10270
FT /note="PEVK 2"
FT REPEAT 10272..10298
FT /note="PEVK 3"
FT REPEAT 10300..10326
FT /note="PEVK 4"
FT REPEAT 10327..10353
FT /note="PEVK 5"
FT REPEAT 10355..10381
FT /note="PEVK 6"
FT REPEAT 10508..10534
FT /note="PEVK 7"
FT REPEAT 10536..10562
FT /note="PEVK 8"
FT REPEAT 10592..10618
FT /note="PEVK 9"
FT REPEAT 10878..10904
FT /note="PEVK 10"
FT REPEAT 10906..10930
FT /note="PEVK 11"
FT REPEAT 10932..10958
FT /note="PEVK 12"
FT REPEAT 10960..10986
FT /note="PEVK 13"
FT REPEAT 10987..11014
FT /note="PEVK 14"
FT REPEAT 11363..11396
FT /note="PEVK 15"
FT REPEAT 11397..11421
FT /note="PEVK 16"
FT REPEAT 11453..11479
FT /note="PEVK 17"
FT REPEAT 11481..11507
FT /note="PEVK 18"
FT REPEAT 11509..11535
FT /note="PEVK 19"
FT REPEAT 11537..11563
FT /note="PEVK 20"
FT REPEAT 11565..11591
FT /note="PEVK 21"
FT REPEAT 11657..11683
FT /note="PEVK 22"
FT REPEAT 11703..11729
FT /note="PEVK 23"
FT REPEAT 11745..11771
FT /note="PEVK 24"
FT REPEAT 11775..11801
FT /note="PEVK 25"
FT REPEAT 11836..11862
FT /note="PEVK 26"
FT REPEAT 11864..11890
FT /note="PEVK 27"
FT REPEAT 11893..11919
FT /note="PEVK 28"
FT REPEAT 11929..11955
FT /note="PEVK 29"
FT REPEAT 11966..11992
FT /note="PEVK 30"
FT REPEAT 11996..12022
FT /note="PEVK 31"
FT DOMAIN 12041..12133
FT /note="Ig-like 80"
FT DOMAIN 12138..12222
FT /note="Ig-like 81"
FT DOMAIN 12233..12318
FT /note="Ig-like 82"
FT DOMAIN 12499..12584
FT /note="Ig-like 83"
FT DOMAIN 12590..12672
FT /note="Ig-like 84"
FT DOMAIN 12766..12850
FT /note="Ig-like 85"
FT DOMAIN 12945..13032
FT /note="Ig-like 86"
FT DOMAIN 13120..13206
FT /note="Ig-like 87"
FT DOMAIN 13210..13295
FT /note="Ig-like 88"
FT DOMAIN 13299..13384
FT /note="Ig-like 89"
FT DOMAIN 13388..13478
FT /note="Ig-like 90"
FT DOMAIN 13479..13562
FT /note="Ig-like 91"
FT DOMAIN 13565..13655
FT /note="Ig-like 92"
FT DOMAIN 13659..13748
FT /note="Ig-like 93"
FT DOMAIN 13749..13833
FT /note="Ig-like 94"
FT DOMAIN 13927..14012
FT /note="Ig-like 95"
FT DOMAIN 14019..14114
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14120..14215
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14221..14316
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14417..14513
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14517..14614
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14615..14708
FT /note="Ig-like 96"
FT DOMAIN 14713..14806
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14812..14907
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14913..15007
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15010..15107
FT /note="Fibronectin type-III 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15113..15207
FT /note="Fibronectin type-III 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15214..15310
FT /note="Fibronectin type-III 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15314..15402
FT /note="Ig-like 97"
FT DOMAIN 15409..15503
FT /note="Fibronectin type-III 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15509..15604
FT /note="Fibronectin type-III 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15608..15724
FT /note="Ig-like 98"
FT DOMAIN 15731..15826
FT /note="Fibronectin type-III 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15832..15926
FT /note="Fibronectin type-III 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15929..16025
FT /note="Fibronectin type-III 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16029..16119
FT /note="Ig-like 99"
FT DOMAIN 16126..16218
FT /note="Fibronectin type-III 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16224..16318
FT /note="Fibronectin type-III 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16322..16420
FT /note="Ig-like 100"
FT DOMAIN 16427..16522
FT /note="Fibronectin type-III 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16528..16628
FT /note="Fibronectin type-III 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16634..16734
FT /note="Fibronectin type-III 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16727..16834
FT /note="Ig-like 101"
FT DOMAIN 16841..16934
FT /note="Fibronectin type-III 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16941..17041
FT /note="Fibronectin type-III 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17044..17139
FT /note="Ig-like 102"
FT DOMAIN 17147..17240
FT /note="Fibronectin type-III 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17246..17345
FT /note="Fibronectin type-III 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17348..17445
FT /note="Fibronectin type-III 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17449..17536
FT /note="Ig-like 103"
FT DOMAIN 17545..17640
FT /note="Fibronectin type-III 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17646..17741
FT /note="Fibronectin type-III 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17745..17834
FT /note="Ig-like 104"
FT DOMAIN 17842..17935
FT /note="Fibronectin type-III 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17941..18036
FT /note="Fibronectin type-III 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18042..18139
FT /note="Fibronectin type-III 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18143..18228
FT /note="Ig-like 105"
FT DOMAIN 18239..18333
FT /note="Fibronectin type-III 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18339..18431
FT /note="Fibronectin type-III 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18435..18526
FT /note="Ig-like 106"
FT DOMAIN 18533..18632
FT /note="Fibronectin type-III 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18633..18727
FT /note="Fibronectin type-III 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18733..18829
FT /note="Fibronectin type-III 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18833..18924
FT /note="Ig-like 107"
FT DOMAIN 18931..19025
FT /note="Fibronectin type-III 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19030..19124
FT /note="Fibronectin type-III 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19128..19219
FT /note="Ig-like 108"
FT DOMAIN 19226..19321
FT /note="Fibronectin type-III 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19325..19420
FT /note="Fibronectin type-III 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19426..19527
FT /note="Fibronectin type-III 41"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19531..19617
FT /note="Ig-like 109"
FT DOMAIN 19628..19722
FT /note="Fibronectin type-III 42"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19728..19823
FT /note="Fibronectin type-III 43"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19826..19914
FT /note="Ig-like 110"
FT DOMAIN 19921..20017
FT /note="Fibronectin type-III 44"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20018..20116
FT /note="Fibronectin type-III 45"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20119..20217
FT /note="Fibronectin type-III 46"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20220..20311
FT /note="Ig-like 111"
FT DOMAIN 20318..20411
FT /note="Fibronectin type-III 47"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20417..20512
FT /note="Fibronectin type-III 48"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20518..20613
FT /note="Fibronectin type-III 49"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20716..20813
FT /note="Fibronectin type-III 50"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20814..20908
FT /note="Fibronectin type-III 51"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20893..20996
FT /note="Ig-like 112"
FT DOMAIN 21006..21101
FT /note="Fibronectin type-III 52"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21105..21200
FT /note="Fibronectin type-III 53"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21203..21299
FT /note="Fibronectin type-III 54"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21303..21395
FT /note="Ig-like 113"
FT DOMAIN 21402..21495
FT /note="Fibronectin type-III 55"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21501..21596
FT /note="Fibronectin type-III 56"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21602..21697
FT /note="Fibronectin type-III 57"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21701..21793
FT /note="Ig-like 114"
FT DOMAIN 21797..21891
FT /note="Fibronectin type-III 58"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21894..21986
FT /note="Fibronectin type-III 59"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21990..22083
FT /note="Ig-like 115"
FT DOMAIN 22088..22182
FT /note="Fibronectin type-III 60"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22188..22283
FT /note="Fibronectin type-III 61"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22286..22382
FT /note="Fibronectin type-III 62"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22386..22477
FT /note="Ig-like 116"
FT DOMAIN 22484..22578
FT /note="Fibronectin type-III 63"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22584..22679
FT /note="Fibronectin type-III 64"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22685..22781
FT /note="Fibronectin type-III 65"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22785..22874
FT /note="Ig-like 117"
FT DOMAIN 22881..22976
FT /note="Fibronectin type-III 66"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22978..23071
FT /note="Fibronectin type-III 67"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23075..23163
FT /note="Ig-like 118"
FT DOMAIN 23170..23264
FT /note="Fibronectin type-III 68"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23270..23364
FT /note="Fibronectin type-III 69"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23368..23463
FT /note="Fibronectin type-III 70"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23468..23555
FT /note="Ig-like 119"
FT DOMAIN 23566..23660
FT /note="Fibronectin type-III 71"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23666..23761
FT /note="Fibronectin type-III 72"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23767..23863
FT /note="Fibronectin type-III 73"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23867..23954
FT /note="Ig-like 120"
FT DOMAIN 23963..24057
FT /note="Fibronectin type-III 74"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24060..24153
FT /note="Fibronectin type-III 75"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24157..24241
FT /note="Ig-like 121"
FT DOMAIN 24252..24346
FT /note="Fibronectin type-III 76"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24352..24446
FT /note="Fibronectin type-III 77"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24450..24546
FT /note="Fibronectin type-III 78"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24550..24641
FT /note="Ig-like 122"
FT DOMAIN 24648..24742
FT /note="Fibronectin type-III 79"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24748..24843
FT /note="Fibronectin type-III 80"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24849..24945
FT /note="Fibronectin type-III 81"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24949..25038
FT /note="Ig-like 123"
FT DOMAIN 25045..25139
FT /note="Fibronectin type-III 82"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25142..25235
FT /note="Fibronectin type-III 83"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25239..25325
FT /note="Ig-like 124"
FT DOMAIN 25335..25428
FT /note="Fibronectin type-III 84"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25434..25529
FT /note="Fibronectin type-III 85"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25532..25627
FT /note="Fibronectin type-III 86"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25632..25722
FT /note="Ig-like 125"
FT DOMAIN 25731..25825
FT /note="Fibronectin type-III 87"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25831..25926
FT /note="Fibronectin type-III 88"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25932..26028
FT /note="Fibronectin type-III 89"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26032..26121
FT /note="Ig-like 126"
FT DOMAIN 26128..26222
FT /note="Fibronectin type-III 90"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26225..26318
FT /note="Fibronectin type-III 91"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26322..26410
FT /note="Ig-like 127"
FT DOMAIN 26417..26510
FT /note="Fibronectin type-III 92"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26516..26611
FT /note="Fibronectin type-III 93"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26614..26710
FT /note="Fibronectin type-III 94"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26714..26801
FT /note="Ig-like 128"
FT DOMAIN 26812..26906
FT /note="Fibronectin type-III 95"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26912..27007
FT /note="Fibronectin type-III 96"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27013..27107
FT /note="Fibronectin type-III 97"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27101..27196
FT /note="Ig-like 129"
FT DOMAIN 27205..27296
FT /note="Fibronectin type-III 98"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27302..27392
FT /note="Fibronectin type-III 99"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27499..27593
FT /note="Fibronectin type-III 100"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27599..27694
FT /note="Fibronectin type-III 101"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27697..27793
FT /note="Fibronectin type-III 102"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27797..27888
FT /note="Ig-like 130"
FT DOMAIN 27895..27989
FT /note="Fibronectin type-III 103"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27995..28090
FT /note="Fibronectin type-III 104"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28096..28192
FT /note="Fibronectin type-III 105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28196..28286
FT /note="Ig-like 131"
FT DOMAIN 28295..28389
FT /note="Fibronectin type-III 106"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28392..28484
FT /note="Fibronectin type-III 107"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28488..28577
FT /note="Ig-like 132"
FT DOMAIN 28583..28680
FT /note="Fibronectin type-III 108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28686..28781
FT /note="Fibronectin type-III 109"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28784..28879
FT /note="Fibronectin type-III 110"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28882..28974
FT /note="Ig-like 133"
FT DOMAIN 28979..29071
FT /note="Fibronectin type-III 111"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29081..29177
FT /note="Fibronectin type-III 112"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29180..29278
FT /note="Fibronectin type-III 113"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29282..29367
FT /note="Ig-like 134"
FT DOMAIN 29378..29473
FT /note="Fibronectin type-III 114"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29475..29568
FT /note="Fibronectin type-III 115"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29568..29663
FT /note="Ig-like 135"
FT DOMAIN 29670..29764
FT /note="Fibronectin type-III 116"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29770..29865
FT /note="Fibronectin type-III 117"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29868..29967
FT /note="Fibronectin type-III 118"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29971..30059
FT /note="Ig-like 136"
FT DOMAIN 30070..30163
FT /note="Fibronectin type-III 119"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30169..30265
FT /note="Fibronectin type-III 120"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30271..30367
FT /note="Fibronectin type-III 121"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30371..30460
FT /note="Ig-like 137"
FT DOMAIN 30467..30561
FT /note="Fibronectin type-III 122"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30564..30658
FT /note="Fibronectin type-III 123"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30663..30754
FT /note="Ig-like 138"
FT DOMAIN 30761..30855
FT /note="Fibronectin type-III 124"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30861..30956
FT /note="Fibronectin type-III 125"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30962..31058
FT /note="Fibronectin type-III 126"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31061..31150
FT /note="Ig-like 139"
FT DOMAIN 31158..31254
FT /note="Fibronectin type-III 127"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31258..31354
FT /note="Fibronectin type-III 128"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31360..31455
FT /note="Fibronectin type-III 129"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31460..31548
FT /note="Ig-like 140"
FT DOMAIN 31653..31748
FT /note="Fibronectin type-III 130"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31754..31849
FT /note="Fibronectin type-III 131"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31855..31945
FT /note="Ig-like 141"
FT DOMAIN 31955..32046
FT /note="Ig-like 142"
FT DOMAIN 32051..32144
FT /note="Fibronectin type-III 132"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 32178..32432
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT DOMAIN 32496..32584
FT /note="Ig-like 143"
FT DOMAIN 32617..32710
FT /note="Ig-like 144"
FT DOMAIN 32722..32811
FT /note="Ig-like 145"
FT DOMAIN 33301..33391
FT /note="Ig-like 146"
FT DOMAIN 33488..33576
FT /note="Ig-like 147"
FT DOMAIN 33645..33732
FT /note="Ig-like 148"
FT DOMAIN 33779..33867
FT /note="Ig-like 149"
FT DOMAIN 33963..34052
FT /note="Ig-like 150"
FT DOMAIN 34061..34149
FT /note="Ig-like 151"
FT DOMAIN 34256..34344
FT /note="Ig-like 152"
FT REGION 244..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..341
FT /note="ZIS1"
FT REGION 333..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1408..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1440
FT /note="ZIS5"
FT REGION 4241..4272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9920..9945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10039..10070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10087..10109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10207..10280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10314..10361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10412..10457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10499..10566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10583..10617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10661..10743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10882..11102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11158..11193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11362..11636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11666..12032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14216..14236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 14891..14921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15911..15939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 16614..16654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 18614..18637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 18716..18743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 19304..19331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 27090..27110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 31238..31267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 33213..33256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 33432..33463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 33584..33638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 33749..33777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 529..561
FT /evidence="ECO:0000255"
FT COILED 2025..2052
FT /evidence="ECO:0000255"
FT COILED 3462..3487
FT /evidence="ECO:0000255"
FT COILED 9534..9577
FT /evidence="ECO:0000255"
FT COMPBIAS 252..266
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4247..4266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9920..9936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10044..10070
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10207..10221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10222..10246
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10247..10261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10330..10350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10439..10457
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10505..10566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10666..10704
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10719..10736
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10882..10948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10991..11016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11032..11098
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11162..11187
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11384..11417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11592..11609
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11610..11630
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11680..11694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11770..11804
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11816..11841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11850..11904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11917..11933
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11935..11949
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11984..11999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12008..12024
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14221..14236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15922..15936
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16621..16638
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19315..19331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31249..31263
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33221..33240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33432..33460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33597..33617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33749..33767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 32298
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 32184..32192
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 32207
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 263
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 265
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 267
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
FT MOD_RES 6920
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 9122
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 11503
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 12007
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
FT MOD_RES 12009
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 12022
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 30443
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
FT MOD_RES 32341
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000269|PubMed:9804419"
FT MOD_RES 33245
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 33247
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 33602
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 33614
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT DISULFID 964..1015
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1724..1777
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2109..2134
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:11525170"
FT DISULFID 2196..2246
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3259..3311
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4404..4455
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4499..4550
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4592..4643
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4686..4737
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4779..4830
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5061..5112
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5248..5299
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5623..5674
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5810..5861
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5903..5954
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6185..6236
