ID   TKN1_UPERU              Reviewed;          11 AA.
AC   P08612;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   29-SEP-2021, entry version 85.
DE   RecName: Full=Uperolein;
OS   Uperoleia rugosa (Wrinkled toadlet) (Pseudophryne rugosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Myobatrachoidea; Myobatrachidae;
OC   Myobatrachinae; Uperoleia.
OX   NCBI_TaxID=8368;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   MET-11.
RC   TISSUE=Skin secretion;
RX   PubMed=1120493; DOI=10.1007/bf02026336;
RA   Anastasi A., Erspamer V., Endean R.;
RT   "Structure of uperolein, a physalaemin-like endecapeptide occurring in the
RT   skin of Uperoleia rugosa and Uperoleia marmorata.";
RL   Experientia 31:394-395(1975).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   PDB; 2GFR; NMR; -; A=1-11.
DR   PDBsum; 2GFR; -.
DR   SMR; P08612; -.
DR   EvolutionaryTrace; P08612; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   InterPro; IPR008215; Tachykinin_dom.
DR   Pfam; PF02202; Tachykinin; 1.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Amphibian defense peptide;
KW   Direct protein sequencing; Neuropeptide; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..11
FT                   /note="Uperolein"
FT                   /id="PRO_0000044414"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:1120493"
FT   MOD_RES         11
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:1120493"
FT   HELIX           4..7
FT                   /evidence="ECO:0007829|PDB:2GFR"
FT   TURN            8..10
FT                   /evidence="ECO:0007829|PDB:2GFR"
SQ   SEQUENCE   11 AA;  1252 MW;  32867C3E59CDD457 CRC64;
     QPDPNAFYGL M