TITIN_MOUSE
ID TITIN_MOUSE Reviewed; 35213 AA.
AC A2ASS6; A2ASS5; A2ASS7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Titin;
DE EC=2.7.11.1;
DE AltName: Full=Connectin;
GN Name=Ttn {ECO:0000312|EMBL:CAM27059.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:CAM23449.1}
RP PROTEIN SEQUENCE OF 28297-28311 AND 34728-34734, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3] {ECO:0000305}
RP DEVELOPMENTAL STAGE.
RX PubMed=9440711; DOI=10.1161/01.res.82.1.124;
RA Gautel M., Fuerst D.O., Cocco A., Schiaffino S.;
RT "Isoform transitions of the myosin binding protein C family in developing
RT human and mouse muscles: lack of isoform transcomplementation in cardiac
RT muscle.";
RL Circ. Res. 82:124-129(1998).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=16702235; DOI=10.1083/jcb.200601014;
RA Weinert S., Bergmann N., Luo X., Erdmann B., Gotthardt M.;
RT "M line-deficient titin causes cardiac lethality through impaired
RT maturation of the sarcomere.";
RL J. Cell Biol. 173:559-570(2006).
RN [5]
RP FUNCTION.
RX PubMed=17261657; DOI=10.1161/circulationaha.106.645499;
RA Peng J., Raddatz K., Molkentin J.D., Wu Y., Labeit S., Granzier H.,
RA Gotthardt M.;
RT "Cardiac hypertrophy and reduced contractility in hearts deficient in the
RT titin kinase region.";
RL Circulation 115:743-751(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9144, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264; THR-266; THR-299;
RP SER-301; SER-307; SER-322; SER-756; SER-1251; SER-1415; SER-1420; SER-1424;
RP SER-1429; SER-1434; SER-2078; SER-2080; SER-3516; SER-3784; THR-8387;
RP SER-9144; SER-9459; SER-10281; THR-12869; SER-12884; SER-12972; SER-13904;
RP SER-21152; SER-21895; SER-21980; SER-22390; SER-25920; SER-32870;
RP THR-33859; SER-33861; SER-33875; SER-33880; SER-33915; SER-34009;
RP SER-34292; SER-34464; THR-34467; SER-34470; SER-34476; THR-34481 AND
RP SER-34756, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3432; SER-3636;
RP SER-3678; SER-3763; SER-3827; THR-3836; SER-4672 AND SER-4720 (ISOFORM 3),
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [8]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-263; ARG-278; ARG-286; ARG-296
RP AND ARG-304, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Key component in the assembly and functioning of vertebrate
CC striated muscles. By providing connections at the level of individual
CC microfilaments, it contributes to the fine balance of forces between
CC the two halves of the sarcomere. The size and extensibility of the
CC cross-links are the main determinants of sarcomere extensibility
CC properties of muscle. In non-muscle cells, seems to play a role in
CC chromosome condensation and chromosome segregation during mitosis.
CC Might link the lamina network to chromatin or nuclear actin, or both
CC during interphase. {ECO:0000250|UniProtKB:Q8WZ42,
CC ECO:0000269|PubMed:16702235, ECO:0000269|PubMed:17261657}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000250|UniProtKB:Q8WZ42};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q8WZ42};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:Q8WZ42};
CC -!- ACTIVITY REGULATION: Full activation of the protein kinase domain
CC requires both phosphorylation of Tyr-33203, preventing it from blocking
CC the catalytic aspartate residue, and binding of Ca/CALM to the C-
CC terminal regulatory tail of the molecule which results in ATP binding
CC to the kinase. {ECO:0000250|UniProtKB:Q8WZ42}.
CC -!- SUBUNIT: Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts
CC with actin, primarily via the PEVK domains and with MYPN. Interacts
CC with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with
CC TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-
CC terminal immunoglobulin domains. Interacts with TRIM63, TRIM55, ANKRD1,
CC ANKRD2, ANKRD23, and CAPN3 through several Ig domains. Interacts with
CC NBR1 through the protein kinase domain (By similarity). Interacts with
CC CMYA5 (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC A2ASS6; Q70IV5: Synm; NbExp=3; IntAct=EBI-9672947, EBI-9989763;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus
CC {ECO:0000250|UniProtKB:Q8WZ42}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A2ASS6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2ASS6-2; Sequence=VSP_052606, VSP_052608;
CC Name=3;
CC IsoId=A2ASS6-3; Sequence=VSP_052606, VSP_052607, VSP_052609;
CC -!- DEVELOPMENTAL STAGE: Expressed in cardiac muscle from 8 dpc and in
CC skeletal muscle from 9 dpc. {ECO:0000269|PubMed:9440711}.
CC -!- DOMAIN: ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for
CC ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1
CC could adopt a closed conformation which would block the TCAP-binding
CC site (By similarity). {ECO:0000250|UniProtKB:Q8WZ42}.
CC -!- DOMAIN: The PEVK region may serve as an entropic spring of a chain of
CC structural folds and may also be an interaction site to other
CC myofilament proteins to form interfilament connectivity in the
CC sarcomere. {ECO:0000250|UniProtKB:Q8WZ42}.
CC -!- PTM: Autophosphorylated.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AL928681; CAM27058.1; -; Genomic_DNA.
DR EMBL; AL928721; CAM27058.1; JOINED; Genomic_DNA.
DR EMBL; AL928789; CAM27058.1; JOINED; Genomic_DNA.
DR EMBL; AL928681; CAM27059.1; -; Genomic_DNA.
DR EMBL; AL928721; CAM27059.1; JOINED; Genomic_DNA.
DR EMBL; AL928789; CAM27059.1; JOINED; Genomic_DNA.
DR EMBL; AL928681; CAM27060.1; -; Genomic_DNA.
DR EMBL; AL928721; CAM27060.1; JOINED; Genomic_DNA.
DR EMBL; AL928721; CAM23448.1; -; Genomic_DNA.
DR EMBL; AL928681; CAM23448.1; JOINED; Genomic_DNA.
DR EMBL; AL928789; CAM23448.1; JOINED; Genomic_DNA.
DR EMBL; AL928721; CAM23449.1; -; Genomic_DNA.
DR EMBL; AL928681; CAM23449.1; JOINED; Genomic_DNA.
DR EMBL; AL928789; CAM23449.1; JOINED; Genomic_DNA.
DR EMBL; AL928721; CAM23450.1; -; Genomic_DNA.
DR EMBL; AL928681; CAM23450.1; JOINED; Genomic_DNA.
DR EMBL; AL928789; CAM24262.1; -; Genomic_DNA.
DR EMBL; AL928681; CAM24262.1; JOINED; Genomic_DNA.
DR EMBL; AL928721; CAM24262.1; JOINED; Genomic_DNA.
DR EMBL; AL928789; CAM24263.1; -; Genomic_DNA.
DR EMBL; AL928681; CAM24263.1; JOINED; Genomic_DNA.
DR EMBL; AL928721; CAM24263.1; JOINED; Genomic_DNA.
DR PDB; 6YJ0; NMR; -; A=9719-9809.
DR PDBsum; 6YJ0; -.
DR SMR; A2ASS6; -.
DR ComplexPortal; CPX-127; Titin-Telethonin complex.
DR IntAct; A2ASS6; 5.
DR MINT; A2ASS6; -.
DR STRING; 10090.ENSMUSP00000097561; -.
DR CarbonylDB; A2ASS6; -.
DR iPTMnet; A2ASS6; -.
DR PhosphoSitePlus; A2ASS6; -.
DR EPD; A2ASS6; -.
DR jPOST; A2ASS6; -.
DR MaxQB; A2ASS6; -.
DR PaxDb; A2ASS6; -.
DR PeptideAtlas; A2ASS6; -.
DR PRIDE; A2ASS6; -.
DR ProteomicsDB; 259027; -. [A2ASS6-1]
DR ProteomicsDB; 259028; -. [A2ASS6-2]
DR ProteomicsDB; 259029; -. [A2ASS6-3]
DR Antibodypedia; 2056; 211 antibodies from 28 providers.
DR Ensembl; ENSMUST00000099980; ENSMUSP00000097560; ENSMUSG00000051747. [A2ASS6-3]
DR UCSC; uc008kfo.1; mouse. [A2ASS6-2]
DR MGI; MGI:98864; Ttn.
DR VEuPathDB; HostDB:ENSMUSG00000051747; -.
DR eggNOG; KOG0613; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR GeneTree; ENSGT01050000244911; -.
DR HOGENOM; CLU_000001_0_2_1; -.
DR InParanoid; A2ASS6; -.
DR OMA; VYEGDSC; -.
DR PhylomeDB; A2ASS6; -.
DR TreeFam; TF316477; -.
DR Reactome; R-MMU-114608; Platelet degranulation.
DR Reactome; R-MMU-390522; Striated Muscle Contraction.
DR ChiTaRS; Ttn; mouse.
DR PRO; PR:A2ASS6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000051747; Expressed in vastus lateralis and 167 other tissues.
DR ExpressionAtlas; A2ASS6; baseline and differential.
DR Genevisible; A2ASS6; MM.
DR GO; GO:0031672; C:A band; IDA:MGI.
DR GO; GO:0000794; C:condensed nuclear chromosome; ISO:MGI.
DR GO; GO:0031674; C:I band; IDA:MGI.
DR GO; GO:0031430; C:M band; IDA:MGI.
DR GO; GO:0005859; C:muscle myosin complex; TAS:MGI.
DR GO; GO:0030017; C:sarcomere; IDA:MGI.
DR GO; GO:0005865; C:striated muscle thin filament; ISO:MGI.
DR GO; GO:1990733; C:titin-telethonin complex; ISO:MGI.
DR GO; GO:0030018; C:Z disc; IDA:MGI.
DR GO; GO:0051015; F:actin filament binding; ISO:MGI.
DR GO; GO:0042805; F:actinin binding; ISO:MGI.
DR GO; GO:0030506; F:ankyrin binding; IPI:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; ISO:MGI.
DR GO; GO:0005516; F:calmodulin binding; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0051371; F:muscle alpha-actinin binding; ISO:MGI.
DR GO; GO:0002020; F:protease binding; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0043621; F:protein self-association; ISO:MGI.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISO:MGI.
DR GO; GO:0004713; F:protein tyrosine kinase activity; ISO:MGI.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
DR GO; GO:0008307; F:structural constituent of muscle; ISO:MGI.
DR GO; GO:0097493; F:structural molecule activity conferring elasticity; ISO:MGI.
DR GO; GO:0031433; F:telethonin binding; ISO:MGI.
DR GO; GO:0007512; P:adult heart development; IMP:MGI.
DR GO; GO:0055013; P:cardiac muscle cell development; ISO:MGI.
DR GO; GO:0060048; P:cardiac muscle contraction; ISO:MGI.
DR GO; GO:0003300; P:cardiac muscle hypertrophy; ISO:MGI.
DR GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IMP:MGI.
DR GO; GO:0055003; P:cardiac myofibril assembly; IMP:MGI.
DR GO; GO:0035995; P:detection of muscle stretch; ISO:MGI.
DR GO; GO:0043056; P:forward locomotion; IMP:MGI.
DR GO; GO:0007507; P:heart development; IEP:BHF-UCL.
DR GO; GO:0060419; P:heart growth; IMP:MGI.
DR GO; GO:0003007; P:heart morphogenesis; IMP:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0006936; P:muscle contraction; IMP:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0050714; P:positive regulation of protein secretion; ISO:MGI.
DR GO; GO:0010737; P:protein kinase A signaling; ISO:MGI.
DR GO; GO:0050790; P:regulation of catalytic activity; ISO:MGI.
DR GO; GO:0045859; P:regulation of protein kinase activity; ISO:MGI.
DR GO; GO:1901897; P:regulation of relaxation of cardiac muscle; IMP:BHF-UCL.
DR GO; GO:0051592; P:response to calcium ion; ISO:MGI.
DR GO; GO:0045214; P:sarcomere organization; IMP:MGI.
DR GO; GO:0048769; P:sarcomerogenesis; ISO:MGI.
DR GO; GO:0030241; P:skeletal muscle myosin thick filament assembly; ISO:MGI.
DR GO; GO:0030240; P:skeletal muscle thin filament assembly; ISO:MGI.
DR GO; GO:0001756; P:somitogenesis; IEP:BHF-UCL.
DR GO; GO:0055002; P:striated muscle cell development; IMP:MGI.
DR GO; GO:0021591; P:ventricular system development; IMP:MGI.
DR CDD; cd00063; FN3; 132.
DR Gene3D; 2.60.40.10; -; 299.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR040849; MyBP-C_THB.
DR InterPro; IPR004168; PPAK_motif.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR015129; Titin_Z_rpt.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR Pfam; PF00041; fn3; 132.
DR Pfam; PF07679; I-set; 161.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF02818; PPAK; 9.
DR Pfam; PF18362; THB; 1.
DR Pfam; PF09042; Titin_Z; 6.
DR SMART; SM00060; FN3; 132.
DR SMART; SM00409; IG; 167.
DR SMART; SM00408; IGc2; 149.
DR SMART; SM00406; IGv; 23.
DR SUPFAM; SSF48726; SSF48726; 167.
DR SUPFAM; SSF49265; SSF49265; 74.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50853; FN3; 132.
DR PROSITE; PS50835; IG_LIKE; 144.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; ATP-binding; Calcium;
KW Calmodulin-binding; Coiled coil; Cytoplasm; Direct protein sequencing;
KW Disulfide bond; Immunoglobulin domain; Kelch repeat; Kinase; Magnesium;
KW Metal-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Serine/threonine-protein kinase; TPR repeat;
KW Transferase; WD repeat.
