ID   TKN2_OCTVU              Reviewed;          92 AA.
AC   Q8I6S2;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Tachykinin-2;
DE   AltName: Full=OctTK-II;
DE   AltName: Full=Tachykinin II;
DE   Flags: Precursor;
OS   Octopus vulgaris (Common octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=6645;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAC53871.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 38-49, FUNCTION, TISSUE
RP   SPECIFICITY, AND AMIDATION AT MET-49.
RC   TISSUE=Posterior salivary gland;
RX   PubMed=12576083; DOI=10.1016/s0196-9781(02)00274-7;
RA   Kanda A., Iwakoshi-Ukena E., Takuwa-Kuroda K., Minakata H.;
RT   "Isolation and characterization of novel tachykinins from the posterior
RT   salivary gland of the common octopus Octopus vulgaris.";
RL   Peptides 24:35-43(2003).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC       {ECO:0000269|PubMed:12576083}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the posterior salivary gland and more
CC       specifically in the mucus-secreting gland cells.
CC       {ECO:0000269|PubMed:12576083}.
CC   -!- SIMILARITY: Belongs to the tachykinin family.
CC       {ECO:0000269|PubMed:12576083}.
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DR   EMBL; AB085917; BAC53871.1; -; mRNA.
DR   AlphaFoldDB; Q8I6S2; -.
DR   Proteomes; UP000515154; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255, ECO:0000303|PubMed:12576083"
FT   PROPEP          23..37
FT                   /evidence="ECO:0000269|PubMed:12576083"
FT                   /id="PRO_0000033519"
FT   PEPTIDE         38..49
FT                   /note="Tachykinin-2"
FT                   /id="PRO_0000033520"
FT   PROPEP          52..92
FT                   /evidence="ECO:0000269|PubMed:12576083"
FT                   /id="PRO_0000033521"
FT   REGION          61..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         49
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:12576083"
SQ   SEQUENCE   92 AA;  10113 MW;  30C88AC19B5AD725 CRC64;
     MIRVGLILCC IFIVGVFEAS SADDILTAHN LIKRSEVKPP SSSEFVGLMG RSEELTRRLI
     QHPGSMSETS KRGPPKKGDF NPNELKPESN IC