ID   TKN1_THECO              Reviewed;          91 AA.
AC   M9P2C1;
DT   13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Tachykinin-like peptide {ECO:0000303|PubMed:23829212};
DE   AltName: Full=Tachykinin-Thel {ECO:0000303|PubMed:23829212};
DE   Flags: Precursor;
OS   Theloderma corticale (Kwangsi warty tree frog) (Theloderma kwangsiense).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Rhacophoridae; Rhacophorinae;
OC   Theloderma.
OX   NCBI_TaxID=126966;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 52-62, FUNCTION,
RP   SUBCELLULAR LOCATION, AMIDATION AT MET-62, AND MASS SPECTROMETRY.
RC   TISSUE=Skin {ECO:0000312|EMBL:AFX61593.1}, and
RC   Skin secretion {ECO:0000269|PubMed:23829212};
RX   PubMed=23829212; DOI=10.2108/zsj.30.529;
RA   Zhang H., Wei L., Zou C., Bai J.J., Song Y., Liu H.;
RT   "Purification and characterization of a tachykinin-like peptide from skin
RT   secretions of the tree frog, Theloderma kwangsiensis.";
RL   Zool. Sci. 30:529-533(2013).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles. In vitro,
CC       induces contraction of guinea pig ileum smooth muscle in a dose-
CC       dependent manner. {ECO:0000269|PubMed:23829212, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23829212}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:23829212}.
CC   -!- MASS SPECTROMETRY: Mass=1309.6; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:23829212};
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000255}.
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DR   EMBL; JQ867270; AFX61593.1; -; mRNA.
DR   AlphaFoldDB; M9P2C1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   InterPro; IPR008216; Tachykinin_fam.
DR   PRINTS; PR01829; PROTACHYKNIN.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..51
FT                   /evidence="ECO:0000269|PubMed:23829212"
FT                   /id="PRO_0000424460"
FT   PEPTIDE         52..62
FT                   /note="Tachykinin-like peptide"
FT                   /evidence="ECO:0000269|PubMed:23829212"
FT                   /id="PRO_0000424461"
FT   PROPEP          66..91
FT                   /evidence="ECO:0000269|PubMed:23829212"
FT                   /id="PRO_0000424462"
FT   REGION          64..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         62
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:23829212"
SQ   SEQUENCE   91 AA;  10658 MW;  1BD5DAB2C18CA5A2 CRC64;
     MKILVAFAVI MLVSAQVLAA EIGLNDEPEW YSDQIQEDLP VFENFLQRIA RKPSPDRFYG
     LMGKRNNGFG QMSRKRSAER NTIHNYERRR K