FT CHAIN 1..35213
FT /note="Titin"
FT /id="PRO_0000311696"
FT DOMAIN 6..98
FT /note="Ig-like 1"
FT /evidence="ECO:0000255"
FT DOMAIN 104..192
FT /note="Ig-like 2"
FT /evidence="ECO:0000255"
FT REPEAT 412..454
FT /note="Z-repeat 1"
FT /evidence="ECO:0000255"
FT REPEAT 463..504
FT /note="Z-repeat 2"
FT /evidence="ECO:0000255"
FT REPEAT 509..548
FT /note="Z-repeat 3"
FT /evidence="ECO:0000255"
FT REPEAT 553..594
FT /note="Z-repeat 4"
FT /evidence="ECO:0000255"
FT REPEAT 599..640
FT /note="Z-repeat 5"
FT /evidence="ECO:0000255"
FT REPEAT 645..686
FT /note="Z-repeat 6"
FT /evidence="ECO:0000255"
FT DOMAIN 946..1034
FT /note="Ig-like 3"
FT /evidence="ECO:0000255"
FT DOMAIN 1084..1174
FT /note="Ig-like 4"
FT /evidence="ECO:0000255"
FT DOMAIN 1293..1384
FT /note="Ig-like 5"
FT /evidence="ECO:0000255"
FT DOMAIN 1463..1552
FT /note="Ig-like 6"
FT /evidence="ECO:0000255"
FT DOMAIN 1562..1652
FT /note="Ig-like 7"
FT /evidence="ECO:0000255"
FT DOMAIN 1709..1799
FT /note="Ig-like 8"
FT /evidence="ECO:0000255"
FT DOMAIN 1847..1934
FT /note="Ig-like 9"
FT /evidence="ECO:0000255"
FT DOMAIN 2084..2173
FT /note="Ig-like 10"
FT /evidence="ECO:0000255"
FT REPEAT 2095..2128
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT DOMAIN 2177..2268
FT /note="Ig-like 11"
FT /evidence="ECO:0000255"
FT DOMAIN 2270..2356
FT /note="Ig-like 12"
FT /evidence="ECO:0000255"
FT DOMAIN 2359..2449
FT /note="Ig-like 13"
FT /evidence="ECO:0000255"
FT DOMAIN 2436..2535
FT /note="Ig-like 14"
FT /evidence="ECO:0000255"
FT DOMAIN 2626..2709
FT /note="Ig-like 15"
FT /evidence="ECO:0000255"
FT REPEAT 2810..2844
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT DOMAIN 2886..2971
FT /note="Ig-like 16"
FT /evidence="ECO:0000255"
FT REPEAT 3028..3068
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT DOMAIN 3064..3147
FT /note="Ig-like 17"
FT /evidence="ECO:0000255"
FT REPEAT 3208..3248
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT DOMAIN 3245..3333
FT /note="Ig-like 18"
FT /evidence="ECO:0000255"
FT DOMAIN 3350..3438
FT /note="Ig-like 19"
FT /evidence="ECO:0000255"
FT DOMAIN 3509..3599
FT /note="Ig-like 20"
FT /evidence="ECO:0000255"
FT DOMAIN 3625..3716
FT /note="Ig-like 21"
FT /evidence="ECO:0000255"
FT DOMAIN 4251..4337
FT /note="Ig-like 22"
FT /evidence="ECO:0000255"
FT DOMAIN 4344..4432
FT /note="Ig-like 23"
FT /evidence="ECO:0000255"
FT DOMAIN 4439..4527
FT /note="Ig-like 24"
FT /evidence="ECO:0000255"
FT DOMAIN 4532..4620
FT /note="Ig-like 25"
FT /evidence="ECO:0000255"
FT DOMAIN 4625..4716
FT /note="Ig-like 26"
FT /evidence="ECO:0000255"
FT DOMAIN 4719..4807
FT /note="Ig-like 27"
FT /evidence="ECO:0000255"
FT DOMAIN 4812..4897
FT /note="Ig-like 28"
FT /evidence="ECO:0000255"
FT DOMAIN 4904..4993
FT /note="Ig-like 29"
FT /evidence="ECO:0000255"
FT DOMAIN 5001..5089
FT /note="Ig-like 30"
FT /evidence="ECO:0000255"
FT DOMAIN 5094..5182
FT /note="Ig-like 31"
FT /evidence="ECO:0000255"
FT REPEAT 5131..5164
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT DOMAIN 5186..5276
FT /note="Ig-like 32"
FT /evidence="ECO:0000255"
FT DOMAIN 5281..5369
FT /note="Ig-like 33"
FT /evidence="ECO:0000255"
FT DOMAIN 5374..5462
FT /note="Ig-like 34"
FT /evidence="ECO:0000255"
FT DOMAIN 5466..5555
FT /note="Ig-like 35"
FT /evidence="ECO:0000255"
FT DOMAIN 5563..5651
FT /note="Ig-like 36"
FT /evidence="ECO:0000255"
FT DOMAIN 5656..5744
FT /note="Ig-like 37"
FT /evidence="ECO:0000255"
FT DOMAIN 5749..5838
FT /note="Ig-like 38"
FT /evidence="ECO:0000255"
FT DOMAIN 5842..5931
FT /note="Ig-like 39"
FT /evidence="ECO:0000255"
FT DOMAIN 5936..6024
FT /note="Ig-like 40"
FT /evidence="ECO:0000255"
FT DOMAIN 6028..6117
FT /note="Ig-like 41"
FT /evidence="ECO:0000255"
FT DOMAIN 6125..6213
FT /note="Ig-like 42"
FT /evidence="ECO:0000255"
FT DOMAIN 6218..6308
FT /note="Ig-like 43"
FT /evidence="ECO:0000255"
FT DOMAIN 6311..6401
FT /note="Ig-like 44"
FT /evidence="ECO:0000255"
FT DOMAIN 6405..6493
FT /note="Ig-like 45"
FT /evidence="ECO:0000255"
FT REPEAT 6435..6468
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT DOMAIN 6498..6587
FT /note="Ig-like 46"
FT /evidence="ECO:0000255"
FT DOMAIN 6591..6682
FT /note="Ig-like 47"
FT /evidence="ECO:0000255"
FT REPEAT 6615..6653
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT DOMAIN 6688..6776
FT /note="Ig-like 48"
FT /evidence="ECO:0000255"
FT DOMAIN 6781..6869
FT /note="Ig-like 49"
FT /evidence="ECO:0000255"
FT DOMAIN 6873..6962
FT /note="Ig-like 50"
FT /evidence="ECO:0000255"
FT DOMAIN 6966..7054
FT /note="Ig-like 51"
FT /evidence="ECO:0000255"
FT DOMAIN 7063..7151
FT /note="Ig-like 52"
FT /evidence="ECO:0000255"
FT DOMAIN 7159..7247
FT /note="Ig-like 53"
FT /evidence="ECO:0000255"
FT DOMAIN 7252..7343
FT /note="Ig-like 54"
FT /evidence="ECO:0000255"
FT DOMAIN 7346..7434
FT /note="Ig-like 55"
FT /evidence="ECO:0000255"
FT DOMAIN 7439..7528
FT /note="Ig-like 56"
FT /evidence="ECO:0000255"
FT DOMAIN 7532..7623
FT /note="Ig-like 57"
FT /evidence="ECO:0000255"
FT DOMAIN 7629..7717
FT /note="Ig-like 58"
FT /evidence="ECO:0000255"
FT DOMAIN 7722..7810
FT /note="Ig-like 59"
FT /evidence="ECO:0000255"
FT DOMAIN 7814..7903
FT /note="Ig-like 60"
FT /evidence="ECO:0000255"
FT DOMAIN 7907..7996
FT /note="Ig-like 61"
FT /evidence="ECO:0000255"
FT DOMAIN 8004..8094
FT /note="Ig-like 62"
FT /evidence="ECO:0000255"
FT DOMAIN 8099..8190
FT /note="Ig-like 63"
FT /evidence="ECO:0000255"
FT DOMAIN 8193..8282
FT /note="Ig-like 64"
FT /evidence="ECO:0000255"
FT DOMAIN 8287..8375
FT /note="Ig-like 65"
FT /evidence="ECO:0000255"
FT DOMAIN 8380..8469
FT /note="Ig-like 66"
FT /evidence="ECO:0000255"
FT DOMAIN 8473..8564
FT /note="Ig-like 67"
FT /evidence="ECO:0000255"
FT DOMAIN 8570..8658
FT /note="Ig-like 68"
FT /evidence="ECO:0000255"
FT DOMAIN 8663..8751
FT /note="Ig-like 69"
FT /evidence="ECO:0000255"
FT DOMAIN 8755..8844
FT /note="Ig-like 70"
FT /evidence="ECO:0000255"
FT DOMAIN 8849..8937
FT /note="Ig-like 71"
FT /evidence="ECO:0000255"
FT DOMAIN 8945..9035
FT /note="Ig-like 72"
FT /evidence="ECO:0000255"
FT DOMAIN 9040..9129
FT /note="Ig-like 73"
FT /evidence="ECO:0000255"
FT DOMAIN 9137..9226
FT /note="Ig-like 74"
FT /evidence="ECO:0000255"
FT REPEAT 9145..9182
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT DOMAIN 9233..9322
FT /note="Ig-like 75"
FT /evidence="ECO:0000255"
FT DOMAIN 9331..9431
FT /note="Ig-like 76"
FT /evidence="ECO:0000255"
FT DOMAIN 9621..9716
FT /note="Ig-like 77"
FT /evidence="ECO:0000255"
FT REPEAT 9662..9695
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT DOMAIN 9721..9812
FT /note="Ig-like 78"
FT /evidence="ECO:0000255"
FT REPEAT 9865..9892
FT /note="PEVK 1"
FT /evidence="ECO:0000255"
FT REPEAT 9940..9963
FT /note="PEVK 2"
FT /evidence="ECO:0000255"
FT REPEAT 9991..10024
FT /note="TPR 7"
FT /evidence="ECO:0000255"
FT REPEAT 10001..10050
FT /note="Kelch 1"
FT /evidence="ECO:0000255"
FT REPEAT 10062..10085
FT /note="PEVK 3"
FT /evidence="ECO:0000255"
FT REPEAT 10091..10115
FT /note="PEVK 4"
FT /evidence="ECO:0000255"
FT REPEAT 10145..10169
FT /note="PEVK 5"
FT /evidence="ECO:0000255"
FT REPEAT 10170..10197
FT /note="PEVK 6"
FT /evidence="ECO:0000255"
FT REPEAT 10198..10225
FT /note="PEVK 7"
FT /evidence="ECO:0000255"
FT REPEAT 10227..10254
FT /note="PEVK 8"
FT /evidence="ECO:0000255"
FT REPEAT 10255..10281
FT /note="PEVK 9"
FT /evidence="ECO:0000255"
FT REPEAT 10282..10307
FT /note="PEVK 10"
FT /evidence="ECO:0000255"
FT REPEAT 10308..10332
FT /note="PEVK 11"
FT /evidence="ECO:0000255"
FT REPEAT 10333..10359
FT /note="PEVK 12"
FT /evidence="ECO:0000255"
FT REPEAT 10397..10431
FT /note="TPR 8"
FT /evidence="ECO:0000255"
FT REPEAT 10404..10427
FT /note="PEVK 13"
FT /evidence="ECO:0000255"
FT REPEAT 10451..10476
FT /note="PEVK 14"
FT /evidence="ECO:0000255"
FT REPEAT 10477..10504
FT /note="PEVK 15"
FT /evidence="ECO:0000255"
FT REPEAT 10505..10532
FT /note="PEVK 16"
FT /evidence="ECO:0000255"
FT REPEAT 10533..10560
FT /note="PEVK 17"
FT /evidence="ECO:0000255"
FT REPEAT 10561..10588
FT /note="PEVK 18"
FT /evidence="ECO:0000255"
FT REPEAT 10683..10707
FT /note="PEVK 19"
FT /evidence="ECO:0000255"
FT REPEAT 10709..10734
FT /note="PEVK 20"
FT /evidence="ECO:0000255"
FT REPEAT 10739..10764
FT /note="PEVK 21"
FT /evidence="ECO:0000255"
FT REPEAT 10765..10790
FT /note="PEVK 22"
FT /evidence="ECO:0000255"
FT REPEAT 10850..10877
FT /note="PEVK 23"
FT /evidence="ECO:0000255"
FT REPEAT 10878..10903
FT /note="PEVK 24"
FT /evidence="ECO:0000255"
FT REPEAT 10904..10931
FT /note="PEVK 25"
FT /evidence="ECO:0000255"
FT REPEAT 10932..10959
FT /note="PEVK 26"
FT /evidence="ECO:0000255"
FT REPEAT 10960..10987
FT /note="PEVK 27"
FT /evidence="ECO:0000255"
FT REPEAT 10988..11011
FT /note="PEVK 28"
FT /evidence="ECO:0000255"
FT REPEAT 11084..11109
FT /note="PEVK 29"
FT /evidence="ECO:0000255"
FT REPEAT 11111..11135
FT /note="PEVK 30"
FT /evidence="ECO:0000255"
FT REPEAT 11136..11160
FT /note="PEVK 31"
FT /evidence="ECO:0000255"
FT REPEAT 11161..11188
FT /note="PEVK 32"
FT /evidence="ECO:0000255"
FT REPEAT 11201..11225
FT /note="PEVK 33"
FT /evidence="ECO:0000255"
FT REPEAT 11226..11248
FT /note="PEVK 34"
FT /evidence="ECO:0000255"
FT REPEAT 11249..11272
FT /note="PEVK 35"
FT /evidence="ECO:0000255"
FT REPEAT 11273..11295
FT /note="PEVK 36"
FT /evidence="ECO:0000255"
FT REPEAT 11373..11400
FT /note="PEVK 37"
FT /evidence="ECO:0000255"
FT REPEAT 11401..11425
FT /note="PEVK 38"
FT /evidence="ECO:0000255"
FT REPEAT 11426..11453
FT /note="PEVK 39"
FT /evidence="ECO:0000255"
FT REPEAT 11454..11481
FT /note="PEVK 40"
FT /evidence="ECO:0000255"
FT REPEAT 11508..11533
FT /note="PEVK 41"
FT /evidence="ECO:0000255"
FT REPEAT 11562..11587
FT /note="PEVK 42"
FT /evidence="ECO:0000255"
FT REPEAT 11671..11698
FT /note="PEVK 43"
FT /evidence="ECO:0000255"
FT REPEAT 11700..11726
FT /note="PEVK 44"
FT /evidence="ECO:0000255"
FT REPEAT 11727..11754
FT /note="PEVK 45"
FT /evidence="ECO:0000255"
FT REPEAT 11755..11782
FT /note="PEVK 46"
FT /evidence="ECO:0000255"
FT REPEAT 11783..11810
FT /note="PEVK 47"
FT /evidence="ECO:0000255"
FT REPEAT 11811..11838
FT /note="PEVK 48"
FT /evidence="ECO:0000255"
FT REPEAT 11839..11866
FT /note="PEVK 49"
FT /evidence="ECO:0000255"
FT REPEAT 11867..11895
FT /note="PEVK 50"
FT /evidence="ECO:0000255"
FT REPEAT 11896..11923
FT /note="PEVK 51"
FT /evidence="ECO:0000255"
FT REPEAT 11924..11950
FT /note="PEVK 52"
FT /evidence="ECO:0000255"
FT REPEAT 11954..11977
FT /note="PEVK 53"
FT /evidence="ECO:0000255"
FT REPEAT 11979..11999
FT /note="PEVK 54"
FT /evidence="ECO:0000255"
FT REPEAT 12004..12026
FT /note="PEVK 55"
FT /evidence="ECO:0000255"
FT REPEAT 12051..12077
FT /note="PEVK 56"
FT /evidence="ECO:0000255"
FT REPEAT 12080..12104
FT /note="PEVK 57"
FT /evidence="ECO:0000255"
FT REPEAT 12105..12126
FT /note="PEVK 58"
FT /evidence="ECO:0000255"
FT REPEAT 12129..12154
FT /note="PEVK 59"
FT /evidence="ECO:0000255"
FT REPEAT 12155..12182
FT /note="PEVK 60"
FT /evidence="ECO:0000255"
FT REPEAT 12183..12210
FT /note="PEVK 61"
FT /evidence="ECO:0000255"
FT REPEAT 12211..12238
FT /note="PEVK 62"
FT /evidence="ECO:0000255"
FT REPEAT 12239..12266
FT /note="PEVK 63"
FT /evidence="ECO:0000255"
FT REPEAT 12267..12294
FT /note="PEVK 64"
FT /evidence="ECO:0000255"
FT REPEAT 12295..12322
FT /note="PEVK 65"
FT /evidence="ECO:0000255"
FT REPEAT 12323..12351
FT /note="PEVK 66"
FT /evidence="ECO:0000255"
FT REPEAT 12352..12379
FT /note="PEVK 67"
FT /evidence="ECO:0000255"
FT REPEAT 12380..12404
FT /note="PEVK 68"
FT /evidence="ECO:0000255"
FT REPEAT 12405..12430
FT /note="PEVK 69"
FT /evidence="ECO:0000255"
FT REPEAT 12431..12458
FT /note="PEVK 70"
FT /evidence="ECO:0000255"
FT REPEAT 12459..12486
FT /note="PEVK 71"
FT /evidence="ECO:0000255"
FT REPEAT 12491..12516
FT /note="PEVK 72"
FT /evidence="ECO:0000255"
FT REPEAT 12517..12542
FT /note="PEVK 73"
FT /evidence="ECO:0000255"
FT REPEAT 12543..12570
FT /note="PEVK 74"
FT /evidence="ECO:0000255"
FT REPEAT 12572..12598
FT /note="PEVK 75"
FT /evidence="ECO:0000255"
FT REPEAT 12599..12626
FT /note="PEVK 76"
FT /evidence="ECO:0000255"
FT DOMAIN 12903..12995
FT /note="Ig-like 79"
FT /evidence="ECO:0000255"
FT DOMAIN 13000..13084
FT /note="Ig-like 80"
FT /evidence="ECO:0000255"
FT DOMAIN 13361..13446
FT /note="Ig-like 81"
FT /evidence="ECO:0000255"
FT DOMAIN 13452..13534
FT /note="Ig-like 82"
FT /evidence="ECO:0000255"
FT DOMAIN 13628..13712
FT /note="Ig-like 83"
FT /evidence="ECO:0000255"
FT DOMAIN 13807..13894
FT /note="Ig-like 84"
FT /evidence="ECO:0000255"
FT REPEAT 13817..13850
FT /note="TPR 9"
FT /evidence="ECO:0000255"
FT DOMAIN 13982..14068
FT /note="Ig-like 85"
FT /evidence="ECO:0000255"
FT DOMAIN 14072..14157
FT /note="Ig-like 86"
FT /evidence="ECO:0000255"
FT DOMAIN 14161..14246
FT /note="Ig-like 87"
FT /evidence="ECO:0000255"
FT DOMAIN 14250..14335
FT /note="Ig-like 88"
FT /evidence="ECO:0000255"
FT DOMAIN 14341..14424
FT /note="Ig-like 89"
