TKNK_BOVIN
ID TKNK_BOVIN Reviewed; 126 AA.
AC P08858;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Tachykinin-3;
DE Contains:
DE RecName: Full=Neurokinin-B;
DE Short=NKB;
DE AltName: Full=Neuromedin-K;
DE Flags: Precursor;
GN Name=TAC3; Synonyms=NKNB;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3462746; DOI=10.1073/pnas.83.18.7074;
RA Kotani H., Hoshimaru M., Nawa H., Nakanishi S.;
RT "Structure and gene organization of bovine neuromedin K precursor.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:7074-7078(1986).
CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC behavioral responses, are potent vasodilators and secretagogues, and
CC contract (directly or indirectly) many smooth muscles. Is a critical
CC central regulator of gonadal function (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR EMBL; M14351; AAA30723.1; -; Genomic_DNA.
DR EMBL; M14347; AAA30723.1; JOINED; Genomic_DNA.
DR EMBL; M14348; AAA30723.1; JOINED; Genomic_DNA.
DR EMBL; M14349; AAA30723.1; JOINED; Genomic_DNA.
DR EMBL; M14350; AAA30723.1; JOINED; Genomic_DNA.
DR PIR; A25905; A25905.
DR RefSeq; NP_851360.1; NM_181017.2.
DR RefSeq; XP_010803423.1; XM_010805121.2.
DR AlphaFoldDB; P08858; -.
DR STRING; 9913.ENSBTAP00000029067; -.
DR PaxDb; P08858; -.
DR Ensembl; ENSBTAT00000029067; ENSBTAP00000029067; ENSBTAG00000021807.
DR GeneID; 281513; -.
DR KEGG; bta:281513; -.
DR CTD; 6866; -.
DR VEuPathDB; HostDB:ENSBTAG00000021807; -.
DR VGNC; VGNC:35556; TAC3.
DR eggNOG; ENOG502S4B9; Eukaryota.
DR GeneTree; ENSGT00390000000335; -.
DR HOGENOM; CLU_138627_0_0_1; -.
DR InParanoid; P08858; -.
DR OMA; GGHNKKD; -.
DR OrthoDB; 1552376at2759; -.
DR TreeFam; TF337038; -.
DR Reactome; R-BTA-380095; Tachykinin receptors bind tachykinins.
DR Reactome; R-BTA-416476; G alpha (q) signalling events.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000021807; Expressed in uterine cervix and 70 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045777; P:positive regulation of blood pressure; IBA:GO_Central.
DR GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR003635; Neurokinin-B/TAC3.
DR InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR PANTHER; PTHR15536; PTHR15536; 1.
DR Pfam; PF03823; Neurokinin_B; 1.
DR PIRSF; PIRSF001843; Neurokinin; 1.
DR PRINTS; PR01828; NEUROKININB.
DR PROSITE; PS00267; TACHYKININ; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..83
FT /id="PRO_0000033562"
FT PEPTIDE 86..95
FT /note="Neurokinin-B"
FT /id="PRO_0000033563"
FT PROPEP 99..126
FT /id="PRO_0000033564"
FT REGION 102..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 95
FT /note="Methionine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 126 AA; 13871 MW; 446EF433498EC059 CRC64;
MRSTLLFAVI LALSSARSLG AVCEESQEQV VPGGGHSKKD SNLYQLPPSL LRRLYDSRVV
SLDGLLKMLS KASVGPKESP LPQKRDMHDF FVGLMGKRNL QPDTPVDINQ ENIPSFGTFK
YPPSVE
