ID   TKNA_CHICK              Reviewed;          11 AA.
AC   P19850;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   11-DEC-2019, entry version 68.
DE   RecName: Full=Substance P;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-11.
RC   TISSUE=Intestine;
RX   PubMed=2452461; DOI=10.1016/0167-0115(88)90050-x;
RA   Conlon J.M., Katsoulis S., Schmidt W.E., Thim L.;
RT   "[Arg3]substance P and neurokinin A from chicken small intestine.";
RL   Regul. Pept. 20:171-180(1988).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; JN0023; JN0023.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   InterPro; IPR008215; Tachykinin_dom.
DR   Pfam; PF02202; Tachykinin; 1.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Neurotransmitter;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..11
FT                   /note="Substance P"
FT                   /id="PRO_0000044421"
FT   MOD_RES         11
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:2452461"
SQ   SEQUENCE   11 AA;  1377 MW;  21487FE3C9D6C6C7 CRC64;
     RPRPQQFFGL M