ID   TKN1_SCYCA              Reviewed;          10 AA.
AC   P08608;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   02-JUN-2021, entry version 65.
DE   RecName: Full=Scyliorhinin-1;
DE   AltName: Full=Scyliorhinin I;
OS   Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=7830;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-10.
RC   TISSUE=Intestine;
RX   PubMed=2422058; DOI=10.1016/0014-5793(86)80521-x;
RA   Conlon J.M., Deacon C.F., O'Toole L., Thim L.;
RT   "Scyliorhinin I and II: two novel tachykinins from dogfish gut.";
RL   FEBS Lett. 200:111-116(1986).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=7685693; DOI=10.1111/j.1432-1033.1993.tb17943.x;
RA   Waugh D., Wang Y., Hazon N., Balment R.J., Conlon J.M.;
RT   "Primary structures and biological activities of substance-P-related
RT   peptides from the brain of the dogfish, Scyliorhinus canicula.";
RL   Eur. J. Biochem. 214:469-474(1993).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   PIR; A24867; A24867.
DR   PDB; 2NOU; NMR; -; A=1-10.
DR   PDBsum; 2NOU; -.
DR   SMR; P08608; -.
DR   EvolutionaryTrace; P08608; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Scyliorhinin-1"
FT                   /id="PRO_0000044410"
FT   MOD_RES         10
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:2422058"
FT   HELIX           5..9
FT                   /evidence="ECO:0007829|PDB:2NOU"
SQ   SEQUENCE   10 AA;  1219 MW;  D0602D6B59C33AA9 CRC64;
     AKFDKFYGLM