TKNK_MOUSE
ID TKNK_MOUSE Reviewed; 116 AA.
AC P55099; Q9QXS9;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Tachykinin-3;
DE AltName: Full=Neurokinin B-like protein Zneurok1;
DE AltName: Full=Preprotachykinin-B;
DE Short=PPT-B;
DE Contains:
DE RecName: Full=Neurokinin-B;
DE Short=NKB;
DE AltName: Full=Neuromedin-K;
DE Flags: Precursor;
GN Name=Tac3; Synonyms=Nknb, Tac2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR; TISSUE=Brain;
RA Kako K., Munekata E., Hosaka M., Murakami K., Nakayama K.;
RT "Cloning and sequence analysis of mouse cDNAs encoding preprotachykinin A
RT and B.";
RL Biomed. Res. 14:253-259(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.;
RT "Mus musculus homolog of neurokinin B.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC behavioral responses, are potent vasodilators and secretagogues, and
CC contract (directly or indirectly) many smooth muscles. Is a critical
CC central regulator of gonadal function (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR EMBL; D14423; BAA03316.1; -; mRNA.
DR EMBL; AF186116; AAF01434.1; -; mRNA.
DR EMBL; BC051476; AAH51476.1; -; mRNA.
DR CCDS; CCDS24248.1; -.
DR PIR; I65342; I65342.
DR RefSeq; NP_001186900.1; NM_001199971.1.
DR RefSeq; NP_033338.2; NM_009312.2.
DR AlphaFoldDB; P55099; -.
DR STRING; 10090.ENSMUSP00000136622; -.
DR PhosphoSitePlus; P55099; -.
DR PaxDb; P55099; -.
DR PRIDE; P55099; -.
DR ProteomicsDB; 259396; -.
DR Antibodypedia; 28422; 267 antibodies from 28 providers.
DR DNASU; 21334; -.
DR Ensembl; ENSMUST00000026466; ENSMUSP00000026466; ENSMUSG00000025400.
DR Ensembl; ENSMUST00000179960; ENSMUSP00000136622; ENSMUSG00000025400.
DR GeneID; 21334; -.
DR KEGG; mmu:21334; -.
DR UCSC; uc007hkj.2; mouse.
DR CTD; 21334; -.
DR MGI; MGI:98476; Tac2.
DR VEuPathDB; HostDB:ENSMUSG00000025400; -.
DR eggNOG; ENOG502S4B9; Eukaryota.
DR GeneTree; ENSGT00390000000335; -.
DR HOGENOM; CLU_138627_0_0_1; -.
DR InParanoid; P55099; -.
DR OMA; GGHNKKD; -.
DR OrthoDB; 1552376at2759; -.
DR PhylomeDB; P55099; -.
DR TreeFam; TF337038; -.
DR Reactome; R-MMU-380095; Tachykinin receptors bind tachykinins.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 21334; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Tac2; mouse.
DR PRO; PR:P55099; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P55099; protein.
DR Bgee; ENSMUSG00000025400; Expressed in gastrula and 66 other tissues.
DR Genevisible; P55099; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0031836; F:neuromedin K receptor binding; ISO:MGI.
DR GO; GO:0031837; F:substance K receptor binding; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISO:MGI.
DR GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR003635; Neurokinin-B/TAC3.
DR InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR PANTHER; PTHR15536; PTHR15536; 1.
DR Pfam; PF03823; Neurokinin_B; 1.
DR PIRSF; PIRSF001843; Neurokinin; 1.
DR PRINTS; PR01828; NEUROKININB.
DR PROSITE; PS00267; TACHYKININ; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..79
FT /id="PRO_0000033568"
FT PEPTIDE 82..91
FT /note="Neurokinin-B"
FT /id="PRO_0000033569"
FT PROPEP 95..116
FT /id="PRO_0000033570"
FT REGION 93..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 91
FT /note="Methionine amide"
FT /evidence="ECO:0000250"
FT CONFLICT 28
FT /note="G -> E (in Ref. 1; BAA03316)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 116 AA; 12737 MW; BD4C8B171C2213CC CRC64;
MRSAMLFAAV LALSLAWTFG AVCEEPQGQG GRLSKDSDLY QLPPSLLRRL YDSRPVSLEG
LLKVLSKASV GPKETSLPQK RDMHDFFVGL MGKRNSQPDT PTDVVEENTP SFGILK
