TKN1_MESAU
ID TKN1_MESAU Reviewed; 130 AA.
AC Q60541; P49110;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Protachykinin-1;
DE AltName: Full=PPT;
DE Contains:
DE RecName: Full=Substance P;
DE Contains:
DE RecName: Full=Neurokinin A;
DE Short=NKA;
DE AltName: Full=Neuromedin L;
DE AltName: Full=Substance K;
DE Contains:
DE RecName: Full=Neuropeptide K;
DE Short=NPK;
DE Contains:
DE RecName: Full=Neuropeptide gamma;
DE Contains:
DE RecName: Full=C-terminal-flanking peptide;
DE Flags: Precursor;
GN Name=TAC1; Synonyms=NKA, NKNA, TAC2;
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA AND GAMMA).
RC STRAIN=Aura; TISSUE=Brain;
RA Heitland A., Kruhoffer M., Juergen Maegert H.J., Forssmann W.-G.;
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC behavioral responses, are potent vasodilators and secretagogues, and
CC contract (directly or indirectly) many smooth muscles.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=Beta;
CC IsoId=Q60541-1; Sequence=Displayed;
CC Name=Alpha;
CC IsoId=Q60541-3; Sequence=Not described;
CC Name=Gamma;
CC IsoId=Q60541-2; Sequence=VSP_006378;
CC Name=Delta;
CC IsoId=Q60541-4; Sequence=Not described;
CC -!- PTM: [Substance P]: The substance P form is cleaved at Pro-59 by the
CC prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is
CC also cleaved and degraded by Angiotensin-converting enzyme (ACE) and
CC neprilysin (MME). {ECO:0000250|UniProtKB:P20366}.
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR EMBL; X80662; CAA56691.1; -; mRNA.
DR EMBL; X80663; CAA56692.1; -; mRNA.
DR PIR; S47038; S47038.
DR PIR; S47039; S47039.
DR AlphaFoldDB; Q60541; -.
DR STRING; 10036.XP_005082986.1; -.
DR eggNOG; ENOG502S1KJ; Eukaryota.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR InterPro; IPR008215; Tachykinin_dom.
DR InterPro; IPR008216; Tachykinin_fam.
DR Pfam; PF02202; Tachykinin; 1.
DR PRINTS; PR01829; PROTACHYKNIN.
DR SMART; SM00203; TK; 2.
DR PROSITE; PS00267; TACHYKININ; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Neuropeptide; Neurotransmitter; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..56
FT /evidence="ECO:0000255"
FT /id="PRO_0000033536"
FT PEPTIDE 58..68
FT /note="Substance P"
FT /id="PRO_0000033537"
FT PEPTIDE 72..107
FT /note="Neuropeptide K"
FT /id="PRO_0000033538"
FT PEPTIDE 72..73
FT /note="Neuropeptide gamma, 1st part"
FT /id="PRO_0000033539"
FT PEPTIDE 89..107
FT /note="Neuropeptide gamma, 2nd part"
FT /id="PRO_0000033540"
FT PEPTIDE 98..107
FT /note="Neurokinin A"
FT /id="PRO_0000033541"
FT PEPTIDE 111..126
FT /note="C-terminal-flanking peptide"
FT /evidence="ECO:0000250"
FT /id="PRO_0000033542"
FT SITE 59..60
FT /note="Cleavage; by FAP"
FT /evidence="ECO:0000250|UniProtKB:P20366"
FT SITE 63..64
FT /note="Cleavage; by MME"
FT /evidence="ECO:0000250|UniProtKB:P20366"
FT SITE 64..65
FT /note="Cleavage; by MME"
FT /evidence="ECO:0000250|UniProtKB:P20366"
FT SITE 65..66
FT /note="Cleavage; by ACE"
FT /evidence="ECO:0000250|UniProtKB:P20366"
FT SITE 66..67
FT /note="Cleavage; by ACE and MME"
FT /evidence="ECO:0000250|UniProtKB:P20366"
FT MOD_RES 68
FT /note="Methionine amide"
FT /evidence="ECO:0000250|UniProtKB:P20366"
FT MOD_RES 107
FT /note="Methionine amide"
FT /evidence="ECO:0000250|UniProtKB:P20366"
FT VAR_SEQ 74..88
FT /note="Missing (in isoform Gamma)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_006378"
SQ SEQUENCE 130 AA; 14907 MW; CC92E9371A646F2E CRC64;
MKILVAVAVF FLVSTQLSAE EIGANDDLNY WSDWSDSDQI KEALPEPFEH ILQRIARRPK
PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT DSFVGLMGKR ALNSVAFERS
AMQNYERRRK