TK1A_HADFO
ID TK1A_HADFO Reviewed; 37 AA.
AC P0C2L8;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Lambda-hexatoxin-Hf1a {ECO:0000305};
DE Short=Lambda-HXTX-Hf1a {ECO:0000305};
DE AltName: Full=Janus-atracotoxin-Hf1a;
DE Short=Janus-AcTx-Hf1a;
DE AltName: Full=Kappa-atracotoxin-Hf1a;
DE Short=Kappa-AcTx-Hf1a;
DE AltName: Full=Kappa-hexatoxin-Hf1a {ECO:0000305};
DE Short=Kappa-HXTX-Hf1a {ECO:0000305};
OS Hadronyche formidabilis (Northern tree funnel-web spider) (Atrax
OS formidabilis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Hexathelidae; Hadronyche.
OX NCBI_TaxID=426499;
RN [1]
RP PROTEIN SEQUENCE.
RA Atkinson R.K., Howden M.E.H., Tyler M.I., Vonarx E.J.;
RT "Insecticidal toxins derived from funnel web (Atrax or Hadronyche)
RT spiders.";
RL Patent number US5763568, 09-JUN-1998.
CC -!- FUNCTION: This excitatory toxin inhibits insect calcium-activated
CC potassium (KCa) channels (Slo-type). {ECO:0000250|UniProtKB:P82228}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 11 (kappa toxin) family.
CC {ECO:0000305}.
CC -!- CAUTION: This toxin has the prefix lambda in its name (instead of
CC kappa), since lambda is the Greek letter attributed to calcium-
CC activated potassium (KCa) channel impairing toxins (according to the
CC nomenclature of King et al., 2008). {ECO:0000305}.
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DR AlphaFoldDB; P0C2L8; -.
DR SMR; P0C2L8; -.
DR ArachnoServer; AS000171; kappa-hexatoxin-Hf1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR012499; Toxin_16.
DR Pfam; PF07945; Toxin_16; 1.
DR PROSITE; PS60020; J_ACTX; 1.
PE 1: Evidence at protein level;
KW Calcium-activated potassium channel impairing toxin;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Knottin; Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin.
FT PEPTIDE 1..37
FT /note="Lambda-hexatoxin-Hf1a"
FT /id="PRO_0000280461"
FT SITE 9
FT /note="Critical for the neurotoxic activity"
FT /evidence="ECO:0000250"
FT SITE 10
FT /note="Critical for the neurotoxic activity"
FT /evidence="ECO:0000250"
FT SITE 14
FT /note="Critical for the neurotoxic activity"
FT /evidence="ECO:0000250"
FT SITE 15
FT /note="Critical for the neurotoxic activity"
FT /evidence="ECO:0000250"
FT SITE 31
FT /note="Important for the neurotoxic activity"
FT /evidence="ECO:0000250"
FT SITE 33
FT /note="Critical for the neurotoxic activity"
FT /evidence="ECO:0000250"
FT DISULFID 4..18
FT /evidence="ECO:0000250"
FT DISULFID 11..23
FT /evidence="ECO:0000250"
FT DISULFID 14..15
FT /evidence="ECO:0000250"
FT DISULFID 17..34
FT /evidence="ECO:0000250"
SQ SEQUENCE 37 AA; 3722 MW; D23A54CDB0B48347 CRC64;
SPTCTGADRP CAACCPCCPG TSCKGPEPNG VSYCRND