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6372..6423
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6465..6516
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6748..6799
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7027..7078
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7123..7174
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7219..7270
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7313..7364
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7406..7457
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7689..7740
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7968..8019
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8064..8115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8160..8211
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8254..8305
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8347..8398
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8630..8681
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8909..8960
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 9005..9056
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 9101..9152
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 9294..9345
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 9693..9743
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 12067..12117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 12611..12660
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 12966..13016
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 13233..13283
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 13322..13372
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 13411..13461
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 13771..13821
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 31481..31532
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 32516..32568
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 33664..33718
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 555..646
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8937992"
FT /id="VSP_019138"
FT VAR_SEQ 556..601
FT /note="Missing (in isoform 3, isoform 9 and isoform 10)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:7569978"
FT /id="VSP_019139"
FT VAR_SEQ 3434
FT /note="E -> EGFSKFEENTSNSQWHVSLSVSFKKEPLGQKPSFIQPLSSLRVHNGE
FT TVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEESTGMALMLIVDAYSEHAGQYSC
FT KAANSAGEATCAATLTVTPKVQALDRQSSGKDVRESAKSQAVADSSFTKEESKISQKEI
FT KSFQGSSYEYEVQVFESVSQSSIHTAASVQDTQLCHTASLSQIAESTELSKECAKESTG
FT EAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESERLKQSQNGNIQF
FT LTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEG (in isoform 12)"
FT /evidence="ECO:0000305"
FT /id="VSP_045935"
FT VAR_SEQ 3434
FT /note="E -> EGFSKFEENTSNSQWHVSLSVSFKKEPLGQKPSFIQPLSSLRVHNGE
FT TVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEESTGMALMLIVDAYSEHAGQYSC
FT KAANSAGEATCAATLTVTPK (in isoform 8 and isoform 10)"
FT /evidence="ECO:0000305"
FT /id="VSP_019140"
FT VAR_SEQ 3434
FT /note="E -> EVQALDRQSSGKDVRESAKSQAVADSSFTKEESKISQKEIKSFQGSS
FT YEYEVQVFESVSQSSIHTAASVQDTQLCHTASLSQIAESTELSKECAKESTGEAPKIFL
FT HLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESERLKQSQNGNIQFLTICNVQ
FT LVDQGLYSCIVHNDCGERTTSAVLSVEG (in isoform 9)"
FT /evidence="ECO:0000305"
FT /id="VSP_042903"
FT VAR_SEQ 3435..3645
FT /note="APESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSE
FT SPVYPTKFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTP
FT SADYKFVFDGDDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTET
FT ESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVV -> VQALDRQSSGKDVR
FT ESTKSQAVADSSFTKEESKISQKEIKSFQGSSYEYEVQVFESVSQSSIHTAASVQDTQL
FT CHTASLSQIAESTELSKECAKESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDV
FT TWTHEGAKIEESERLKQSQNGNIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVE
FT GAPESILHERIEQEIEMEMK (in isoform 7)"
FT /evidence="ECO:0000305"
FT /id="VSP_019141"
FT VAR_SEQ 3454..4380
FT /note="Missing (in isoform 4 and isoform 11)"
FT /evidence="ECO:0000303|PubMed:7569978"
FT /id="VSP_019142"
FT VAR_SEQ 3455..5604
FT /note="FSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTGPIFI
FT KEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILFT
FT KLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFL
FT KELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVND
FT PQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTPEAPEDFPQTPLKG
FT PAVEALDSEQEIATFVKDTILKAALITEENQQLSYEHIAKANELSSQLPLGAQELQSIL
FT EQDKLTPESTREFLCINGSIHFQPLKEPSPNLQLQIVQSQKTFSKEGILMPEEPETQAV
FT LSDTEKIFPSAMSIEQINSLTVEPLKTLLAEPEGNYPQSSIEPPMHSYLTSVAEEVLSP
FT KEKTVSDTNREQRVTLQKQEAQSALILSQSLAEGHVESLQSPDVMISQVNYEPLVPSEH
FT SCTEGGKILIESANPLENAGQDSAVRIEEGKSLRFPLALEEKQVLLKEEHSDNVVMPPD
FT QIIESKREPVAIKKVQEVQGRDLLSKESLLSGIPEEQRLNLKIQICRALQAAVASEQPG
FT LFSEWLRNIEKVEVEAVNITQEPRHIMCMYLVTSAKSVTEEVTIIIEDVDPQMANLKME
FT LRDALCAIIYEEIDILTAEGPRIQQGAKTSLQEEMDSFSGSQKVEPITEPEVESKYLIS
FT TEEVSYFNVQSRVKYLDATPVTKGVASAVVSDEKQDESLKPSEEKEESSSESGTEEVAT
FT VKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLTTSITNAKEVNWYFENKLVPSDEK
FT FKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEP
FT LEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDC
FT GEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIET
FT IWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIII
FT DKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIAT
FT LEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHC
FT KLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGS
FT DSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKY
FT RLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIAL
FT GGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYT
FT CLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDG
FT RPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAP
FT FFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEI
FT IRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQG
FT STPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECS
FT ANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMS
FT FVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEY
FT DVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRV
FT TNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEI
FT TEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEA
FT VSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKK
FT DSGEYTFEVQNDVGRSSCKARINVLDLIIPPSF -> LFSEGESEHSERDTRDAFSDSE
FT DIDHKSMAAKRYASRISSTSSWPEYFKPSFTQKLTFKYVLEGEPVVFTCRLIACPTPEM
FT TWFHNNRPIPTGLRRIIKAESDLHHHSSSLEIKRVQDRDSGSYRLLAINSEGSAESTAS
FT LLVIQKGQDEKYLEFLKRAERTHENVEALVERGEDRIKVDLRFTGSPFNKKQDVEQKGM
FT MRTIHFKTMSSAKKTDYMYDEEYLESKSDIRGWLNVGESFLDKETKVKLQRLREARKTL
FT MEKKKLSLLDTSSEISSRTLRSEASDKDILFSREDMKIRSMSDLAESYKVDHSAESIVQ
FT NPHALSNQMDQNIESEELPTSFQTIVDEEIFQTEIRMSQEALVKESLPKDHLYGEILVN
FT ENTQARGQLEEIMANTTIGESSTYITNVCEKEEVYETPENVSQAITPHASESFGTLVNV
FT EESEEIASERIKKDDLRELQLSASTRIDEFKTEQKEENMRFFENSFRKRPQRCPPSFLQ
FT EIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLENYSILTLSSVH
FT HQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKVPVFHDYLDEEEELALVFDQA
FT KGAHPSMSQEGQTNLHLLKTNPPVPPSGDTELLSFPVEIQVTAATPIPEQDKESKEVFQ
FT TEELEPKAMPQDQVTQSPKHRFVFLSDITNEPPKMLQEMPKHARCREGDSIILECLISG
FT EPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQDSGKYKCVAENNSGAVESV
FT SDLTVEPVTYRENSQFENIGEIYGKYSRDQQLQDQGESVRAHFYDYPAGPFTPWTNVKE
FT YSVRDYFQSLETIEQIDQKEQVRCIPSREKIPRFVHGASRTIKISKPIRAEFIQCQAEG
FT KERHVSEKSKLHQAEGTVYPFVDDFSDVTIKKEIRNNFGKLGRSEKENVQECAQSDYLP
FT NIHSERISDSYNTKDSSAIVYEESLGEEIHYPGKKVKHRIIEFEKLHVEKGVLEKRPTR
FT TSIVNPPQKKIDDKAFSLKQRESRSSNLNANMYQAEKMSPNTESDSSNIAINLKLLSSQ
FT THKEFDAQEREQQEKISLIDKPAISKRAEHESPITFDLKQFHTQIKHTDVKFQELDSGQ
FT PEEAYFKIQHPADTENIVFDLKQMYSHIGDPALEFQGQETREQQEIHYKEKIPSPETLQ
FT PDTHNISKSVQNNVFASQEISSSQELSNRTMVEKSSIDENSISLEKEVRHVQEQNLDIL
FT KTDLSLKSFSEEIYSESCALLPTSSADIEETDLSEKSCPLENGGRSSISHLKKAASEEK
FT PLGVGEMEEECTLEPELAAFPKQDGGTQEYTDATLEDHRGDVQEADTLHRQLSLSQCFP
FT LLMTEEQQNPGEQISTNIHASGEEKCYEEVQVQNEASFSTLEGEMIETSFSQNIPKLDE
FT AHTTEAAESETSLTQYLLAAGKREVPETKDTRDQAKLVQSESITSMEVEEVTFNTVYEY
FT YNQKQESLGRPLSPESDISIGVGSTTSEEISELDQFYTPPSSVEYFESPKSPDLYFNPS
FT DITKQSSIHSGGETVERYSTPLGEVAERYSTPSEGEVGERYSTPPGETLERYSTPPGET
FT LERYSTPPGETLERYSTPPGETLERYSTPPGETLERYSTPPGEALERYSIPTGGPNPTG
FT TFKTYPSKIEREDGTPNEHFYTPTEERGSAYEIWRSDSFGTPNEAIEPKDNEMPPSFIE
FT PLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCSLEISNIQ
FT KGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEHTTSSRTP
FT SPQEIVLEVELSEKDVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLPFNFVDPNMDSREG
FT EDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPD
FT NIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKK
FT SKVTLSSLMEELVLKSNYTDSFFEFQVVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSP
FT RPTVYWYKDGKLVQGRRFTVEESGTGFHNLFITSLVKSDEGEYRCVATNKSGMAESFAA
FT LTLT (in isoform 6)"
FT /evidence="ECO:0000305"
FT /id="VSP_019143"
FT VAR_SEQ 3646..4380
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000305"
FT /id="VSP_019144"
FT VAR_SEQ 4474..11851
FT /note="Missing (in isoform 3, isoform 9 and isoform 10)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:7569978"
FT /id="VSP_019145"
FT VAR_SEQ 5605..34350
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000305"
FT /id="VSP_019146"
FT VAR_SEQ 10382..10645
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:12785098"
FT /id="VSP_019147"
FT VAR_SEQ 10742..10931
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:12785098"
FT /id="VSP_019148"
FT VAR_SEQ 11015..11163
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:12785098"
FT /id="VSP_019149"
FT VAR_SEQ 11117
FT /note="I -> VPKKPVPEKKVPVPAPKKVEPPPPPKVPEI (in isoform 12)"
FT /evidence="ECO:0000305"
FT /id="VSP_045929"
FT VAR_SEQ 11133
FT /note="E -> EAPPAKVSVVPKKPEPEKKVPPPGLKKAV (in isoform 12)"
FT /evidence="ECO:0000305"
FT /id="VSP_045930"
FT VAR_SEQ 11223..11852
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:12785098"
FT /id="VSP_019150"
FT VAR_SEQ 11421
FT /note="K -> KAPEVPKKIVPEEKVREAVLKKPEVPPAKVPGMPKKSVQEEKSPIVI
FT SEDTEMYIYEASEEAVLEEKVLVTQPQKTKPKLAKVPEPPKKVVPEDKIYVTIPKKRET
FT PATKEPDTTRGIFPEVEPPEAIPEIPEHPPTEEFEVFKEVIPEGETPIVKRRKTPSPTV
FT PESPREIVPVKETPMAAPLEIEIPPTKAPEAMKEVVPEMKIFEDVPEEPETPRMKTPEA
FT PQEIIPAKTVPSKKREPPSVKVPEALQEIVPEKKTLVVPLRKPEVLPDEVPEALREVVP
FT EKKVHPPQRAEVVPVKVHEAPKEIIPEKKVSVVPPKKPEVPPVKVPEASKEVIREEKVP
FT LAPPKEPEVPPVKVPEPPKEVVPEKKAPVAPPKEPEVPPVKVPEAPKEVVPEKKVPVPP
FT PKKPEVPPTKVPEVPKAAVPEKKLPEAIPPKPESPPPE (in isoform 12)"
FT /evidence="ECO:0000305"
FT /id="VSP_045931"
FT VAR_SEQ 11450
FT /note="P -> PKVPEAPKEVVLEKKASVAVPKKPEAPRAKVPEAAQEVVPEKKIPKA
FT PIKKPEAPAVTVPEVPQEATEKEIPVAPPKKPEAPIVPVPEAQEVVPEKKVPKAPPTKP
FT EAPPATVPEVPQEIVPEKKTLVLPKKPEVPPVTVPEAPKEVVLEKKVPSAPPKKPEVPP
FT V (in isoform 12)"
FT /evidence="ECO:0000305"
FT /id="VSP_045932"
FT VAR_SEQ 11507
FT /note="E -> EVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVLEKKASV
FT AVPKKPEAPRAKVPEAAQEVVPEKKIPKAPIKKPEAPAVTVPEVPQEAAEKEIPVAPPK
FT KPEAPIVPVPEAQEVVPEKKVPKAPPTKPEAPPATVPEVPQEIVPEKKTLVLPKKPEVP
FT PVTVPEAPKEVVLEKKVPSTPPKKPEVPPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTK
FT VPEVPKAAVPEKKVPEAIPPKPESPPPEVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKV
FT PEAPKEVVLEKKVSVAVPKKPEAPRAKVPEAAQEVVPEKKIPKAPIKKPEAPAVTVPEV
FT PQEAAEKEIPVAPPKKPEAPIVPVPEAQEVVPEKKVPKAPPTKPEAPPATVPEVPQEIV
FT PEKKTLVLPKKPEVPPVTVPEAPKEVVLEKKVPLAPPKKPEVPPVKVPEAPKEVVPEKK
FT VPVTPPKKPEVPPVKVPEAPIEVVPEKKMPLAPPKKPEVPPVKVPEAPKEVVPEKKVPS
FT APPKKPEVPPVK (in isoform 12)"
FT /evidence="ECO:0000305"
FT /id="VSP_045933"
FT VAR_SEQ 11507
FT /note="E -> EVFEEPEESPSAPPKKPEVPPVR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:7569978"
FT /id="VSP_019151"
FT VAR_SEQ 11790
FT /note="P -> PKEPEMPKKVVPVKKVPTVKKPETPAAKVPEVPKKLVPVKKEPVPVT
FT KKPEVLPEKVPKVPEKIIPEKEVSVPIPAEPEVPPAEVEETPEEIIYEEKASITIGRKE
FT TPPVEEREIEKYIKPEEPEPEPQPEEIPV (in isoform 13)"
FT /evidence="ECO:0000305"
FT /id="VSP_047142"
FT VAR_SEQ 11793
FT /note="P -> PEMPKKVVPVKKVPTVKKPETPAAKVPEVPKKLVPVKKEPVPVTKKP
FT EVLPEKVPKVPEKIIPEKEVSVPIPAEPEVPPAEVEETPEEIIYEEKASITIGRKETPP
FT VEEREIEKYIKPEEPEPEPQPEEIPVKEP (in isoform 12)"
FT /evidence="ECO:0000305"
FT /id="VSP_045934"
FT VAR_SEQ 11985..12201
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:12785098"
FT /id="VSP_019152"
FT VARIANT 54
FT /note="V -> M (in CMD1G; affects interaction with TCAP/
FT telethonin; dbSNP:rs139517732)"
FT /evidence="ECO:0000269|PubMed:11846417"
FT /id="VAR_026685"
FT VARIANT 60
FT /note="D -> Y (in dbSNP:rs35683768)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040078"
FT VARIANT 115
FT /note="V -> M (in a metastatic melanoma sample; somatic
FT mutation; dbSNP:rs564777385)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040079"
FT VARIANT 279
FT /note="R -> W (in MFM9; disrupts NBR1-binding;
FT dbSNP:rs138060032)"
FT /evidence="ECO:0000269|PubMed:15802564"
FT /id="VAR_026634"
FT VARIANT 328
FT /note="R -> C (in dbSNP:rs16866538)"
FT /evidence="ECO:0000269|PubMed:11846417,
FT ECO:0000269|PubMed:17344846"
FT /id="VAR_026686"
FT VARIANT 360
FT /note="R -> T (in dbSNP:rs56128843)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040080"
FT VARIANT 498
FT /note="V -> I (in dbSNP:rs72647851)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040081"
FT VARIANT 740
FT /note="R -> L (in CMH9; dbSNP:rs28933405)"
FT /evidence="ECO:0000269|PubMed:10462489"
FT /id="VAR_026687"
FT VARIANT 743
FT /note="A -> V (in CMD1G; affects interaction with TCAP/
FT telethonin; dbSNP:rs267607157)"
FT /evidence="ECO:0000269|PubMed:11846417"
FT /id="VAR_026688"
FT VARIANT 799
FT /note="T -> M (in a colorectal adenocarcinoma sample;
FT somatic mutation; dbSNP:rs149061352)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040082"
FT VARIANT 811
FT /note="T -> I (in dbSNP:rs35813871)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040083"
FT VARIANT 922
FT /note="R -> H (in dbSNP:rs56046320)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040084"
FT VARIANT 937
FT /note="E -> D (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040085"
FT VARIANT 976
FT /note="W -> R (in CMD1G; dbSNP:rs267607155)"
FT /evidence="ECO:0000269|PubMed:11788824"
FT /id="VAR_026689"
FT VARIANT 1081
FT /note="A -> T (in dbSNP:rs55914517)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040086"
FT VARIANT 1137
FT /note="G -> R (in dbSNP:rs72647870)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040087"
FT VARIANT 1201
FT /note="K -> E (in dbSNP:rs10497520)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040088"
FT VARIANT 1202
FT /note="V -> A (in dbSNP:rs150667217)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040089"
FT VARIANT 1249
FT /note="S -> L (in dbSNP:rs1552280)"
FT /id="VAR_056081"
FT VARIANT 1295
FT /note="S -> L (in dbSNP:rs1552280)"
FT /evidence="ECO:0000269|PubMed:10850961,
FT ECO:0000269|PubMed:11717165, ECO:0000269|PubMed:17344846"
FT /id="VAR_040090"
FT VARIANT 1345
FT /note="G -> D (in dbSNP:rs36021856)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040091"
FT VARIANT 1347
FT /note="A -> T (in a metastatic melanoma sample; somatic
FT mutation; dbSNP:rs267599092)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040092"
FT VARIANT 1350
FT /note="R -> H (in a gastric adenocarcinoma sample; somatic
FT mutation; dbSNP:rs539470256)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040093"
FT VARIANT 1353
FT /note="V -> L (in dbSNP:rs36062108)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040094"
FT VARIANT 1393
FT /note="I -> V (in dbSNP:rs16866531)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040095"
FT VARIANT 1416
FT /note="R -> C (in dbSNP:rs72647875)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040096"
FT VARIANT 1441
FT /note="R -> P (in dbSNP:rs72647876)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040097"
FT VARIANT 1544
FT /note="I -> V (in dbSNP:rs72647877)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040098"
FT VARIANT 1572
FT /note="R -> Q (in dbSNP:rs12476289)"
FT /evidence="ECO:0000269|PubMed:10850961,
FT ECO:0000269|PubMed:11717165, ECO:0000269|PubMed:17344846"
FT /id="VAR_040099"
FT VARIANT 1658
FT /note="R -> G (in dbSNP:rs56270960)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040100"
FT VARIANT 1664
FT /note="R -> Q (in an ovarian mucinous carcinoma sample;
FT somatic mutation; dbSNP:rs375029799)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040101"
FT VARIANT 1692
FT /note="G -> D (in a lung squamous cell carcinoma sample;
FT somatic mutation; dbSNP:rs370004591)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040102"
FT VARIANT 1744
FT /note="P -> L (in dbSNP:rs75686037)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040103"
FT VARIANT 1772
FT /note="S -> G (in dbSNP:rs150725992)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040104"
FT VARIANT 1907
FT /note="T -> I (in a colorectal adenocarcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040105"
FT VARIANT 1998
FT /note="R -> H (in dbSNP:rs144135510)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040106"
FT VARIANT 2107
FT /note="P -> L (in a colorectal adenocarcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040107"
FT VARIANT 2118
FT /note="I -> T (in dbSNP:rs56404770)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040108"
FT VARIANT 2164
FT /note="A -> T (in dbSNP:rs56285559)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040109"
FT VARIANT 2240
FT /note="D -> Y"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040110"
FT VARIANT 2392
FT /note="G -> S (in dbSNP:rs4894048)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040111"
FT VARIANT 2432
FT /note="L -> F (in a lung neuroendocrine carcinoma sample;
FT somatic mutation; dbSNP:rs571572592)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040112"
FT VARIANT 2610
FT /note="M -> I (in dbSNP:rs56142888)"
FT /evidence="ECO:0000269|PubMed:10850961,
FT ECO:0000269|PubMed:11717165, ECO:0000269|PubMed:17344846"
FT /id="VAR_040113"
FT VARIANT 2771
FT /note="I -> M (in a breast infiltrating ductal carcinoma
FT sample; somatic mutation; dbSNP:rs576644663)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040114"
FT VARIANT 2823
FT /note="V -> F (in dbSNP:rs33917087)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040115"
FT VARIANT 2831
FT /note="S -> N (in dbSNP:rs2306636)"
FT /evidence="ECO:0000269|PubMed:10850961,
FT ECO:0000269|PubMed:11717165, ECO:0000269|PubMed:17344846"
FT /id="VAR_040116"
FT VARIANT 2930
FT /note="V -> I (in dbSNP:rs56373393)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040117"
FT VARIANT 2963
FT /note="T -> P (in dbSNP:rs200875815)"
FT /evidence="ECO:0000269|PubMed:25173926"
FT /id="VAR_074293"
FT VARIANT 3026
FT /note="N -> I (in dbSNP:rs11900987)"
FT /id="VAR_056082"
FT VARIANT 3154
FT /note="K -> R (in dbSNP:rs4893853)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040118"
FT VARIANT 3191
FT /note="Q -> E (in dbSNP:rs33997263)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040119"
FT VARIANT 3238
FT /note="P -> L (in a bladder carcinoma sample; somatic
FT mutation; dbSNP:rs397517792)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040120"
FT VARIANT 3250
FT /note="V -> G (in dbSNP:rs55634230)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040121"
FT VARIANT 3261
FT /note="V -> M (in dbSNP:rs2291311)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040122"
FT VARIANT 3367
FT /note="R -> Q (in dbSNP:rs34819099)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040123"
FT VARIANT 3419
FT /note="S -> N (in dbSNP:rs2291310)"
FT /evidence="ECO:0000269|PubMed:7569978"
FT /id="VAR_056083"
FT VARIANT 3482
FT /note="E -> K (in a metastatic melanoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040124"
FT VARIANT 3491
FT /note="P -> S (in dbSNP:rs2627037)"
FT /evidence="ECO:0000269|PubMed:10850961,
FT ECO:0000269|PubMed:11717165, ECO:0000269|PubMed:7569978"
FT /id="VAR_040125"
FT VARIANT 3570
FT /note="E -> K (in a breast pleomorphic lobular carcinoma
FT sample; somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040126"
FT VARIANT 3590
FT /note="L -> V (in dbSNP:rs55853696)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040127"
FT VARIANT 3637
FT /note="P -> S (in dbSNP:rs757223770)"
FT /id="VAR_056084"
FT VARIANT 3762
FT /note="I -> V (in dbSNP:rs34070843)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040128"
FT VARIANT 3799
FT /note="S -> Y (in CMD1G)"
FT /evidence="ECO:0000269|PubMed:11846417"
FT /id="VAR_026690"
FT VARIANT 3877
FT /note="I -> F (in dbSNP:rs34618570)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040129"
FT VARIANT 3965
FT /note="I -> L (in dbSNP:rs56244420)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040130"
FT VARIANT 4084
FT /note="R -> Q (in dbSNP:rs200431386)"
FT /evidence="ECO:0000269|PubMed:11846417"
FT /id="VAR_026691"
FT VARIANT 4215
FT /note="T -> P (in dbSNP:rs2562829)"
FT /evidence="ECO:0000269|PubMed:10051295,
FT ECO:0000269|PubMed:10850961, ECO:0000269|PubMed:11717165,
FT ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:17344846"
FT /id="VAR_026635"
FT VARIANT 4238
FT /note="G -> W (in dbSNP:rs56030296)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040131"
FT VARIANT 4283
FT /note="L -> F (in dbSNP:rs1883085)"
FT /evidence="ECO:0000269|PubMed:10051295,
FT ECO:0000269|PubMed:10850961, ECO:0000269|PubMed:11717165,
FT ECO:0000269|PubMed:17344846"
FT /id="VAR_026636"
FT VARIANT 4291
FT /note="I -> T (in a colorectal adenocarcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040132"
FT VARIANT 4303
FT /note="G -> D (in dbSNP:rs55857742)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040133"
FT VARIANT 4427
FT /note="D -> E (in dbSNP:rs55906845)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040134"
FT VARIANT 4465
FT /note="S -> N (in CMD1G; dbSNP:rs281864908)"
FT /evidence="ECO:0000269|PubMed:11846417"
FT /id="VAR_026692"
FT VARIANT 8288
FT /note="A -> V (in dbSNP:rs16866412)"
FT /id="VAR_056085"
FT VARIANT 8474
FT /note="I -> T (in dbSNP:rs4893852)"
FT /id="VAR_056086"
FT VARIANT 12310
FT /note="G -> E (in dbSNP:rs55723264)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040135"
FT VARIANT 12383
FT /note="H -> R (in dbSNP:rs2288563)"
FT /evidence="ECO:0000269|PubMed:10850961"
FT /id="VAR_040136"
FT VARIANT 12469
FT /note="V -> A (in dbSNP:rs34706299)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040137"
FT VARIANT 12642
FT /note="R -> C (in a gastric adenocarcinoma sample; somatic
FT mutation; dbSNP:rs199684560)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040138"
FT VARIANT 12657
FT /note="E -> K (in a Wilms tumor; somatic mutation;
FT dbSNP:rs778634417)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040139"
FT VARIANT 12679
FT /note="K -> E (in dbSNP:rs6723526)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040140"
FT VARIANT 12720
FT /note="S -> F (in a metastatic melanoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040141"
FT VARIANT 12798
FT /note="R -> C (in dbSNP:rs200914097)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040142"
FT VARIANT 13049
FT /note="E -> G"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040143"
FT VARIANT 13083
FT /note="E -> K (in a metastatic melanoma sample; somatic
FT mutation; dbSNP:rs1458591077)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040144"
FT VARIANT 13096
FT /note="R -> L (in dbSNP:rs373298007)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040145"
FT VARIANT 13099
FT /note="Q -> R (in a lung small cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040146"
FT VARIANT 13297
FT /note="V -> A (in dbSNP:rs571522834)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040147"
FT VARIANT 13399
FT /note="I -> M (in dbSNP:rs74580375)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040148"
FT VARIANT 13418
FT /note="A -> T (in dbSNP:rs144668626)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040149"
FT VARIANT 13428
FT /note="E -> V (in dbSNP:rs114331773)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040150"
FT VARIANT 13430
FT /note="I -> T (in dbSNP:rs184078045)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040151"
FT VARIANT 13434
FT /note="R -> K (in a breast pleomorphic lobular carcinoma
FT sample; somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040152"
FT VARIANT 13469
FT /note="D -> N (in dbSNP:rs17354992)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040153"