FT /evidence="ECO:0000255"
FT DOMAIN 14427..14517
FT /note="Ig-like 90"
FT /evidence="ECO:0000255"
FT DOMAIN 14521..14610
FT /note="Ig-like 91"
FT /evidence="ECO:0000255"
FT REPEAT 14576..14615
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT DOMAIN 14611..14695
FT /note="Ig-like 92"
FT /evidence="ECO:0000255"
FT DOMAIN 14789..14874
FT /note="Ig-like 93"
FT /evidence="ECO:0000255"
FT DOMAIN 14881..14976
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 14946..14998
FT /note="RCC1 1"
FT /evidence="ECO:0000255"
FT DOMAIN 14982..15077
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 15047..15100
FT /note="RCC1 2"
FT /evidence="ECO:0000255"
FT DOMAIN 15083..15178
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15279..15374
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15379..15476
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15477..15570
FT /note="Ig-like 94"
FT /evidence="ECO:0000255"
FT DOMAIN 15575..15668
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15674..15769
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 15690..15738
FT /note="Kelch 2"
FT /evidence="ECO:0000255"
FT DOMAIN 15775..15869
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 15794..15839
FT /note="Kelch 3"
FT /evidence="ECO:0000255"
FT REPEAT 15848..15898
FT /note="Kelch 4"
FT /evidence="ECO:0000255"
FT DOMAIN 15872..15969
FT /note="Fibronectin type-III 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15975..16069
FT /note="Fibronectin type-III 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16076..16172
FT /note="Fibronectin type-III 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16176..16264
FT /note="Ig-like 95"
FT /evidence="ECO:0000255"
FT DOMAIN 16271..16365
FT /note="Fibronectin type-III 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16371..16466
FT /note="Fibronectin type-III 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 16436..16492
FT /note="RCC1 3"
FT /evidence="ECO:0000255"
FT DOMAIN 16470..16586
FT /note="Ig-like 96"
FT /evidence="ECO:0000255"
FT DOMAIN 16593..16688
FT /note="Fibronectin type-III 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16694..16793
FT /note="Fibronectin type-III 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16794..16887
FT /note="Fibronectin type-III 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 16988..17080
FT /note="Fibronectin type-III 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 16996..17042
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT DOMAIN 17086..17180
FT /note="Fibronectin type-III 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17184..17282
FT /note="Ig-like 97"
FT /evidence="ECO:0000255"
FT DOMAIN 17289..17384
FT /note="Fibronectin type-III 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 17309..17355
FT /note="Kelch 5"
FT /evidence="ECO:0000255"
FT DOMAIN 17390..17490
FT /note="Fibronectin type-III 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17496..17596
FT /note="Fibronectin type-III 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17589..17696
FT /note="Ig-like 98"
FT /evidence="ECO:0000255"
FT DOMAIN 17703..17796
FT /note="Fibronectin type-III 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17803..17903
FT /note="Fibronectin type-III 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17906..18001
FT /note="Ig-like 99"
FT /evidence="ECO:0000255"
FT DOMAIN 18009..18102
FT /note="Fibronectin type-III 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18108..18207
FT /note="Fibronectin type-III 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18210..18307
FT /note="Fibronectin type-III 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18311..18398
FT /note="Ig-like 100"
FT /evidence="ECO:0000255"
FT DOMAIN 18407..18502
FT /note="Fibronectin type-III 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 18508..18603
FT /note="Fibronectin type-III 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 18573..18631
FT /note="RCC1 4"
FT /evidence="ECO:0000255"
FT DOMAIN 18607..18696
FT /note="Ig-like 101"
FT /evidence="ECO:0000255"
FT DOMAIN 18703..18797
FT /note="Fibronectin type-III 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 18792..18831
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT DOMAIN 18803..18898
FT /note="Fibronectin type-III 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 18868..18921
FT /note="RCC1 5"
FT /evidence="ECO:0000255"
FT DOMAIN 18904..19001
FT /note="Fibronectin type-III 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19005..19090
FT /note="Ig-like 102"
FT /evidence="ECO:0000255"
FT DOMAIN 19101..19195
FT /note="Fibronectin type-III 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 19120..19164
FT /note="Kelch 6"
FT /evidence="ECO:0000255"
FT REPEAT 19165..19220
FT /note="RCC1 6"
FT /evidence="ECO:0000255"
FT DOMAIN 19201..19293
FT /note="Fibronectin type-III 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19297..19388
FT /note="Ig-like 103"
FT /evidence="ECO:0000255"
FT REPEAT 19330..19363
FT /note="TPR 10"
FT /evidence="ECO:0000255"
FT DOMAIN 19395..19494
FT /note="Fibronectin type-III 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19495..19589
FT /note="Fibronectin type-III 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19595..19691
FT /note="Fibronectin type-III 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19695..19786
FT /note="Ig-like 104"
FT /evidence="ECO:0000255"
FT DOMAIN 19793..19887
FT /note="Fibronectin type-III 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19892..19986
FT /note="Fibronectin type-III 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 19990..20081
FT /note="Ig-like 105"
FT /evidence="ECO:0000255"
FT DOMAIN 20088..20183
FT /note="Fibronectin type-III 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 20152..20208
FT /note="RCC1 7"
FT /evidence="ECO:0000255"
FT DOMAIN 20187..20282
FT /note="Fibronectin type-III 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 20252..20305
FT /note="RCC1 8"
FT /evidence="ECO:0000255"
FT DOMAIN 20288..20389
FT /note="Fibronectin type-III 41"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20393..20479
FT /note="Ig-like 106"
FT /evidence="ECO:0000255"
FT DOMAIN 20490..20584
FT /note="Fibronectin type-III 42"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 20509..20554
FT /note="Kelch 7"
FT /evidence="ECO:0000255"
FT DOMAIN 20590..20685
FT /note="Fibronectin type-III 43"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20688..20776
FT /note="Ig-like 107"
FT /evidence="ECO:0000255"
FT DOMAIN 20783..20877
FT /note="Fibronectin type-III 44"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20880..20978
FT /note="Fibronectin type-III 45"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 20981..21079
FT /note="Fibronectin type-III 46"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21082..21173
FT /note="Ig-like 108"
FT /evidence="ECO:0000255"
FT DOMAIN 21180..21273
FT /note="Fibronectin type-III 47"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21279..21374
FT /note="Fibronectin type-III 48"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21380..21475
FT /note="Fibronectin type-III 49"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21578..21672
FT /note="Fibronectin type-III 50"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21675..21770
FT /note="Fibronectin type-III 51"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 21868..21963
FT /note="Fibronectin type-III 52"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 21887..21932
FT /note="Kelch 8"
FT /evidence="ECO:0000255"
FT DOMAIN 21967..22062
FT /note="Fibronectin type-III 53"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 22052..22093
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT DOMAIN 22065..22161
FT /note="Fibronectin type-III 54"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 22084..22129
FT /note="Kelch 9"
FT /evidence="ECO:0000255"
FT DOMAIN 22165..22257
FT /note="Ig-like 109"
FT /evidence="ECO:0000255"
FT DOMAIN 22264..22357
FT /note="Fibronectin type-III 55"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22363..22458
FT /note="Fibronectin type-III 56"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 22428..22482
FT /note="RCC1 9"
FT /evidence="ECO:0000255"
FT DOMAIN 22464..22559
FT /note="Fibronectin type-III 57"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22659..22753
FT /note="Fibronectin type-III 58"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22756..22848
FT /note="Fibronectin type-III 59"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 22950..23044
FT /note="Fibronectin type-III 60"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23050..23145
FT /note="Fibronectin type-III 61"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23148..23244
FT /note="Fibronectin type-III 62"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 23168..23212
FT /note="Kelch 10"
FT /evidence="ECO:0000255"
FT DOMAIN 23248..23339
FT /note="Ig-like 110"
FT /evidence="ECO:0000255"
FT DOMAIN 23346..23440
FT /note="Fibronectin type-III 63"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23446..23541
FT /note="Fibronectin type-III 64"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23547..23643
FT /note="Fibronectin type-III 65"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 23566..23612
FT /note="Kelch 11"
FT /evidence="ECO:0000255"
FT DOMAIN 23647..23736
FT /note="Ig-like 111"
FT /evidence="ECO:0000255"
FT DOMAIN 23743..23838
FT /note="Fibronectin type-III 66"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 23840..23933
FT /note="Fibronectin type-III 67"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 23903..23953
FT /note="RCC1 10"
FT /evidence="ECO:0000255"
FT DOMAIN 23937..24025
FT /note="Ig-like 112"
FT /evidence="ECO:0000255"
FT DOMAIN 24032..24126
FT /note="Fibronectin type-III 68"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 24041..24087
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT DOMAIN 24132..24227
FT /note="Fibronectin type-III 69"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24230..24325
FT /note="Fibronectin type-III 70"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24330..24417
FT /note="Ig-like 113"
FT /evidence="ECO:0000255"
FT DOMAIN 24428..24522
FT /note="Fibronectin type-III 71"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 24513..24556
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT DOMAIN 24528..24623
FT /note="Fibronectin type-III 72"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24629..24725
FT /note="Fibronectin type-III 73"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24729..24816
FT /note="Ig-like 114"
FT /evidence="ECO:0000255"
FT DOMAIN 24825..24919
FT /note="Fibronectin type-III 74"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 24922..25015
FT /note="Fibronectin type-III 75"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 24941..24986
FT /note="Kelch 12"
FT /evidence="ECO:0000255"
FT DOMAIN 25019..25108
FT /note="Ig-like 115"
FT /evidence="ECO:0000255"
FT DOMAIN 25114..25208
FT /note="Fibronectin type-III 76"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 25123..25169
FT /note="WD 10"
FT /evidence="ECO:0000255"
FT DOMAIN 25214..25308
FT /note="Fibronectin type-III 77"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25312..25408
FT /note="Fibronectin type-III 78"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25412..25503
FT /note="Ig-like 116"
FT /evidence="ECO:0000255"
FT DOMAIN 25510..25604
FT /note="Fibronectin type-III 79"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25610..25705
FT /note="Fibronectin type-III 80"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 25711..25807
FT /note="Fibronectin type-III 81"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 25730..25778
FT /note="Kelch 13"
FT /evidence="ECO:0000255"
FT REPEAT 25891..25935
FT /note="WD 11"
FT /evidence="ECO:0000255"
FT DOMAIN 25907..26002
FT /note="Fibronectin type-III 82"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26004..26097
FT /note="Fibronectin type-III 83"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26101..26187
FT /note="Ig-like 117"
FT /evidence="ECO:0000255"
FT DOMAIN 26197..26290
FT /note="Fibronectin type-III 84"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 26281..26324
FT /note="WD 12"
FT /evidence="ECO:0000255"
FT DOMAIN 26296..26390
FT /note="Fibronectin type-III 85"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26394..26489
FT /note="Fibronectin type-III 86"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26494..26584
FT /note="Ig-like 118"
FT /evidence="ECO:0000255"
FT DOMAIN 26593..26687
FT /note="Fibronectin type-III 87"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26693..26788
FT /note="Fibronectin type-III 88"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26794..26890
