ID   TKNA_SCYCA              Reviewed;          11 AA.
AC   P41333;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   11-DEC-2019, entry version 50.
DE   RecName: Full=Substance P;
OS   Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=7830;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-11.
RC   TISSUE=Brain;
RX   PubMed=7685693; DOI=10.1111/j.1432-1033.1993.tb17943.x;
RA   Waugh D., Wang Y., Hazon N., Balment R.J., Conlon J.M.;
RT   "Primary structures and biological activities of substance-P-related
RT   peptides from the brain of the dogfish, Scyliorhinus canicula.";
RL   Eur. J. Biochem. 214:469-474(1993).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   PIR; S33300; S33300.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Neurotransmitter;
KW   Secreted.
FT   PEPTIDE         1..11
FT                   /note="Substance P"
FT                   /id="PRO_0000044424"
FT   MOD_RES         11
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:7685693"
SQ   SEQUENCE   11 AA;  1278 MW;  214860DEC9D6D867 CRC64;
     KPRPGQFFGL M