FT VARIANT 13495
FT /note="K -> N (in dbSNP:rs72677225)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040154"
FT VARIANT 13785
FT /note="N -> S (in a breast pleomorphic lobular carcinoma
FT sample; somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040155"
FT VARIANT 13870
FT /note="Q -> H (in a lung small cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040156"
FT VARIANT 14109
FT /note="V -> I (in dbSNP:rs72677232)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040157"
FT VARIANT 14131
FT /note="R -> Q (in dbSNP:rs72677233)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040158"
FT VARIANT 14208
FT /note="P -> T (in dbSNP:rs146181477)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040159"
FT VARIANT 14728
FT /note="L -> V (in a lung adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040160"
FT VARIANT 14750
FT /note="R -> Q (in dbSNP:rs200944827)"
FT /evidence="ECO:0000269|PubMed:25173926"
FT /id="VAR_074294"
FT VARIANT 14999
FT /note="S -> T (in dbSNP:rs55663050)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040161"
FT VARIANT 15021
FT /note="N -> T (in dbSNP:rs36043230)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040162"
FT VARIANT 15520
FT /note="A -> V (in dbSNP:rs16866412)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040163"
FT VARIANT 15555
FT /note="R -> I (in a colorectal adenocarcinoma sample;
FT somatic mutation; dbSNP:rs751398376)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040164"
FT VARIANT 15620
FT /note="R -> Q (in dbSNP:rs201825412)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040165"
FT VARIANT 15629
FT /note="S -> I (in dbSNP:rs200650668)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040166"
FT VARIANT 15635
FT /note="Y -> C (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040167"
FT VARIANT 15700
FT /note="R -> Q (in dbSNP:rs370390570)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040168"
FT VARIANT 15705
FT /note="L -> P (in dbSNP:rs755155531)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040169"
FT VARIANT 15837
FT /note="I -> M (in dbSNP:rs554368924)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040170"
FT VARIANT 16046
FT /note="G -> V (in dbSNP:rs780672348)"
FT /evidence="ECO:0000269|PubMed:23033978"
FT /id="VAR_069432"
FT VARIANT 16058
FT /note="R -> H (in dbSNP:rs72646808)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040171"
FT VARIANT 16067
FT /note="K -> I (in dbSNP:rs2303832)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040172"
FT VARIANT 16090
FT /note="I -> T (in dbSNP:rs72646809)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040173"
FT VARIANT 16195
FT /note="R -> H (in a gastric adenocarcinoma sample; somatic
FT mutation; dbSNP:rs373526624)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040174"
FT VARIANT 16409
FT /note="R -> C (in dbSNP:rs55734111)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040175"
FT VARIANT 16424
FT /note="R -> P"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040176"
FT VARIANT 16575
FT /note="V -> M (in dbSNP:rs3813243)"
FT /id="VAR_056087"
FT VARIANT 16629
FT /note="I -> M (in dbSNP:rs55809450)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040177"
FT VARIANT 16877
FT /note="K -> R (in dbSNP:rs72646823)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040178"
FT VARIANT 17060
FT /note="N -> D (in dbSNP:rs1001238)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040179"
FT VARIANT 17637
FT /note="I -> V (in dbSNP:rs56025724)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040180"
FT VARIANT 17838
FT /note="R -> H (in dbSNP:rs2288569)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040181"
FT VARIANT 17866
FT /note="D -> N"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040182"
FT VARIANT 17906
FT /note="G -> E (in a metastatic melanoma sample; somatic
FT mutation; dbSNP:rs374713701)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040183"
FT VARIANT 18094
FT /note="E -> A (in dbSNP:rs769852851)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040184"
FT VARIANT 18109
FT /note="G -> S (in dbSNP:rs200732032)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040185"
FT VARIANT 18164
FT /note="R -> T (in an ovarian serous carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040186"
FT VARIANT 18221
FT /note="P -> L (in dbSNP:rs16866406)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040187"
FT VARIANT 18222
FT /note="A -> T"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040188"
FT VARIANT 18726
FT /note="R -> Q (in dbSNP:rs141973925)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040189"
FT VARIANT 18835
FT /note="V -> A (in a breast infiltrating ductal carcinoma
FT sample; somatic mutation; dbSNP:rs1336054298)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040190"
FT VARIANT 18881
FT /note="R -> K (in a metastatic melanoma sample; somatic
FT mutation; dbSNP:rs1204056923)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040191"
FT VARIANT 18939
FT /note="N -> S (in dbSNP:rs1470758075)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040192"
FT VARIANT 19000
FT /note="R -> Q (in dbSNP:rs199895260)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040193"
FT VARIANT 19060
FT /note="L -> Q (in a lung large cell carcinoma sample;
FT somatic mutation; dbSNP:rs1383995916)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040194"
FT VARIANT 19091
FT /note="R -> K (in a lung large cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040195"
FT VARIANT 19224
FT /note="P -> S (in a colorectal adenocarcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040196"
FT VARIANT 19367
FT /note="T -> I (in dbSNP:rs72646850)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040197"
FT VARIANT 19392
FT /note="E -> K (in a lung neuroendocrine carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040198"
FT VARIANT 19480
FT /note="A -> S (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040199"
FT VARIANT 19495
FT /note="D -> G (in dbSNP:rs773075736)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040200"
FT VARIANT 19665
FT /note="R -> H (in dbSNP:rs202240487)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040201"
FT VARIANT 19762
FT /note="T -> I (in dbSNP:rs2042996)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040202"
FT VARIANT 19947
FT /note="G -> R (in dbSNP:rs181717727)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040203"
FT VARIANT 19956
FT /note="V -> M (in dbSNP:rs150661999)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040204"
FT VARIANT 19992
FT /note="R -> Q (in dbSNP:rs141965360)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040205"
FT VARIANT 20057
FT /note="R -> C (in dbSNP:rs72646861)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040206"
FT VARIANT 20075
FT /note="S -> L (in dbSNP:rs13021201)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040207"
FT VARIANT 20179
FT /note="T -> K"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040208"
FT VARIANT 20198
FT /note="A -> T (in dbSNP:rs56378177)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040209"
FT VARIANT 20198
FT /note="A -> V (in dbSNP:rs55948748)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040210"
FT VARIANT 20331
FT /note="R -> H (in dbSNP:rs200217934)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040211"
FT VARIANT 20359
FT /note="R -> K (in dbSNP:rs9808036)"
FT /id="VAR_056088"
FT VARIANT 20408
FT /note="A -> T (in a metastatic melanoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040212"
FT VARIANT 20564
FT /note="R -> K (in dbSNP:rs72646869)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040213"
FT VARIANT 20718
FT /note="V -> I (in dbSNP:rs2303838)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040214"
FT VARIANT 20726
FT /note="S -> P (in dbSNP:rs72646873)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040215"
FT VARIANT 20892
FT /note="T -> N"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040216"
FT VARIANT 20894
FT /note="S -> R (in dbSNP:rs750847940)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040217"
FT VARIANT 21125
FT /note="D -> E (in dbSNP:rs534340303)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040218"
FT VARIANT 21403
FT /note="P -> S (in dbSNP:rs55980498)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040219"
FT VARIANT 21730
FT /note="R -> C (in dbSNP:rs56141309)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040220"
FT VARIANT 21747
FT /note="R -> Q (in dbSNP:rs55853138)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040221"
FT VARIANT 21851
FT /note="C -> R (in a gastric adenocarcinoma sample; somatic
FT mutation; dbSNP:rs55713867)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040222"
FT VARIANT 21925
FT /note="G -> R (in dbSNP:rs55801134)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040223"
FT VARIANT 21995
FT /note="R -> H (in dbSNP:rs56071233)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040224"
FT VARIANT 22045
FT /note="A -> V (in dbSNP:rs55903402)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040225"
FT VARIANT 22149
FT /note="R -> H (in dbSNP:rs55677134)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040226"
FT VARIANT 22160
FT /note="V -> I (in dbSNP:rs55885640)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040227"
FT VARIANT 22261
FT /note="I -> T (in dbSNP:rs55837610)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040228"
FT VARIANT 22306
FT /note="K -> N (in dbSNP:rs56019808)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040229"
FT VARIANT 22357
FT /note="R -> H (in dbSNP:rs10164753)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040230"
FT VARIANT 22408
FT /note="L -> P (in dbSNP:rs56399205)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040231"
FT VARIANT 22537
FT /note="Q -> H (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040232"
FT VARIANT 22584
FT /note="P -> L (in dbSNP:rs55992239)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040233"
FT VARIANT 22646
FT /note="L -> P (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040234"
FT VARIANT 22670
FT /note="T -> A (in dbSNP:rs56201325)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040235"
FT VARIANT 22770
FT /note="A -> D (in dbSNP:rs55991022)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040236"
FT VARIANT 22801
FT /note="A -> T (in a metastatic melanoma sample; somatic
FT mutation; dbSNP:rs764005465)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040237"
FT VARIANT 22823
FT /note="R -> W (in a metastatic melanoma sample; somatic
FT mutation; dbSNP:rs369098292)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040238"
FT VARIANT 22968
FT /note="E -> Q (in dbSNP:rs55762754)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040239"
FT VARIANT 23074
FT /note="P -> L (in dbSNP:rs55713856)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040240"
FT VARIANT 23079
FT /note="L -> F (in a metastatic melanoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040241"
FT VARIANT 23282
FT /note="D -> N (in a breast infiltrating ductal carcinoma
FT sample; somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040242"
FT VARIANT 23303
FT /note="H -> Y (in a metastatic melanoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040243"
FT VARIANT 23306
FT /note="R -> C (in dbSNP:rs744426)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040244"
FT VARIANT 23515
FT /note="A -> S (in a lung squamous cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040245"
FT VARIANT 23551
FT /note="E -> Q (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040246"
FT VARIANT 23807
FT /note="S -> N (in dbSNP:rs3813243)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040247"
FT VARIANT 23872
FT /note="D -> N (in an ovarian serous carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040248"
FT VARIANT 23891
FT /note="V -> A (in dbSNP:rs55984930)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040249"
FT VARIANT 23933
FT /note="Y -> H (in dbSNP:rs3813245)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040250"
FT VARIANT 23939
FT /note="T -> M (in dbSNP:rs56372592)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040251"
FT VARIANT 23952
FT /note="F -> L (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040252"
FT VARIANT 24098
FT /note="A -> G (in dbSNP:rs56391938)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040253"
FT VARIANT 24098
FT /note="A -> T (in dbSNP:rs4894028)"
FT /id="VAR_056089"
FT VARIANT 24119
FT /note="N -> S (in dbSNP:rs3813246)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040254"
FT VARIANT 24133
FT /note="V -> I (in dbSNP:rs56340968)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040255"
FT VARIANT 24159
FT /note="V -> A (in a head and neck squamous cell carcinoma
FT sample; somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040256"
FT VARIANT 24239
FT /note="T -> A (in dbSNP:rs56018860)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040257"
FT VARIANT 24265
FT /note="E -> K (in dbSNP:rs56341835)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040258"
FT VARIANT 24584
FT /note="I -> T (in dbSNP:rs12463674)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040259"
FT VARIANT 24781
FT /note="I -> T (in dbSNP:rs3731745)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040260"
FT VARIANT 24799
FT /note="R -> H (in dbSNP:rs56044609)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040261"
FT VARIANT 24954
FT /note="D -> H (in dbSNP:rs56307213)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040262"
FT VARIANT 24980
FT /note="T -> M (in dbSNP:rs3731746)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040263"
FT VARIANT 25659
FT /note="R -> H (in dbSNP:rs55850344)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040264"
FT VARIANT 25679
FT /note="A -> T (in dbSNP:rs56365600)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040265"
FT VARIANT 25720
FT /note="P -> A (in dbSNP:rs56137800)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040266"
FT VARIANT 25821
FT /note="T -> K (in dbSNP:rs55933739)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040267"
FT VARIANT 25859
FT /note="E -> K (in a metastatic melanoma sample; somatic
FT mutation; dbSNP:rs375422359)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040268"
FT VARIANT 25879
FT /note="N -> K (in dbSNP:rs56264840)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040269"
FT VARIANT 25923
FT /note="A -> V (in dbSNP:rs55634791)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040270"
FT VARIANT 26045
FT /note="V -> I (in dbSNP:rs56309296)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040271"
FT VARIANT 26059
FT /note="K -> E (in a lung small cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040272"
FT VARIANT 26134
FT /note="I -> V (in dbSNP:rs3829746)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040273"
FT VARIANT 26477
FT /note="R -> C (in dbSNP:rs56057221)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040274"
FT VARIANT 26843
FT /note="D -> Y (in dbSNP:rs56330345)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040275"
FT VARIANT 27346
FT /note="K -> R (in dbSNP:rs1186947794)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040276"
FT VARIANT 27652
FT /note="R -> C (in dbSNP:rs191482653)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040277"
FT VARIANT 27728
FT /note="G -> V (in dbSNP:rs55898359)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040278"
FT VARIANT 27754
FT /note="F -> L (in dbSNP:rs55940667)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040279"
FT VARIANT 27755
FT /note="I -> T (in dbSNP:rs9808377)"
FT /evidence="ECO:0000269|PubMed:17344846,
FT ECO:0000269|PubMed:7569978"
FT /id="VAR_040280"
FT VARIANT 27929
FT /note="I -> V (in dbSNP:rs139506970)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040281"
FT VARIANT 28132
FT /note="I -> L (in dbSNP:rs77853750)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040282"
FT VARIANT 28168
FT /note="R -> Q (in dbSNP:rs72648238)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040283"
FT VARIANT 28538
FT /note="R -> H (in dbSNP:rs149567378)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040284"
FT VARIANT 28572
FT /note="I -> T (in dbSNP:rs114026724)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040285"
FT VARIANT 28948
FT /note="A -> T (in dbSNP:rs148617456)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040286"
FT VARIANT 28986
FT /note="I -> V (in dbSNP:rs535151633)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040287"
FT VARIANT 28993
FT /note="G -> E (in dbSNP:rs376628842)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040288"
FT VARIANT 28998
FT /note="L -> V (in dbSNP:rs373049260)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040289"
FT VARIANT 29070
FT /note="V -> M (in dbSNP:rs747122)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040290"
FT VARIANT 29090
FT /note="I -> V (in dbSNP:rs16866391)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040291"
FT VARIANT 29419
FT /note="R -> C (in dbSNP:rs750303653)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040292"
FT VARIANT 29479
FT /note="L -> P (in dbSNP:rs1310673663)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040293"
FT VARIANT 29880
FT /note="S -> L (in a colorectal adenocarcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040294"
FT VARIANT 29976
FT /note="D -> E (in dbSNP:rs72648256)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040295"
FT VARIANT 30042
FT /note="S -> G (in dbSNP:rs72648257)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040296"
FT VARIANT 30107
FT /note="R -> C (in dbSNP:rs142525903)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040297"
FT VARIANT 30125
FT /note="S -> F (in dbSNP:rs191484894)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040298"
FT VARIANT 30211
FT /note="L -> P (in dbSNP:rs62621206)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040299"
FT VARIANT 30412
FT /note="I -> T (in dbSNP:rs62621236)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040300"
FT VARIANT 30617
FT /note="T -> S (in a renal chromophobe cancer sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040301"
FT VARIANT 30674
FT /note="T -> I (in dbSNP:rs56027402)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040302"
FT VARIANT 30809
FT /note="V -> I (in a gastric adenocarcinoma sample; somatic
FT mutation; dbSNP:rs397517769)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040303"
FT VARIANT 30818
FT /note="F -> I (in dbSNP:rs56009327)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040304"
FT VARIANT 30825
FT /note="E -> K (in dbSNP:rs55915651)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040305"
FT VARIANT 30856
FT /note="I -> T (in dbSNP:rs55660660)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040306"
FT VARIANT 30887
FT /note="G -> D (in dbSNP:rs56066673)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040307"
FT VARIANT 30887
FT /note="G -> S (in dbSNP:rs56233675)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040308"
FT VARIANT 30897
FT /note="R -> H (in dbSNP:rs3731749)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040309"
FT VARIANT 30907
FT /note="R -> H (in dbSNP:rs55676195)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040310"
FT VARIANT 30946
FT /note="R -> H (in dbSNP:rs55704830)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040311"
FT VARIANT 31081
FT /note="I -> F (in dbSNP:rs72648270)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040312"
FT VARIANT 31107
FT /note="R -> C (in dbSNP:rs72648272)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040313"
FT VARIANT 31124
FT /note="A -> G (in dbSNP:rs72648273)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040314"
FT VARIANT 31156
FT /note="N -> S (in dbSNP:rs149001703)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040315"
FT VARIANT 31246
FT /note="P -> T (in dbSNP:rs55653324)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040316"
FT VARIANT 31330
FT /note="R -> H (in dbSNP:rs4894028)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040317"
FT VARIANT 31690
FT /note="C -> R (in dbSNP:rs56061641)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040318"
FT VARIANT 31724
FT /note="R -> Q (in dbSNP:rs55742743)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040319"
FT VARIANT 31725
FT /note="V -> I (in dbSNP:rs55675869)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040320"
FT VARIANT 31732
FT /note="G -> S (in dbSNP:rs55880786)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040321"
FT VARIANT 31886
FT /note="V -> I (in dbSNP:rs2278196)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040322"
FT VARIANT 32097
FT /note="R -> C (in dbSNP:rs56273463)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040323"
FT VARIANT 32171
FT /note="T -> N (in a lung large cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040324"
FT VARIANT 32248
FT /note="V -> I (in dbSNP:rs34924609)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040325"
FT VARIANT 32281
FT /note="Q -> H (in dbSNP:rs55886356)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040326"
FT VARIANT 32323
FT /note="R -> H (in dbSNP:rs55669553)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040327"
FT VARIANT 32411
FT /note="R -> W (in a gastric adenocarcinoma sample; somatic
FT mutation; dbSNP:rs756924372)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040328"
FT VARIANT 32558
FT /note="I -> V (in dbSNP:rs56347248)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040329"
FT VARIANT 32610
FT /note="M -> V (in dbSNP:rs56173891)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040330"
FT VARIANT 32637
FT /note="G -> V (in dbSNP:rs3731752)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040331"
FT VARIANT 32742
FT /note="E -> Q (in dbSNP:rs148525155)"
FT /evidence="ECO:0000269|PubMed:23033978"
FT /id="VAR_069433"
FT VARIANT 32922
FT /note="V -> A (in dbSNP:rs55945684)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040332"
FT VARIANT 32943
FT /note="L -> R (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040333"
FT VARIANT 32953
FT /note="R -> H (in dbSNP:rs3829747)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040334"
FT VARIANT 32996
FT /note="R -> Q (in CMD1G; dbSNP:rs199642423)"
FT /evidence="ECO:0000269|PubMed:16465475"
FT /id="VAR_026693"
FT VARIANT 33213
FT /note="V -> L (in dbSNP:rs55866005)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040335"
FT VARIANT 33242
FT /note="R -> C (in a gastric adenocarcinoma sample; somatic
FT mutation; dbSNP:rs1003158162)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040336"
FT VARIANT 33387
FT /note="T -> M (in dbSNP:rs56001826)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040337"
FT VARIANT 33419
FT /note="E -> D (in dbSNP:rs56308529)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040338"
FT VARIANT 33536
FT /note="V -> M (in dbSNP:rs55865284)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040339"
FT VARIANT 33568
FT /note="K -> Q (in dbSNP:rs56365812)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040340"
FT VARIANT 33616
FT /note="E -> K (in dbSNP:rs56324595)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040341"
FT VARIANT 33620
FT /note="P -> L (in dbSNP:rs16866380)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040342"
FT VARIANT 33886
FT /note="E -> V (in dbSNP:rs55725279)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040343"
FT VARIANT 33899
FT /note="I -> T (in dbSNP:rs55880440)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040344"
FT VARIANT 33904
FT /note="L -> P (in a gastric adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040345"
FT VARIANT 33955
FT /note="T -> I (in dbSNP:rs55842557)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040346"
FT VARIANT 34115
FT /note="V -> A (in dbSNP:rs16866378)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040347"
FT VARIANT 34306
FT /note="I -> N (in TMD; dbSNP:rs281864928)"
FT /evidence="ECO:0000269|PubMed:12891679"
FT /id="VAR_026694"
FT VARIANT 34315
FT /note="L -> P (in TMD; dbSNP:rs267607156)"
FT /evidence="ECO:0000269|PubMed:12145747"
FT /id="VAR_026695"
FT MUTAGEN 32207
FT /note="K->A: Disrupts catalytic activity."