FT /note="Fibronectin type-III 89"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 26894..26983
FT /note="Ig-like 119"
FT /evidence="ECO:0000255"
FT DOMAIN 26990..27084
FT /note="Fibronectin type-III 90"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27087..27180
FT /note="Fibronectin type-III 91"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27168..27272
FT /note="Ig-like 120"
FT /evidence="ECO:0000255"
FT DOMAIN 27279..27372
FT /note="Fibronectin type-III 92"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 27363..27406
FT /note="WD 13"
FT /evidence="ECO:0000255"
FT DOMAIN 27378..27475
FT /note="Fibronectin type-III 93"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27476..27572
FT /note="Fibronectin type-III 94"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27576..27663
FT /note="Ig-like 121"
FT /evidence="ECO:0000255"
FT DOMAIN 27674..27768
FT /note="Fibronectin type-III 95"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27774..27869
FT /note="Fibronectin type-III 96"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 27875..27969
FT /note="Fibronectin type-III 97"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 27939..27989
FT /note="RCC1 11"
FT /evidence="ECO:0000255"
FT DOMAIN 27963..28058
FT /note="Ig-like 122"
FT /evidence="ECO:0000255"
FT DOMAIN 28069..28164
FT /note="Fibronectin type-III 98"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 28133..28182
FT /note="RCC1 12"
FT /evidence="ECO:0000255"
FT DOMAIN 28166..28259
FT /note="Fibronectin type-III 99"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 28185..28230
FT /note="Kelch 14"
FT /evidence="ECO:0000255"
FT DOMAIN 28361..28455
FT /note="Fibronectin type-III 100"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28461..28556
FT /note="Fibronectin type-III 101"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28559..28655
FT /note="Fibronectin type-III 102"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28659..28750
FT /note="Ig-like 123"
FT /evidence="ECO:0000255"
FT REPEAT 28669..28706
FT /note="TPR 11"
FT /evidence="ECO:0000255"
FT DOMAIN 28757..28851
FT /note="Fibronectin type-III 103"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 28857..28952
FT /note="Fibronectin type-III 104"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 28923..28957
FT /note="TPR 12"
FT /evidence="ECO:0000255"
FT DOMAIN 28958..29054
FT /note="Fibronectin type-III 105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29058..29148
FT /note="Ig-like 124"
FT /evidence="ECO:0000255"
FT DOMAIN 29157..29251
FT /note="Fibronectin type-III 106"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29254..29346
FT /note="Fibronectin type-III 107"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29350..29439
FT /note="Ig-like 125"
FT /evidence="ECO:0000255"
FT DOMAIN 29445..29542
FT /note="Fibronectin type-III 108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 29468..29513
FT /note="Kelch 15"
FT /evidence="ECO:0000255"
FT REPEAT 29533..29576
FT /note="WD 14"
FT /evidence="ECO:0000255"
FT DOMAIN 29548..29643
FT /note="Fibronectin type-III 109"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29646..29741
FT /note="Fibronectin type-III 110"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29745..29836
FT /note="Ig-like 126"
FT /evidence="ECO:0000255"
FT DOMAIN 29844..29937
FT /note="Fibronectin type-III 111"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 29943..30039
FT /note="Fibronectin type-III 112"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30045..30140
FT /note="Fibronectin type-III 113"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30144..30229
FT /note="Ig-like 127"
FT /evidence="ECO:0000255"
FT DOMAIN 30240..30335
FT /note="Fibronectin type-III 114"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30337..30430
FT /note="Fibronectin type-III 115"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 30399..30432
FT /note="TPR 13"
FT /evidence="ECO:0000255"
FT DOMAIN 30430..30523
FT /note="Ig-like 128"
FT /evidence="ECO:0000255"
FT DOMAIN 30532..30626
FT /note="Fibronectin type-III 116"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30632..30727
FT /note="Fibronectin type-III 117"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30730..30829
FT /note="Fibronectin type-III 118"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 30833..30921
FT /note="Ig-like 129"
FT /evidence="ECO:0000255"
FT DOMAIN 30932..31025
FT /note="Fibronectin type-III 119"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31028..31127
FT /note="Fibronectin type-III 120"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31133..31229
FT /note="Fibronectin type-III 121"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31233..31322
FT /note="Ig-like 130"
FT /evidence="ECO:0000255"
FT DOMAIN 31329..31423
FT /note="Fibronectin type-III 122"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31426..31521
FT /note="Fibronectin type-III 123"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31525..31616
FT /note="Ig-like 131"
FT /evidence="ECO:0000255"
FT DOMAIN 31623..31717
FT /note="Fibronectin type-III 124"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31723..31817
FT /note="Fibronectin type-III 125"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 31742..31787
FT /note="Kelch 16"
FT /evidence="ECO:0000255"
FT DOMAIN 31824..31920
FT /note="Fibronectin type-III 126"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 31923..32012
FT /note="Ig-like 132"
FT /evidence="ECO:0000255"
FT DOMAIN 32020..32116
FT /note="Fibronectin type-III 127"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 32120..32216
FT /note="Fibronectin type-III 128"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 32222..32317
FT /note="Fibronectin type-III 129"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 32322..32410
FT /note="Ig-like 133"
FT /evidence="ECO:0000255"
FT DOMAIN 32515..32610
FT /note="Fibronectin type-III 130"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 32601..32644
FT /note="WD 15"
FT /evidence="ECO:0000255"
FT DOMAIN 32616..32711
FT /note="Fibronectin type-III 131"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 32717..32807
FT /note="Ig-like 134"
FT /evidence="ECO:0000255"
FT REPEAT 32754..32799
FT /note="WD 16"
FT /evidence="ECO:0000255"
FT DOMAIN 32817..32908
FT /note="Ig-like 135"
FT /evidence="ECO:0000255"
FT DOMAIN 32913..33006
FT /note="Fibronectin type-III 132"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 32932..32977
FT /note="Kelch 17"
FT /evidence="ECO:0000255"
FT DOMAIN 33040..33294
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REPEAT 33152..33189
FT /note="WD 17"
FT /evidence="ECO:0000255"
FT DOMAIN 33358..33446
FT /note="Ig-like 136"
FT /evidence="ECO:0000255"
FT REPEAT 33366..33411
FT /note="Kelch 18"
FT /evidence="ECO:0000255"
FT DOMAIN 33478..33571
FT /note="Ig-like 137"
FT /evidence="ECO:0000255"
FT DOMAIN 33583..33672
FT /note="Ig-like 138"
FT /evidence="ECO:0000255"
FT REPEAT 34097..34130
FT /note="TPR 14"
FT /evidence="ECO:0000255"
FT DOMAIN 34163..34253
FT /note="Ig-like 139"
FT /evidence="ECO:0000255"
FT DOMAIN 34350..34438
FT /note="Ig-like 140"
FT /evidence="ECO:0000255"
FT REPEAT 34380..34413
FT /note="TPR 15"
FT /evidence="ECO:0000255"
FT DOMAIN 34507..34596
FT /note="Ig-like 141"
FT /evidence="ECO:0000255"
FT DOMAIN 34641..34729
FT /note="Ig-like 142"
FT /evidence="ECO:0000255"
FT DOMAIN 34923..35011
FT /note="Ig-like 143"
FT /evidence="ECO:0000255"
FT DOMAIN 35118..35209
FT /note="Ig-like 144"
FT /evidence="ECO:0000255"
FT REGION 243..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..340
FT /note="ZIS1"
FT /evidence="ECO:0000250|UniProtKB:Q8WZ42"
FT REGION 854..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1405..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1446
FT /note="ZIS5"
FT /evidence="ECO:0000250|UniProtKB:Q8WZ42"
FT REGION 4205..4243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9873..9910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9962..9984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9999..10025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10163..10258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10275..10318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10371..10401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10436..10513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10525..10566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10585..10719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10859..11270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11370..11460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11572..11602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11630..11655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11671..12421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12454..12501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12561..12894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15753..15777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 16772..16801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 20167..20195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 20268..20289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 27952..27974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 31800..31832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 32102..32129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34010..34031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34080..34118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34449..34506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34611..34635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2031..2058
FT /evidence="ECO:0000255"
FT COILED 9495..9538
FT /evidence="ECO:0000255"
FT COMPBIAS 251..265
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4224..4241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9873..9889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9890..9909
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9963..9984
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10005..10025
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10163..10180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10181..10205
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10206..10221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10236..10258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10290..10306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10371..10391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10453..10468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10479..10513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10585..10612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10613..10644
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10645..10664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10668..10687
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10859..10925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10968..10993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11010..11073
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11081..11097
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11112..11162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11163..11200
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11226..11269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11392..11451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11680..11694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11791..11832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11857..11875
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11882..11903
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11962..11993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12247..12288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12327..12345
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12388..12402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12466..12483
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12484..12498
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12561..12593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12608..12642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12653..12772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12781..12796
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12798..12812
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12822..12836
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12846..12861
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12870..12886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16784..16798
