ID   TKN4_RABIT              Reviewed;         100 AA.
AC   Q6ECK6; Q6ECK5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Tachykinin-4;
DE   AltName: Full=Preprotachykinin-C;
DE            Short=PPT-C;
DE   Contains:
DE     RecName: Full=Endokinin-1;
DE   Contains:
DE     RecName: Full=Endokinin-2;
DE   Flags: Precursor;
GN   Name=TAC4 {ECO:0000312|EMBL:AAS46598.1};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1] {ECO:0000312|EMBL:AAS46598.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA   Page N.M.;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Alpha;
CC         IsoId=Q6ECK6-1; Sequence=Displayed;
CC       Name=2; Synonyms=Beta;
CC         IsoId=Q6ECK6-2; Sequence=VSP_052682;
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000255}.
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DR   EMBL; AY471576; AAS46598.1; -; mRNA.
DR   EMBL; AY471577; AAS46599.1; -; mRNA.
DR   RefSeq; NP_001075634.1; NM_001082165.1. [Q6ECK6-1]
DR   AlphaFoldDB; Q6ECK6; -.
DR   STRING; 9986.ENSOCUP00000019855; -.
DR   Ensembl; ENSOCUT00000024419; ENSOCUP00000019855; ENSOCUG00000023306. [Q6ECK6-1]
DR   GeneID; 100008925; -.
DR   KEGG; ocu:100008925; -.
DR   CTD; 255061; -.
DR   eggNOG; ENOG502TEEE; Eukaryota.
DR   GeneTree; ENSGT00390000015220; -.
DR   HOGENOM; CLU_133899_1_0_1; -.
DR   InParanoid; Q6ECK6; -.
DR   OMA; LMELFVC; -.
DR   OrthoDB; 1512743at2759; -.
DR   TreeFam; TF338519; -.
DR   Proteomes; UP000001811; Chromosome 19.
DR   Bgee; ENSOCUG00000023306; Expressed in prefrontal cortex and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:1902093; P:positive regulation of flagellated sperm motility; IEA:Ensembl.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..55
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000320017"
FT   PEPTIDE         58..67
FT                   /note="Endokinin-1"
FT                   /evidence="ECO:0000312|EMBL:AAS46598.1"
FT                   /id="PRO_5000092471"
FT   PEPTIDE         71..82
FT                   /note="Endokinin-2"
FT                   /evidence="ECO:0000312|EMBL:AAS46598.1"
FT                   /id="PRO_5000092472"
FT   PROPEP          85..100
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000320018"
FT   REGION          80..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         74..91
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_052682"
SQ   SEQUENCE   100 AA;  10487 MW;  A22C9F1D1F456BE7 CRC64;
     MPSSVTLLLL MGLSVCTSAE DGGEEQTLGA EAGPWVTVTL EAGAVASIQL QLQEVKRGKA
     SQFFGLMGKR VRGYQMGQRG LLGRRASSTK GSVDEDQGAE