FT /evidence="ECO:0000269|PubMed:9804419"
FT MUTAGEN 32341
FT /note="Y->E: No phosphorylation on tyrosine."
FT /evidence="ECO:0000269|PubMed:9804419"
FT CONFLICT 132
FT /note="T -> N (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="P -> H (in Ref. 3; CAD12455/CAD12456/CAD12457)"
FT /evidence="ECO:0000305"
FT CONFLICT 1472..1474
FT /note="QTA -> ANC (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 1730
FT /note="G -> S (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 3919
FT /note="P -> L (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 4525
FT /note="R -> K (in Ref. 3; CAD12456)"
FT /evidence="ECO:0000305"
FT CONFLICT 6619
FT /note="R -> E (in Ref. 1; CAA62189 and 3; CAD12456)"
FT /evidence="ECO:0000305"
FT CONFLICT 7145
FT /note="D -> H (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 7441
FT /note="S -> N (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 8038
FT /note="A -> E (in Ref. 3; CAD12456)"
FT /evidence="ECO:0000305"
FT CONFLICT 8225
FT /note="Q -> H (in Ref. 3; CAD12456)"
FT /evidence="ECO:0000305"
FT CONFLICT 8850
FT /note="A -> P (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 9693
FT /note="C -> V (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 9892
FT /note="I -> V (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 10205
FT /note="I -> V (in Ref. 3; CAD12456 and 9; AAP80791)"
FT /evidence="ECO:0000305"
FT CONFLICT 10305
FT /note="G -> R (in Ref. 3; CAD12456)"
FT /evidence="ECO:0000305"
FT CONFLICT 10566
FT /note="R -> K (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 10779
FT /note="R -> H (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 11424
FT /note="E -> D (in Ref. 3; CAD12456)"
FT /evidence="ECO:0000305"
FT CONFLICT 11511
FT /note="A -> V (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 11626
FT /note="K -> N (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 11838
FT /note="K -> N (in Ref. 1; CAA62189)"
FT /evidence="ECO:0000305"
FT CONFLICT 12994
FT /note="A -> T (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 13795..13797
FT /note="YKF -> IQI (in Ref. 11)"
FT /evidence="ECO:0000305"
FT CONFLICT 14590
FT /note="A -> T (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 14792
FT /note="V -> A (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 15974
FT /note="E -> K (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 16234..16235
FT /note="TK -> QR (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 17238
FT /note="R -> H (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 17423
FT /note="R -> S (in Ref. 3; CAD12456)"
FT /evidence="ECO:0000305"
FT CONFLICT 19734
FT /note="V -> A (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 20517
FT /note="G -> A (in Ref. 1; CAA62188 and 3; CAD12455)"
FT /evidence="ECO:0000305"
FT CONFLICT 20622
FT /note="L -> H (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 20775
FT /note="A -> P (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 21625
FT /note="Y -> I (in Ref. 13; CAA45939)"
FT /evidence="ECO:0000305"
FT CONFLICT 21795..21800
FT /note="PGPVLN -> ARPSPQ (in Ref. 13; CAA45939)"
FT /evidence="ECO:0000305"
FT CONFLICT 22176
FT /note="C -> W (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 22816
FT /note="A -> D (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 22837
FT /note="T -> A (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 24176
FT /note="I -> M (in Ref. 1; CAA62188 and 13; CAA45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 24181
FT /note="S -> F (in Ref. 13; CAA45940)"
FT /evidence="ECO:0000305"
FT CONFLICT 25731
FT /note="P -> S (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 26573
FT /note="M -> V (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 26846..26848
FT /note="IVE -> HRK (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 27879
FT /note="G -> A (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 28936
FT /note="D -> N (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 29222
FT /note="A -> T (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 29518
FT /note="F -> L (in Ref. 1; CAA62188)"
FT /evidence="ECO:0000305"
FT CONFLICT 29701
FT /note="T -> P (in Ref. 14; CAA45938/CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 29873
FT /note="E -> G (in Ref. 14; CAA45938/CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 29878
FT /note="T -> Q (in Ref. 14; CAA45938/CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 30209
FT /note="K -> E (in Ref. 1; CAA62188 and 14; CAA45938/
FT CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 30256
FT /note="A -> R (in Ref. 1; CAA62188 and 14; CAA45938/
FT CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 30496
FT /note="V -> I (in Ref. 1; CAA62188 and 14; CAA45938/
FT CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 30534
FT /note="Y -> H (in Ref. 1; CAA62188 and 14; CAA45938/
FT CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 30748
FT /note="S -> L (in Ref. 14; CAA45938/CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 31303
FT /note="W -> V (in Ref. 1; CAA62188 and 14; CAA45938/
FT CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 32060
FT /note="V -> A (in Ref. 1; CAA62188 and 14; CAA45938/
FT CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 33084
FT /note="D -> N (in Ref. 1; CAA62188 and 14; CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 33120
FT /note="R -> W (in Ref. 15; CAD28458)"
FT /evidence="ECO:0000305"
FT CONFLICT 33382
FT /note="A -> R (in Ref. 14; CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 33424
FT /note="S -> P (in Ref. 1; CAA62188 and 14; CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 33526
FT /note="Q -> R (in Ref. 14; CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 33633
FT /note="T -> I (in Ref. 1; CAA62188 and 14; CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 33716
FT /note="Y -> V (in Ref. 15; CAD28458)"
FT /evidence="ECO:0000305"
FT CONFLICT 33995
FT /note="V -> A (in Ref. 15; CAD28458)"
FT /evidence="ECO:0000305"
FT CONFLICT 34071
FT /note="N -> G (in Ref. 5; AAI07798)"
FT /evidence="ECO:0000305"
FT CONFLICT 34082
FT /note="C -> R (in Ref. 14; CAA49245)"
FT /evidence="ECO:0000305"
FT CONFLICT 34253
FT /note="G -> R (in Ref. 5; AAI07798)"
FT /evidence="ECO:0000305"
FT STRAND 4..10
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 15..18
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 23..33
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 36..45
FT /evidence="ECO:0007829|PDB:2A38"
FT TURN 48..50
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 55..59
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 62..69
FT /evidence="ECO:0007829|PDB:2A38"
FT HELIX 72..74
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 76..84
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 87..98
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 102..108
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 113..116
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 119..131
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 134..139
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 142..144
FT /evidence="ECO:0007829|PDB:1YA5"
FT STRAND 147..155
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 158..166
FT /evidence="ECO:0007829|PDB:2A38"
FT HELIX 168..170
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 172..180
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 183..194
FT /evidence="ECO:0007829|PDB:2A38"
FT STRAND 199..205
FT /evidence="ECO:0007829|PDB:6FWX"
FT STRAND 209..213
FT /evidence="ECO:0007829|PDB:6FWX"
FT STRAND 225..233
FT /evidence="ECO:0007829|PDB:6FWX"
FT STRAND 236..241
FT /evidence="ECO:0007829|PDB:6FWX"
FT STRAND 1850..1852
FT /evidence="ECO:0007829|PDB:6DL4"
FT STRAND 1858..1863
FT /evidence="ECO:0007829|PDB:6DL4"
FT STRAND 1866..1869
FT /evidence="ECO:0007829|PDB:6DL4"
FT STRAND 1871..1876
FT /evidence="ECO:0007829|PDB:6DL4"
FT TURN 1891..1893
FT /evidence="ECO:0007829|PDB:6DL4"
FT STRAND 1894..1899
FT /evidence="ECO:0007829|PDB:6DL4"
FT STRAND 1908..1916
FT /evidence="ECO:0007829|PDB:6DL4"
FT STRAND 1919..1929
FT /evidence="ECO:0007829|PDB:6DL4"
FT STRAND 2076..2082
FT /evidence="ECO:0007829|PDB:1G1C"
FT STRAND 2087..2090
FT /evidence="ECO:0007829|PDB:1G1C"
FT STRAND 2095..2105
FT /evidence="ECO:0007829|PDB:1G1C"
FT STRAND 2108..2113
FT /evidence="ECO:0007829|PDB:1G1C"
FT STRAND 2122..2130
FT /evidence="ECO:0007829|PDB:1G1C"
FT STRAND 2133..2138
FT /evidence="ECO:0007829|PDB:1G1C"
FT HELIX 2143..2145
FT /evidence="ECO:0007829|PDB:1G1C"
FT STRAND 2147..2155
FT /evidence="ECO:0007829|PDB:1G1C"
FT STRAND 2158..2169
FT /evidence="ECO:0007829|PDB:1G1C"
FT STRAND 2797..2799
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2804..2807
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2812..2820
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2826..2829
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2838..2845
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2848..2853
FT /evidence="ECO:0007829|PDB:5JDD"
FT HELIX 2858..2860
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2862..2868
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2871..2880
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2884..2886
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2891..2894
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2899..2907
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2914..2916
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2924..2932
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2935..2940
FT /evidence="ECO:0007829|PDB:5JDD"
FT HELIX 2945..2947
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2949..2955
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2958..2967
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2971..2973
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2978..2981
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 2986..2994
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 3000..3003
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 3012..3019
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 3022..3027
FT /evidence="ECO:0007829|PDB:5JDD"
FT HELIX 3032..3034
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 3036..3042
FT /evidence="ECO:0007829|PDB:5JDD"
FT STRAND 3045..3053
FT /evidence="ECO:0007829|PDB:5JDD"
FT HELIX 9506..9510
FT /evidence="ECO:0007829|PDB:7NIP"
FT HELIX 9518..9525
FT /evidence="ECO:0007829|PDB:7NIP"
FT HELIX 9530..9543
FT /evidence="ECO:0007829|PDB:7NIP"
FT STRAND 9582..9587
FT /evidence="ECO:0007829|PDB:5JOE"
FT STRAND 9592..9595
FT /evidence="ECO:0007829|PDB:5JOE"
FT STRAND 9600..9608
FT /evidence="ECO:0007829|PDB:5JOE"
FT STRAND 9616..9619
FT /evidence="ECO:0007829|PDB:5JOE"
FT STRAND 9628..9635
FT /evidence="ECO:0007829|PDB:5JOE"
FT STRAND 9638..9643
FT /evidence="ECO:0007829|PDB:5JOE"
FT HELIX 9648..9650
FT /evidence="ECO:0007829|PDB:5JOE"
FT STRAND 9652..9658
FT /evidence="ECO:0007829|PDB:5JOE"
FT STRAND 9661..9670
FT /evidence="ECO:0007829|PDB:5JOE"
FT STRAND 9674..9676
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9681..9684
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9689..9697
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9703..9706
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9717..9722
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9725..9732
FT /evidence="ECO:0007829|PDB:7AHS"
FT HELIX 9735..9737
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9739..9745