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20177..20195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32111..32125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34080..34102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34459..34479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34483..34497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 33160
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:P28523,
FT ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 33046..33054
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:P28523,
FT ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 33069
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:P28523,
FT ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 263
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 264
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 266
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 278
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 286
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 296
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 296
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 299
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 304
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 756
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1251
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1415
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1420
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1424
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1429
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1434
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2078
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2080
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 3516
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 3784
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 8387
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 9144
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 9164
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WZ42"
FT MOD_RES 9168
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8WZ42"
FT MOD_RES 9459
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 10281
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 12869
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 12884
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 12972
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 13904
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 21152
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 21895
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 21980
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 22390
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 23387
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WZ42"
FT MOD_RES 23396
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8WZ42"
FT MOD_RES 25920
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 32870
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 33203
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8WZ42"
FT MOD_RES 33859
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 33861
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 33875
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 33880
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 33915
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 34009
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 34292
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 34464
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 34467
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 34470
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 34476
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 34481
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 34756
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT DISULFID 967..1018
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1730..1783
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 2202..2252
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3265..3317
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4365..4416
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4460..4511
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4553..4604
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4647..4698
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4740..4791
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5022..5073
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5209..5260
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5584..5635
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5771..5822
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 5864..5915
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6146..6197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6333..6384
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6426..6477
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6709..6760
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 6988..7039
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7084..7135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7180..7231
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7274..7325
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7367..7418
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7650..7701
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 7929..7980
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8025..8076
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8121..8172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8215..8266
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8308..8359
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8591..8642
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8870..8921
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 8966..9017
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 9062..9113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 9255..9306
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 9654..9704
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 12929..12979
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 13473..13522
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 13828..13878
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 14095..14145
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 14184..14234
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 14273..14323
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 14633..14683
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 32343..32394
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 33378..33430
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 34526..34580
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 556..601
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_052606"
FT VAR_SEQ 3461..5499
FT /note="IASLLSAEEDFQTYSSDLRLPNANETLELLSEPPARSTQFDSRQEGAAPVFI
FT REISDVEISVEDVAKLSVTVTGCPKPKIQWFFNGMLLTPSADYKFVFDGDTHSLIILFT
FT RFQDEGEYTCLASNEYGKAVCSAHLRISPRGERSTEMESGEKKALEKPKGPCPPYFFKE
FT LKPVHCGPGIPAVFEYSVHGEPAPTVLWFKEDMPLYTSVCYTIIHSPDGSGTFIVNDPQ
FT RGDSGLYLCKAQNLWGESTCAAELLVLPEDTDVPDASCKEESTLGVPGDFLETSARGPL
FT VQGVDSRQEITAFAEGTISKAALIAEETLQLSYERSVDDSEVGTGVTIGAQKLPPVVLS
FT TPQGTGELPSIDGAVHTQPGRGPPPTLNLQAVQAQTTLPKEATLQFEEPEGVFPGASSA
FT AQVSPVTIKPLITLTAEPKGNYPQSSTAAPDHALLSSVAAETLQLGEKKIPEVDKAQRA
FT LLLSQSLAEGCVESLEVPDVAVSNMRSEPQVPFQHTCTEGKILMASADTLKSTGQDVAL
FT RTEEGKSLSFPLALEEKQVLLKEEQSEVVAVPTSQTSKSEKEPEAIKGVKEVREQELLS
FT KETLFPSMPEEQRLHLKTQVRRALQAAVAREQANLFSEWLRNIDKVEVTAVNFTQEPKR
FT ILCTYLITSVSSLTEELTVTIEDIDPQMANLETGLKDALCSIVCEERNILMAEDPRIHE
FT EDKIDVQGGRDHLSDAQKVETVIEAEADSKYLVSKEEVSWSKVESQLKDGDTNEVPQAE
FT TLKLAEESGTQKTSTEMSQEEAEGTLADLCPAVLKHLVDTISEEGDTVHLTSSISNAKE
FT VHWYFKGNLVPSDGKFKCLKEQNAYTLVIEAVKTEDEGEYVCEASNDSGKAKTSAKLTV
FT GERAAPVIKRRIEPLEVALGHLAKFTCEIQGAPNVRFQWFKAGREIYESDKCSIRSSNY
FT VSSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKALTTFVGKAA
FT KFLCTVSGTPVIEIIWQKDGAALSPSPDCRVTDADNKHSLELSNLTVQDRGIYSCKASN
FT KFGADICQAELTIIDKPHFIKELEAVQSAINKKIHLECQVDEDRKVTITWSKDGQKLPA
FT GKDYKIYFEDKIASLEIPLAKLKDSGTYTCTASNEAGSSSSSAAVAVREPPSFVKKVDP
FT SYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMSFVNSEAILDITDVKVDD
FT SGTYSCEATNDVGSDSCSTEVVIKEPPSFIKTLEPADIVRGANALLQCEIAGTGPFEVN
FT WFKDKKQIRSSKKYRLFTQKTFVYLEISSFNSADVGDYECVVANEVGKCGCVATHLLKE
FT PPTFVKKVDDFTALAGQTVTLQAAVRGSEPISVMWMKGQEVIKEDGKIKMSFSNGVAVL
FT TIPDVQISLGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTV
FT SGTPELKPKWYKDGRPLVASKKYRISFKNNIAQLKFYSAELHDSGQYTFEISNEVGSSS
FT CETTFTVLDRDIAPLFTKPLRNVDSVVGGACRLDCKIAGSLPMRVSWFKDGKELTASDR
FT YQIAFVEGTASLEISRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSRDV
FT LPGSAVCLKSAFQGSAPLTIKWFKGDKELVSGGSCYITKETSESSLELYAVKTSDSGTY
FT TCKVSNVAGSVECSADLFVKEPATFIEKLEPSQLLKKGDGTQLACKVTGTPPIKITWFA
FT NDRELRESSKHKMSFAESTAVLRLTDVAIEDSGEYMCEAQNEAGSDHCTGIVIVKESPY
FT FTKEFKSIEVLKEYDVMLLAEVAGTPPFEITWFKDNTTLRSGRKYKTFLQDQLVSLQVL
FT KFVAADAGEYQCRVTNEVGSSTCSARVTLREPPSFIKKIEATSSLRGGTAAFQATLKGS
FT LPITVTWLKDNDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSA
FT LLSVKEPATIMEEAVSIDVTQGDPATLQVKFSGTKEISAK -> ELFEGEADGSGDARG
FT AFSDSEDIDHHSLMARRYANRTSSTSSWPEYFKPTFTQKLTFQYALEGEPIVFTCSLVA
FT YPTPEMTWFHNNRPIPTGLRRVVRTETDLHQHSSSLEVKRVQGRDSGSYRFLAVNSEGS
FT AESSASLHVIQKGQDERYLEFLKRAEQTWENTRGLGERREERIKVGLRFTGSPFNKKQD
FT VEEKGMVRTIHFRSASPVRRADYVYNDEWSESKFDIRGCLSVGESFLDEETKMKLQRLR
FT EARKIFLEKKKLSLLEASSEVNSVTVRSEDIVGDAPLSREEGKRGFGREFAEDRHRVDN
FT SAEGVIENPYSVPNQIHQNREPPSSVRATGDEDLQTENSPDQETFLEESLQKGYLCEHV
FT LVGENLQAVEWFEESVTSTVIREPLPFTSNEEVHGYKSRGICESPDKVSQVLTPYPSES
FT LDTFVDAKETEDVDSGGGTQRGWQEGQCHASTKVEEFKVEHEEKTRSFENYFQKHPQRC
FT PPSFLQDIESQEVYEGDSCKFVCHFQGYPQPIVTWYNNEMPVPRSQGFTTHTFENYSTL
FT TFPSVQPQHGGSVTCVLFNQYGTVKATSMLRVKAKPRYESQPHKVPVWPDYADEEEELA
FT LVFDQARRIHPSFSQERQEHLHMLKAHLPELPSADRELLSFPVEIQITAATPTPEQNKE
FT CRELFELEPEVTPRDQAIQSPKHKFIFSSDITNEPPKMLQEMPRSASCREGNSVMLECL
FT ISGEPQPVVMWFHNGVLVKPNQRFEMEEVNCSYRLYINDASSQDSGRYQCVAQNDSGIA
FT ESILDLTVEPITYREYSQLENESRIYAQYSKNQQTQVQGEPVRTHFYDHTVSPFAAQSN
FT IKEYTIREYFQSLETVGELEKKNEVYCPTTVEKLSKSMQHASRPTDIEKPHRMEFLQCQ
FT DEEHIGERSQSLQAGATICPFVDDFSKANIRNKVSDDVGYHGPDWGNMKGHSQSDYVLN
FT IHSKRTSNTVQDVEDSPVPTYEEALEEERYYPGKKVRHKVIAFEKLQRAERGVVEKRRT
FT KKSFVTAPQKKWDNREFSLTQNEPGSSNMYRAEEVASHTEADSSNIIMDLKQLSSQAHE
FT EFEIEERGRQEEILPLDQEKFELEAPVTFDLKQFHSQIESTGMNFQGLANGQQDKSSLK
FT TQQPASEMANPEDVVFDLKQMYSHIEDPGEVFQGQETESKQETCHKEEISIYQSFQYAQ
FT EENTAILKPDHVPESFSEVIHGEARALFQTPSADVEEANVSETGASVENGDKTFISQLK
FT RAASEEECLEDHEMEDGPTLKPAFGMTQGYEGTLENPRGAVHGAEVPHRRLSLSQDLPF
FT LMTGEQQDLKEQLSESIEASGEETYHEVHVPSESSFSTMEGEKIEKSLLENLPRLEEAQ
FT TTKEGEYETSLTQYLLAEGRYEVPEVRDTKHKAQLVQSDSTTSMEVEEVTFNTVYEYYN
FT QKQESVGRPYSPESDISIDVGSTSSEDLSELDQFYSPPSSVENLESPKSPDLYFKPSDR
FT IEQPVANSRAEENGERYSTPSEGEIPERYSTPSGEALERYSTPPGEALERYSTPPGEAL
FT ERYSTPPGEALERFSTPPGEALERFSTPPGEALERYSTPPGEALERFSTPPGEKLERGF
FT IPTRGPNHARNVSRNLSELEREDSTANEHFHTPTDERSSPYETWRSDSFGTPNEAIEPK
FT DNEMPPSFIEPLSRRKIYENTTLGFIIEVEGLPVPGVKWYRNKSLLEPDDRIKMERVGN
FT VCSLEIANIQKGDGGEYLCHAVNIIGEAKSFAIVDVIPQEERAVALPPPVTHQHIMEFD
FT VANSNSSRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVPEFTPDHKSMIVSLDILPLSL
FT VDPSAESQGQEGREFKIDLEAFEMPPRFITPICDFRIPENSSAVFKCSVIGIPPPEVRW
FT YKEYMCIEPDDTKYVISEEKGSHSLRIQDVGPSDCATYRCRALNSAGEAICRGFLTMGD
FT SQVSAVATRTSKVTLSSQKEELVLRSRYADSFFEFQVVDGPPRFIKGISDCHAPLGTAA
FT YFQCLVRGSPRPTVSWYKDGKLVQGSRFSAEESGIGFHNLFITGLVKGDEGEYSCVATN
FT NSGMARSSAILTLS (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_052607"
FT VAR_SEQ 4435..12715
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_052608"
FT VAR_SEQ 5500..35213
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_052609"
FT STRAND 9724..9726
FT /evidence="ECO:0007829|PDB:6YJ0"
FT STRAND 9731..9746
FT /evidence="ECO:0007829|PDB:6YJ0"
FT STRAND 9751..9756
FT /evidence="ECO:0007829|PDB:6YJ0"
FT STRAND 9764..9772
FT /evidence="ECO:0007829|PDB:6YJ0"
FT STRAND 9775..9782
FT /evidence="ECO:0007829|PDB:6YJ0"
FT HELIX 9785..9787
FT /evidence="ECO:0007829|PDB:6YJ0"
FT STRAND 9789..9796
FT /evidence="ECO:0007829|PDB:6YJ0"
FT STRAND 9798..9800
FT /evidence="ECO:0007829|PDB:6YJ0"
FT STRAND 9803..9809
FT /evidence="ECO:0007829|PDB:6YJ0"
FT MOD_RES A2ASS6-3:3432
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES A2ASS6-3:3636
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES A2ASS6-3:3678
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES A2ASS6-3:3763
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES A2ASS6-3:3827
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES A2ASS6-3:3836
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES A2ASS6-3:4672
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES A2ASS6-3:4720
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 35213 AA; 3906488 MW; C761D2E29FF1AC14 CRC64;
MTTQAPMFTQ PLQSVVVLEG STATFEAHVS GSPVPEVSWF RDGQVISTST LPGVQISFSD
GRARLMIPAV TKANSGRYSL RATNGSGQAT STAELLVTAE TAPPNFSQRL QSMTVRQGSQ
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN
SVGRATSTAE LVVQGEEVVP AKKTKTIVST AQISETRQTR IEKKIEAHFD ARSIATVEMV
IDGATGQLPH KTPPRIPPKP KSRSPTPPSI AAKAQLARQQ SPSPIRHSPS PVRHVRAPTP
SPVRSVSPAG RISTSPIRSV KSPLLIRKTQ TTTMATGPEV PPPWKQEGYV ASSTEAEMRE
TTMTSSTQIR REERWEGRYG VQEQVTISGA AAAAASASVS SSFTAGAITT GTKEVKQETD
KSAAVATVVA AVDMARVREP AISAVEQTAQ RTTTTAVHIQ PAQEQARKEA EKTAVTKVVV
AADKAKEQEL KSRTREVMVT TQEQTHISHE QIRKETEKAF VPKVVISATK AKEQETRITG
EITTKQEQKR ITQETIRQET EEIAASMVVV ATAKSTKLEA AVGVQEETAI QQDQMHLTHE
QMMKETRKTV VPKVIVATPK IKEQDLVSRS REAITTKRDQ VQITQEKKRK EVETTALSTI
AVATAKAKEQ ETVLRSREAM ATRQEHIQVT HGQVGVGKKA EAVATVVAAV DQARVREPRE
PTHVEESHSQ QTTLEYGYKE HISTTKVPEQ PRRPASEPHV VPQAVKPAVI QAPSETHIKT
TDQMGMHISS QVKKTTDIST ERLVHVDKRP RTASPHFTVS KISVPKTEHG YEASIAGSAI
ATLQKELSAT SSTQKITKSV KAPTVKPGET RVRAEPTPSP QFPFADMPPP DTYKSQAGIE
VKKEVGVSIS GSTVREEHFE VLRGREAKVT ETARVPAPAE VPVTPPTLVS GLKNVTVIEG
ESVTLECHIS GYPSPKVTWY REDYQIESSI DFQITFQGGI ARLMIREAFA EDSGRFTCSA
VNEAGTVSTS CYLAVQVSEE FDKETTLTEK FATEEKRFVE SRDVVMTDTS ITEEQAGPGE
PAAPFFISKP VVQKLVEGGS VVFECQIGGN PKPHVYWKKS GVPLTTGYRY KVSYNKQTGE
CRLVISMTFA DDAGEYTIVI RNKHGETSAS ASLLEEADYE ALVKTQQEML YQTQMSTFIQ
EPKVGEIAPG FAYSEYEKEY EKEQALIRKK MAKDTVMVRT FVEDQEFHIS SFEERLIKEI
EYRIIKTTLE ELLEEDGEEK MAVDISESEA IESGFDIRIK NYRILEGMGV TFHCKMSGYP
LPKIAWYKDG KRIRHGERYQ MDFLQDGRAS LRIPVVLPED EGIYTAFASN IKGNAICSGK
LYVEPAAPFS APTYMPTPEA VSRIRSVSPR SLSRSPIRMS PAMSPARMSP ARMSPARMSP
ARMSPGRRLE ETDESQLERL YKPVFVLKPA SFKCLEGQTA RFDLKVVGRP MPETFWFHNG
QQIVNDYTHK VVIKEDGTQS LIIVPASPSD SGEWTVVAQN RAGKSTISVT LTVEAVEHQI
KPAFVEKLKN VNIKEGSRLE MKVRATGNPN PDIVWLKNSD IIVPHKYPRI RIEGTRGEAA
LKIDSIISQD SAWYTATAIN KAGRDTTRCK VNVEVEFAEP EPERKLIIPR GTYRAKEIAA
PELEPLHLRY GQEQWEEGDL YDKEKQQKPF FKKKLTSLRL KRFGPAHFEC RLTPIGDPTM
VVEWLHDGKP LEAANRLRMI NEFGYCSLDY GAAYSRDSGV ITCRATNKYG TDHTSATLIV
KDEKSLVEES QLPDGKKGLQ RIEELERMAH EGALTGVTTD QKEKQKPDIV LFPEPVRVLE
GETARFRCRV TGYPQPKVNW YLNGQLIRKS KRFRVRYDGI HYLDIVDCKS YDTGEVKVTA
ENPEGVTEHK VKLEIQQRED FRSVLRRAPE PKPEFHVHEP GKLQFEVQKV DRPVDTSETK
EVVKLKRAER ITHEKVSEES EELRSKFKRR TEEGYYEAIT AVELKSRKKD ESYEELLKKT
KDELLHWTKE LTEEEKKALA EEGKITIPTF KPERIELSPS MEAPKIFERI QSQTVGQGSD
AHFRVRVVGK PDPECEWYKN GVKIERSDRI YWYWPEDNVC ELVIRDVTAE DSASIMVKAI
NIAGETSSHA FLLVQAKQLI TFTQELQDVV AKEKDTMATF ECETSEPFIK VKWYKDGIEV
HAGDKYRMHS DRKVHFLSVL TIDTSDAEDY SCVLVEDENI KTTAKLIVEG AVVEFVKELQ
DIEVPESYSG ELECIISPEN IEGKWYHNDV ELKSNGKYSI TSRRGRQNLT VKDVTKEDQG
EYSFVVDGKK TTCKLKMKPR PIAILQGLSD QKVCEGDIVQ LEVKVSLENV EGVWMKDGQE
VQHSDRVHIV IDKQSHMLLI EDMTKEDAGN YSFTIPALGL STSGNVSVYS VDVITPLKDV
NVIEGTKAVL ECKVSVPDVT SVKWYLNDEQ IKPDDRVQSI VKGTKQRLVI NRTHASDEGP
YKLMVGRVET SCNLSVEKIK IIRGLRDLTC TETQNVVFEV ELSHSGIDVV WNFKGKEIKP
SSKYKIEAHG KIYKLTVLNM MKDDEGEYAF YAGENTTSGK LTVAGGAIST PLTDQTVAES
QEAVFECEVA NPESEGEWLK DGKHLALSNN FRGESDGHKR RLVIAAAKLD DAGEYTYKVA
TSKTSAKLKV EAVKIKKTLR NLTVTETQDA VFSVELTHPD VKGVQWIKNG VVLDSNDKYE
ISVKGTLYSL KIKNCAMADE SVYGFKLGRL GASARLHVET VKIIKKPKDV TALENATVTF
EVSVSHDTVP VKWFHKNVEI KPSDKHRLVS ERKVHKLMLQ SISPSDAGEY TAMVGQLECK
AKLFVETLHI TKTMKSIEVP ETKAASFECE VSHFNVPSMW LKNGVEIEMS EKFKIVVQGK
LHQLIIMNTS TEDSAEYTFV CGNDQVSATL TVTPIMITSM LKDINAEEKD TITFEVTVNY
EGISYKWLKN GVEIKSTDRC QMRTKKLTHS LNIRNVHFGD AADYTFVAGK ATSTATLYVE
ARHIEFRKHI KDIKVLEKKR AMFECEVSEP DITVQWMKDG QELQIADRIK IQKEKYVHRL
LIPSTRMSDA GKYTVVAGGN MSTANLFVEG RDVRIRSIKK EVQVIEKQRA VVEFEVNEDD
VDAHWYKDGI EINFQVQERH QYVVERRIHR MFISETRHSD AGEYTFVAGR NRSSVTLYVN
APEPPQVLQE LQPVTVQSGK PARFCAVISG RPQPKISWYK EEQLLSTGFK CKFLHDGQEY
TLLLIEAFPE DAAVYTCEAK NDYGVATTSA SLSVEVPEVV SPDQEMPVYP PAIVTPLQDT
VTSEGRPARF QCQVSGTDLK VSWYCKDKKI KPSRFFRMTQ FEDTYQLEIA EAYPEDEGTY
AFVANNAVGQ VSSTATLRLE APESILHERI GQQIEMEMKE IASLLSAEED FQTYSSDLRL
PNANETLELL SEPPARSTQF DSRQEGAAPV FIREISDVEI SVEDVAKLSV TVTGCPKPKI
QWFFNGMLLT PSADYKFVFD GDTHSLIILF TRFQDEGEYT CLASNEYGKA VCSAHLRISP
RGERSTEMES GEKKALEKPK GPCPPYFFKE LKPVHCGPGI PAVFEYSVHG EPAPTVLWFK
EDMPLYTSVC YTIIHSPDGS GTFIVNDPQR GDSGLYLCKA QNLWGESTCA AELLVLPEDT
DVPDASCKEE STLGVPGDFL ETSARGPLVQ GVDSRQEITA FAEGTISKAA LIAEETLQLS
YERSVDDSEV GTGVTIGAQK LPPVVLSTPQ GTGELPSIDG AVHTQPGRGP PPTLNLQAVQ
AQTTLPKEAT LQFEEPEGVF PGASSAAQVS PVTIKPLITL TAEPKGNYPQ SSTAAPDHAL
LSSVAAETLQ LGEKKIPEVD KAQRALLLSQ SLAEGCVESL EVPDVAVSNM RSEPQVPFQH
TCTEGKILMA SADTLKSTGQ DVALRTEEGK SLSFPLALEE KQVLLKEEQS EVVAVPTSQT
SKSEKEPEAI KGVKEVREQE LLSKETLFPS MPEEQRLHLK TQVRRALQAA VAREQANLFS
EWLRNIDKVE VTAVNFTQEP KRILCTYLIT SVSSLTEELT VTIEDIDPQM ANLETGLKDA
LCSIVCEERN ILMAEDPRIH EEDKIDVQGG RDHLSDAQKV ETVIEAEADS KYLVSKEEVS
WSKVESQLKD GDTNEVPQAE TLKLAEESGT QKTSTEMSQE EAEGTLADLC PAVLKHLVDT
ISEEGDTVHL TSSISNAKEV HWYFKGNLVP SDGKFKCLKE QNAYTLVIEA VKTEDEGEYV
CEASNDSGKA KTSAKLTVGE RAAPVIKRRI EPLEVALGHL AKFTCEIQGA PNVRFQWFKA
GREIYESDKC SIRSSNYVSS LEILRTQVVD CGEYTCKASN EYGSVSCTAT LTVTEAYPPT
FLSRPKALTT FVGKAAKFLC TVSGTPVIEI IWQKDGAALS PSPDCRVTDA DNKHSLELSN
LTVQDRGIYS CKASNKFGAD ICQAELTIID KPHFIKELEA VQSAINKKIH LECQVDEDRK
VTITWSKDGQ KLPAGKDYKI YFEDKIASLE IPLAKLKDSG TYTCTASNEA GSSSSSAAVA
VREPPSFVKK VDPSYLMLPG ESARLHCKLK GSPVIQVTWF KNNKELSESN TVRMSFVNSE
AILDITDVKV DDSGTYSCEA TNDVGSDSCS TEVVIKEPPS FIKTLEPADI VRGANALLQC
EIAGTGPFEV NWFKDKKQIR SSKKYRLFTQ KTFVYLEISS FNSADVGDYE CVVANEVGKC
GCVATHLLKE PPTFVKKVDD FTALAGQTVT LQAAVRGSEP ISVMWMKGQE VIKEDGKIKM
SFSNGVAVLT IPDVQISLGG KYTCLAENEA GSQTSVGELI VKEPAKIIER AELIQVTAGD
PATLEYTVSG TPELKPKWYK DGRPLVASKK YRISFKNNIA QLKFYSAELH DSGQYTFEIS
NEVGSSSCET TFTVLDRDIA PLFTKPLRNV DSVVGGACRL DCKIAGSLPM RVSWFKDGKE
LTASDRYQIA FVEGTASLEI SRVDMNDAGN FTCRATNSVG SKDSSGALIV QEPPSFVTKP
GSRDVLPGSA VCLKSAFQGS APLTIKWFKG DKELVSGGSC YITKETSESS LELYAVKTSD
SGTYTCKVSN VAGSVECSAD LFVKEPATFI EKLEPSQLLK KGDGTQLACK VTGTPPIKIT
WFANDRELRE SSKHKMSFAE STAVLRLTDV AIEDSGEYMC EAQNEAGSDH CTGIVIVKES
PYFTKEFKSI EVLKEYDVML LAEVAGTPPF EITWFKDNTT LRSGRKYKTF LQDQLVSLQV
LKFVAADAGE YQCRVTNEVG SSTCSARVTL REPPSFIKKI EATSSLRGGT AAFQATLKGS
LPITVTWLKD NDEITEDDNI RMTFENNVAS LYLSGIEVKH DGKYVCQAKN DAGIQRCSAL
LSVKEPATIM EEAVSIDVTQ GDPATLQVKF SGTKEISAKW FKDGQELTLG PKYKISVTDT
VSILKIISTE KKDSGEYTFE VQNDVGRSSC KASINVLDLI IPPSFTKKLR KMDSIKGSFI
DLECIVAGSH PISIQWFKDD QEISASDKHK FSFHDNTAFL EISQLEGTDS GTYTCSATNK
AGHSQCSGHL TVKEPPYFVE KPQSQDVNPG TRVQLKALVG GTAPMTIKWF KDNKELHPGA
ARSVWKDDTS TILELFSAKA ADSGTYICQL SNDVGTTSSK ATIFVKEPPQ FIKKPSPVLV
LRNGQSTTFE CQVTGTPEIR VSWYLDGNEI TDLRKYGISF VDGLATFQIS NARVENSGTY
VCEARNDAGT ASCSIELKVK EPPIFIRELE PVEVVKDSDV ELECEVMGTT PFEVTWLKNN
KEIRSGKKYT MSEKMSVFYL HITKCDPSDV GEYQCIIANE GGSCACSARV ALKEPPSFIK
KIENVTTVLK SSATFQSTVA GSPPISITWL KDDQILEEND NVHISFEDSV ATLQVRSVDN
GHSGRYTCQA KNESGIERCY AFLLVQEPAQ IIEKAKSVDV TEKDPVTLEC VVAGTPELKV
KWLKDGKQIV PSRYFSMSFE NNVASFRIQS VMKQDSGQYT FKVENDFGSS SCDAYLRVLD
QDIPPSFTKK LTKMDKVLGS SIHMECKVSG SLPISAQWFK DGKEISTSAK YRLVCHENTV
SLEVSNLELE DTANYTCKVS NVAGDNACSG ILTVKEPPSF LVKPERQQAI PDSTVEFKAV
LKGTPPFKIK WLKDDVELVS GPKCFIGLEG STSFLNLYSV DSSKTGQYTC QVTNDVGSDS
CTTMLLVTEP PKFVKKLEAS KIIKAGDSAR LECKITGSPE IQVVWYRNEH ELTASDKYQM
TFIDSVAVIQ MNSLGTEDSG DFICEAQNPA GSTSCSTKVI VKEPPVFSSF PPIVETLKNT
EVSLECELSG TPPFEVVWYK DKRQLRSSKK YKVASKNFHA SIHILNVEST DIGEYHCKAQ
NEVGSDACVC AVKLKEPPKF ISKLNSLTVV AGEPAELQAS IEGAQPISVQ WLKEKEEVIR
ESENIRISFV NNVATLQFAK VEPANAGKYI CQVKNDGGVR ENMATLTVLE PAVIIEKAGS
MTVTVGETCA LECKVAGTPE LSVEWYKDGK LLTSSQKHKF SFYNKISSLK ILSVEKEDAG
TYTFQVQNNV GKSSCTAVVD VSDRMVPPSF TRRLKDTGGV LGTSCILECK VAGSSPISIA
WFHEKTKIVS GAKYQTTFSD NVCTLQLNSL DSSDMGSYTC VAANVAGSDE CRALLTVQEP
PSFVKEPEPL EVLPGKNITF TSVIRGTPPF KVGWFRGARE LVKGNRCNIY FEDTVAELEL
FNIDISQSGE YTCVVSNNAG QASCTTRLFV KEPATFVKKL SDHSVEPGKS IILEGTYTGT
LPISVTWKKD GVSITPSERC NIVTTEKTCI LEILSSTKGD AGHYSCEIEN EAGRDACDAL
VSTLEPPYFV TELEPLEASV GDSVSLQCQV AGTPEITVSW FKGDTKLRST PEYRTYFTNN
VATLVFNKVS INDSGEYTCM AENSIGTAAS KTIFRIQERQ LPPSFARQLK DIEQTVGLPV
TLTCRLNGSA PIQVCWYRDG VLLRDDENLQ MSFVDNVATL KILQTDLSHS GQYSCSASNP
LGTASSTARL TAREPKKSPF FDIKPVSIDV IAGESADFEC HVTGAQPMRV TWSKDNKEIR
PGGNYTITCV GNTPHLRILK VGKGDSGQYT CQATNDVGKD MCSAQLSVKE PPKFIKKLDA
SKVAKQGESI QLECKISGSP EIKVVWFRND SELHESWKYN MSFVNSVALL TINEASAEDT
GDYICEAHNG VGDASCSTAL KVKAPPVFTQ KPPPVGALKG SDVILQCEIS GTPPFEVVWV
KDRKQVRSSK KFKITSKNFD TSLHIFNLEA PDIGEYHCKA TNEVGSDTCA CTVKFKEPPR
FVKKLSDAST LIGDPVELQA VVEGFQPISV VWLKDKGEVI RESENVRISF VDNIATLQLG
SPEASQSGKY VCQIKNDAGM RECSAVLTVL EPATIVEKPE PMTVTTGNPF TLECVVAGTP
ELSAKWFKDG RELSSGSRHH ITFVRNLASL KIPSAEMNDK GLYTFEVENR VGKSSCTVSV
HVSDRVVPPS FVRRLKDTSA TLGASVVLEC RVSGSAPISV GWFLDGNEII SSPKCQSSFA
DNVCTLTLSS LEPSDTGAYT CVAANVAGQD ESSAVLTVQE PPSFEQTPDS VEVLPGMSLT
FTSVIRGTPP FKVKWFKGSR ELVSGEACTI SLEDFVTELE LLEVEPGQSG DYSCLVTNDA
GSASCTTHLF VKEPATFVKR LADTSVETGS PIVLEATYSG TPPISVSWMK NEYPLSQSPN
CGITTTEKSS ILEILESTIE DYAQYACLIE NEAGQDICEA LVSVLEPPYF IEPLEHVEAA
IGEPITLQCK VDGTPEIRIS WYKEHTKLRS APAYKMQFKN NVASLVINKV DHSDVGEYTC
KAENSVGAVA SSAVLVIKER KLPPSFARKL KDVHETLGFP VAFECRINGS EPLQVSWYKD
GELLKDDANL QMSFVHHVAT LQILQTDQSH VGQYNCSASN PLGTASSSAK LILSEHEVPP
FFDLKPVSVD LALGESGSFK CHVTGTAPIK ITWAKDNREI RPGGNYKMTL VENTATLTVL
KVAKGDAGQY TCYASNVAGK DSCSAQLGVQ EPPRFIKKLD QSRIVKQDEY TRYECKIGGS
PEIKVLWYKD EVEIQESSKF RMSFEDSVAI LEMHSLSVED SGDYTCEARN AAGSASSSTS
LKVKEPPVFR KKPFPVETLK GADVHLECEL QGTPPFQVSW HKDKRELRSG KKYKIMSENL
LTSIHILNVD TADIGEYQCK ATNDVGSDTC VGSVTMKAPP QFVKKLTDIS TIIGKEVQLQ
TTIEGAEPIS VAWFKDKGEI VRESDNIWIS YSENIATLQF SRAEPANAGK YTCQIKNDAG
MQECYATLSV LEPAAIVEKP ESIKVTTGDT CTLECTVSGT PELSTKWFKD GKELTSDNKY
KISFFNKVSG LKIINVVPGD SGVYSFEVQN PVGKDSCKVS IQVSDRIIPP SFTRKLKETN
GLSGSSVVME CKVYGSPPIS VLWFHDGNEI SSGRKYQTTL TDNTCALTVN MLEEADAGDY
TCIATNVAGS DECSAPLTVR EPPSFVQKPD PMDVLTGSNV TFTSIVKGSP PFTVSWFKGS
TELVPGARCN VSLQDSVGEL ELFDVDTSQS GEYTCIVSNE AGRASCTTRL FVKAPAIFVK
RLNDYSIEKG KPLILEGTFS GTPPISVTWK KNGINVIASQ RCNITTTEKS AILEILSSTV
EDSGQYNCYI ENASGKDSCS AQILILEPPY FVKQLEPVKV TVGDSASLQC QLAGTPEIGV
SWYKGDTKLR PTATCKMHFK NNVATLVFTQ VDSSDSGEYI CRAENSVGEV SSSTFLTVQE
QKLPPSFSRQ LRDVQETVGL PVVFECAVSG SEPISVSWYK DGKPLKDSPN IQTSFLDNIA
TLNIFKTDRS LSGQYSCTAT NPIGSASSGA KLILTEGKNP PFFDIPLAPM DAVVGESADL
ECHVTGTQPI KVTWAKDNRE IRSGGNYQIS YLENSAHLTI VKVDKGDSGQ YTCYAVNEVG
KDSCTAQLNI KERLIPPSFT KKLSETVEET EGNSFKLEGR VAGSQPITVA WYKNNVEIHP
TSNCEIMFKN NALLLQVKRA SMADAGLYTC KATNDAGSAL CTSSIVIKEP KKPPVFDQHL
APVTASEGDS VQLSCHVQGS EPIRIQWLKA GREVKPSDRC SFSFASGTAM LELKETAKAD
SGDYVCKASN VAGSDTSKCK VTIKEKPAAA PAAKKAAVDG KLFFVSEPQS IRVVEKTTAT
FIAKVGGDPI PNVKWTKGKW RQLNQGGRIL IHQKGDEAKL EIRDTTKTDS GLYRCVAFNK
HGEIESNVNL QVDERKKQEK IEGDLRAMLK KTPALKKGSG EEEEIDIMEL LKNVDPKEYE
KYARMYGITD FRGLLQAFEL LKQSQEEETH RLEIEELEKS ERDEKEFEEL VAFIQQRLTQ
TEPVTLIKDI ENQTVLKDND AIFEIDIKIN YPEIKLSWYK GTEKLEPSNK YEISIDGDRH
TLRVKNCQPK DQGNYRLVCG PHIASAKLTV IEPAWERHLQ DVTLKEGQTC TMTCQFSVPN
VKSEWFRNGR VLKPQGRVKT EVEHKVHKLT IADVRAEDQG QYTCKHEDLE TSAELRIEAE
PIQFTKRIQN IVVSEHQSAT FECEVSFDDA IVTWYKGPTE LTESQKYNFR NDGRCHYMTI
HNVTPDDEGV YSVIARLEPR GEARSTAELY LTTKEIKLEM KPPDIPDSRV PIPTMPIRAV
PPEEIPPAVA PSIPLLLPLP EEKKPPAKRI EVTKKGVKKD TKKVVTKPKE EAPPPPVAKK
PPPPTPMIPA KASEIIDVSS KAEEVKITTI TRKKEVHKEK EAVYEREEAV YEKKVHIEPW
EEPYEELETE PYTEPYEEPY YEEPDEDYEE IKVEAKKQVH EEWEEDFEEG QEYYEREEGY
DEGEEEWEEI YHEREIIQVQ KEVHEELHEK KIPAKVPEKK VPPPKVVKKP VVEKVEKTTR
RMEEEKVQVI KVPEVSKKIV PQKPSRTPVQ EEIIEVKVPA VHTKKMVISE EKMFFASHTE
EEVSVSVPEV QKKTVTEEKI HVAVSKKIEP PPKVPEPPKK PVPEEVVPVP IPKKVEPPAA
KVPEAPKKPV PEEKKPVPIP KKKEPAAPPQ VPEAPKKPAP EEKIPVPVTK KKEAPPAKVP
EVQKKVVTEE KIAIITQREE SPPPAVPEIP KKKVPEEKRP VPRKEEVPPP KVPVPPKKAV
PEAVVPAPIP KKAPPRAEVS KKTVVEEKRF AAEEKLSVAV PQRVELMRHE EEEWTYSEEE
ERVSVSVYRE EERDEEEAEI TEYEVLEEPE EYVVEEKMHF ISKKVEVEPA KVPEKKIIPK
PKVPAKIEEP PPTKVPEPPK KIVPEKKVPA PAPKKVPPAK APEESKRPVP EKRAPAEEVG
IEEPPPTKVA ERHMKITQEE KVLVAVTKKE APPRARVPEE PKKVAPEERF PKLKPRREEE
PPAKVTEVRK RAVKEEKVSI EVPKREPRPT KEVTVTEEKK WSYTREEETV SEHREEEYED
YEDYEEYKEF EEYEPTEEYD QYDEYAEREV EHYEEHEEYV TEPKKPVPVK PAQEPVPAKP
KAPPPKVLKK AVPEEKAPLP IQKKLKPLPP KAPEEPKKVV EEKIQISITK REKQQVTEPV
AKVPMKPKRV VPEAKIPAPT KEVAVPVRVP GVPKKRELEE VVVFKEEVEA HEEYIVEEEE
EYVHEEEYVH KEEYVHEEEY VHKEEYIHEE EEHLHEEEET IAEEEVVPVA PVKVPVVPKK
PVPEEKKPVP VPKKKEAPPA KVPEIPKKPE EKVPVPIPKK EKAPPAKVPE VPKKPVPEEK
PPVPVPKKVE PPPAKVPEVP KKPVPEKKVP APTPKKVEAP PAKVPEVPKK PIPEEKKPTA
LLKKMEAPPP KAPKKREVVP VPVALPREEE EEEVPFEEVP EEEILPEEEV PSEEEAPPEE
VPPEEEEVLP EEEEVLPEEE EVLPEEEEVQ PEEEALPEIK PKVPKPAPVP KKTVPEKKVP
VPVPKKVEPP PPPKVPEIKK KVPEKKVVVP KKEEAPPTKV PEVSKKVEER RIIPPKEEEV
PPAEVYEEAE EPTPEEIPEE PPSIEEEEIV EEEEEEEEVL PPRAPEVVKK AVPEAPTPVP
KKAEAPPAKV PKKIPEEKVP VPVQKKEAPP AKVPEKKKIP EKKVPVPKKE AVPPAKGKAV
FEEKISVAYQ QEELVQERIE LELVEAKVEE AFEEEEFHEV QEYFEEEEFH EVEEFIRVEE
RRFQEEHKVE EVHRVIEFLE AEEVEVYEKP KIPPKKGPEV SEKVIPPKKP PTKVIPRKEP
PAKVPEVTKK TVVEEKIRAP EEPKVPAPKA PEVPKKITPE EKVREAVPKK PEVPPPKVPE
VPKKIIQEEK LPVVLPEDTE IYMYEASEET VIEEEHVTLP QKARLKVAKV PAPPQTVVTE
EKTYVTIRKT RETLALKESE TTREAFPELK SYKAVPEIPE PPSPEDLEII EDVLPEKRPP
ASKRRKTQLP TAPEAPREMP PEMNTFEEIS VEPEMLPTQV LDTYQEATVE KKTLRISRKK
PELPSDEEVP EAPREVVAKK KVLPPQVPEV VPVKVPGAPK EVVSERKSLE EPPKKPAVRP
VTVPEEPKEV IPEKKVSLVP PKKPAAPPVT VPEAPEEVFS EDEETLAPPQ EPEAPPAKVP
EAPKEVVPEK KVSVVPPKKP EAPPAKVPEA PKEAAPEKKV PVAPKKKPEA PPVKVPEAPK
KVVPEKKLPV AAPKKPEAPA AEVPEVPKTA VPQKKIPEAI PPKPESPPLE VPEVPPKEVT
