TKN4_MOUSE
ID TKN4_MOUSE Reviewed; 128 AA.
AC Q99N14;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Tachykinin-4;
DE AltName: Full=Preprotachykinin-C;
DE Short=PPT-C;
DE Contains:
DE RecName: Full=Hemokinin;
DE AltName: Full=HK1;
DE AltName: Full=Hemokinin-1;
DE AltName: Full=Hemokinin-I;
DE Short=HK-I;
DE Flags: Precursor;
GN Name=Tac4 {ECO:0000312|MGI:MGI:1931130};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK15025.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND AMIDATION AT
RP MET-66.
RX PubMed=11062498; DOI=10.1038/80826;
RA Zhang Y., Lu L., Furlonger C., Wu G.E., Paige C.J.;
RT "Hemokinin is a hematopoietic-specific tachykinin that regulates B
RT lymphopoiesis.";
RL Nat. Immunol. 1:392-397(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAP30873.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=CD-1 {ECO:0000312|EMBL:AAP30873.1};
RX PubMed=12716968; DOI=10.1073/pnas.0931458100;
RA Page N.M., Bell N.J., Gardiner S.M., Manyonda I.T., Brayley K.J.,
RA Strange P.G., Lowry P.J.;
RT "Characterization of the endokinins: human tachykinins with cardiovascular
RT activity.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:6245-6250(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000312|EMBL:AAI19427.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=11725292; DOI=10.1038/ni1201-1088;
RA Morteau O., Lu B., Gerard C., Gerard N.P.;
RT "Hemokinin 1 is a full agonist at the substance P receptor.";
RL Nat. Immunol. 2:1088-1088(2001).
RN [6] {ECO:0000305}
RP SYNTHESIS, AND FUNCTION.
RX PubMed=11786503; DOI=10.1038/sj.bjp.0704443;
RA Bellucci F., Carini F., Catalani C., Cucchi P., Lecci A., Meini S.,
RA Patacchini R., Quartara L., Ricci R., Tramontana M., Giuliani S.,
RA Maggi C.A.;
RT "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.";
RL Br. J. Pharmacol. 135:266-274(2002).
RN [7] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=12383518; DOI=10.1016/s0378-1119(02)00861-2;
RA Kurtz M.M., Wang R., Clements M.K., Cascieri M.A., Austin C.P.,
RA Cunningham B.R., Chicchi G.G., Liu Q.;
RT "Identification, localization and receptor characterization of novel
RT mammalian substance P-like peptides.";
RL Gene 296:205-212(2002).
RN [8] {ECO:0000305}
RP SYNTHESIS, AND FUNCTION.
RX PubMed=12044836; DOI=10.1016/s0024-3205(02)01682-x;
RA Camarda V., Rizzi A., Calo G., Guerrini R., Salvadori S., Regoli D.;
RT "Pharmacological profile of hemokinin 1: a novel member of the tachykinin
RT family.";
RL Life Sci. 71:363-370(2002).
RN [9] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12842130; DOI=10.1016/s0028-3908(03)00150-3;
RA Duffy R.A., Hedrick J.A., Randolph G., Morgan C.A., Cohen-Williams M.E.,
RA Vassileva G., Lachowicz J.E., Laverty M., Maguire M., Shan L.-S.,
RA Gustafson E., Varty G.B.;
RT "Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor
RT agonist, produces substance P-like behavioral effects in mice and
RT gerbils.";
RL Neuropharmacology 45:242-250(2003).
RN [10] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15153465; DOI=10.4049/jimmunol.172.11.6528;
RA Metwali A., Blum A.M., Elliott D.E., Setiawan T., Weinstock J.V.;
RT "Hemokinin has substance P-like function and expression in inflammation.";
RL J. Immunol. 172:6528-6532(2004).
RN [11] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15342200; DOI=10.1016/j.jneuroim.2004.06.005;
RA Nelson D.A., Marriott I., Bost K.L.;
RT "Expression of hemokinin 1 mRNA by murine dendritic cells.";
RL J. Neuroimmunol. 155:94-102(2004).
RN [12] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15647454; DOI=10.1095/biolreprod.104.036814;
RA Patak E., Pinto F.M., Story M.E., Pintado C.O., Fleming A., Page N.M.,
RA Pennefather J.N., Candenas M.L.;
RT "Functional and molecular characterization of tachykinins and tachykinin
RT receptors in the mouse uterus.";
RL Biol. Reprod. 72:1125-1133(2005).
RN [13] {ECO:0000305}
RP SYNTHESIS, AND FUNCTION.
RX PubMed=16102736; DOI=10.1016/j.brainres.2005.07.020;
RA Fu C.-Y., Kong Z.-Q., Wang K.-R., Yang Q., Zhai K., Chen Q., Wang R.;
RT "Effects and mechanisms of supraspinal administration of rat/mouse
RT hemokinin-1, a mammalian tachykinin peptide, on nociception in mice.";
RL Brain Res. 1056:51-58(2005).
RN [14] {ECO:0000305}
RP SYNTHESIS, AND FUNCTION.
RX PubMed=17628523; DOI=10.1016/j.ejphar.2007.06.014;
RA Fu C.-Y., Kong Z.-Q., Long Y., Chen Q., Wang R.;
RT "Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin
RT peptide: systemic study in anesthetized rats.";
RL Eur. J. Pharmacol. 572:175-181(2007).
CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC behavioral responses, are potent vasodilators and secretagogues, and
CC contract (directly or indirectly) many smooth muscles. Hemokinin
CC induces plasma extravasation, mast cell degranulation, muscle
CC contraction, salivary secretion and scratching behavior. Increases
CC sperm motility. Induces potent analgesic effects and may play a role in
CC pain modulation. Promotes survival of bone marrow B lineage cells and
CC of cultured LPS-stimulated pre-B cells and may act as an autocrine
CC factor required for B-cell survival and proliferation. Lowers systemic
CC arterial pressure following intravenous injection. Induces interferon-
CC gamma production and may play a role in the inflammatory response.
CC Shows potent affinity and specificity for the NK-1 receptor.
CC {ECO:0000269|PubMed:11062498, ECO:0000269|PubMed:11725292,
CC ECO:0000269|PubMed:11786503, ECO:0000269|PubMed:12044836,
CC ECO:0000269|PubMed:12842130, ECO:0000269|PubMed:15153465,
CC ECO:0000269|PubMed:16102736, ECO:0000269|PubMed:17628523}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in hematopoietic cells with highest
CC levels in pre- and pro-B cells but not in later developmental stages.
CC Also detected in uterus, skeletal muscle, brain, spleen, stomach, skin
CC and lactating mammary gland and in cells of myeloid lineage including
CC dendritic and microglial cells and macrophages. In uterus, highest
CC expression is observed in non-pregnant diestrus mice and in day 5
CC pregnant mice. Compared with mice in diestrus, decreases 2.6-fold in
CC uteri from non-pregnant mice in estrus and 10.2-fold in day 17 pregnant
CC mice. Detected at sites of chronic inflammation such as granulomas.
CC {ECO:0000269|PubMed:11062498, ECO:0000269|PubMed:12383518,
CC ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:12842130,
CC ECO:0000269|PubMed:15153465, ECO:0000269|PubMed:15342200,
CC ECO:0000269|PubMed:15647454}.
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000255}.
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DR EMBL; AF235035; AAK15025.1; -; mRNA.
DR EMBL; AF515827; AAP30873.1; -; mRNA.
DR EMBL; AL627222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119426; AAI19427.1; -; mRNA.
DR CCDS; CCDS25274.1; -.
DR RefSeq; NP_444323.1; NM_053093.1.
DR AlphaFoldDB; Q99N14; -.
DR STRING; 10090.ENSMUSP00000021242; -.
DR PaxDb; Q99N14; -.
DR PRIDE; Q99N14; -.
DR Antibodypedia; 68331; 66 antibodies from 12 providers.
DR DNASU; 93670; -.
DR Ensembl; ENSMUST00000021242; ENSMUSP00000021242; ENSMUSG00000020872.
DR GeneID; 93670; -.
DR KEGG; mmu:93670; -.
DR UCSC; uc007lac.1; mouse.
DR CTD; 255061; -.
DR MGI; MGI:1931130; Tac4.
DR VEuPathDB; HostDB:ENSMUSG00000020872; -.
DR eggNOG; ENOG502TEEE; Eukaryota.
DR GeneTree; ENSGT00390000015220; -.
DR HOGENOM; CLU_133899_0_0_1; -.
DR InParanoid; Q99N14; -.
DR OMA; YQLGRIV; -.
DR OrthoDB; 1512743at2759; -.
DR PhylomeDB; Q99N14; -.
DR TreeFam; TF338519; -.
DR BioGRID-ORCS; 93670; 6 hits in 71 CRISPR screens.
DR PRO; PR:Q99N14; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q99N14; protein.
DR Bgee; ENSMUSG00000020872; Expressed in lip and 24 other tissues.
DR Genevisible; Q99N14; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0048018; F:receptor ligand activity; IDA:UniProtKB.
DR GO; GO:0005102; F:signaling receptor binding; IDA:MGI.
DR GO; GO:0031837; F:substance K receptor binding; IPI:UniProtKB.
DR GO; GO:0031835; F:substance P receptor binding; IPI:UniProtKB.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR GO; GO:1904057; P:negative regulation of sensory perception of pain; ISO:MGI.
DR GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISO:MGI.
DR GO; GO:0046878; P:positive regulation of saliva secretion; IDA:MGI.
DR GO; GO:1904058; P:positive regulation of sensory perception of pain; ISO:MGI.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISO:MGI.
DR GO; GO:0007217; P:tachykinin receptor signaling pathway; IDA:UniProtKB.
DR InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR PROSITE; PS00267; TACHYKININ; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Hypotensive agent;
KW Mast cell degranulation; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT PROPEP 17..54
FT /evidence="ECO:0000250"
FT /id="PRO_0000320014"
FT PEPTIDE 56..66
FT /note="Hemokinin"
FT /evidence="ECO:0000269|PubMed:11062498"
FT /id="PRO_0000320015"
FT PROPEP 69..128
FT /evidence="ECO:0000250"
FT /id="PRO_0000320016"
FT REGION 96..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 66
FT /note="Methionine amide"
FT /evidence="ECO:0000255, ECO:0000303|PubMed:11062498"
SQ SEQUENCE 128 AA; 13937 MW; FED91DCAB39CB444 CRC64;
MLPLLALLLL IGPSVCTTAG DREELAFGAE AESWVTVNLK GIPVPSIELK LQELKRSRTR
QFYGLMGKRV GGYQLGRIVQ DLLGTRGLSI EGTCRQAASQ QRARPGAVTR ESLQSREEDE
APLTTSNV