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9748..9757
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9763..9765
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9770..9772
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9778..9786
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9790..9795
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9803..9811
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9814..9819
FT /evidence="ECO:0007829|PDB:7AHS"
FT HELIX 9824..9826
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9828..9835
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 9841..9850
FT /evidence="ECO:0007829|PDB:7AHS"
FT STRAND 12680..12682
FT /evidence="ECO:0007829|PDB:1WAA"
FT STRAND 12687..12690
FT /evidence="ECO:0007829|PDB:1WAA"
FT STRAND 12691..12693
FT /evidence="ECO:0007829|PDB:6I0Y"
FT STRAND 12695..12705
FT /evidence="ECO:0007829|PDB:1WAA"
FT STRAND 12709..12712
FT /evidence="ECO:0007829|PDB:1WAA"
FT STRAND 12719..12722
FT /evidence="ECO:0007829|PDB:1TIU"
FT STRAND 12723..12728
FT /evidence="ECO:0007829|PDB:1WAA"
FT STRAND 12731..12736
FT /evidence="ECO:0007829|PDB:1WAA"
FT HELIX 12741..12743
FT /evidence="ECO:0007829|PDB:1WAA"
FT STRAND 12745..12751
FT /evidence="ECO:0007829|PDB:1WAA"
FT STRAND 12754..12763
FT /evidence="ECO:0007829|PDB:1WAA"
FT STRAND 14223..14228
FT /evidence="ECO:0007829|PDB:4O00"
FT STRAND 14232..14240
FT /evidence="ECO:0007829|PDB:4O00"
FT STRAND 14252..14259
FT /evidence="ECO:0007829|PDB:4O00"
FT STRAND 14275..14281
FT /evidence="ECO:0007829|PDB:4O00"
FT STRAND 14288..14296
FT /evidence="ECO:0007829|PDB:4O00"
FT STRAND 14308..14314
FT /evidence="ECO:0007829|PDB:4O00"
FT STRAND 22291..22296
FT /evidence="ECO:0007829|PDB:1BPV"
FT STRAND 22299..22303
FT /evidence="ECO:0007829|PDB:1BPV"
FT STRAND 22319..22324
FT /evidence="ECO:0007829|PDB:1BPV"
FT STRAND 22340..22345
FT /evidence="ECO:0007829|PDB:1BPV"
FT STRAND 22354..22361
FT /evidence="ECO:0007829|PDB:1BPV"
FT STRAND 22367..22377
FT /evidence="ECO:0007829|PDB:1BPV"
FT HELIX 22381..22384
FT /evidence="ECO:0007829|PDB:1BPV"
FT STRAND 22883..22890
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 22895..22900
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 22912..22919
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 22926..22932
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 22934..22939
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 22947..22956
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 22970..22972
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 22982..22987
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 22992..22996
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 23009..23016
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 23023..23035
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 23043..23052
FT /evidence="ECO:0007829|PDB:3LPW"
FT STRAND 31458..31464
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31469..31472
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31475..31487
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31490..31495
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31498..31500
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31504..31520
FT /evidence="ECO:0007829|PDB:3LCY"
FT HELIX 31524..31526
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31528..31535
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31540..31555
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31563..31568
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31573..31583
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31586..31591
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31600..31606
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31608..31617
FT /evidence="ECO:0007829|PDB:3LCY"
FT HELIX 31620..31623
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31625..31632
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31637..31647
FT /evidence="ECO:0007829|PDB:3LCY"
FT STRAND 31856..31859
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31864..31867
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31872..31879
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31885..31890
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31893..31895
FT /evidence="ECO:0007829|PDB:2J8O"
FT STRAND 31899..31907
FT /evidence="ECO:0007829|PDB:2J8H"
FT TURN 31908..31910
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31911..31916
FT /evidence="ECO:0007829|PDB:2J8H"
FT HELIX 31921..31923
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31925..31933
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31936..31952
FT /evidence="ECO:0007829|PDB:2J8H"
FT HELIX 31956..31959
FT /evidence="ECO:0007829|PDB:2NZI"
FT STRAND 31961..31967
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31973..31982
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31985..31992
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 31997..32000
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 32002..32005
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 32007..32013
FT /evidence="ECO:0007829|PDB:2J8H"
FT HELIX 32020..32022
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 32024..32032
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 32035..32046
FT /evidence="ECO:0007829|PDB:2J8H"
FT STRAND 32053..32061
FT /evidence="ECO:0007829|PDB:6YGN"
FT STRAND 32063..32070
FT /evidence="ECO:0007829|PDB:6YGN"
FT STRAND 32076..32078
FT /evidence="ECO:0007829|PDB:2NZI"
FT STRAND 32082..32089
FT /evidence="ECO:0007829|PDB:6YGN"
FT STRAND 32095..32111
FT /evidence="ECO:0007829|PDB:6YGN"
FT STRAND 32117..32125
FT /evidence="ECO:0007829|PDB:6YGN"
FT HELIX 32142..32154
FT /evidence="ECO:0007829|PDB:6YGN"
FT STRAND 32167..32170
FT /evidence="ECO:0007829|PDB:6YGN"
FT TURN 32175..32177
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32178..32186
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32188..32197
FT /evidence="ECO:0007829|PDB:1TKI"
FT TURN 32198..32201
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32202..32209
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32214..32228
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32237..32243
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32246..32251
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32259..32263
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32265..32267
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32272..32291
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32301..32303
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32304..32310
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32314..32316
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32330..32336
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32338..32340
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32343..32346
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32353..32369
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32379..32388
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32395..32398
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32403..32410
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32417..32419
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32423..32428
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32430..32433
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32436..32438
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32447..32457
FT /evidence="ECO:0007829|PDB:1TKI"
FT HELIX 32466..32472
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32474..32476
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32483..32489
FT /evidence="ECO:0007829|PDB:1TKI"
FT STRAND 32504..32506
FT /evidence="ECO:0007829|PDB:2BK8"
FT STRAND 32512..32520
FT /evidence="ECO:0007829|PDB:2BK8"
FT STRAND 32526..32531
FT /evidence="ECO:0007829|PDB:2BK8"
FT STRAND 32538..32547
FT /evidence="ECO:0007829|PDB:2BK8"
FT STRAND 32550..32555
FT /evidence="ECO:0007829|PDB:2BK8"
FT HELIX 32560..32562
FT /evidence="ECO:0007829|PDB:2BK8"
FT STRAND 32564..32571
FT /evidence="ECO:0007829|PDB:2BK8"
FT STRAND 32576..32585
FT /evidence="ECO:0007829|PDB:2BK8"
FT TURN 32586..32588
FT /evidence="ECO:0007829|PDB:2BK8"
FT STRAND 32720..32726
FT /evidence="ECO:0007829|PDB:6HCI"
FT STRAND 32731..32734
FT /evidence="ECO:0007829|PDB:6HCI"
FT STRAND 32739..32749
FT /evidence="ECO:0007829|PDB:6HCI"
FT STRAND 32752..32757
FT /evidence="ECO:0007829|PDB:6HCI"
FT TURN 32765..32767
FT /evidence="ECO:0007829|PDB:6HCI"
FT STRAND 32768..32773
FT /evidence="ECO:0007829|PDB:6HCI"
FT TURN 32774..32776
FT /evidence="ECO:0007829|PDB:6HCI"
FT STRAND 32777..32784
FT /evidence="ECO:0007829|PDB:6HCI"
FT HELIX 32787..32789
FT /evidence="ECO:0007829|PDB:6HCI"
FT STRAND 32791..32799
FT /evidence="ECO:0007829|PDB:6HCI"
FT STRAND 32802..32813
FT /evidence="ECO:0007829|PDB:6HCI"
FT TURN 33294..33297
FT /evidence="ECO:0007829|PDB:3QP3"
FT STRAND 33299..33305
FT /evidence="ECO:0007829|PDB:6H4L"
FT STRAND 33310..33313
FT /evidence="ECO:0007829|PDB:6H4L"
FT STRAND 33318..33328
FT /evidence="ECO:0007829|PDB:6H4L"
FT STRAND 33331..33336
FT /evidence="ECO:0007829|PDB:6H4L"
FT STRAND 33345..33352
FT /evidence="ECO:0007829|PDB:6H4L"
FT STRAND 33355..33360
FT /evidence="ECO:0007829|PDB:6H4L"
FT HELIX 33365..33367
FT /evidence="ECO:0007829|PDB:6H4L"
FT STRAND 33369..33377
FT /evidence="ECO:0007829|PDB:6H4L"
FT STRAND 33380..33391
FT /evidence="ECO:0007829|PDB:6H4L"
FT STRAND 33489..33492
FT /evidence="ECO:0007829|PDB:1NCT"
FT STRAND 33497..33503
FT /evidence="ECO:0007829|PDB:1NCT"
FT STRAND 33509..33512
FT /evidence="ECO:0007829|PDB:1NCT"
FT STRAND 33514..33516
FT /evidence="ECO:0007829|PDB:1TNM"
FT STRAND 33523..33526
FT /evidence="ECO:0007829|PDB:1NCT"
FT STRAND 33532..33538
FT /evidence="ECO:0007829|PDB:1NCT"
FT STRAND 33540..33547
FT /evidence="ECO:0007829|PDB:1NCT"
FT STRAND 33556..33560
FT /evidence="ECO:0007829|PDB:1NCT"
FT STRAND 33571..33577
FT /evidence="ECO:0007829|PDB:1NCT"
FT STRAND 33777..33783
FT /evidence="ECO:0007829|PDB:3PUC"
FT STRAND 33788..33794
FT /evidence="ECO:0007829|PDB:3PUC"
FT STRAND 33796..33806
FT /evidence="ECO:0007829|PDB:3PUC"
FT STRAND 33809..33814
FT /evidence="ECO:0007829|PDB:3PUC"
FT STRAND 33821..33830
FT /evidence="ECO:0007829|PDB:3PUC"
FT STRAND 33833..33838
FT /evidence="ECO:0007829|PDB:3PUC"
FT HELIX 33843..33845
FT /evidence="ECO:0007829|PDB:3PUC"
FT STRAND 33847..33855
FT /evidence="ECO:0007829|PDB:3PUC"
FT STRAND 33858..33869
FT /evidence="ECO:0007829|PDB:3PUC"
FT STRAND 34060..34071
FT /evidence="ECO:0007829|PDB:4UOW"
FT STRAND 34078..34088
FT /evidence="ECO:0007829|PDB:4UOW"
FT STRAND 34091..34096
FT /evidence="ECO:0007829|PDB:4UOW"
FT TURN 34104..34106
FT /evidence="ECO:0007829|PDB:4UOW"
FT STRAND 34107..34112
FT /evidence="ECO:0007829|PDB:4UOW"
FT STRAND 34115..34122
FT /evidence="ECO:0007829|PDB:4UOW"
FT HELIX 34125..34127
FT /evidence="ECO:0007829|PDB:4UOW"
FT STRAND 34129..34136
FT /evidence="ECO:0007829|PDB:4UOW"
FT STRAND 34138..34148
FT /evidence="ECO:0007829|PDB:4UOW"
FT STRAND 34254..34258
FT /evidence="ECO:0007829|PDB:3KNB"
FT STRAND 34263..34268
FT /evidence="ECO:0007829|PDB:3KNB"
FT STRAND 34271..34283
FT /evidence="ECO:0007829|PDB:3KNB"
FT STRAND 34286..34291
FT /evidence="ECO:0007829|PDB:3KNB"
FT HELIX 34300..34302
FT /evidence="ECO:0007829|PDB:3KNB"
FT STRAND 34304..34308
FT /evidence="ECO:0007829|PDB:3KNB"
FT STRAND 34310..34319
FT /evidence="ECO:0007829|PDB:3KNB"
FT HELIX 34322..34324
FT /evidence="ECO:0007829|PDB:3KNB"
