ID   TKNK_RAT                Reviewed;         116 AA.
AC   P08435;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Tachykinin-3;
DE   Contains:
DE     RecName: Full=Neurokinin-B;
DE              Short=NKB;
DE     AltName: Full=Neuromedin-K;
DE   Flags: Precursor;
GN   Name=Tac3; Synonyms=Nknb, Tac2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3479225; DOI=10.1016/0169-328x(87)90031-3;
RA   Bonner T.I., Affolter H.-U., Young A.C., Young W.S. III;
RT   "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B.";
RL   Brain Res. 388:243-249(1987).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles. Is a critical
CC       central regulator of gonadal function (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   EMBL; M16410; AAA41711.1; -; mRNA.
DR   PIR; A43779; A43779.
DR   RefSeq; NP_062035.1; NM_019162.2.
DR   AlphaFoldDB; P08435; -.
DR   SMR; P08435; -.
DR   STRING; 10116.ENSRNOP00000005679; -.
DR   PaxDb; P08435; -.
DR   GeneID; 29191; -.
DR   KEGG; rno:29191; -.
DR   CTD; 6866; -.
DR   RGD; 3809; Tac3.
DR   eggNOG; ENOG502S4B9; Eukaryota.
DR   InParanoid; P08435; -.
DR   OrthoDB; 1552376at2759; -.
DR   PhylomeDB; P08435; -.
DR   Reactome; R-RNO-380095; Tachykinin receptors bind tachykinins.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   PRO; PR:P08435; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045777; P:positive regulation of blood pressure; IDA:RGD.
DR   GO; GO:0043278; P:response to morphine; IEP:RGD.
DR   GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR003635; Neurokinin-B/TAC3.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PANTHER; PTHR15536; PTHR15536; 1.
DR   Pfam; PF03823; Neurokinin_B; 1.
DR   PIRSF; PIRSF001843; Neurokinin; 1.
DR   PRINTS; PR01828; NEUROKININB.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..79
FT                   /id="PRO_0000033571"
FT   PEPTIDE         82..91
FT                   /note="Neurokinin-B"
FT                   /id="PRO_0000033572"
FT   PROPEP          95..116
FT                   /id="PRO_0000033573"
FT   REGION          92..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         91
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   116 AA;  12660 MW;  C73EC67F2BAF8C8C CRC64;
     MRSAMLFAAV LALSLAWTFG AACEEPQEQG GRLSKDSDLS LLPPPLLRRL YDSRSISLEG
     LLKVLSKASV GPKETSLPQK RDMHDFFVGL MGKRNSQPDT PADVVEENTP SFGVLK