ID   TKNG_ONCMY              Reviewed;          21 AA.
AC   Q9PRZ3;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Neuropeptide gamma {ECO:0000303|PubMed:7694488};
DE            Short=NPgamma {ECO:0000303|PubMed:7694488};
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Intestine {ECO:0000269|PubMed:7694488};
RX   PubMed=7694488; DOI=10.1152/ajpregu.1993.265.4.r804;
RA   Jensen J., Olson K.R., Conlon J.M.;
RT   "Primary structures and effects on gastrointestinal motility of tachykinins
RT   from the rainbow trout.";
RL   Am. J. Physiol. 265:R804-R810(1993).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND SYNTHESIS OF 1-21.
RX   PubMed=16316456; DOI=10.1111/j.1399-3011.2005.00308.x;
RA   Kim E.J., Kim C.H., Seo J.K., Go H.J., Lee S., Takano Y., Chung J.K.,
RA   Hong Y.K., Park N.G.;
RT   "Structure-activity relationship of neuropeptide gamma derived from
RT   mammalian and fish.";
RL   J. Pept. Res. 66:395-403(2005).
RN   [3] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=17766308; DOI=10.1242/jeb.006106;
RA   Le Mevel J.C., Lancien F., Mimassi N., Conlon J.M.;
RT   "Ventilatory and cardiovascular actions of centrally administered trout
RT   tachykinins in the unanesthetized trout.";
RL   J. Exp. Biol. 210:3301-3310(2007).
RN   [4] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=19456365; DOI=10.1111/j.1749-6632.2009.04428.x;
RA   Lancien F., Mimassi N., Conlon J.M., Le Mevel J.C.;
RT   "Central effects of trout tachykinins on heart rate variability in trout.";
RL   Ann. N. Y. Acad. Sci. 1163:379-382(2009).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, and contract (directly or indirectly) many smooth
CC       muscles. Is a potent vasoconstrictor and secretagogue that plays a
CC       regulatory role in the central control of ventilation, in particular,
CC       the heart rate variability (HRV). {ECO:0000269|PubMed:16316456,
CC       ECO:0000269|PubMed:17766308, ECO:0000269|PubMed:19456365,
CC       ECO:0000269|PubMed:7694488}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P25421}.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000255}.
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DR   AlphaFoldDB; Q9PRZ3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0002027; P:regulation of heart rate; IDA:UniProtKB.
DR   GO; GO:0006940; P:regulation of smooth muscle contraction; IDA:UniProtKB.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Neurotransmitter;
KW   Secreted.
FT   PEPTIDE         1..21
FT                   /note="Neuropeptide gamma"
FT                   /evidence="ECO:0000269|PubMed:7694488"
FT                   /id="PRO_0000423411"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         21
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P25421"
SQ   SEQUENCE   21 AA;  2385 MW;  080CAC6E36997A29 CRC64;
     SSANPQITRK RHKINSFVGL M