FT STRAND 34326..34334
FT /evidence="ECO:0007829|PDB:3KNB"
FT STRAND 34337..34348
FT /evidence="ECO:0007829|PDB:3KNB"
FT CONFLICT Q8WZ42-6:3732
FT /note="L -> F (in Ref. 3; CAD12457)"
FT /evidence="ECO:0000305"
FT CONFLICT Q8WZ42-6:5139
FT /note="R -> M (in Ref. 3; CAD12457)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 34350 AA; 3816030 MW; DEB216410AD560D9 CRC64;
MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN
AVGQVSSTAN LSLEAPESIL HERIEQEIEM EMKEFSSSFL SAEEEGLHSA ELQLSKINET
LELLSESPVY PTKFDSEKEG TGPIFIKEVS NADISMGDVA TLSVTVIGIP KPKIQWFFNG
VLLTPSADYK FVFDGDDHSL IILFTKLEDE GEYTCMASND YGKTICSAYL KINSKGEGHK
DTETESAVAK SLEKLGGPCP PHFLKELKPI RCAQGLPAIF EYTVVGEPAP TVTWFKENKQ
LCTSVYYTII HNPNGSGTFI VNDPQREDSG LYICKAENML GESTCAAELL VLLEDTDMTD
TPCKAKSTPE APEDFPQTPL KGPAVEALDS EQEIATFVKD TILKAALITE ENQQLSYEHI
AKANELSSQL PLGAQELQSI LEQDKLTPES TREFLCINGS IHFQPLKEPS PNLQLQIVQS
QKTFSKEGIL MPEEPETQAV LSDTEKIFPS AMSIEQINSL TVEPLKTLLA EPEGNYPQSS
IEPPMHSYLT SVAEEVLSPK EKTVSDTNRE QRVTLQKQEA QSALILSQSL AEGHVESLQS
PDVMISQVNY EPLVPSEHSC TEGGKILIES ANPLENAGQD SAVRIEEGKS LRFPLALEEK
QVLLKEEHSD NVVMPPDQII ESKREPVAIK KVQEVQGRDL LSKESLLSGI PEEQRLNLKI
QICRALQAAV ASEQPGLFSE WLRNIEKVEV EAVNITQEPR HIMCMYLVTS AKSVTEEVTI
IIEDVDPQMA NLKMELRDAL CAIIYEEIDI LTAEGPRIQQ GAKTSLQEEM DSFSGSQKVE
PITEPEVESK YLISTEEVSY FNVQSRVKYL DATPVTKGVA SAVVSDEKQD ESLKPSEEKE
ESSSESGTEE VATVKIQEAE GGLIKEDGPM IHTPLVDTVS EEGDIVHLTT SITNAKEVNW
YFENKLVPSD EKFKCLQDQN TYTLVIDKVN TEDHQGEYVC EALNDSGKTA TSAKLTVVKR
AAPVIKRKIE PLEVALGHLA KFTCEIQSAP NVRFQWFKAG REIYESDKCS IRSSKYISSL
EILRTQVVDC GEYTCKASNE YGSVSCTATL TVTEAYPPTF LSRPKSLTTF VGKAAKFICT
VTGTPVIETI WQKDGAALSP SPNWRISDAE NKHILELSNL TIQDRGVYSC KASNKFGADI
CQAELIIIDK PHFIKELEPV QSAINKKVHL ECQVDEDRKV TVTWSKDGQK LPPGKDYKIC
FEDKIATLEI PLAKLKDSGT YVCTASNEAG SSSCSATVTV REPPSFVKKV DPSYLMLPGE
SARLHCKLKG SPVIQVTWFK NNKELSESNT VRMYFVNSEA ILDITDVKVE DSGSYSCEAV
NDVGSDSCST EIVIKEPPSF IKTLEPADIV RGTNALLQCE VSGTGPFEIS WFKDKKQIRS
SKKYRLFSQK SLVCLEIFSF NSADVGEYEC VVANEVGKCG CMATHLLKEP PTFVKKVDDL
IALGGQTVTL QAAVRGSEPI SVTWMKGQEV IREDGKIKMS FSNGVAVLII PDVQISFGGK
YTCLAENEAG SQTSVGELIV KEPAKIIERA ELIQVTAGDP ATLEYTVAGT PELKPKWYKD
GRPLVASKKY RISFKNNVAQ LKFYSAELHD SGQYTFEISN EVGSSSCETT FTVLDRDIAP
FFTKPLRNVD SVVNGTCRLD CKIAGSLPMR VSWFKDGKEI AASDRYRIAF VEGTASLEII
RVDMNDAGNF TCRATNSVGS KDSSGALIVQ EPPSFVTKPG SKDVLPGSAV CLKSTFQGST
PLTIRWFKGN KELVSGGSCY ITKEALESSL ELYLVKTSDS GTYTCKVSNV AGGVECSANL
FVKEPATFVE KLEPSQLLKK GDATQLACKV TGTPPIKITW FANDREIKES SKHRMSFVES
TAVLRLTDVG IEDSGEYMCE AQNEAGSDHC SSIVIVKESP YFTKEFKPIE VLKEYDVMLL
AEVAGTPPFE ITWFKDNTIL RSGRKYKTFI QDHLVSLQIL KFVAADAGEY QCRVTNEVGS
SICSARVTLR EPPSFIKKIE STSSLRGGTA AFQATLKGSL PITVTWLKDS DEITEDDNIR
MTFENNVASL YLSGIEVKHD GKYVCQAKND AGIQRCSALL SVKEPATITE EAVSIDVTQG
DPATLQVKFS GTKEITAKWF KDGQELTLGS KYKISVTDTV SILKIISTEK KDSGEYTFEV
QNDVGRSSCK ARINVLDLII PPSFTKKLKK MDSIKGSFID LECIVAGSHP ISIQWFKDDQ
EISASEKYKF SFHDNTAFLE ISQLEGTDSG TYTCSATNKA GHNQCSGHLT VKEPPYFVEK
PQSQDVNPNT RVQLKALVGG TAPMTIKWFK DNKELHSGAA RSVWKDDTST SLELFAAKAT
DSGTYICQLS NDVGTATSKA TLFVKEPPQF IKKPSPVLVL RNGQSTTFEC QITGTPKIRV
SWYLDGNEIT AIQKHGISFI DGLATFQISG ARVENSGTYV CEARNDAGTA SCSIELKVKE
PPTFIRELKP VEVVKYSDVE LECEVTGTPP FEVTWLKNNR EIRSSKKYTL TDRVSVFNLH
ITKCDPSDTG EYQCIVSNEG GSCSCSTRVA LKEPPSFIKK IENTTTVLKS SATFQSTVAG
SPPISITWLK DDQILDEDDN VYISFVDSVA TLQIRSVDNG HSGRYTCQAK NESGVERCYA
FLLVQEPAQI VEKAKSVDVT EKDPMTLECV VAGTPELKVK WLKDGKQIVP SRYFSMSFEN
NVASFRIQSV MKQDSGQYTF KVENDFGSSS CDAYLRVLDQ NIPPSFTKKL TKMDKVLGSS
IHMECKVSGS LPISAQWFKD GKEISTSAKY RLVCHERSVS LEVNNLELED TANYTCKVSN
VAGDDACSGI LTVKEPPSFL VKPGRQQAIP DSTVEFKAIL KGTPPFKIKW FKDDVELVSG
PKCFIGLEGS TSFLNLYSVD ASKTGQYTCH VTNDVGSDSC TTMLLVTEPP KFVKKLEASK
IVKAGDSSRL ECKIAGSPEI RVVWFRNEHE LPASDKYRMT FIDSVAVIQM NNLSTEDSGD
FICEAQNPAG STSCSTKVIV KEPPVFSSFP PIVETLKNAE VSLECELSGT PPFEVVWYKD
KRQLRSSKKY KIASKNFHTS IHILNVDTSD IGEYHCKAQN EVGSDTCVCT VKLKEPPRFV
SKLNSLTVVA GEPAELQASI EGAQPIFVQW LKEKEEVIRE SENIRITFVE NVATLQFAKA
EPANAGKYIC QIKNDGGMRE NMATLMVLEP AVIVEKAGPM TVTVGETCTL ECKVAGTPEL
SVEWYKDGKL LTSSQKHKFS FYNKISSLRI LSVERQDAGT YTFQVQNNVG KSSCTAVVDV
SDRAVPPSFT RRLKNTGGVL GASCILECKV AGSSPISVAW FHEKTKIVSG AKYQTTFSDN
VCTLQLNSLD SSDMGNYTCV AANVAGSDEC RAVLTVQEPP SFVKEPEPLE VLPGKNVTFT
SVIRGTPPFK VNWFRGAREL VKGDRCNIYF EDTVAELELF NIDISQSGEY TCVVSNNAGQ
ASCTTRLFVK EPAAFLKRLS DHSVEPGKSI ILESTYTGTL PISVTWKKDG FNITTSEKCN
IVTTEKTCIL EILNSTKRDA GQYSCEIENE AGRDVCGALV STLEPPYFVT ELEPLEAAVG
DSVSLQCQVA GTPEITVSWY KGDTKLRPTP EYRTYFTNNV ATLVFNKVNI NDSGEYTCKA
ENSIGTASSK TVFRIQERQL PPSFARQLKD IEQTVGLPVT LTCRLNGSAP IQVCWYRDGV
LLRDDENLQT SFVDNVATLK ILQTDLSHSG QYSCSASNPL GTASSSARLT AREPKKSPFF
DIKPVSIDVI AGESADFECH VTGAQPMRIT WSKDNKEIRP GGNYTITCVG NTPHLRILKV
GKGDSGQYTC QATNDVGKDM CSAQLSVKEP PKFVKKLEAS KVAKQGESIQ LECKISGSPE
IKVSWFRNDS ELHESWKYNM SFINSVALLT INEASAEDSG DYICEAHNGV GDASCSTALT
VKAPPVFTQK PSPVGALKGS DVILQCEISG TPPFEVVWVK DRKQVRNSKK FKITSKHFDT
SLHILNLEAS DVGEYHCKAT NEVGSDTCSC SVKFKEPPRF VKKLSDTSTL IGDAVELRAI
VEGFQPISVV WLKDRGEVIR ESENTRISFI DNIATLQLGS PEASNSGKYI CQIKNDAGMR
ECSAVLTVLE PARIIEKPEP MTVTTGNPFA LECVVTGTPE LSAKWFKDGR ELSADSKHHI
TFINKVASLK IPCAEMSDKG LYSFEVKNSV GKSNCTVSVH VSDRIVPPSF IRKLKDVNAI
LGASVVLECR VSGSAPISVG WFQDGNEIVS GPKCQSSFSE NVCTLNLSLL EPSDTGIYTC
VAANVAGSDE CSAVLTVQEP PSFEQTPDSV EVLPGMSLTF TSVIRGTPPF KVKWFKGSRE
LVPGESCNIS LEDFVTELEL FEVQPLESGD YSCLVTNDAG SASCTTHLFV KEPATFVKRL
ADFSVETGSP IVLEATYTGT PPISVSWIKD EYLISQSERC SITMTEKSTI LEILESTIED
YAQYSCLIEN EAGQDICEAL VSVLEPPYFI EPLEHVEAVI GEPATLQCKV DGTPEIRISW
YKEHTKLRSA PAYKMQFKNN VASLVINKVD HSDVGEYSCK ADNSVGAVAS SAVLVIKARK
LPPFFARKLK DVHETLGFPV AFECRINGSE PLQVSWYKDG VLLKDDANLQ TSFVHNVATL
QILQTDQSHI GQYNCSASNP LGTASSSAKL ILSEHEVPPF FDLKPVSVDL ALGESGTFKC
HVTGTAPIKI TWAKDNREIR PGGNYKMTLV ENTATLTVLK VGKGDAGQYT CYASNIAGKD
SCSAQLGVQE PPRFIKKLEP SRIVKQDEFT RYECKIGGSP EIKVLWYKDE TEIQESSKFR
MSFVDSVAVL EMHNLSVEDS GDYTCEAHNA AGSASSSTSL KVKEPPIFRK KPHPIETLKG
ADVHLECELQ GTPPFHVSWY KDKRELRSGK KYKIMSENFL TSIHILNVDA ADIGEYQCKA
TNDVGSDTCV GSIALKAPPR FVKKLSDIST VVGKEVQLQT TIEGAEPISV VWFKDKGEIV
RESDNIWISY SENIATLQFS RVEPANAGKY TCQIKNDAGM QECFATLSVL EPATIVEKPE
SIKVTTGDTC TLECTVAGTP ELSTKWFKDG KELTSDNKYK ISFFNKVSGL KIINVAPSDS
GVYSFEVQNP VGKDSCTASL QVSDRTVPPS FTRKLKETNG LSGSSVVMEC KVYGSPPISV
SWFHEGNEIS SGRKYQTTLT DNTCALTVNM LEESDSGDYT CIATNMAGSD ECSAPLTVRE
PPSFVQKPDP MDVLTGTNVT FTSIVKGTPP FSVSWFKGSS ELVPGDRCNV SLEDSVAELE
LFDVDTSQSG EYTCIVSNEA GKASCTTHLY IKAPAKFVKR LNDYSIEKGK PLILEGTFTG
TPPISVTWKK NGINVTPSQR CNITTTEKSA ILEIPSSTVE DAGQYNCYIE NASGKDSCSA
QILILEPPYF VKQLEPVKVS VGDSASLQCQ LAGTPEIGVS WYKGDTKLRP TTTYKMHFRN
NVATLVFNQV DINDSGEYIC KAENSVGEVS ASTFLTVQEQ KLPPSFSRQL RDVQETVGLP
VVFDCAISGS EPISVSWYKD GKPLKDSPNV QTSFLDNTAT LNIFKTDRSL AGQYSCTATN
PIGSASSSAR LILTEGKNPP FFDIRLAPVD AVVGESADFE CHVTGTQPIK VSWAKDSREI
RSGGKYQISY LENSAHLTVL KVDKGDSGQY TCYAVNEVGK DSCTAQLNIK ERLIPPSFTK
RLSETVEETE GNSFKLEGRV AGSQPITVAW YKNNIEIQPT SNCEITFKNN TLVLQVRKAG
MNDAGLYTCK VSNDAGSALC TSSIVIKEPK KPPVFDQHLT PVTVSEGEYV QLSCHVQGSE
PIRIQWLKAG REIKPSDRCS FSFASGTAVL ELRDVAKADS GDYVCKASNV AGSDTTKSKV
TIKDKPAVAP ATKKAAVDGR LFFVSEPQSI RVVEKTTATF IAKVGGDPIP NVKWTKGKWR
QLNQGGRVFI HQKGDEAKLE IRDTTKTDSG LYRCVAFNEH GEIESNVNLQ VDERKKQEKI
EGDLRAMLKK TPILKKGAGE EEEIDIMELL KNVDPKEYEK YARMYGITDF RGLLQAFELL
KQSQEEETHR LEIEEIERSE RDEKEFEELV SFIQQRLSQT EPVTLIKDIE NQTVLKDNDA
VFEIDIKINY PEIKLSWYKG TEKLEPSDKF EISIDGDRHT LRVKNCQLKD QGNYRLVCGP
HIASAKLTVI EPAWERHLQD VTLKEGQTCT MTCQFSVPNV KSEWFRNGRI LKPQGRHKTE
VEHKVHKLTI ADVRAEDQGQ YTCKYEDLET SAELRIEAEP IQFTKRIQNI VVSEHQSATF
ECEVSFDDAI VTWYKGPTEL TESQKYNFRN DGRCHYMTIH NVTPDDEGVY SVIARLEPRG
EARSTAELYL TTKEIKLELK PPDIPDSRVP IPTMPIRAVP PEEIPPVVAP PIPLLLPTPE
EKKPPPKRIE VTKKAVKKDA KKVVAKPKEM TPREEIVKKP PPPTTLIPAK APEIIDVSSK
AEEVKIMTIT RKKEVQKEKE AVYEKKQAVH KEKRVFIESF EEPYDELEVE PYTEPFEQPY
YEEPDEDYEE IKVEAKKEVH EEWEEDFEEG QEYYEREEGY DEGEEEWEEA YQEREVIQVQ
KEVYEESHER KVPAKVPEKK APPPPKVIKK PVIEKIEKTS RRMEEEKVQV TKVPEVSKKI
VPQKPSRTPV QEEVIEVKVP AVHTKKMVIS EEKMFFASHT EEEVSVTVPE VQKEIVTEEK
IHVAISKRVE PPPKVPELPE KPAPEEVAPV PIPKKVEPPA PKVPEVPKKP VPEEKKPVPV
PKKEPAAPPK VPEVPKKPVP EEKIPVPVAK KKEAPPAKVP EVQKGVVTEE KITIVTQREE
SPPPAVPEIP KKKVPEERKP VPRKEEEVPP PPKVPALPKK PVPEEKVAVP VPVAKKAPPP
RAEVSKKTVV EEKRFVAEEK LSFAVPQRVE VTRHEVSAEE EWSYSEEEEG VSISVYREEE
REEEEEAEVT EYEVMEEPEE YVVEEKLHII SKRVEAEPAE VTERQEKKIV LKPKIPAKIE
EPPPAKVPEA PKKIVPEKKV PAPVPKKEKV PPPKVPEEPK KPVPEKKVPP KVIKMEEPLP
AKVTERHMQI TQEEKVLVAV TKKEAPPKAR VPEEPKRAVP EEKVLKLKPK REEEPPAKVT
EFRKRVVKEE KVSIEAPKRE PQPIKEVTIM EEKERAYTLE EEAVSVQREE EYEEYEEYDY
KEFEEYEPTE EYDQYEEYEE REYERYEEHE EYITEPEKPI PVKPVPEEPV PTKPKAPPAK
VLKKAVPEEK VPVPIPKKLK PPPPKVPEEP KKVFEEKIRI SITKREKEQV TEPAAKVPMK
PKRVVAEEKV PVPRKEVAPP VRVPEVPKEL EPEEVAFEEE VVTHVEEYLV EEEEEYIHEE
EEFITEEEVV PVIPVKVPEV PRKPVPEEKK PVPVPKKKEA PPAKVPEVPK KPEEKVPVLI
PKKEKPPPAK VPEVPKKPVP EEKVPVPVPK KVEAPPAKVP EVPKKPVPEK KVPVPAPKKV
EAPPAKVPEV PKKLIPEEKK PTPVPKKVEA PPPKVPKKRE PVPVPVALPQ EEEVLFEEEI
VPEEEVLPEE EEVLPEEEEV LPEEEEVLPE EEEIPPEEEE VPPEEEYVPE EEEFVPEEEV
LPEVKPKVPV PAPVPEIKKK VTEKKVVIPK KEEAPPAKVP EVPKKVEEKR IILPKEEEVL
PVEVTEEPEE EPISEEEIPE EPPSIEEVEE VAPPRVPEVI KKAVPEAPTP VPKKVEAPPA
KVSKKIPEEK VPVPVQKKEA PPAKVPEVPK KVPEKKVLVP KKEAVPPAKG RTVLEEKVSV
AFRQEVVVKE RLELEVVEAE VEEIPEEEEF HEVEEYFEEG EFHEVEEFIK LEQHRVEEEH
RVEKVHRVIE VFEAEEVEVF EKPKAPPKGP EISEKIIPPK KPPTKVVPRK EPPAKVPEVP
KKIVVEEKVR VPEEPRVPPT KVPEVLPPKE VVPEKKVPVP PAKKPEAPPP KVPEAPKEVV
PEKKVPVPPP KKPEVPPTKV PEVPKAAVPE KKVPEAIPPK PESPPPEVPE APKEVVPEKK
VPAAPPKKPE VTPVKVPEAP KEVVPEKKVP VPPPKKPEVP PTKVPEVPKV AVPEKKVPEA
IPPKPESPPP EVFEEPEEVA LEEPPAEVVE EPEPAAPPQV TVPPKKPVPE KKAPAVVAKK
PELPPVKVPE VPKEVVPEKK VPLVVPKKPE APPAKVPEVP KEVVPEKKVA VPKKPEVPPA
KVPEVPKKPV LEEKPAVPVP ERAESPPPEV YEEPEEIAPE EEIAPEEEKP VPVAEEEEPE
VPPPAVPEEP KKIIPEKKVP VIKKPEAPPP KEPEPEKVIE KPKLKPRPPP PPPAPPKEDV
KEKIFQLKAI PKKKVPEKPQ VPEKVELTPL KVPGGEKKVR KLLPERKPEP KEEVVLKSVL
RKRPEEEEPK VEPKKLEKVK KPAVPEPPPP KPVEEVEVPT VTKRERKIPE PTKVPEIKPA
IPLPAPEPKP KPEAEVKTIK PPPVEPEPTP IAAPVTVPVV GKKAEAKAPK EEAAKPKGPI
KGVPKKTPSP IEAERRKLRP GSGGEKPPDE APFTYQLKAV PLKFVKEIKD IILTESEFVG
SSAIFECLVS PSTAITTWMK DGSNIRESPK HRFIADGKDR KLHIIDVQLS DAGEYTCVLR
LGNKEKTSTA KLVVEELPVR FVKTLEEEVT VVKGQPLYLS CELNKERDVV WRKDGKIVVE
KPGRIVPGVI GLMRALTIND ADDTDAGTYT VTVENANNLE CSSCVKVVEV IRDWLVKPIR
DQHVKPKGTA IFACDIAKDT PNIKWFKGYD EIPAEPNDKT EILRDGNHLY LKIKNAMPED
IAEYAVEIEG KRYPAKLTLG EREVELLKPI EDVTIYEKES ASFDAEISEA DIPGQWKLKG
ELLRPSPTCE IKAEGGKRFL TLHKVKLDQA GEVLYQALNA ITTAILTVKE IELDFAVPLK
DVTVPERRQA RFECVLTREA NVIWSKGPDI IKSSDKFDII ADGKKHILVI NDSQFDDEGV
YTAEVEGKKT SARLFVTGIR LKFMSPLEDQ TVKEGETATF VCELSHEKMH VVWFKNDAKL
HTSRTVLISS EGKTHKLEMK EVTLDDISQI KAQVKELSST AQLKVLEADP YFTVKLHDKT
AVEKDEITLK CEVSKDVPVK WFKDGEEIVP SPKYSIKADG LRRILKIKKA DLKDKGEYVC
DCGTDKTKAN VTVEARLIKV EKPLYGVEVF VGETAHFEIE LSEPDVHGQW KLKGQPLTAS
PDCEIIEDGK KHILILHNCQ LGMTGEVSFQ AANAKSAANL KVKELPLIFI TPLSDVKVFE
KDEAKFECEV SREPKTFRWL KGTQEITGDD RFELIKDGTK HSMVIKSAAF EDEAKYMFEA
EDKHTSGKLI IEGIRLKFLT PLKDVTAKEK ESAVFTVELS HDNIRVKWFK NDQRLHTTRS
VSMQDEGKTH SITFKDLSID DTSQIRVEAM GMSSEAKLTV LEGDPYFTGK LQDYTGVEKD
EVILQCEISK ADAPVKWFKD GKEIKPSKNA VIKADGKKRM LILKKALKSD IGQYTCDCGT
DKTSGKLDIE DREIKLVRPL HSVEVMETET ARFETEISED DIHANWKLKG EALLQTPDCE
IKEEGKIHSL VLHNCRLDQT GGVDFQAANV KSSAHLRVKP RVIGLLRPLK DVTVTAGETA
TFDCELSYED IPVEWYLKGK KLEPSDKVVP RSEGKVHTLT LRDVKLEDAG EVQLTAKDFK
THANLFVKEP PVEFTKPLED QTVEEGATAV LECEVSRENA KVKWFKNGTE ILKSKKYEIV
ADGRVRKLVI HDCTPEDIKT YTCDAKDFKT SCNLNVVPPH VEFLRPLTDL QVREKEMARF
ECELSRENAK VKWFKDGAEI KKGKKYDIIS KGAVRILVIN KCLLDDEAEY SCEVRTARTS
GMLTVLEEEA VFTKNLANIE VSETDTIKLV CEVSKPGAEV IWYKGDEEII ETGRYEILTE
