ID   TKNA_GADMO              Reviewed;          11 AA.
AC   P28498;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Substance P;
OS   Gadus morhua (Atlantic cod).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX   NCBI_TaxID=8049;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=1376687; DOI=10.1111/j.1432-1033.1992.tb16971.x;
RA   Jensen J., Conlon J.M.;
RT   "Substance-P-related and neurokinin-A-related peptides from the brain of
RT   the cod and trout.";
RL   Eur. J. Biochem. 206:659-664(1992).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S23306; S23306.
DR   Proteomes; UP000694546; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Neurotransmitter;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..11
FT                   /note="Substance P"
FT                   /id="PRO_0000044422"
FT   MOD_RES         11
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   11 AA;  1315 MW;  214860D759D6C6C7 CRC64;
     KPRPQQFIGL M