BSMA_ECOLI
ID BSMA_ECOLI Reviewed; 109 AA.
AC P39297; Q2M6B6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Lipoprotein BsmA;
DE AltName: Full=Biofilm stress and motility protein;
DE Flags: Precursor;
GN Name=bsmA; Synonyms=yjfO; OrderedLocusNames=b4189, JW5743;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=19833773; DOI=10.1099/mic.0.031468-0;
RA Weber M.M., French C.L., Barnes M.B., Siegele D.A., McLean R.J.;
RT "A previously uncharacterized gene, yjfO (bsmA), influences Escherichia
RT coli biofilm formation and stress response.";
RL Microbiology 156:139-147(2010).
CC -!- FUNCTION: Involved in protection of biofilms against oxidative stress.
CC {ECO:0000269|PubMed:19833773}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- INDUCTION: Up-regulated in biofilms. {ECO:0000269|PubMed:19833773}.
CC -!- DISRUPTION PHENOTYPE: Mutant exhibits reduced microcolony formation and
CC greatly enhanced flagellar motility. Biofilms from the mutant strain
CC are less able to resist acid and peroxide stresses.
CC {ECO:0000269|PubMed:19833773}.
CC -!- SIMILARITY: Belongs to the BhsA/McbA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA97085.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U14003; AAA97085.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC77146.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE78190.1; -; Genomic_DNA.
DR PIR; S56414; S56414.
DR RefSeq; NP_418610.4; NC_000913.3.
DR RefSeq; WP_000254633.1; NZ_LN832404.1.
DR AlphaFoldDB; P39297; -.
DR SMR; P39297; -.
DR BioGRID; 4263355; 8.
DR STRING; 511145.b4189; -.
DR PaxDb; P39297; -.
DR PRIDE; P39297; -.
DR DNASU; 948708; -.
DR EnsemblBacteria; AAC77146; AAC77146; b4189.
DR EnsemblBacteria; BAE78190; BAE78190; BAE78190.
DR GeneID; 948708; -.
DR KEGG; ecj:JW5743; -.
DR KEGG; eco:b4189; -.
DR PATRIC; fig|1411691.4.peg.2512; -.
DR EchoBASE; EB2382; -.
DR eggNOG; COG3650; Bacteria.
DR HOGENOM; CLU_144052_1_0_6; -.
DR OMA; PGQWYSQ; -.
DR PhylomeDB; P39297; -.
DR BioCyc; EcoCyc:G7852-MON; -.
DR PRO; PR:P39297; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR GO; GO:0044010; P:single-species biofilm formation; IEP:EcoCyc.
DR Gene3D; 3.30.1660.10; -; 1.
DR InterPro; IPR025543; Dodecin-like.
DR InterPro; IPR036275; YdgH-like_sf.
DR InterPro; IPR010854; YdgH/BhsA/McbA-like_dom.
DR Pfam; PF07338; DUF1471; 1.
DR SUPFAM; SSF159871; SSF159871; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW Signal; Stress response.
FT SIGNAL 1..24
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 25..109
FT /note="Lipoprotein BsmA"
FT /id="PRO_0000018058"
FT LIPID 25
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 25
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 109 AA; 12038 MW; EBF2229815CEDEDE CRC64;
MVSRKRNSVI YRFASLLLVL MLSACSALQG TPQPAPPVTD HPQEIRRDQT QGLQRIGSVS
TMVRGSPDDA LAEIKAKAVA AKADYYVVVM VDETIVTGQW YSQAILYRK