PEKKVPAAPP TKPEIPPPKV PEAPQAAVVE EKTPEALPKK AEAAPVPVPQ VQETVPEKTR
PVGPPKKPEA TTVPVPKVQK TIPEKTRPEA PPKRPEARTV PETVPEKTRP MAPPKKPEAT
TLPVPEVQET VPEKTRPVGP PKKPEATTVP VPEVQETIPE KTRPPKKPEA TPVPVPEVQE
TVPEKTRPVG PPKKPEATTV SVPEVQETIP EKTRPAAPPK KPEATAVPET IPEKTRPEAP
PKRPEATTVP VPEADQAVVP EKKVPRVPPK KVEAPPITVP EEPKEVIPEK KVSLVPPKKP
AAPPVTVPEA PEEVFSEDEE TLAPPQEPEA PPAKVPEAPK EVVPEKKVSV VPPKKPEAPP
AKVPEAPKEA APEKKVPVAP KKKPEAPPVK VPEAPKKVVP EKKLPVAAPK KPEAPAAEVP
EVPKAAVPQK KIPEAIPPKP ESPPPEVYEE PEEEIVPEEP PEEAVEEPVP APPPKVTEPP
KKPVPEKKAP PAVVKKPEPP PAKVPEVPKE APPEKKVPPK KPEAPPAKVP EVPKEVVTEK
KVAVPKKPEV PPAKVPEVPK KPVIEEKPAI PVVEKVASPP AEVYEEPEEV TAEEEEPAPA
VEEEEYEAPP PPAPVPEEPK KVVPEKKFPV IKKPEAPPPK VPEVPKKAVP VKKVPVVKKP
EPPEAEVPEV PKKLVPVKKE PVPVTKKTEV LPEKVPEAPK KITPEKKESV PVPEEPEAPP
ASVEETPEET IYEEKATITI GRKETPPVEE REIEKFIQPE EPELEPEPEE IPVQEPEPEK
KVIEKPKLKP RPPARPPSPP KEDVKEKMFQ LKAVSKKKVP EKPEVVEKVE PAPLKVPTAE
KKVRKLLPEP KPQPKEEVVL KSVLRKKPEE EEPKVEPKKV EKAKKPEEPQ PPPKAVEVEA
PPEPTPKERK VPEPAKVPEI KPAIPLPGPE PKPKPEPEVK TMKAPPIEPA PTPIAAPVTA
PVVGKKAEAK PKDEAAKPKG PIKGVAKKTP SPIEAERKKL RPGSGGEKPP DEAPFTYQLK
AVPLKFVKEI KDIVLTEAES VGSSAIFECL VSPSTAITTW MKDGSNIRES PKHRFIADGK
DRKLHIIDVQ LSDAGEYTCV LRLGNKEKTS TAKLIVEELP VRFVKTLEEE VTVVKGQPLY
LSCELNKERD VVWRKDGKIV VEKPGRIVPG VIGLMRALTI NDADDTDAGT YTVTVENANN
LECSSCVKVV EIIREWLVKP IRDQHVKPKG TAVFTCDIAK DTPNIKWFKG YDEIPLEPND
KTEILKEGNH LFLKVKNAMP EDIDEYAVEI EGKRYPAKLT LGEREVELLK PIEDVTIYEK
ESASFDAEIS EEDIPGEWKL KGELLRPSPT CEIKAEGGKR FLTLHKVKLD QAGEVLYQAC
NAITTAILTV KEIELDFAVP LKDVTVPEKR QARFECVLTR EANVIWSKGP DIIKASDKFD
IIADGKKHIL VINDSQFDDE GVYTAEVEGK KTSAQLFVTG IRLKFISPLE DQTVKEGQTA
TFVCELSHEK MHVVWFKNDV KLHTTRTVLM SSEGKTYKLE IRETTLDDIS QIKAQVKNLS
STANLKVLEA DPYFTVKLHD KTGVEKDEII LKCEVSKDVP VKWFKDGEEI VPSPKHSVKT
DGLRRILKIK KAELKDKGEY VCDCGTDTTK ANVTVEARLI KVEKPLYGVE VFVGETARFE
IELSEPDVHG QWKLKGEPLT ASPDCEIIED GKKHVLVLYN CQLDMTGEIS FQAANAKSAA
NLKVKELPLI FITPLSDVKV FEKDEAKFEC EVSREPKTFR WLKGTQEITG DDRFELIKDG
TRHSLVIKSA AFEDEAKYMF EAEDKRTSGK LIIEGIRLKF LTPLKDVTAK ERENAVFTVE
LSHDNIPVSW FKNDQRLHTS KRVSMHDEGK THSITFKDLS IDDTSQIRVE AMGISSEAKL
TVLEGDPYFT GKLQDYTGVE KDEVILQCEI SKADAPVKWF KDGKEIKPSK NVVIKADGKK
RMLILKKALK SDIGQYTCDC GTDQTSGKLD IEDREIKLVR PLYSVEVMET ETARFETEIS
EDDIHANWKL KGEALLQTPE CEIKEEGKIH VLILHNCRLD QTGGVDFQAA NVKSSAHLRV
KPRVIGLLRP LKDVTVTAGE TATFDCELSY EDIPVEWYLK GKKLEPNDKV VTRSEGRVHT
LTLRDVKLED AGEVQLTAKD FKTQANLFVK EPPVEFTKPL EDQTVEEEAT AVLECEVSRE
NAKVKWFKNG TEILKSKKYE IVADGRVRKL IIHGCTPEDI KTYTCDAKDF KTSCNLNVVP
PHVEFLRPLT DLQVKEKETA RFECEISKEN EKVQWFKDGA EIKKGKKYDI ISKGAVRILV
INKCLLNDEA EYSCEVRTAR TSGMLTVLEE EAVFTKNLAN LEVSEGDTIK LVCEVSKPGA
EVIWYKGDEE IIETGRFEIL TDGRKRILII QNAQLEDAGS YNCRLPSSRT DSKVKVHELA
AEFISKPQNL EILEGEKAEF VCTISKESFE VQWKRDDQTL ESGDKYDIIA DGKKRVLVVK
DATLQDMGTY VVMVGAARAA AHLTVIEKLR IIVPLKDTKV KEQQEVVFNC EVNTEGAKAK
WFRNEEAIFD SSKYIILQKD LVYTLRIRDA RLDDQANFNV SLTNHRGENV KSAANLIVEE
EDLRIVEPLK DIETMEKKSV TFWCKVNRLN VTLKWTKNGE EVAFDNRISY RIDKYKHSLI
IKDCGFPDEG EYVVTAGQDK SVAELLIIEA PTEFVEHLED QTVTEFDDAV FSCQLSREKA
NVKWYRNGRE IKEGKKYKFE KDGSIHRLII KDCRLEDECE YACGVEDRKS RARLFVEEIP
VEIIRPPQDI LEAPGADVIF LAELNKDKVE VQWLRNNMIV VQGDKHQMMS EGKIHRLQIC
DIKPRDQGEY RFIAKDKEAR AKLELAAAPK IKTADQDLVV DAGQPLTMVV PYDAYPKAEA
EWFKENEPLS TKTVDTTAEQ TSFRISEAKK DDKGRYKIVL QNKHGKAEGF INLQVIDVPG
PVRNLEVTET FDGEVSLAWE EPLTDGGSKI IGYVVERRDI KRKTWVLVTD RADSCEFTVT
GLQKGGVEYL FRVSARNRVG TGEPVETDSP VEARSKYDVP GPPLNVTITD VNRFGVSLTW
EPPEYDGGAE ITNYVIELRD KTSIRWDTAM TVRAEDLSAT VTDVVEGQEY SFRVRAQNRI
GVGKPSAATP FVKVADPIER PSPPVNLNAS EQTQSSVQLT WEPPLKDGGS PILGYIIERR
EEGKDNWIRC NMKPVPELTY KVTGLQKGNK YLYRVSAENA AGVSDPSEIL GPLTADDAFV
EPTMDLSAFK DGLEVIVPNP IKILVPSTGY PRPKATWTFG DQVLEEGDRV KMKTISAYAE
LVISPSERTD KGIYTLTLEN PVKSISGEIN VNVIAPPSAP KELKFSDITK DSVHLTWEPP
DDDGGSPLTG YVVEKRDMSR KTWTKVMDFV TDLEFTVPDL VQGKEYLFKV CARNKCGPGE
PAYTDEPVNM SAPATVPDPP ENVKWRDRTA NSIFLTWDPP KNDGGSRIKG YIVEKCPRGS
DKWVACGEPV PDTKMEVTGL EEGKWYAYRV KALNRQGASK PSKPTEEIQA VDTQEAPEIF
LDVKLLAGIT VKAGTKIELP ATVTGKPEPK ITWTKADTLL KPDQRITIEN VPKKSTVTIT
DSKRSDTGTY IIEAVNVCGR ATAVVEVNVL DKPGPPAAFD ITDVTNESCL LTWNPPRDDG
GSKITNYVVE RKATDSDVWH KLSSTVKDTN FKATKLTPNK EYIFRVAAEN MYGVGEPVQA
APIIAKYQFD PPGPPTRLEP SDITKDAVTL TWCEPDDDGG SPITGYWVER LDPDTDKWVR
CNKMPVKDTT YRVKGLTNKK KYRFRVLAEN LAGPGKPSRS TEPILIKDPI DPPWPPGKPT
VKDIGKTSLV LNWTKPEHDG GAKIESYVIE MLKTGTDEWV RVAEGVPTTE HLLTGLMEGQ
EYSFRVRAVN KAGESEPSEP SDPVLCREKL YPPSPPRWLE VINITKNTAD LKWTVPEKDG
GSPITNYIVE KRDVRRKGWQ TVDTTVKDTK CTVTPLTEGS LYVFRVAAEN AIGQSDYTEI
GDSVLAKDTF TTPGPPYALT VVDVTKRHVD LKWEPPKNDG GRPIQRYIIE KKEKLGTRWV
KAGKTSGPDC NFRVTDVIEG TEVQFQVRAE NEAGVGHPSE PTEILSIEDP TSPPSPPLDL
HVTDAGRKHI AIAWKPPEKN GGSPIIGYHV EMCPVGTEKW MRVNSRPIKD LKFKVEEGIV
PDKEYVLRVR AVNAVGVSEP SEISENVVAK DPDCKPTIDL ETHDIVVIEG EKLNIPVPFR
AVPVPTVSWH KDGKEVKASD RLTMKNDHIS AHLEVPKSVH ADAGVYTITL ENKLGSATAS
INVKVIGLPG PCKDIKASDI TKSSCKLTWE PPEFDGGSPI LHYVLERREA GRRTYIPVMS
GENKLSWTVK DLIPNGEYFF RVKAVNKIGG GEYIELKNPV IAQDPKQPPD PPVDVEVHNP
TAKAMTITWK PPLYDGGSKI MGYIIEKITK GEDRWKRCNE HLVPVLTYTA KGLEEGKEYQ
FRVRAENAAG IGEPSRATPP TKAVDPIDAP KVILRTSLEV KRGDEIALDA TISGSPYPTI
TWIKDENVIV PEEIKKRAAP PVRRKKGEAE EEEPFSLPLT ERLSINNSKQ GESQLRIRDS
LRPDHGQYMI KVENDHGVAK APCSVSVLDT PGPPINFVFE DIRKDSVLCK WEPPLDDGGS
EIINYTLEKK DKTKPDSDWI VITSTLRNCK YSVTKLIEGK EYLFRVRAEN RFGPGPPCVS
KPLLAKDPFE PPDAPDKPIV EDVTSNSMLV KWNEPKDNGS PILGYWLEKR EVNSTHWSRV
NKTLLSSLKT KVDGLLEGLT YVFRVCAENA AGPGKFSPPS DPKTARDPIS PPGPPVPRVA
DTSSTTIELE WEPPAFNGGG EIMGYFVDKQ LVGTNEWSRC TEKMIKVRQF TVKEIREGAD
YKLRVSAVNA AGEGPPGETE PVTVAEPQEP PTVELDVSVK GGIQIMAGKT LRIPAEVTGR
PVPTKVWTIE EGELDKERVI IENVGTKSEL IIKNALRKDH GRYVITATNS CGSKFAAVRV
EVFDVPGPVL DLKPVVTNRK MCLLNWSDPA DDGGSDITGF IIERKDAKMH TWRQPIETER
SKCDITGLIE GQEYKFRVIA KNKFGCGPPV EIGPILAVDP LGPPTSPERL TYTERTKSTI
TLDWKEPRSD GGSPIQGYII EKRRHDKPDF ERVNKRLCPT TSFLVENLDE HQMYEFRVKA
VNDVGESEPS LPLNVVIQDD EVPPTIKLRL AVRGDTIKVK AGEPVNIPAD VTGLPMPKIE
WSKNEKVIDK PTDTLNITKE EVSRSEAKTE LSIPKAARED KGTYTITASN RLGSVFRNVH
VEVYDRPSPP RNLAVTDIKA ESCYLTWDAP LDNGGSEITH YIIDKRDASR KKSEWEEVTN
TAVERRYGIW KLIPNGQYEF RVRAVNKYGI SDECKSDKVV IQDPYRLPGP PGKPKVLERT
KGSMLVSWTP PLDNGGSPIT GYWLEKREEG GTYWSRVSRA PITKVGLKGV EFNVPRLIEG
VKYQFRAMAI NAAGIGPPSE PSDPAVAGDP IYPPGPPSCP EVKDKTKSSI SLAWKPPAKD
GGSPIKGYIV EMQEEGTTDW KPVNEPDKLL TACECVVPNL KELRKYRFRV KAVNEAGESE
PSDTTGEIPA TDIQEVPEVF IDIGAQDCLV CKAGSQVKIP AVIKGRPTPK SSWEFDGKAK
KAMKDGVHDI PEDAQLETAE NSSVIIIPEC TRAHSGKYSI TAKNKAGQKT ANCRVKVMDA
PGPPKDLKVS DITRGSCRLS WKMPDDDGGD RIKGYVIEKK TIDGKAWTKV NPNCGSTTFV
VPDLISEQQY FFRVRAENRF GIGPPAETIQ RTTARDPIYP PDPPIKLKIG LITKNTVHLS
WKPPKNDGGS PVTHYIVECL AWDPTGKKKE AWRQCNRRDV EELEFTVEDL IEGGEYEFRV
KAVNEAGVSK PSATVGPVIV KDQTCPPAIE LKEFMEVEEG TDVNIVAKIK GVPFPTLTWF
KAPPKKPDSK EPVVYDTHVN KQVVDDTCTL VIPQSRRSDT GLYSITAVNN LGTASKEMRL
NVLGRPGPPV GPIKFESISA DQMTLSWLPP KDDGGSKITN YVIEKREANR KTWVRVSSEP
KECMYTIPKL LEGHEYVFRI MAQNKYGIGE PLDSEPETAR NLFSVPGAPD KPTVSSVTRN
SMTVNWEEPE YDGGSPVTGY WLEMKDTTSK RWKRVNRDPI KAMTLGVSYK VTGLIEGSDY
QFRVYAINAA GVGPASLPSD PVTARDPVAP PGPPFPKVTD WTKSSVDLEW SPPLKDGGSK
ITGYIVEYKE EGKEEWEKGK DKEVRGTKLV VTGLKEGAFY KFRVRAVNVA GVGEPGEVTD
VIEMKDRIVS PDLQLDASVR DRIVVHAGGV IRIIAYVSGK PPPTVTWSMN ERALPQEAAI
ETTAISSSMV IKNCQRSHQG VYSLLAKNEG GERKKTIIVD VLDVPGPVGI PFLSDNLTND
SCKLTWFSPE DDGGSPITNY VIQKREADRR AWTPVTYTVT RQNATVQGLI QGKSYFFRIA
AENSIGMGPF VETPNALVIR DPITVPERPE DLEVKEVTKN TVSLTWNPPK YDGGSEIINY
VLESRLIGTE KFHKVTNDNL LSRKYTVKGL KEGDTYEYRV SAVNIVGQGK PSFCTKPITC
KDELAPPTLD LDFRDKLTVR VGESFALTGR YSGKPKPKID WFKDEADVLE DDRTHIKTTP
TTLALEKTKA KRSDSGKYCV VVENSTGSRK GFCQVNVVDR PGPPVGPVIF DEVTKEYMVI
SWKPPLDDGG SEITNYIIEK KELGKDIWMP VTSASAKTTC KVPKLLEGKD YIFRIHAENL
YGISDPLVSD SMKAKDRFRV PDAPEQPVVT EVTKDSALVT WNKPNDGGKP ITNYILEKRE
TMSKRWVRVT KEPIHPYTKY RVPDLLEGCQ YEFRVSAENE IGIGDPSPPS KPVFARDPIA
KPSPPINPEA IDTTCNSVEL TWQPPRHDGG SKILGYIVEY QKVGDEEWRR ANHTPESCPE
TKYKVTGLRD GQSYKFRVLA VNEAGESDPA HVPEPVLVKD RLEPPELILD ANMAREQHIR
VGDTLRLSAI IKGVPFPKVT WKKEDREAPT KAQIDVTPVG SKLEIRNAAH EDGGIYSLTV
ENPAGTKTVS VKVLVLDKPG PPRDLEVSEI RKDSCYLTWK EPLDDGGSVV TNYVVERKDV
ATAQWSPLST TSKKKSHMAK HLTEGNQYLF RVAAENQYGR GPFVETPKPI KALDPLHPPG
PPKDLHHVDV DKTEVSLVWN KPDRDGGSPI TGYLVEYQEE GDKDWIKFKT VKNLDCVVTG
LQQGKTYRFR VKAENIIGLG LPDTTIPIEC QEKLVPPSVE LDVKLIEGLV VKAGTTVRFP
AIIRGVPVPT AKWTTDGTEI KTDDHYTVET DSFSSVLTIK NCLRKDTGEY QLTVSNAAGT
KTVAVHLTVL DVPGPPTGPI NILDVTPEYM TISWQPPKDD GGSPVINYIV EKQDTRKGTW
GVVSAGSSKL KLKVPHLQKG CEYVFRVKAE NKMGVGPPLD SIPTVAKHKF SPPSPPGKPV
VTDITENAAT VSWTLPKSDG GSPITGYYVE RREITGKWVR VNKTPIADLK FRVTGLYEGN
TYEFRVFAEN LAGLSNPSPS SDPIKACRPI KPPGPPINPK LKDKSKESAD LVWTKPLSDG
GSPILGYVVE YQKPGTAQWD RINKDELIRQ CAFRVPGLIE GNEYRFRIRA ANIVGEGEPR
ELAESVIAKD ILHPPEVELD VTCRDVITVR VGQTIRILAR VKGRPEPDIT WSKEGKVLVK
DKRVDLIHDL PRVELQIKEA VRADHGKYII SAKNSSGHAQ GSAIVNVLDR PGPCQNLKVS
NVTKENCTIS WENPLDNGGS EITNFIVEYR KPNQKGWSIV ASDVTKRLVK ANLLANNEYY
FRVCAENKVG VGPTIETKTP ILAINPIDRP GEPENLHIAD KGKTFVYLKW RRPDYDGGSP
NLSYHVERRL KGSADWERVH KGSIKETHYM VDKCVENQIY EFRVQTKNEG GESDWVRTEE
VVVKEDLQKP VLDLKLSGVL TVKAGDTIRL EAGVRGKPFP EVAWTKDKDA TDLTRSPRVK
IDTSAESSKF SLTKAKRSDG GKYVITATNP AGSFVAYATV NVLDKPGPVR NLKITDVSSD
RCTIRWDPPE DDGGCEIQNY ILEKCESKRM VWSTYSANVL TPSATVTRLI EGNEYIFRVR
AENKIGTGPP TESKPVIAKT KYDRPGRPDP PEVTKVSKEE MTVVWNAPEY DGGKSITGYY
LEKKEKHAVR WVPVNKSAIP ERRLKVQNLL PGHEYQFRVK AENEVGIGEP SLPSRPVVAK
DPIEPPGPPT NFKVVDTTKS SITLAWGKPV YDGGAPIIGY VVEMRPKIAD ASPDEGWKRC
NAAAQLIRME FTVTSLDENQ EYEFRVCAQN QVGIGRPAEL KEAIKPKEIL EPPEIDLDAS
MRKLVVVRAG CPIRLFAIVR GRPAPKVTWR KVGIDNVVRK GQVDLVDTMA FLVIPNSTRD
DSGKYSLTLV NPAGEKAVFV NVKVLDTPGP VADLKVSDVT KTSCHVSWAP PENDGGSQVT
HYIVEKREAE RKTWSTVTPE VKKTSFNVTN LVPGNEYFFR VTAVNEYGPG VPTDIPKPVL
ASDPLSEPDP PRKLEVTEMT KNSATLAWLP PLRDGGAKID GYIISYREED QPADRWTEYS
VVKDLSLIVT GLKEGKKYKF RVAARNAVGV SMPREAEGVY EAKEQLLPPK ILMPEQITIK
AGKKLRVEAH VYGKPNPICK WKKGDDEVVT SSHLAIHKAD GSSVLIIKDV TRKDSGYYSL
TAENSSGSDT QKIKVTVMDA PGPPQPPFDI SEIDADACSL SWHIPLEDGG SNITNYIVEK
CDVSRGDWVT ALASVTKTSC RVGKLIPGQE YIFRVRAENR FGISEPLTSP KMLAKFPFDV
PSEPKNARVT KVNKDCIFVA WDRPDSDGGS PITGYLIERK ERNSLLWVKA NDTIVRSTEY
PCAGLVEGLE YSFRIYALNK AGSSPPSKPT EYVTARMPVD PPGKPEVVDV TKNSASLIWA
RPKHDGGSRI IGYFVEACKL PGDKWVRCNT TPHQIPQEEY TATGLEENAQ YQFRAIAKTA
VNISQPSEPS DPVTILAENV PPRIELSVEM KSLLTVKAGT NVCLDATVFG KPMPTVSWKK
DTTPIKQAEG IKMAMKRNLC TLELFSVNRK DSGDYTITAE NSSGSKSATI KLKVLDKPGP
PASVKINKMY ADRAMLSWEP PLEDGGSEIT NYIIDKRETS RPNWAQVSAT VPITSCTVEK
LIEGHEYQFR ICAENKYGVG DPILTEPAIA KNPYDPPGRC DPPVISNITK DHMTVSWKAP
ADDGGSPITG YLVEKRETQA VNWTKVNRKP VIERTLKATG LQEGTEYEFR VTAINKAGPG
KPSDASKAVY AQDPLYPPGP PAFPKVYDTT RSSVSLSWGK PAYDGGSPII GYLVEVKRAD
SDHWVRCNLP EKLQKTRFEV TGLMENTEYQ FRVYAVNKIG YSDPSDVPDK HCPKDILIPP
EGELDAELRK TLILRAGVTM RLYVPVKGRP PPKITWSKPN VNLRERIGLD IKSTDFDTFL
RCENVNKYDA GKYILTLENS CGKKEYTIVV KVLDTPGPPV NVTVKEVSKD SAYVTWDPPI
IDGGSPIINY VVEKRDAERK SWSTVTTECS KTSFRVSNLE EGKSYFFRVF AENEYGIGDP
GETRDAVKAS ETPGPVVDLK ALAITKSSCT IGWKKPRSDG GSRITGYVVD FLTEENKWQR
VMKSLSLQYS TKDLKEGKEY TFRVSAENEN GEGTPSEIVV VAKDDVVAPD LDLKDLPDLC
YLAKENSNFR LKIPIKGKPA PSVSWKKGED PLATDTRVSV ESTAVNTTLV VYDCQKSDAG
KYTITLKNVA GTKEGTLSIK VVGKPGIPTG PIKFDEVTAE AMTLKWGPPK DDGGSEITNY
VLEKRDSVNN KWVTCASAVQ KTTFRVTRLH EGIEYTFRVS AENKYGVGEG LKSEPIVAKH
PFDVPDAPPP PNIVDVRHDS VSLTWTDPKK TGGSPITGYH IEFKERNSLL WKRANKTPIR
MKDFKVTGLT EGLEYEFRVM AINLAGVGKP SLPSEPVVAL DPIDPPGKPE VISVTRNSVT
LIWTEPKYDG GHKLTGYIVE KRDLPSKSWM KANHVNVPDC AFTVTDLVEG GKYEFRIRAK
NTAGAISAPS ESTGTIICKD EYEAPTIVLD PTIKDGLTVK AGDSIVLSAI SILGKPLPKS
SWSRAGKDIR PSDIAQITST PTSSMLTVKY ATRKDAGEYT ITATNPFGTK EEHVKVSVLD
VPGPPGPIEI SNVSAEKATL TWTPPLEDGG SPIKAYVLEK RETSRLLWTV VSEDIQACRH
VVTKLIQGNE YLFRVSAVNH YGKGEPVQSE PVKMVDRFGP PGPPGKPEIS NVTKNTATVS
WKRPTDDGGS EITGYHVERR EKKGLRWVRA TKTPVSDLRC KVTGLQEGNT YEFRVSAENR
AGIGPPSDAS NPVLMKDVAY PPGPPSNAHV TDTTKKSASL AWGKPHYDGG LEITGYVVEH
QKVGDDAWIK DTTGTALRIT QFVVPDLQTK EKYNFRISAI NDAGVGEPAV IPNVEIVEKE
VAPDFELDAE LRRTLVVRAG LSIRIFVPIK GRPAPEVTWT KDNINLKHRA NIENTESFTL
LIIPECNRYD TGKFVMTIEN PAGKKSGFVN VRVLDTPGPV LNLRPTDITK DSVTLHWDLP
LIDGGSRITN YIVEKREATR KSYSTVTTKC HKCTYKVTGL TEGCEYFFRV MAENEYGVGE
PTETTEPVRA SEAPLPPDSL NIMDITKNTV SLAWPKPRHD GGSKITGYVI EAQRKGSDQW
THISTVKGLE CVVRNLTEGE EYTFQVMAVN SAGRSAPRES RPVIVKEQTM LPELDLRGIY
QKLVIARAGD NIKVEIPVLG RPKPTVTWKK GDQILKQTQR VNVENTATST ILNINECVRS
DSGPYPLTAK NTVGEVGDVI TIQVHDIPGP PTGPIKFDEV SSDFVTFSWE PPENDGGVPI
SNYVVEMRQT DSTTWVELAT TVIRTTYKAT RLTTGVEYQF RVRAQNRYGV GPGITSASVV
ANYPFKVPGP PGTPQVTAVT KDSMTISWHE PLSDGGSPIL GYHIERKERN GILWQTVSKA
LVPGNIFKST GLTDGIAYEF RVIAENMAGK SKPSKPSEPM FALDPIDPPG KPVPLNITRH
TVALKWAKPE YTGGFKITSY VVEKRDLPNG RWLKANFSNI LENEFTVSGL TEDAAYEFRV
IAKNAAGAIS PPSEPSDAIT CRDDLEAPRI MVDVRFKDTI TLKAGEAFKL EADVSGRPPP
TMEWTKDGKE LEGTGKLEIK IADFSTHLIN KDSSRTDSGA YILTATNPGG FAKHIFNVKV
LDRPGPPEGP LAVSDVTSEK CVLSWLPPLD DGGAKIDHYI VQKRETSRLA WTNVATEVQV
TKLKVTKLLK GNEYIFRVMA VNKYGVGEPL ESEPVLAVDP YGPPDPPKNP EVTTITKDSM
VVCWGHPDSD GGSEIINYIV ERRDKAGQRW VKCNKKALTD LRFKVSGLTE GHEYEFRIMA