GRKRILVIQN AHLEDAGNYN CRLPSSRTDG KVKVHELAAE FISKPQNLEI LEGEKAEFVC
SISKESFPVQ WKRDDKTLES GDKYDVIADG KKRVLVVKDA TLQDMGTYVV MVGAARAAAH
LTVIEKLRIV VPLKDTRVKE QQEVVFNCEV NTEGAKAKWF RNEEAIFDSS KYIILQKDLV
YTLRIRDAHL DDQANYNVSL TNHRGENVKS AANLIVEEED LRIVEPLKDI ETMEKKSVTF
WCKVNRLNVT LKWTKNGEEV PFDNRVSYRV DKYKHMLTIK DCGFPDEGEY IVTAGQDKSV
AELLIIEAPT EFVEHLEDQT VTEFDDAVFS CQLSREKANV KWYRNGREIK EGKKYKFEKD
GSIHRLIIKD CRLDDECEYA CGVEDRKSRA RLFVEEIPVE IIRPPQDILE APGADVVFLA
ELNKDKVEVQ WLRNNMVVVQ GDKHQMMSEG KIHRLQICDI KPRDQGEYRF IAKDKEARAK
LELAAAPKIK TADQDLVVDV GKPLTMVVPY DAYPKAEAEW FKENEPLSTK TIDTTAEQTS
FRILEAKKGD KGRYKIVLQN KHGKAEGFIN LKVIDVPGPV RNLEVTETFD GEVSLAWEEP
LTDGGSKIIG YVVERRDIKR KTWVLATDRA ESCEFTVTGL QKGGVEYLFR VSARNRVGTG
EPVETDNPVE ARSKYDVPGP PLNVTITDVN RFGVSLTWEP PEYDGGAEIT NYVIELRDKT
SIRWDTAMTV RAEDLSATVT DVVEGQEYSF RVRAQNRIGV GKPSAATPFV KVADPIERPS
PPVNLTSSDQ TQSSVQLKWE PPLKDGGSPI LGYIIERCEE GKDNWIRCNM KLVPELTYKV
TGLEKGNKYL YRVSAENKAG VSDPSEILGP LTADDAFVEP TMDLSAFKDG LEVIVPNPIT
ILVPSTGYPR PTATWCFGDK VLETGDRVKM KTLSAYAELV ISPSERSDKG IYTLKLENRV
KTISGEIDVN VIARPSAPKE LKFGDITKDS VHLTWEPPDD DGGSPLTGYV VEKREVSRKT
WTKVMDFVTD LEFTVPDLVQ GKEYLFKVCA RNKCGPGEPA YVDEPVNMST PATVPDPPEN
VKWRDRTANS IFLTWDPPKN DGGSRIKGYI VERCPRGSDK WVACGEPVAE TKMEVTGLEE
GKWYAYRVKA LNRQGASKPS RPTEEIQAVD TQEAPEIFLD VKLLAGLTVK AGTKIELPAT
VTGKPEPKIT WTKADMILKQ DKRITIENVP KKSTVTIVDS KRSDTGTYII EAVNVCGRAT
AVVEVNVLDK PGPPAAFDIT DVTNESCLLT WNPPRDDGGS KITNYVVERR ATDSEVWHKL
SSTVKDTNFK ATKLIPNKEY IFRVAAENMY GVGEPVQASP ITAKYQFDPP GPPTRLEPSD
ITKDAVTLTW CEPDDDGGSP ITGYWVERLD PDTDKWVRCN KMPVKDTTYR VKGLTNKKKY
RFRVLAENLA GPGKPSKSTE PILIKDPIDP PWPPGKPTVK DVGKTSVRLN WTKPEHDGGA
KIESYVIEML KTGTDEWVRV AEGVPTTQHL LPGLMEGQEY SFRVRAVNKA GESEPSEPSD
PVLCREKLYP PSPPRWLEVI NITKNTADLK WTVPEKDGGS PITNYIVEKR DVRRKGWQTV
DTTVKDTKCT VTPLTEGSLY VFRVAAENAI GQSDYTEIED SVLAKDTFTT PGPPYALAVV
DVTKRHVDLK WEPPKNDGGR PIQRYVIEKK ERLGTRWVKA GKTAGPDCNF RVTDVIEGTE
VQFQVRAENE AGVGHPSEPT EILSIEDPTS PPSPPLDLHV TDAGRKHIAI AWKPPEKNGG
SPIIGYHVEM CPVGTEKWMR VNSRPIKDLK FKVEEGVVPD KEYVLRVRAV NAIGVSEPSE
ISENVVAKDP DCKPTIDLET HDIIVIEGEK LSIPVPFRAV PVPTVSWHKD GKEVKASDRL
TMKNDHISAH LEVPKSVRAD AGIYTITLEN KLGSATASIN VKVIGLPGPC KDIKASDITK
SSCKLTWEPP EFDGGTPILH YVLERREAGR RTYIPVMSGE NKLSWTVKDL IPNGEYFFRV
KAVNKVGGGE YIELKNPVIA QDPKQPPDPP VDVEVHNPTA EAMTITWKPP LYDGGSKIMG
YIIEKIAKGE ERWKRCNEHL VPILTYTAKG LEEGKEYQFR VRAENAAGIS EPSRATPPTK
AVDPIDAPKV ILRTSLEVKR GDEIALDASI SGSPYPTITW IKDENVIVPE EIKKRAAPLV
RRRKGEVQEE EPFVLPLTQR LSIDNSKKGE SQLRVRDSLR PDHGLYMIKV ENDHGIAKAP
CTVSVLDTPG PPINFVFEDI RKTSVLCKWE PPLDDGGSEI INYTLEKKDK TKPDSEWIVV
TSTLRHCKYS VTKLIEGKEY LFRVRAENRF GPGPPCVSKP LVAKDPFGPP DAPDKPIVED
VTSNSMLVKW NEPKDNGSPI LGYWLEKREV NSTHWSRVNK SLLNALKANV DGLLEGLTYV
FRVCAENAAG PGKFSPPSDP KTAHDPISPP GPPIPRVTDT SSTTIELEWE PPAFNGGGEI
VGYFVDKQLV GTNEWSRCTE KMIKVRQYTV KEIREGADYK LRVSAVNAAG EGPPGETQPV
TVAEPQEPPA VELDVSVKGG IQIMAGKTLR IPAVVTGRPV PTKVWTKEEG ELDKDRVVID
NVGTKSELII KDALRKDHGR YVITATNSCG SKFAAARVEV FDVPGPVLDL KPVVTNRKMC
LLNWSDPEDD GGSEITGFII ERKDAKMHTW RQPIETERSK CDITGLLEGQ EYKFRVIAKN
KFGCGPPVEI GPILAVDPLG PPTSPERLTY TERTKSTITL DWKEPRSNGG SPIQGYIIEK
RRHDKPDFER VNKRLCPTTS FLVENLDEHQ MYEFRVKAVN EIGESEPSLP LNVVIQDDEV
PPTIKLRLSV RGDTIKVKAG EPVHIPADVT GLPMPKIEWS KNETVIEKPT DALQITKEEV
SRSEAKTELS IPKAVREDKG TYTVTASNRL GSVFRNVHVE VYDRPSPPRN LAVTDIKAES
CYLTWDAPLD NGGSEITHYV IDKRDASRKK AEWEEVTNTA VEKRYGIWKL IPNGQYEFRV
RAVNKYGISD ECKSDKVVIQ DPYRLPGPPG KPKVLARTKG SMLVSWTPPL DNGGSPITGY
WLEKREEGSP YWSRVSRAPI TKVGLKGVEF NVPRLLEGVK YQFRAMAINA AGIGPPSEPS
DPEVAGDPIF PPGPPSCPEV KDKTKSSISL GWKPPAKDGG SPIKGYIVEM QEEGTTDWKR
VNEPDKLITT CECVVPNLKE LRKYRFRVKA VNEAGESEPS DTTGEIPATD IQEEPEVFID
IGAQDCLVCK AGSQIRIPAV IKGRPTPKSS WEFDGKAKKA MKDGVHDIPE DAQLETAENS
SVIIIPECKR SHTGKYSITA KNKAGQKTAN CRVKVMDVPG PPKDLKVSDI TRGSCRLSWK
MPDDDGGDRI KGYVIEKRTI DGKAWTKVNP DCGSTTFVVP DLLSEQQYFF RVRAENRFGI
GPPVETIQRT TARDPIYPPD PPIKLKIGLI TKNTVHLSWK PPKNDGGSPV THYIVECLAW
DPTGTKKEAW RQCNKRDVEE LQFTVEDLVE GGEYEFRVKA VNAAGVSKPS ATVGPVTVKD
QTCPPSIDLK EFMEVEEGTN VNIVAKIKGV PFPTLTWFKA PPKKPDNKEP VLYDTHVNKL
VVDDTCTLVI PQSRRSDTGL YTITAVNNLG TASKEMRLNV LGRPGPPVGP IKFESVSADQ
MTLSWFPPKD DGGSKITNYV IEKREANRKT WVHVSSEPKE CTYTIPKLLE GHEYVFRIMA
QNKYGIGEPL DSEPETARNL FSVPGAPDKP TVSSVTRNSM TVNWEEPEYD GGSPVTGYWL
EMKDTTSKRW KRVNRDPIKA MTLGVSYKVT GLIEGSDYQF RVYAINAAGV GPASLPSDPA
TARDPIAPPG PPFPKVTDWT KSSADLEWSP PLKDGGSKVT GYIVEYKEEG KEEWEKGKDK
EVRGTKLVVT GLKEGAFYKF RVRAVNIAGI GEPGEVTDVI EMKDRLVSPD LQLDASVRDR
IVVHAGGVIR IIAYVSGKPP PTVTWNMNER TLPQEATIET TAISSSMVIK NCQRSHQGVY
SLLAKNEAGE RKKTIIVDVL DVPGPVGTPF LAHNLTNESC KLTWFSPEDD GGSPITNYVI
EKRESDRRAW TPVTYTVTRQ NATVQGLIQG KAYFFRIAAE NSIGMGPFVE TSEALVIREP
ITVPERPEDL EVKEVTKNTV TLTWNPPKYD GGSEIINYVL ESRLIGTEKF HKVTNDNLLS
RKYTVKGLKE GDTYEYRVSA VNIVGQGKPS FCTKPITCKD ELAPPTLHLD FRDKLTIRVG
EAFALTGRYS GKPKPKVSWF KDEADVLEDD RTHIKTTPAT LALEKIKAKR SDSGKYCVVV
ENSTGSRKGF CQVNVVDRPG PPVGPVSFDE VTKDYMVISW KPPLDDGGSK ITNYIIEKKE
VGKDVWMPVT SASAKTTCKV SKLLEGKDYI FRIHAENLYG ISDPLVSDSM KAKDRFRVPD
APDQPIVTEV TKDSALVTWN KPHDGGKPIT NYILEKRETM SKRWARVTKD PIHPYTKFRV
PDLLEGCQYE FRVSAENEIG IGDPSPPSKP VFAKDPIAKP SPPVNPEAID TTCNSVDLTW
QPPRHDGGSK ILGYIVEYQK VGDEEWRRAN HTPESCPETK YKVTGLRDGQ TYKFRVLAVN
AAGESDPAHV PEPVLVKDRL EPPELILDAN MAREQHIKVG DTLRLSAIIK GVPFPKVTWK
KEDRDAPTKA RIDVTPVGSK LEIRNAAHED GGIYSLTVEN PAGSKTVSVK VLVLDKPGPP
RDLEVSEIRK DSCYLTWKEP LDDGGSVITN YVVERRDVAS AQWSPLSATS KKKSHFAKHL
NEGNQYLFRV AAENQYGRGP FVETPKPIKA LDPLHPPGPP KDLHHVDVDK TEVSLVWNKP
DRDGGSPITG YLVEYQEEGT QDWIKFKTVT NLECVVTGLQ QGKTYRFRVK AENIVGLGLP
DTTIPIECQE KLVPPSVELD VKLIEGLVVK AGTTVRFPAI IRGVPVPTAK WTTDGSEIKT
DEHYTVETDN FSSVLTIKNC LRRDTGEYQI TVSNAAGSKT VAVHLTVLDV PGPPTGPINI
LDVTPEHMTI SWQPPKDDGG SPVINYIVEK QDTRKDTWGV VSSGSSKTKL KIPHLQKGCE
YVFRVRAENK IGVGPPLDST PTVAKHKFSP PSPPGKPVVT DITENAATVS WTLPKSDGGS
PITGYYMERR EVTGKWVRVN KTPIADLKFR VTGLYEGNTY EFRVFAENLA GLSKPSPSSD
PIKACRPIKP PGPPINPKLK DKSRETADLV WTKPLSDGGS PILGYVVECQ KPGTAQWNRI
NKDELIRQCA FRVPGLIEGN EYRFRIKAAN IVGEGEPREL AESVIAKDIL HPPEVELDVT
CRDVITVRVG QTIRILARVK GRPEPDITWT KEGKVLVREK RVDLIQDLPR VELQIKEAVR
ADHGKYIISA KNSSGHAQGS AIVNVLDRPG PCQNLKVTNV TKENCTISWE NPLDNGGSEI
TNFIVEYRKP NQKGWSIVAS DVTKRLIKAN LLANNEYYFR VCAENKVGVG PTIETKTPIL
AINPIDRPGE PENLHIADKG KTFVYLKWRR PDYDGGSPNL SYHVERRLKG SDDWERVHKG
SIKETHYMVD RCVENQIYEF RVQTKNEGGE SDWVKTEEVV VKEDLQKPVL DLKLSGVLTV
KAGDTIRLEA GVRGKPFPEV AWTKDKDATD LTRSPRVKID TRADSSKFSL TKAKRSDGGK
YVVTATNTAG SFVAYATVNV LDKPGPVRNL KIVDVSSDRC TVCWDPPEDD GGCEIQNYIL
EKCETKRMVW STYSATVLTP GTTVTRLIEG NEYIFRVRAE NKIGTGPPTE SKPVIAKTKY
DKPGRPDPPE VTKVSKEEMT VVWNPPEYDG GKSITGYFLE KKEKHSTRWV PVNKSAIPER
RMKVQNLLPD HEYQFRVKAE NEIGIGEPSL PSRPVVAKDP IEPPGPPTNF RVVDTTKHSI
TLGWGKPVYD GGAPIIGYVV EMRPKIADAS PDEGWKRCNA AAQLVRKEFT VTSLDENQEY
EFRVCAQNQV GIGRPAELKE AIKPKEILEP PEIDLDASMR KLVIVRAGCP IRLFAIVRGR
PAPKVTWRKV GIDNVVRKGQ VDLVDTMAFL VIPNSTRDDS GKYSLTLVNP AGEKAVFVNV
RVLDTPGPVS DLKVSDVTKT SCHVSWAPPE NDGGSQVTHY IVEKREADRK TWSTVTPEVK
KTSFHVTNLV PGNEYYFRVT AVNEYGPGVP TDVPKPVLAS DPLSEPDPPR KLEVTEMTKN
SATLAWLPPL RDGGAKIDGY ITSYREEEQP ADRWTEYSVV KDLSLVVTGL KEGKKYKFRV
AARNAVGVSL PREAEGVYEA KEQLLPPKIL MPEQITIKAG KKLRIEAHVY GKPHPTCKWK
KGEDEVVTSS HLAVHKADSS SILIIKDVTR KDSGYYSLTA ENSSGTDTQK IKVVVMDAPG
PPQPPFDISD IDADACSLSW HIPLEDGGSN ITNYIVEKCD VSRGDWVTAL ASVTKTSCRV
GKLIPGQEYI FRVRAENRFG ISEPLTSPKM VAQFPFGVPS EPKNARVTKV NKDCIFVAWD
RPDSDGGSPI IGYLIERKER NSLLWVKAND TLVRSTEYPC AGLVEGLEYS FRIYALNKAG
SSPPSKPTEY VTARMPVDPP GKPEVIDVTK STVSLIWARP KHDGGSKIIG YFVEACKLPG
DKWVRCNTAP HQIPQEEYTA TGLEEKAQYQ FRAIARTAVN ISPPSEPSDP VTILAENVPP
RIDLSVAMKS LLTVKAGTNV CLDATVFGKP MPTVSWKKDG TLLKPAEGIK MAMQRNLCTL
ELFSVNRKDS GDYTITAENS SGSKSATIKL KVLDKPGPPA SVKINKMYSD RAMLSWEPPL
EDGGSEITNY IVDKRETSRP NWAQVSATVP ITSCSVEKLI EGHEYQFRIC AENKYGVGDP
VFTEPAIAKN PYDPPGRCDP PVISNITKDH MTVSWKPPAD DGGSPITGYL LEKRETQAVN
WTKVNRKPII ERTLKATGLQ EGTEYEFRVT AINKAGPGKP SDASKAAYAR DPQYPPGPPA
FPKVYDTTRS SVSLSWGKPA YDGGSPIIGY LVEVKRADSD NWVRCNLPQN LQKTRFEVTG
LMEDTQYQFR VYAVNKIGYS DPSDVPDKHY PKDILIPPEG ELDADLRKTL ILRAGVTMRL
YVPVKGRPPP KITWSKPNVN LRDRIGLDIK STDFDTFLRC ENVNKYDAGK YILTLENSCG
KKEYTIVVKV LDTPGPPVNV TVKEISKDSA YVTWEPPIID GGSPIINYVV QKRDAERKSW
STVTTECSKT SFRVANLEEG KSYFFRVFAE NEYGIGDPGE TRDAVKASQT PGPVVDLKVR
SVSKSSCSIG WKKPHSDGGS RIIGYVVDFL TEENKWQRVM KSLSLQYSAK DLTEGKEYTF
RVSAENENGE GTPSEITVVA RDDVVAPDLD LKGLPDLCYL AKENSNFRLK IPIKGKPAPS
VSWKKGEDPL ATDTRVSVES SAVNTTLIVY DCQKSDAGKY TITLKNVAGT KEGTISIKVV
GKPGIPTGPI KFDEVTAEAM TLKWAPPKDD GGSEITNYIL EKRDSVNNKW VTCASAVQKT
TFRVTRLHEG MEYTFRVSAE NKYGVGEGLK SEPIVARHPF DVPDAPPPPN IVDVRHDSVS
LTWTDPKKTG GSPITGYHLE FKERNSLLWK RANKTPIRMR DFKVTGLTEG LEYEFRVMAI
NLAGVGKPSL PSEPVVALDP IDPPGKPEVI NITRNSVTLI WTEPKYDGGH KLTGYIVEKR
DLPSKSWMKA NHVNVPECAF TVTDLVEGGK YEFRIRAKNT AGAISAPSES TETIICKDEY
EAPTIVLDPT IKDGLTIKAG DTIVLNAISI LGKPLPKSSW SKAGKDIRPS DITQITSTPT
SSMLTIKYAT RKDAGEYTIT ATNPFGTKVE HVKVTVLDVP GPPGPVEISN VSAEKATLTW
TPPLEDGGSP IKSYILEKRE TSRLLWTVVS EDIQSCRHVA TKLIQGNEYI FRVSAVNHYG
KGEPVQSEPV KMVDRFGPPG PPEKPEVSNV TKNTATVSWK RPVDDGGSEI TGYHVERREK
KSLRWVRAIK TPVSDLRCKV TGLQEGSTYE FRVSAENRAG IGPPSEASDS VLMKDAAYPP
GPPSNPHVTD TTKKSASLAW GKPHYDGGLE ITGYVVEHQK VGDEAWIKDT TGTALRITQF
VVPDLQTKEK YNFRISAIND AGVGEPAVIP DVEIVEREMA PDFELDAELR RTLVVRAGLS
IRIFVPIKGR PAPEVTWTKD NINLKNRANI ENTESFTLLI IPECNRYDTG KFVMTIENPA
GKKSGFVNVR VLDTPGPVLN LRPTDITKDS VTLHWDLPLI DGGSRITNYI VEKREATRKS
YSTATTKCHK CTYKVTGLSE GCEYFFRVMA ENEYGIGEPT ETTEPVKASE APSPPDSLNI
MDITKSTVSL AWPKPKHDGG SKITGYVIEA QRKGSDQWTH ITTVKGLECV VRNLTEGEEY
TFQVMAVNSA GRSAPRESRP VIVKEQTMLP ELDLRGIYQK LVIAKAGDNI KVEIPVLGRP
KPTVTWKKGD QILKQTQRVN FETTATSTIL NINECVRSDS GPYPLTARNI VGEVGDVITI
QVHDIPGPPT GPIKFDEVSS DFVTFSWDPP ENDGGVPISN YVVEMRQTDS TTWVELATTV
IRTTYKATRL TTGLEYQFRV KAQNRYGVGP GITSACIVAN YPFKVPGPPG TPQVTAVTKD
SMTISWHEPL SDGGSPILGY HVERKERNGI LWQTVSKALV PGNIFKSSGL TDGIAYEFRV
IAENMAGKSK PSKPSEPMLA LDPIDPPGKP VPLNITRHTV TLKWAKPEYT GGFKITSYIV
EKRDLPNGRW LKANFSNILE NEFTVSGLTE DAAYEFRVIA KNAAGAISPP SEPSDAITCR
DDVEAPKIKV DVKFKDTVIL KAGEAFRLEA DVSGRPPPTM EWSKDGKELE GTAKLEIKIA
DFSTNLVNKD STRRDSGAYT LTATNPGGFA KHIFNVKVLD RPGPPEGPLA VTEVTSEKCV
LSWFPPLDDG GAKIDHYIVQ KRETSRLAWT NVASEVQVTK LKVTKLLKGN EYIFRVMAVN
KYGVGEPLES EPVLAVNPYG PPDPPKNPEV TTITKDSMVV CWGHPDSDGG SEIINYIVER
RDKAGQRWIK CNKKTLTDLR YKVSGLTEGH EYEFRIMAEN AAGISAPSPT SPFYKACDTV
FKPGPPGNPR VLDTSRSSIS IAWNKPIYDG GSEITGYMVE IALPEEDEWQ IVTPPAGLKA
TSYTITGLTE NQEYKIRIYA MNSEGLGEPA LVPGTPKAED RMLPPEIELD ADLRKVVTIR
ACCTLRLFVP IKGRPAPEVK WARDHGESLD KASIESTSSY TLLIVGNVNR FDSGKYILTV
ENSSGSKSAF VNVRVLDTPG PPQDLKVKEV TKTSVTLTWD PPLLDGGSKI KNYIVEKRES
TRKAYSTVAT NCHKTSWKVD QLQEGCSYYF RVLAENEYGI GLPAETAESV KASERPLPPG
KITLMDVTRN SVSLSWEKPE HDGGSRILGY IVEMQTKGSD KWATCATVKV TEATITGLIQ
GEEYSFRVSA QNEKGISDPR QLSVPVIAKD LVIPPAFKLL FNTFTVLAGE DLKVDVPFIG
RPTPAVTWHK DNVPLKQTTR VNAESTENNS LLTIKDACRE DVGHYVVKLT NSAGEAIETL
NVIVLDKPGP PTGPVKMDEV TADSITLSWG PPKYDGGSSI NNYIVEKRDT STTTWQIVSA
TVARTTIKAC RLKTGCEYQF RIAAENRYGK STYLNSEPTV AQYPFKVPGP PGTPVVTLSS
RDSMEVQWNE PISDGGSRVI GYHLERKERN SILWVKLNKT PIPQTKFKTT GLEEGVEYEF
RVSAENIVGI GKPSKVSECY VARDPCDPPG RPEAIIVTRN SVTLQWKKPT YDGGSKITGY
IVEKKELPEG RWMKASFTNI IDTHFEVTGL VEDHRYEFRV IARNAAGVFS EPSESTGAIT
ARDEVDPPRI SMDPKYKDTI VVHAGESFKV DADIYGKPIP TIQWIKGDQE LSNTARLEIK
STDFATSLSV KDAVRVDSGN YILKAKNVAG ERSVTVNVKV LDRPGPPEGP VVISGVTAEK
CTLAWKPPLQ DGGSDIINYI VERRETSRLV WTVVDANVQT LSCKVTKLLE GNEYTFRIMA
VNKYGVGEPL ESEPVVAKNP FVVPDAPKAP EVTTVTKDSM IVVWERPASD GGSEILGYVL
EKRDKEGIRW TRCHKRLIGE LRLRVTGLIE NHDYEFRVSA ENAAGLSEPS PPSAYQKACD
PIYKPGPPNN PKVIDITRSS VFLSWSKPIY DGGCEIQGYI VEKCDVSVGE WTMCTPPTGI
NKTNIEVEKL LEKHEYNFRI CAINKAGVGE HADVPGPIIV EEKLEAPDID LDLELRKIIN
