ID   TKNA_LITCT              Reviewed;          11 AA.
AC   P22688;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   26-FEB-2020, entry version 70.
DE   RecName: Full=Ranatachykinin-A;
DE            Short=RTK A;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   PROTEIN SEQUENCE, SYNTHESIS, AND AMIDATION AT MET-11.
RC   TISSUE=Brain, and Intestine;
RX   PubMed=2043143; DOI=10.1016/0006-291x(91)92024-e;
RA   Kozawa H., Hino J., Minamino N., Kangawa K., Matsuo H.;
RT   "Isolation of four novel tachykinins from frog (Rana catesbeiana) brain and
RT   intestine.";
RL   Biochem. Biophys. Res. Commun. 177:588-595(1991).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Intestine;
RX   PubMed=8210506; DOI=10.1016/0167-0115(93)90016-2;
RA   Kangawa K., Kozawa H., Hino J., Minamino N., Matsuo H.;
RT   "Four novel tachykinins in frog (Rana catesbeiana) brain and intestine.";
RL   Regul. Pept. 46:81-88(1993).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A61033; A61033.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   InterPro; IPR008215; Tachykinin_dom.
DR   Pfam; PF02202; Tachykinin; 1.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..11
FT                   /note="Ranatachykinin-A"
FT                   /id="PRO_0000044405"
FT   MOD_RES         11
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:2043143"
SQ   SEQUENCE   11 AA;  1311 MW;  200D60CC59D40AB7 CRC64;
     KPSPDRFYGL M