ENAAGISAPS ATSPFYKACD TVFKPGPPGN PRVLDTSRSS ISIAWNKPIY DGGSEITGYM
VEIALPEEDE WQVVTPPAGL KATSYTITSL IENQEYKIRI YAMNSEGLGE PALVPGTPKA
EERMLPPEIE LDADLRKVVT IRACCTLRLF VPIKGRPAPE VKWAREHGES LDKASIESTS
SYTLLVVGNV NRFDSGKYIL TVENSSGSKS AFVNVRVLDT PGPPQNLKIK EVTKTSVTLT
WEPPLLDGGS KIKNYIVEKR ESTRKAYSTV ATNCHKTSWK VDQLQEGCSY YFRVLAENEY
GIGLPAETAE SVKASERPLP PGKITLTDVT RNSVSLSWEK PEHDGGSRIL GYIVEMQSKG
SDRWATCATV KVTEATITGL IQGEEYSFRV SAQNEKGISD PRQLSVPVIA KDLVIPPAFK
LLFNTFTVLA GEDLKIDVPF IGRPPPAVTW HKDDIPLKQT TRVNAESTEN NSLLTIKEAC
REDVGHYTVK LTNSAGEATE TLNVIVLDKP GPPTGPVKMD EVTADSVTLS WEPPKYDGGS
SINNYIVEKR DTSTTAWQIV SATVARTTIK ACRLKTGCEY QFRIAAENRY GKSTYLNSEP
VVAQYPFKVP GPPGTPFVTL ASKDSMEVQW HEPVSDGGSK VIGYHLERKE RNSILWVKLN
KTPIPQTKFK TTGLEEGIEY EFRVSAENIV GIGKPSKPSE CYAAHDPCDP PGRPEAIIVT
RNSVTLQWKK PTYDGGSKIT GYIVEKKELP DGRWMKASFT NIIDTQFEVT GLLEDHRYEF
RVIARNAAGV FSEPSESTGA ITARDEVEPP RISMDPKYRD TVVVQAGESF KIDADIYGKP
IPTTQWVKGD QELSSTARLE IKSTDFATSL SVKDAVRVDS GNYILKAKNV AGEKSVTINV
KVLDRPGPPE GPVAISGVTA EKCTLAWKPP LQDGGSDITN YIVERRETSR LVWTLVDANV
QTLSCKVLKL LEGNEYIFRI MAVNKYGVGE PLESESLIAK NPFVVPDAPK APEVTAVTKD
SMIVVWERPA SDGGSEILGY VLEKRDKEGI RWTRCHKRLI GELRLRVTGL LENHNYEFRV
SAENAAGLSE PSPPSAYQKA CDPIYKPGPP NNPKVMDVTR SSVFLSWTKP IYDGGCEIQG
YIVEKCDVSV GEWTMCTPPT GINKTNLEVE KLLEKHEYNF RICAINKAGV GEHADVPGPV
MVEEKLEAPD IDLDLELRKV INIRAGGSLR LFVPIKGRPT PEVKWGKVDG DIRDAAIIDV
TSSFTSLVLD NVNRYDSGKY TLTLENSSGT KSAFVTVRVL DTPSPPVNLK VTEITKDSVS
ITWEPPLLDG GSKIKNYIVE KREATRKSYA AVVTNCHKNS WKIDQLQEGC SYYFRVTAEN
EYGIGLPART ADPIKVAEVP QPPGKITVDD VTRNSVSLSW TKPEHDGGSK IIQYIVEMQA
KNTDKWSECA RVKSLDAVIT NLTQGEEYLF RVIAVNEKGR SDPRSLAVPI IAKDLVIEPD
VRPAFSSYSV QVGQDLKIEV PISGRPKPSI SWTKDGMPLK QTTRINVTDS LDLTTLSIKE
THKDDGGQYG ITVSNVVGQK TAAIEIITLD KPDPPKGPVK FDEISAESIT LSWNPPLYTG
GCQITNYIVQ KRDTTTTVWD VVSATVARTT LKVTKLKTGT EYQFRIFAEN RYGQSFALES
EPVVAQYPYK EPGPPGTPFV TAISKESMVV QWHEPINNGG SPVIGYHLER KERNSILWTK
VNKTIIHDTQ FKALNLEEGI EYEFRVYAEN IVGVGKASKN SECYVARDPC DPPGTPEAII
VKRNEITLQW TKPVYDGGSM ITGYIVEKRD LPEGRWMKAS FTNVIETQFT VSGLTEDQRY
EFRVIAKNAA GAISKPSDST GPITAKDEVE LPRISMDPKF RDTIVVNAGE TFRLEADVHG
KPLPTIEWLR GDKEIEESAR CEIKNTDFKA LLIVKDAIRI DGGQYILRAS NVAGSKSFPV
NVKVLDRPGP PEGPVQVTGV TAEKCTLAWS PPLQDGGSDI SHYVVEKRET SRLAWTVVAS
EVVTNSLKVT KLLEGNKYIF RIMAVNKYGV GEPLESAPVL MKNPFVLPGP PKSLEVTNIA
KDSMTVCWNR PDSDGGSEII GYIVEKRDRS GIRWIKCNKR RITDLRLRVT GLTEDHEYEF
RVSAENAAGV GEPSPATVYY KACDPVFKPG PPTNAHVVDT TKNSITLAWS KPIYDGGSEI
LGYVVEICKA DEEEWQIVTP QTGLRVTRFE IAKLIEHQEY KIRVCALNKV GLGEAASVPG
TVKPEDKLEA PELDLDSELR KGIVVRAGGS ARIHIPFKGR PTPEITWSKE EGEFTDKVQI
EKGINFTQLS IDNCDRNDAG KYILKLENSS GSKSAFVTVK VLDTPGPPQN LAVKEVRKDS
VLLVWEPPII DGGAKVKNYV IDKRESTRKA YANVSSKCNK TSFRVENLTE GAIYYFRVMA
ENEFGVGVPT ETSDAVKASE PPSPPGKVTL TDVSQTSASL MWEKPEHDGG SRILGYVVEM
QPKGTEKWSV VAESKVCNAV VSGLSSGQEY QFRVKAYNEK GKSDPRVLGI PVIAKDLTIQ
PSFKLPFNTY SVQAGEDLKI EIPVIGRPRP KISWVKDGEP LKQTTRVNVE ETATSTILHI
KESSKDDFGK YSVTATNSAG TATENLSVIV LEKPGPPVGP VKFDEVSADF VVISWEPPAY
TGGCQISNYI VEKRDTTTTN WQMVSATVAR TTIKISKLKT GTEYQFRIFA ENRYGKSTPL
DSKPVVVQYP FKEPGPPGTP FVTSISKDQM LVQWHEPVND GGSKVTGYHL EQKEKNSILW
VKLNKIPIQD TKFKTTGLDE GLEYEFRVSA ENIVGIGKPS KVSECYVARD PCDPPGRPEA
IVITRNSVTL KWKKPVYDGG SKITGYIVEK KDLPDGRWMK ASFTNVVETE FTVTGLVEDQ
RYEFRVIARN AADNFSEPSE SSGAITARDE IDAPNASLDP KYRDVIIVHA GETFVLEADI
RGKPIPDIIW SKDGNELEET AARMEIKSTL QKTTLIVKDC IRTDGGQYTL KLSNVGGTKT
IPITVKVLDR PGPPEGPLKV TGVTAEKCYL AWNPPLQDGG ASISHYIIEK RETSRLSWTQ
VSNEVQALNY KVTKLLPGNE YIFRVMAVNK YGIGEALESE PVIACNPYKR PGPPSTPEAS
AITKDSMVLT WTRPVDDGGA EIEGYILEKR DKEGIRWTKC NKKTLTDLRF RVTGLTEGHS
YEFRVAAENA AGVGEPSEPS VFYRACDALY PPGPPSNPKV TDTSRSSVSL AWNKPIYDGG
APVRGYVIEL KKAAADEWTT CTPPSGLQGK QFTVTKLKEN TEYNFRICAF NTEGVGEPAT
IPGSVVAQER MEAPEIELDA DLRKVVTLRA SATLRLFVTI KGRPEPEVKW EKAEGILTER
AQIEVTSSYT MLVIDNVTRF DSGRYNLTLE NNSGSKTAFV NVRVLDSPSA PVNLTIREVK
KDSVTLSWEP PLIDGGAKIT NYIVEKRETT RKAYATITNN CTKNTFKIEN LQEGCSYYFR
VLASNEYGIG LPAETAEPVK VSEPPLPPGR VTLVDVTRNT ATIKWEKPES DGGSKITGYV
VEMQTKGSEK WSACTQVKTL ETTISGLTAG EEYVFRVAAV NEKGRSDPRQ LGVPVIAKDI
EIKPSVELPF NTFNVKANDQ LKIDIPFKGR PQATVAWKKD GQVLRETTRV NVASSKTVTT
LSIKEASRED VGTYELCVSN TAGSITVPIT VIVLDRPGPP GPIRIDEVSC DNVSISWNPP
EYDGGCQISN YIVEKRETTS TTWQVVSQAV ARTSIKIVRL TTGSEYQFRV CAENRYGKSS
YSESSAVVAE YPFSPPGPPG TPKVVHATKS TMVVSWQVPV NDGGSQVIGY HLEYKERSSI
LWSKANKVLI ADTQMKVSGL DEGLMYEYRV YAENIAGIGK CSKACEPVPA RDPCDPPGQP
EVTNITRKSV SLKWSKPRYD GGAKITGYIV ERRELPDGRW LKCNFTNVQE TYFEVTELTE
DQRYEFRVFA RNAADSVSEP SESTGPITVK DDVEAPRIMM DVKFRDVIIV KAGEVLKINA
DIAGRPLPVI SWAKDGVEIE ERAKTEIVST DYTTTLTVKD CVRRDTGQYV LTLKNVAGTR
TMAVNCKVLD KPGPPAGPLE INGLTAEKCS LSWGRPQEDG GADIDYYIVE KRETSRLAWT
ICEAELRTTS CKVTKLLKGN EYIFRVTGVN KYGVGEPLES MAVKALDPFT TPSPPTSLEI
TSVTKDSMTL CWSRPETDGG SDISGYIIER REKNSLRWMR VNKKPVYDLR VKSTGLREGC
EYEYRVFAEN AAGLSLPSET SPLVRAEDPV FLPSPPSKPK IVDSGKTTIT IGWVKPLFDG
GAPITGYTVE YKKSEETDWK VAIQSFRGTE YTMSGLTTGD EYVFRVRSLN KMGASDPSDS
SDPQVAKERE EEPVFDVDSE MRKTLIVKAG SSFTMTVPFR GRPIPNVSWS KPDTDLRTRA
YIDSTDSRTL LTIENANRND SGKYTLTIQN VLSAASMTFV VKVLDSPGPP ANITVREVTK
ETAMLSWDVP ENDGGAPVKN YHIEKREASK KAWVSVTNNC NRLSYKVTNL QEGAIYYFRV
SGENEFGVGV PAETKEGVKI TEKPSPPEKL GVTSVSKDSV SLSWLKPEHD GGSRIIHYVV
EALEKGQKTW VKCAVVKTTH HVVSGLRESH EYFFRVFAEN QAGLSDPREL LLPVLIKDQL
EPPEIDMKNF PSHTVYVRAG SNLKVDIPIS GKPLPKVTLS RDGVPLKATM RFNTEITAEN
LTINLKESVT TDAGRYEITA ANSSGTTKTF INIIVLDRPG PPTGPVAISD ITEESVTLKW
EPPKYDGGSH VTNYIVLKRE TSTAVWSEVS ATVARTMIKV MKLTTGEEYQ FRIKAENRFG
ISDHIDSVCV VVKLPYTTPG PPSTPWVSNV TRESITVGWH EPVSNGGSAV TGYHLEMKDR
NSILWQKANK MIIRTTHFKV TTISAGLIYE FRVYAENAAG IGKPSHPSEP VLAIDACEPP
RNVRITDISK NSVNLSWQQP AFDGGSKITG YIVERRDLPD GRWTKASFTN VIETQFTVSG
LTQNSQYEFR VFARNAVGSV SNPSEVVGPI TCIDSYGGPV IDLPLEYTEV VKYRAGTSVK
LRAGISGKPE PTIEWYKDDK ELQTNALVCV ENSTDLASIL IKDANRLNSG SYELKLRNAM
GSASATIRVQ ILDKPGPPGG PIEFKTVTAE KITLLWRPPA DDGGAKITHY IVEKRETSRV
VWSMVAENLE ECIVTTTKII KGNEYVFRVR AVNKYGIGEP LESEPVVAKN AFVTPGPPSI
PEVTKITKNS MTVVWDRPTV DGGSEINGYF LERRDKKSLA WLKVLKETIR DTRQKVTGLT
ENSDYQYRVC AVNAAGVGPF SEPSDFYKAA DPIDPPGPPA KIRIADSTKS SITLGWSKPV
YDGGSDVTGY VVEMKQGDEE EWTIVSTRGE VRTTEYVVSN LKPGVNYYFQ VSAVNCAGQG
EPITMTEPAQ AKDVLEEPEI DLDVALRTSV IAKAGEDVQL LIPFKGRPPP TVTWRKDEKN
LGSDTRYSIQ NTDSSSLLVI PQVTRNDTGK YILTIENGVG QPKSSTVSVK VLDTPAACQK
LQVKHVSLGT VTLLWDPPLI DGGSPIINYV IEKRDATKRT WSVVSHKCSG TSFKVTDLSE
KTPFFFRVLA ENEIGIGEPC ETTEPVKAAE VPAPIRDLSM KDSTKTSVVL SWTKPDFDGG
SIITDYLVER KGKGEQAWSH AGISKTCEIE IGQLKEQSVL EFRVSARNEK GQSDPVTIGP
LTVKELVITP EVDLSEIPGA QISVRIGHNV HLELPYKGKP KPSISWLKDG LPLKESEYVR
FSKTENKITL SIKNSKKEHG GKYTVILDNA VCRNSFPITI ITLGPPSKPK GPIRFDEIKA
DSAIMSWDIP EDDGGGEITC YSIEKREASQ TNWKMVCSSV ARTTFKVSNL VKDSEYQFRV
RAENRYGVSE PLASNIIVAK HQFRIPGPPG KPVIYNVTSD GMSLTWDAPV YDGGSEVTGF
HVEKKERNSI LWQRVNTSPI SGREYRATGL IEGLDYQFRV YAENSAGLSS PSDPSKFTLA
VSPVDPPGTP DYIDVTRETI TLKWNPPLRD GGSKIVAYSI EKRQGSDRWV RCNFTDVSEC
QYTVTGLSPG DRYEFRIIAR NAVGTISPPS QSSGLIMTRD ENVPPTVEFG PEYFDGLVIK
SGDSLRIKAL VQGRPVPRVT WFKDGVEIER RMNMEITDVL GSTSLFVRDA TRDHRGVYTV
EAKNVSGSTK AEVTVKVQDT PGKVVGPIRF TNITGEKMTL WWEAPLNDGC APVTHYIIEK
RETSRLAWAL IEDNCEALSY TAIKLITGNE YQFRISAVNK FGVGRPLESD PVVAQIQYTI
PDAPGVPEPS NVTGNSITLT WTRPESDGGS EIQHYILERR EKKSTRWVKV ISKRPISETR
FKVTGLVEGN EYEFHVMAEN AAGIGPASGI SRLIKCREPV NPPSAPSVVK VTDTSKTTVS
LEWARPVFDG GMEIIGYIIE MCKADLGDWH KVNTEPCVKT RYTVTDLQAG EEYKFRVSAV
NGAGKGDSCE VTGTIKAVDR LSAPELDIDA NFKQTHIVRA GVSIRLFIAY QGRPTPTAVW
SKPDSNLSIR ADIHTTDSFS TLTVENCNRN DAGKYTLTVE NNSGKKSITF TVKVLDSPGP
PGPITFKDVT RGSATLMWDA PLLDGGARIH HYVIEKREAS RRSWQVVSEK CTRQILKVSE
LTEGVPYYFR VSAENEYGVG EPYEMPEPIV ATEQPAPPRR LDVVDTSKSS AVLAWLKPDH
DGGSRITSYL LEMRQKGSDF WVEAGHTKQL TFTVERLVEN TEYEFRVKAK NDAGYSEPRE
AFSSVIIKEP QIEPTADLTG ITNQLITCKA GSTFTIDVPI SGRPAPKVTW KLEEMRLKET
DRMSIATTKD RTTLTVKDSM RGDSGRYFLT LENTAGVKTF TITVVVIGRP GPVTGPIEVS
SVSAESCVLS WTEPKDDGGT EITNYIVEKR ESGTTAWQLI NSSVKRTQIK VTHLTKYKEY
CFRVSSENRF GVSKPLESVP IVAEHPFVPP SAPTRPEVYY VSANAMSIRW EEPYHDGGSK
IVGYWVEKKE RNTILWVKEN KVPCLECNYK VTGLVEGLEY QFRTYALNAA GVSKASEASR
PIMAQNPVDP PGRPEVTDVT RSTVSLIWSA PVYDGGSKVV GYIIERKPVS EVGDGRWLKC
NYTIVSDNFF TVTALSEGDT YEFRVLAKNA AGVISKGSES TGPVTCRDEY APPKAELDAR
LQGDLVTIRA GSDLVLDAAV GGKPEPKIIW TKGDKELDLC EKISLQYTGK RATAVIKYCD
RSDSGKYTLT VKNASGTKSV SVMVKVLDSP GPCGKLTVSR VTEEKCTLAW SLPQEDGGAE
ITHYIVERRE TSRLNWVIVE GECLTASYVV TRLIKNNEYT FRVRAVNKYG LGVPVESEPI
VARNSFTIPS QPGIPEEVGA GKEHIIIQWT KPESDGGNEI SNYLVDKREK KSLRWTRVNK
DYVVYDTRLK VTSLMEGCDY QFRVTAVNAA GNSEPSEASN FISCREPSYT PGPPSAPRVV
DTTKRSISLA WTKPMYDGGT DIIGYVLEMQ EKDTDQWCRV HTNATIRNNE FTVPDLKMGQ
KYSFRVAAVN AKGMSDYSET TAEIEPVERL EIPDLELADD LKKTVIVRAG ASLRLMVSVS
GRPSPVITWS KKGIDLANRA IIDNTESYSL LIVDKVNRYD AGKYTIEAEN QSGKKSATVL
VKVYDTPGPC PSVSVKEVSR DSVTITWEIP TIDGGAPVNN YIIEKREAAM RAFKTVTTKC
SKTLYRISGL VEGTMYYFRV LPENIYGIGE PCETSDAVLV SEVPLVPTKL EVVDVTKSTV
TLAWEKPLYD GGSRLTGYVL EACKAGTERW MKVVTLKPTV LEHTVISLNE GEQYLFRVRA
QNEKGVSEPR EIVTPVTVQD LRVLPTIDLS TMPQKTIHVP AGRPIELVIP ITGRPPPTAS
WFFAGSKLRE SERVTVETHT KVTKLTIRET TIRDTGEYTL ELKNVTGTTS ETIKVIILDK
PGPPTGPIKI DEIDATSVTI SWEPPELDGG APLSGYVVEQ RDAHRPGWLP VSESVTRPTF
KFTRLTEGNE YVFRVAATNR FGIGSYLQSE VIECRSSISI PGPPETLQIF DVSRDGMTLT
WYPPEDDGGS QVTGYIVERK EVRADRWVRV NKVPVTMTRY RSTGLIEGLE YEHRVTAINA
RGTGKPSRPS KPTVAMDPIA PPGKPQNPRV TDTTRTSVSL AWSVPEDEGG SKVTGYLIEM
QKVDQREWTK CNTTPTKIRE YTLTHLPQGA EYRFRVLACN AGGPGEPAEV PGTVKVTEML
EYPDYELDER YQEGVFVRQG GVIRLTIPIK GKPFPVCKWT KEGQDISKRA MIATSETHTE
LVIKEADRND SGTYDLVLEN KCGKKTVYIK VKVIGSPNTP EGPLEYDDIQ ARSVRVSWRP
PADDGGADIL GYILERREVP KAAWYTIDSR VRGTSLVVKG LKENVEYHFR VSAENQFGIS
KPLKSEEPVI PKTPLNPPEP PSNPPEVLDV TKSSVSLSWS RPKDDGGSRV TGYYIERKET
STDKWVRHNK TQITTTMYTV TGLVPDAEYQ FRIIAQNDVG LSETSPASEP VVCKDPFDKP
SQPGELEILS ISKDSVTLQW EKPECDGGKE ILGYWVEYRQ SGDSAWKKSN KERIKDRQFT
IGGLLEATEY EFRVFAENET GLSRPRRTAM SVKTKLTSGE APGVRKEMAD VTTKLGEAAQ
LSCQIVGRPL PDIKWYRFGK ELIQSRKYKM SSDGRTHTLT VMTDEQEDEG VYTCVATNEV
GEVESSSKLL LQAAPQFHPG YPLKEKYYGA VGSTLRLHVM YIGRPVPAMT WFHGQKLLQN
SEKITIENTE HYTHLVMKNV QRKTHAGKYK VQLSNAFGTV DATLDVEIQD KPDKPTGPIV
IEALLKNSVV ISWKPPADDG GSWITNYVVE KCEAKEGAEW QLVSSAISVT TCRIVNLTEN
AGYYFRVSAQ NTFGISEPLE VASIVIIKSP FEKPGVPGKP TITAVTKDSC VVAWKPPASD
GGAKIRNYYL ERREKKQNKW IAVTTEEIRE TVFSVQNLIE GLEYEFRVKC ENLGGESEWS
EISEPVTPKS DVPIQAPHFK EELRNLNVRY QSNATLVCKV TGHPKPIVKW YRQGKEIIAD
GLKYRIQEFK GGYHQLIIAS VTDDDATVYQ VRATNQGGSV SGTASLEVEV PAKIHLPKTL
EGMGAVHALR GEVVSIKIPF SGKPDPVITW QKGQDLIDNN GHYQVIVTRS FTSLVFSNGV
ERKDAGFYVV CAKNRFGIDQ KTVELDVADV PDPPRGVKVS DVSRDSVNLT WTEPASDGGS
KVTNYIVEKC ATTAERWLRV GQARETRYTV INLFGKTSYQ FRVIAENKFG LSKPSEPSEP
TVTKEDKTRA MNYDDEVDET REVTTTKASH SKTKELYEKY MIAEDLGRGE FGIVHRCVET
SSKRTFMAKF VKVKGTDQVL VKKEISILNI ARHRNILYLH ESFESMEELV MIFEFISGLD
IFERINTSAF ELNEREIVSY VRQVCEALEF LHSQNIGHFD IRPENIIYQT RKNSTIKIIE
FGQARQLKPG DNFRLLFTAP EYYAPEVHQH DVVSTATDMW SLGTLVYVLL SGINPFLAET
NQQMIENIMN AEYTFDEEAF KEISLEAMDF VDRLLVKERK SRMTASEALQ HPWLKQRIDR
VSTKVIRTLK HRRYYHTLIK KDLNMVVSAA RISCGGAIRS QRGVSVAKVK VASIEIGPVS
GQIMHAIGEE GGYVKYVCKI ENYDQSTQVT WYFGVRQLEN SEKYEITYED GVATMYVKDI
TKFDDGTYRC KVVNDYGEDS SYAELFVKGV REVYDYYCRR TKKVKRRTDA MRLLERPPEF
TLPLYNKTAY VGENVRFGVT ITVHPEPRVT WYKSGQKIKP GDDEKKYTFE SDKGLYQLTI
NSVTTDDDAE YTVVARNKHG EDSCKAKLTV TLHPPPTETT LRPMFKRLLA NAECHEGQSV
CFEIRVSGIP APTLKWEKDG QPLSLGPHIE IVHEGLDYYA LHIRDTLPED TGYYRVTATN
TAGSTSCQAH LQVERLRYVK QEFQSKEERE RHVQKQIDKT LRMAEILSGT ETVPLTPVAQ
EALREAAILY KPAVSTKTVK GEYRLQTEEK KEERKLRMPY EVPEPRRFKQ ATVEEDQRIK
QFVPMSDMKW YKKIRDQYEM PGKLDRVVQK RPKRIRLSRW EQFYVMPLPR ITDQYRPKWR
IPKLTQDDLE MVRPARRRTP SPDYDLYYYR RRRRSLGDMS DEELLLPIDD YLAMKRTEEE
RLRLEEELEL GFSASPPSRS PPRFELSSLR YSSPPAHVKV EDRRRDFRYS TYHVPTKEET
STSYAELRER HAQASYRQPK LRQRIMAEKE EEELLRPVTT TQRLSEYKSE LDYMSKEEKS
KKKSKRQRQV TEITEIEEEY EISRRAQRES SSSVSRLLRR RRSLSPTYIE LMRPVSELIR
SHPRPAEEYE DDAERRSPTP ERTRPRSPSP VSSERSLSRF ERSARFDIFS RYESMKAALK
TQKTSERKYE VLSQQPFTLD HAPRITLRMR SHRVPCGQNT RFILNVQSKP TAEVKWYHNG
VELQESSKIH YTNTSGVLTL EILDCQTEDG GTYRAVCTNY KGEASDYATL DVTGGAYTTY
ASQRRDEEVP KSVFPELTKT EAYAVSSFKR TSELEAASSV REVKSQMTET RESLSTYEHY
ASAEMKSATS EEKSLEEKAT VRKIKTTLAA RILTKPRSIT VHEGESARFS CDTDGEPVPT
VTWLREGQVV STSARHQVTT TKYKSTFEIS SVQASDEGNY SVVVENSDGK QEAQFTLTVQ
KARVIEKAVT SPPRVKSPEP RVKSPETVKS PKRVKSPEPV TSHPKAVSPT ETKPTEKGQH
LPVSAPPKIT QSLKAEASKD IAKLTCAVES SALCAKEVAW YKDGKKLKEN GHFQFHYSAD
GTYELKIHNL SESDCGEYVC EVSGEGGTSK TSFQFTGQSF KSIHEQVSSI SETTKSVQKT
AESPEAKKQE PIAPESISSK PVIVTGLRDT TVSSDSVAKF TIKVTGEPQP TITWTKDGKA
IAQGSKYKLS SNKEEFILEI LKTETSDGGL YACTVTNSAG SVSSSCKLTI KAVKDTEAQK
VSTQKTSEVT SQKKASAQEE ISQKALTSEE IKMSEVKSHE TLAIKEEASK VLIAEEVKRS
AAASLEKSIV HEEVTKTSQA SEEVKTHAEI KTLSTQMNIT KGQRATLKAN IAGATDVKWV
LNGTELPNSE EYRYGVSGSD QTLTIKQASH REEGILSCIG KTSQGVVKCQ FDLTLSEELS
DAPSFITQPR SQNINEGQNV LFSCEVSGEP SPEIEWFKNN LPISISSNIS VSRSRNVYTL
EIRNAAVSDS GKYTIKAKNF HGQCSATASL TVLPLVEEPP REVVLKTSSD VSLHGSVSSQ
SVQMSASKQE ASFSSFSSSS ASSMTEMKFA SMSAQSMSSM QESFVEMSSS SFMGKSSMTQ
LESSTSRMLK AGGRGIPPKI EALPSDISID EGKVLTVACA FTGEPTPEIT WSCGGRKIQN
QEQQGRFHIE NTDDLTTLII MDVQKQDGGL YTLSLGNEFG SDSATVNINI RSM