IRAGGSLRLF VPIKGRPTPE VKWGKVDGEI RDAAIIDVTS SFTSLVLDNV NRYDSGKYTL
TLENSSGTKS AFVTVRVLDT PSPPVNLKVT EITKDSVSIT WEPPLLDGGS KIKNYIVEKR
EATRKSYAAV VTNCHKNSWK IDQLQEGCSY YFRVTAENEY GIGLPAQTAD PIKVAEVPQP
PGKITVDDVT RNSVSLSWTK PEHDGGSKII QYIVEMQAKH SEKWSECARV KSLQAVITNL
TQGEEYLFRV VAVNEKGRSD PRSLAVPIVA KDLVIEPDVK PAFSSYSVQV GQDLKIEVPI
SGRPKPTITW TKDGLPLKQT TRINVTDSLD LTTLSIKETH KDDGGQYGIT VANVVGQKTA
SIEIVTLDKP DPPKGPVKFD DVSAESITLS WNPPLYTGGC QITNYIVQKR DTTTTVWDVV
SATVARTTLK VTKLKTGTEY QFRIFAENRY GQSFALESDP IVAQYPYKEP GPPGTPFATA
ISKDSMVIQW HEPVNNGGSP VIGYHLERKE RNSILWTKVN KTIIHDTQFK AQNLEEGIEY
EFRVYAENIV GVGKASKNSE CYVARDPCDP PGTPEPIMVK RNEITLQWTK PVYDGGSMIT
GYIVEKRDLP DGRWMKASFT NVIETQFTVS GLTEDQRYEF RVIAKNAAGA ISKPSDSTGP
ITAKDEVELP RISMDPKFRD TIVVNAGETF RLEADVHGKP LPTIEWLRGD KEIEESARCE
IKNTDFKALL IVKDAIRIDG GQYILRASNV AGSKSFPVNV KVLDRPGPPE GPVQVTGVTS
EKCSLTWSPP LQDGGSDISH YVVEKRETSR LAWTVVASEV VTNSLKVTKL LEGNEYVFRI
MAVNKYGVGE PLESAPVLMK NPFVLPGPPK SLEVTNIAKD SMTVCWNRPD SDGGSEIIGY
IVEKRDRSGI RWIKCNKRRI TDLRLRVTGL TEDHEYEFRV SAENAAGVGE PSPATVYYKA
CDPVFKPGPP TNAHIVDTTK NSITLAWGKP IYDGGSEILG YVVEICKADE EEWQIVTPQT
GLRVTRFEIS KLTEHQEYKI RVCALNKVGL GEATSVPGTV KPEDKLEAPE LDLDSELRKG
IVVRAGGSAR IHIPFKGRPT PEITWSREEG EFTDKVQIEK GVNYTQLSID NCDRNDAGKY
ILKLENSSGS KSAFVTVKVL DTPGPPQNLA VKEVRKDSAF LVWEPPIIDG GAKVKNYVID
KRESTRKAYA NVSSKCSKTS FKVENLTEGA IYYFRVMAEN EFGVGVPVET VDAVKAAEPP
SPPGKVTLTD VSQTSASLMW EKPEHDGGSR VLGYVVEMQP KGTEKWSIVA ESKVCNAVVT
GLSSGQEYQF RVKAYNEKGK SDPRVLGVPV IAKDLTIQPS LKLPFNTYSI QAGEDLKIEI
PVIGRPRPNI SWVKDGEPLK QTTRVNVEET ATSTVLHIKE GNKDDFGKYT VTATNSAGTA
TENLSVIVLE KPGPPVGPVR FDEVSADFVV ISWEPPAYTG GCQISNYIVE KRDTTTTTWH
MVSATVARTT IKITKLKTGT EYQFRIFAEN RYGKSAPLDS KAVIVQYPFK EPGPPGTPFV
TSISKDQMLV QWHEPVNDGG TKIIGYHLEQ KEKNSILWVK LNKTPIQDTK FKTTGLDEGL
EYEFKVSAEN IVGIGKPSKV SECFVARDPC DPPGRPEAIV ITRNNVTLKW KKPAYDGGSK
ITGYIVEKKD LPDGRWMKAS FTNVLETEFT VSGLVEDQRY EFRVIARNAA GNFSEPSDSS
GAITARDEID APNASLDPKY KDVIVVHAGE TFVLEADIRG KPIPDVVWSK DGKELEETAA
RMEIKSTIQK TTLVVKDCIR TDGGQYILKL SNVGGTKSIP ITVKVLDRPG PPEGPLKVTG
VTAEKCYLAW NPPLQDGGAN ISHYIIEKRE TSRLSWTQVS TEVQALNYKV TKLLPGNEYI
FRVMAVNKYG IGEPLESGPV TACNPYKPPG PPSTPEVSAI TKDSMVVTWA RPVDDGGTEI
EGYILEKRDK EGVRWTKCNK KTLTDLRLRV TGLTEGHSYE FRVAAENAAG VGEPSEPSVF
YRACDALYPP GPPSNPKVTD TSRSSVSLAW SKPIYDGGAP VKGYVVEVKE AAADEWTTCT
PPTGLQGKQF TVTKLKENTE YNFRICAINS EGVGEPATLP GSVVAQERIE PPEIELDADL
RKVVVLRASA TLRLFVTIKG RPEPEVKWEK AEGILTDRAQ IEVTSSFTML VIDNVTRFDS
GRYNLTLENN SGSKTAFVNV RVLDSPSAPV NLTIREVKKD SVTLSWEPPL IDGGAKITNY
IVEKRETTRK AYATITNNCT KTTFRIENLQ EGCSYYFRVL ASNEYGIGLP AETTEPVKVS
EPPLPPGRVT LVDVTRNTAT IKWEKPESDG GSKITGYVVE MQTKGSEKWS TCTQVKTLEA
TISGLTAGEE YVFRVAAVNE KGRSDPRQLG VPVIARDIEI KPSVELPFHT FNVKAREQLK
IDVPFKGRPQ ATVNWRKDGQ TLKETTRVNV SSSKTVTSLS IKEASKEDVG TYELCVSNSA
GSITVPITII VLDRPGPPGP IRIDEVSCDS ITISWNPPEY DGGCQISNYI VEKKETTSTT
WHIVSQAVAR TSIKIVRLTT GSEYQFRVCA ENRYGKSSYS ESSAVVAEYP FSPPGPPGTP
KVVHATKSTM LVTWQVPVND GGSRVIGYHL EYKERSSILW SKANKILIAD TQMKVSGLDE
GLMYEYRVYA ENIAGIGKCS KSCEPVPARD PCDPPGQPEV TNITRKSVSL KWSKPHYDGG
AKITGYIVER RELPDGRWLK CNYTNIQETY FEVTELTEDQ RYEFRVFARN AADSVSEPSE
STGPIIVKDD VEPPRVMMDV KFRDVIVVKA GEVLKINADI AGRPLPVISW AKDGIEIEER
ARTEIISTDN HTLLTVKDCI RRDTGQYVLT LKNVAGTRSV AVNCKVLDKP GPPAGPLEIN
GLTAEKCSLS WGRPQEDGGA DIDYYIVEKR ETSHLAWTIC EGELQMTSCK VTKLLKGNEY
IFRVTGVNKY GVGEPLESVA IKALDPFTVP SPPTSLEITS VTKESMTLCW SRPESDGGSE
ISGYIIERRE KNSLRWVRVN KKPVYDLRVK STGLREGCEY EYRVYAENAA GLSLPSETSP
LIRAEDPVFL PSPPSKPKIV DSGKTTITIA WVKPLFDGGA PITGYTVEYK KSDDTDWKTS
IQSLRGTEYT ISGLTTGAEY VFRVKSVNKV GASDPSDSSD PQIAKEREEE PLFDIDSEMR
KTLIVKAGAS FTMTVPFRGR PVPNVLWSKP DTDLRTRAYV DTTDSRTSLT IENANRNDSG
KYTLTIQNVL SAASLTLVVK VLDTPGPPTN ITVQDVTKES AVLSWDVPEN DGGAPVKNYH
IEKREASKKA WVSVTNNCNR LSYKVTNLQE GAIYYFRVSG ENEFGVGIPA ETKEGVKITE
KPSPPEKLGV TSISKDSVSL TWLKPEHDGG SRIVHYVVEA LEKGQKNWVK CAVAKSTHHV
VSGLRENSEY FFRVFAENQA GLSDPRELLL PVLIKEQLEP PEIDMKNFPS HTVYVRAGSN
LKVDIPISGK PLPKVTLSRD GVPLKATMRF NTEITAENLT INLKESVTAD AGRYEITAAN
SSGTTKAFIN IVVLDRPGPP TGPVVISDIT EESVTLKWEP PKYDGGSQVT NYILLKRETS
TAVWTEVSAT VARTMMKVMK LTTGEEYQFR IKAENRFGIS DHIDSACVTV KLPYTTPGPP
STPWVTNVTR ESITVGWHEP VSNGGSAVVG YHLEMKDRNS ILWQKANKLV IRTTHFKVTT
ISAGLIYEFR VYAENAAGVG KPSHPSEPVL AIDACEPPRN VRITDISKNS VSLSWQQPAF
DGGSKITGYI VERRDLPDGR WTKASFTNVT ETQFIISGLT QNSQYEFRVF ARNAVGSISN
PSEVVGPITC IDSYGGPVID LPLEYTEVVK YRAGTSVKLR AGISGKPAPT IEWYKDDKEL
QTNALVCVEN TTDLASILIK DADRLNSGCY ELKLRNAMGS ASATIRVQIL DKPGPPGGPI
EFKTVTAEKI TLLWRPPADD GGAKITHYIV EKRETSRVVW SMVSEHLEEC IITTTKIIKG
NEYIFRVRAV NKYGIGEPLE SDSVVAKNAF VTPGPPGIPE VTKITKNSMT VVWSRPIADG
GSDISGYFLE KRDKKSLGWF KVLKETIRDT RQKVTGLTEN SDYQYRVCAV NAAGQGPFSE
PSEFYKAADP IDPPGPPAKI RIADSTKSSI TLGWSKPVYD GGSAVTGYVV EIRQGEEEEW
TTVSTKGEVR TTEYVVSNLK PGVNYYFRVS AVNCAGQGEP IEMNEPVQAK DILEAPEIDL
DVALRTSVIA KAGEDVQVLI PFKGRPPPTV TWRKDEKNLG SDARYSIENT DSSSLLTIPQ
VTRNDTGKYI LTIENGVGEP KSSTVSVKVL DTPAACQKLQ VKHVSRGTVT LLWDPPLIDG
GSPIINYVIE KRDATKRTWS VVSHKCSSTS FKLIDLSEKT PFFFRVLAEN EIGIGEPCET
TEPVKAAEVP APIRDLSMKD STKTSVILSW TKPDFDGGSV ITEYVVERKG KGEQTWSHAG
ISKTCEIEVS QLKEQSVLEF RVFAKNEKGL SDPVTIGPIT VKELIITPEV DLSDIPGAQV
TVRIGHNVHL ELPYKGKPKP SISWLKDGLP LKESEFVRFS KTENKITLSI KNAKKEHGGK
YTVILDNAVC RIAVPITVIT LGPPSKPKGP IRFDEIKADS VILSWDVPED NGGGEITCYS
IEKRETSQTN WKMVCSSVAR TTFKVPNLVK DAEYQFRVRA ENRYGVSQPL VSSIIVAKHQ
FRIPGPPGKP VIYNVTSDGM SLTWDAPVYD GGSEVTGFHV EKKERNSILW QKVNTSPISG
REYRATGLVE GLDYQFRVYA ENSAGLSSPS DPSKFTLAVS PVDPPGTPDY IDVTRETITL
KWNPPLRDGG SKIVGYSIEK RQGNERWVRC NFTDVSECQY TVTGLSPGDR YEFRIIARNA
VGTISPPSQS SGIIMTRDEN VPPIVEFGPE YFDGLIIKSG ESLRIKALVQ GRPVPRVTWF
KDGVEIEKRM NMEITDVLGS TSLFVRDATR DHRGVYTVEA KNASGSAKAE IKVKVQDTPG
KVVGPIRFTN ITGEKMTLWW DAPLNDGCAP ITHYIIEKRE TSRLAWALIE DKCEAQSYTA
IKLINGNEYQ FRVSAVNKFG VGRPLDSDPV VAQIQYTVPD APGIPEPSNI TGNSITLTWA
RPESDGGSEI QQYILERREK KSTRWVKVIS KRPISETRFK VTGLTEGNEY EFHVMAENAA
GVGPASGISR LIKCREPVNP PGPPTVVKVT DTSKTTVSLE WSKPVFDGGM EIIGYIIEMC
KADLGDWHKV NAEACVKTRY TVTDLQAGEE YKFRVSAING AGKGDSCEVT GTIKAVDRLT
APELDIDANF KQTHVVRAGA SIRLFIAYQG RPTPTAVWSK PDSNLSLRAD IHTTDSFSTL
TVENCNRNDA GKYTLTVENN SGSKSITFTV KVLDTPGPPG PITFKDVTRG SATLMWDAPL
LDGGARIHHY VVEKREASRR SWQVISEKCT RQIFKVNDLA EGVPYYFRVS AVNEYGVGEP
YEMPEPIVAT EQPAPPRRLD VVDTSKSSAV LAWLKPDHDG GSRITGYLLE MRQKGSDFWV
EAGHTKQLTF TVERLVEKTE YEFRVKAKND AGYSEPREAF SSVIIKEPQI EPTADLTGIT
NQLITCKAGS PFTIDVPISG RPAPKVTWKL EEMRLKETDR VSITTTKDRT TLTVKDSMRG
DSGRYFLTLE NTAGVKTFSV TVVVIGRPGP VTGPIEVSSV SAESCVLSWG EPKDGGGTEI
TNYIVEKRES GTTAWQLVNS SVKRTQIKVT HLTKYMEYSF RVSSENRFGV SKPLESAPII
AEHPFVPPSA PTRPEVYHVS ANAMSIRWEE PYHDGGSKII GYWVEKKERN TILWVKENKV
PCLECNYKVT GLVEGLEYQF RTYALNAAGV SKASEASRPI MAQNPVDAPG RPEVTDVTRS
TVSLIWSAPA YDGGSKVVGY IIERKPVSEV GDGRWLKCNY TIVSDNFFTV TALSEGDTYE
FRVLAKNAAG VISKGSESTG PVTCRDEYAP PKAELDARLH GDLVTIRAGS DLVLDAAVGG
KPEPKIIWTK GDKELDLCEK VSLQYTGKRA TAVIKFCDRS DSGKYTLTVK NASGTKAVSV
MVKVLDSPGP CGKLTVSRVT QEKCTLAWSL PQEDGGAEIT HYIVERRETS RLNWVIVEGE
CPTLSYVVTR LIKNNEYIFR VRAVNKYGPG VPVESEPIVA RNSFTIPSPP GIPEEVGTGK
EHIIIQWTKP ESDGGNEISN YLVDKREKKS LRWTRVNKDY VVYDTRLKVT SLMEGCDYQF
RVTAVNAAGN SEPSEASNFI SCREPSYTPG PPSAPRVVDT TKHSISLAWT KPMYDGGTDI
VGYVLEMQEK DTDQWYRVHT NATIRNTEFT VPDLKMGQKY SFRVAAVNVK GMSEYSESIA
EIEPVERIEI PDLELADDLK KTVTIRAGAS LRLMVSVSGR PPPVITWSKQ GIDLASRAII
DTTESYSLLI VDKVNRYDAG KYTIEAENQS GKKSATVLVK VYDTPGPCPS VKVKEVSRDS
VTITWEIPTI DGGAPVNNYI VEKREAAMRA FKTVTTKCSK TLYRISGLVE GTMYYFRVLP
ENIYGIGEPC ETSDAVLVSE VPLVPAKLEV VDVTKSTVTL AWEKPLYDGG SRLTGYVLEA
CKAGTERWMK VVTLKPTVLE HTVTSLNEGE QYLFRIRAQN EKGVSEPRET VTAVTVQDLR
VLPTIDLSTM PQKTIHVPAG RPVELVIPIA GRPPPAASWF FAGSKLRESE RVTVETHTKV
AKLTIRETTI RDTGEYTLEL KNVTGTTSET IKVIILDKPG PPTGPIKIDE IDATSITISW
EPPELDGGAP LSGYVVEQRD AHRPGWLPVS ESVTRSTFKF TRLTEGNEYV FRVAATNRFG
IGSYLQSEVI ECRSSIRIPG PPETLQIFDV SRDGMTLTWY PPEDDGGSQV TGYIVERKEV
RADRWVRVNK VPVTMTRYRS TGLTEGLEYE HRVTAINARG SGKPSRPSKP IVAMDPIAPP
GKPQNPRVTD TTRTSVSLAW SVPEDEGGSK VTGYLIEMQK VDQHEWTKCN TTPTKIREYT
LTHLPQGAEY RFRVLACNAG GPGEPAEVPG TVKVTEMLEY PDYELDERYQ EGIFVRQGGV
IRLTIPIKGK PFPICKWTKE GQDISKRAMI ATSETHTELV IKEADRGDSG TYDLVLENKC
GKKAVYIKVR VIGSPNSPEG PLEYDDIQVR SVRVSWRPPA DDGGADILGY ILERREVPKA
AWYTIDSRVR GTSLVVKGLK ENVEYHFRVS AENQFGISKP LKSEEPVTPK TPLNPPEPPS
NPPEVLDVTK SSVSLSWSRP KDDGGSRVTG YYIERKETST DKWVRHNKTQ ITTTMYTVTG
LVPDAEYQFR IIAQNDVGLS ETSPASEPVV CKDPFDKPSQ PGELEILSIS KDSVTLQWEK
PECDGGKEIL GYWVEYRQSG DSAWKKSNKE RIKDKQFTIG GLLEATEYEF RVFAENETGL
SRPRRTAMSI KTKLTSGEAP GIRKEMKDVT TKLGEAAQLS CQIVGRPLPD IKWYRFGKEL
IQSRKYKMSS DGRTHTLTVM TEEQEDEGVY TCIATNEVGE VETSSKLLLQ ATPQFHPGYP
LKEKYYGAVG STLRLHVMYI GRPVPAMTWF HGQKLLQNSE NITIENTEHY THLVMKNVQR
KTHAGKYKVQ LSNVFGTVDA ILDVEIQDKP DKPTGPIVIE ALLKNSAVIS WKPPADDGGS
WITNYVVEKC EAKEGAEWQL VSSAISVTTC RIVNLTENAG YYFRVSAQNT FGISDPLEVS
SVVIIKSPFE KPGAPGKPTI TAVTKDSCVV AWKPPASDGG AKIRNYYLEK REKKQNKWIS
VTTEEIRETV FSVKNLIEGL EYEFRVKCEN LGGESEWSEI SEPITPKSDV PIQAPHFKEE
LRNLNVRYQS NATLVCKVTG HPKPIVKWYR QGKEIIADGL KYRIQEFKGG YHQLIIASVT
DDDATVYQVR ATNQGGSVSG TASLEVEVPA KIHLPKTLEG MGAVHALRGE VVSIKIPFSG
KPDPVITWQK GQDLIDNNGH YQVIVTRSFT SLVFPNGVER KDAGFYVVCA KNRFGIDQKT
VELDVADVPD PPRGVKVSDV SRDSVNLTWT EPASDGGSKI TNYIVEKCAT TAERWLRVGQ
ARETRYTVIN LFGKTSYQFR VIAENKFGLS KPSEPSEPTI TKEDKTRAMN YDEEVDETRE
VSMTKASHSS TKELYEKYMI AEDLGRGEFG IVHRCVETSS KKTYMAKFVK VKGTDQVLVK
KEISILNIAR HRNILHLHES FESMEELVMI FEFISGLDIF ERINTSAFEL NEREIVSYVH
QVCEALQFLH SHNIGHFDIR PENIIYQTRR SSTIKIIEFG QARQLKPGDN FRLLFTAPEY
YAPEVHQHDV VSTATDMWSL GTLVYVLLSG INPFLAETNQ QIIENIMNAE YTFDEEAFKE
ISIEAMDFVD RLLVKERKSR MTASEALQHP WLKQKIERVS TKVIRTLKHR RYYHTLIKKD
LNMVVSAARI SCGGAIRSQK GVSVAKVKVA SIEIGPVSGQ IMHAVGEEGG HVKYVCKIEN
YDQSTQVTWY FGVRQLENSE KYEITYEDGV AILYVKDITK LDDGTYRCKV VNDYGEDSSY
AELFVKGVRE VYDYYCRRTM KKIKRRTDTM RLLERPPEFT LPLYNKTAYV GENVRFGVTI
TVHPEPHVTW YKSGQKIKPG DNDKKYTFES DKGLYQLTIN SVTTDDDAEY TVVARNKYGE
DSCKAKLTVT LHPPPTDSTL RPMFKRLLAN AECQEGQSVC FEIRVSGIPP PTLKWEKDGQ
PLSLGPNIEI IHEGLDYYAL HIRDTLPEDT GYYRVTATNT AGSTSCQAHL QVERLRYKKQ
EFKSKEEHER HVQKQIDKTL RMAEILSGTE SVPLTQVAKE ALREAAVLYK PAVSTKTVKG
EFRLEIEEKK EERKLRMPYD VPEPRKYKQT TIEEDQRIKQ FVPMSDMKWY KKIRDQYEMP
GKLDRVVQKR PKRIRLSRWE QFYVMPLPRI TDQYRPKWRI PKLSQDDLEI VRPARRRTPS
PDYDFYYRPR RRSLGDISDE ELLLPIDDYL AMKRTEEERL RLEEELELGF SASPPSRSPP
HFELSSLRYS SPQAHVKVEE TRKDFRYSTY HIPTKAEAST SYAELRERHA QAAYRQPKQR
QRIMAEREDE ELLRPVTTTQ HLSEYKSELD FMSKEEKSRK KSRRQREVTE ITEIEEEYEI
SKHAQRESSS SASRLLRRRR SLSPTYIELM RPVSELIRSR PQPAEEYEDD TERRSPTPER
TRPRSPSPVS SERSLSRFER SARFDIFSRY ESMKAALKTQ KTSERKYEVL SQQPFTLDHA
PRITLRMRSH RVPCGQNTRF ILNVQSKPTA EVKWYHNGVE LQESSKIHYT NTSGVLTLEI
LDCHTDDSGT YRAVCTNYKG EASDYATLDV TGGDYTTYAS QRRDEEVPRS VFPELTRTEA
YAVSSFKKTS EMEASSSVRE VKSQMTETRE SLSSYEHSAS AEMKSAALEE KSLEEKSTTR
KIKTTLAARI LTKPRSMTVY EGESARFSCD TDGEPVPTVT WLRKGQVLST SARHQVTTTK
YKSTFEISSV QASDEGNYSV VVENSEGKQE AEFTLTIQKA RVTEKAVTSP PRVKSPEPRV
KSPEAVKSPK RVKSPEPSHP KAVSPTETKP TPTEKVQHLP VSAPPKITQF LKAEASKEIA
KLTCVVESSV LRAKEVTWYK DGKKLKENGH FQFHYSADGT YELKINNLTE SDQGEYVCEI
SGEGGTSKTN LQFMGQAFKS IHEKVSKISE TKKSDQKTTE STVTRKTEPK APEPISSKPV
IVTGLQDTTV SSDSVAKFAV KATGEPRPTA IWTKDGKAIT QGGKYKLSED KGGFFLEIHK
TDTSDSGLYT CTVKNSAGSV SSSCKLTIKA IKDTEAQKVS TQKTSEITPQ KKAVVQEEIS
QKALRSEEIK MSEAKSQEKL ALKEEASKVL ISEEVKKSAA TSLEKSIVHE EITKTSQASE
EVRTHAEIKA FSTQMSINEG QRLVLKANIA GATDVKWVLN GVELTNSEEY RYGVSGSDQT
LTIKQASHRD EGILTCISKT KEGIVKCQYD LTLSKELSDA PAFISQPRSQ NINEGQNVLF
TCEISGEPSP EIEWFKNNLP ISISSNVSIS RSRNVYSLEI RNASVSDSGK YTIKAKNFRG
QCSATASLMV LPLVEEPSRE VVLRTSGDTS LQGSFSSQSV QMSASKQEAS FSSFSSSSAS
SMTEMKFASM SAQSMSSMQE SFVEMSSSSF MGISNMTQLE SSTSKMLKAG IRGIPPKIEA
LPSDISIDEG KVLTVACAFT GEPTPEVTWS CGGRKIHSQE QGRFHIENTD DLTTLIIMDV
QKQDGGLYTL SLGNEFGSDS ATVNIHIRSI
