ID   TKNK_PIG                Reviewed;         126 AA.
AC   P67934; P01292; Q5UAF7;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Neurokinin-B;
DE            Short=NKB;
DE   AltName: Full=Neuromedin-K;
DE   Flags: Precursor;
GN   Name=TAC3; Synonyms=NKNB;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=15670142; DOI=10.1111/j.1365-2052.2004.01227.x;
RA   Li S.J., Zhao S.H., Tuggle C.K.;
RT   "Somatic cell hybrid and RH mapping of the tachykinin 3 gene to porcine
RT   chromosome 5.";
RL   Anim. Genet. 36:90-91(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 86-95, AND AMIDATION AT MET-95.
RC   TISSUE=Spinal cord;
RX   PubMed=6576785; DOI=10.1016/0006-291x(83)90813-6;
RA   Kangawa K., Minamino N., Fukuda A., Matsuo H.;
RT   "Neuromedin K: a novel mammalian tachykinin identified in porcine spinal
RT   cord.";
RL   Biochem. Biophys. Res. Commun. 114:533-540(1983).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles. Is a critical
CC       central regulator of gonadal function (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   EMBL; AY758208; AAV32522.1; -; Genomic_DNA.
DR   EMBL; AY769936; AAV37188.1; -; mRNA.
DR   PIR; A01560; SPPGNK.
DR   RefSeq; NP_001007197.1; NM_001007196.1.
DR   AlphaFoldDB; P67934; -.
DR   STRING; 9823.ENSSSCP00000000446; -.
DR   PaxDb; P67934; -.
DR   PRIDE; P67934; -.
DR   Ensembl; ENSSSCT00000000452; ENSSSCP00000000446; ENSSSCG00000000418.
DR   Ensembl; ENSSSCT00045050255; ENSSSCP00045034974; ENSSSCG00045029463.
DR   Ensembl; ENSSSCT00050010454; ENSSSCP00050004483; ENSSSCG00050007642.
DR   Ensembl; ENSSSCT00055030644; ENSSSCP00055024396; ENSSSCG00055015473.
DR   Ensembl; ENSSSCT00065021846; ENSSSCP00065008862; ENSSSCG00065016431.
DR   Ensembl; ENSSSCT00070058751; ENSSSCP00070049975; ENSSSCG00070029266.
DR   GeneID; 492314; -.
DR   KEGG; ssc:492314; -.
DR   CTD; 6866; -.
DR   VGNC; VGNC:93698; TAC3.
DR   eggNOG; ENOG502S4B9; Eukaryota.
DR   GeneTree; ENSGT00390000000335; -.
DR   InParanoid; P67934; -.
DR   OMA; GGHNKKD; -.
DR   OrthoDB; 1552376at2759; -.
DR   Proteomes; UP000008227; Chromosome 5.
DR   Proteomes; UP000314985; Chromosome 5.
DR   Bgee; ENSSSCG00000000418; Expressed in ileum and 10 other tissues.
DR   ExpressionAtlas; P67934; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045777; P:positive regulation of blood pressure; IBA:GO_Central.
DR   GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR003635; Neurokinin-B/TAC3.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PANTHER; PTHR15536; PTHR15536; 1.
DR   Pfam; PF03823; Neurokinin_B; 1.
DR   PIRSF; PIRSF001843; Neurokinin; 1.
DR   PRINTS; PR01828; NEUROKININB.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..83
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000397864"
FT   PEPTIDE         86..95
FT                   /note="Neurokinin-B"
FT                   /id="PRO_0000044428"
FT   PROPEP          99..126
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000397865"
FT   REGION          101..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         95
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:6576785"
SQ   SEQUENCE   126 AA;  13651 MW;  9B06D7A11CE61C74 CRC64;
     MRSTLLFVAI LALSLAWSLG AACEESQEQL MPGGGHSKKD SNLYQLPSSL LRRLCDSRSI
     SLDGLLKMLS KASVGAKESS LPQKRDMHDF FVGLMGKRNI QPGTPVDGNQ ENAPSLGTFK
     YPPSVE